Brittany M Wilson, Frank C Ko, Meghan M Moran, Amal Adra, Martin B Rasmussen, Thomas Thymann, Per T Sangild, D Rick Sumner
Preterm birth affects about 10% of all live births with many resultant health challenges, including metabolic bone disease of prematurity (MBDP) which is characterized by elevated alkaline phosphatase, suppressed phosphate, and deficient skeletal development. Because of the lack of an animal model, very little is known about bone structure, strength, and quality after preterm birth. This study investigated the utility of a pig model to replicate clinical features of preterm birth, including MBDP, and sought to determine if early postnatal administration of insulin-like growth factor (IGF)-1 was an effective treatment...
April 24, 2024: Journal of Bone and Mineral Research