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https://www.readbyqxmd.com/read/28821921/anti-nociceptive-effect-of-stigmasterol-in-mouse-models-of-acute-and-chronic-pain
#1
Cristiani Isabel Banderó Walker, Sara Marchesan Oliveira, Raquel Tonello, Mateus Fortes Rossato, Evelyne da Silva Brum, Juliano Ferreira, Gabriela Trevisan
Stigmasterol is a common sterol found in plants, but the anti-nociceptive effect of this compound and its mechanism of action are not fully explored. Thus, in the present study, the anti-nociceptive effect of stigmasterol was investigated in acute and chronic models of pain and its mechanism of action. We used adult male albino Swiss mice (25-35 g) to observe the anti-nociceptive effect of stigmasterol in acetic-acid writhing test or in complete Freund's adjuvant injection, surgical incision in hind paw, or partial sciatic nerve ligation...
August 18, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28819596/complex-regional-pain-syndrome-following-an-episode-of-herpes-zoster-a-case-report
#2
Christopher E Marrero, Neuyen Mclean, Keyana Varnado
INTRODUCTION: Complex regional pain syndrome (CRPS) is characterized by searing pain, hyperalgesia, edema, allodynia, and skin changes. CRPS may be difficult to diagnose and to treat given poorly understood mechanisms as well as its presentation of symptoms that may mimic common conditions such as joint stiffness in this condition as well as rheumatoid arthritis. CASE REPORT: A 71-year-old female presented to our clinic post shingles of the right upper extremity...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28812173/melatonin-attenuates-pain-hypersensitivity-and-decreases-astrocyte-mediated-spinal-neuroinflammation-in-a-rat-model-of-oxaliplatin-induced-pain
#3
Ye-Song Wang, Yuan-Yuan Li, Wei Cui, Li-Bin Li, Zhao-Cai Zhang, Bao-Ping Tian, Gen-Sheng Zhang
Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and anti-allodynia effects in both preclinical and clinical studies. In the present study, we investigated the role of systemic administration of melatonin on oxaliplatin-induced pain. Intraperitoneal (i.p.) injection with oxaliplatin induced significantly mechanical allodynia and thermal hyperalgesia. Melatonin (i.p.) significantly alleviated mechanical allodynia and thermal hyperalgesia in the oxaliplatin but not sham-treated rats...
August 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28806211/the-opiorphin-analog-str-324-decreases-sensory-hypersensitivity-in-a-rat-model-of-neuropathic-pain
#4
Alain Van Elstraete, Philippe Sitbon, Leila Hamdi, Victor Juarez-Perez, Jean-Xavier Mazoit, Dan Benhamou, Catherine Rougeot
BACKGROUND: Neuropathic pain represents a therapeutic challenge, and treatments with increased efficacy and tolerability still need to be developed. Opiorphin protects endogenous enkephalins from degradation, potentiating enkephalin-dependent analgesia via the activation of opioid pathways. Enkephalins are natural ligands of opioid receptors, with strong affinity for δ-opioid receptors. Expression of functional δ-opioid receptors increases in sensory neurons after peripheral nerve injury in neuropathic pain models...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28801728/arctium-minus-crude-extract-presents-antinociceptive-effect-in-a-mice-acute-gout-attack-model
#5
Susana Paula Moreira Fischer, Indiara Brusco, Camila Camponogara, Mariana Piana, Henrique Faccin, Luciana Assis Gobo, Leandro Machado de Carvalho, Sara Marchesan Oliveira
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g)...
August 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28801619/repetitive-motor-cortex-stimulation-reinforces-the-pain-modulation-circuits-of-peripheral-neuropathic-pain
#6
Myeounghoon Cha, Sun Woo Um, Minjee Kwon, Taick Sang Nam, Bae Hwan Lee
Recent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism of the effects of MCS using an animal model of neuropathic pain. After 10 daily sessions of MCS, repetitive MCS reduced mechanical allodynia and contributed to neuronal changes in the anterior cingulate cortex (ACC). Interestingly, inhibition of protein kinase M zeta (PKMζ), a regulator of synaptic plasticity, in the ACC blocked the effects of repetitive MCS...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798688/establishment-and-characterization-of-a-novel-rat-model-of-mechanical-low-back-pain-using-behavioral-pharmacologic-and-histologic-methods
#7
Arjun Muralidharan, Thomas S W Park, John T Mackie, Luiz G S Gimenez, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith
Chronic low back pain (LBP), the leading cause of disability globally, is notoriously difficult to treat. Most rodent models of LBP mimic lumbar radicular pain rather than mechanical LBP. Here, we describe establishment of a new rat model of mechanical LBP that is devoid of a neuropathic component. Groups of adult male Sprague Dawley rats were anesthetized and their lumbar L4/L5 and L5/L6 intervertebral disks (IVDs) were punctured (0.5 mm outer diameter, 2mm-deep) 5 (LPB-5X), or 10 (LBP-10X) times per disk...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28795616/the-effects-of-glial-cell-line-derived-neurotrophic-factor-after-spinal-cord-injury
#8
Konstantin Rosich, Bishoy Hanna, Rami K Ibrahim, Daniel Joseph Hellenbrand, Amgad Hanna
Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. The use of growth factors is a potential treatment for reducing secondary damage, promoting axon growth and restoring some of the lost function after SCI. Glial cell line-derived neurotrophic factor (GDNF) is an important growth factor, because it can affect both neurons and support cells. Here, we give an in depth review of the previously published literature where GDNF was used to treat SCI. The effects of GDNF have been shown to decrease lesion size, improve allodynia, and regenerate axons in the central nervous system and peripheral nervous system...
August 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28795389/anti-nociceptive-effect-of-patchouli-alcohol-involving-attenuation-of-cyclooxygenase-2-and-modulation-of-mu-opioid-receptor
#9
Xuan Yu, Xin-Pei Wang, Xiao-Jin Yan, Jing-Fei Jiang, Fan Lei, Dong-Ming Xing, Yue-Ying Guo, Li-Jun Du
OBJECTIVE: To explore the anti-nociceptive effect of patchouli alcohol (PA), the essential oil isolated from Pogostemon cablin (Blanco) Bent, and determine the mechanism in molecular levels. METHODS: The acetic acid-induced writhing test and formalin-induced plantar injection test in mice were employed to confifirm the effect in vivo. Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR). Cyclooxygenase 2 (COX2) and MOR of mouse brain were expressed for determination of PA's target...
August 9, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28780471/neuropathic-pain-attenuating-effects-of-perampanel-in-an-experimental-model-of-chronic-constriction-injury-in-rats
#10
Ravneet Kaur Khangura, Anjana Bali, Gunjanpreet Kaur, Nirmal Singh, Amteshwar Singh Jaggi
The present study explores the pain attenuating effect of perampanel, AMPA receptor antagonist, in chronic constriction injury-induced neuropathic pain. Chronic Constriction Injury was performed by putting four loose ligatures around the sciatic nerve. Pain was assessed by determining mechanical hyperalgesia, cold allodynia and heat hyperalgesia on 7th and 14th day post surgery. Perampanel (3mg and 6mg/kg, p.o.) was administered 30min before pain assessment test on 14th day post-surgery. CCI led to significant development of pain and peak symptoms were observed on 14th day...
August 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28777065/possible-role-of-antioxidative-capacity-of-epigallocatechin-3-gallate-treatment-in-morphological-and-neurobehavioral-recovery-after-sciatic-nerve-crush-injury
#11
Waleed M Renno, Ludmil Benov, Khalid M Khan
OBJECTIVE This study examined the capacity of the major polyphenolic green tea extract (-)-epigallocatechin-3-gallate (EGCG) to suppress oxidative stress and stimulate the recovery and prompt the regeneration of sciatic nerve after crush injury. METHODS Adult male Wistar rats were randomly assigned to one of 4 groups: 1) Naïve, 2) Sham (sham injury, surgical control group), 3) Crush (sciatic nerve crush injury treated with saline), and 4) Crush+EGCG (sciatic nerve crush injury treated with intraperitoneally administered EGCG, 50 mg/kg)...
August 4, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28776762/vein-wrapping-facilitates-basic-fibroblast-growth-factor-induced-heme-oxygenase-1-expression-following-chronic-nerve-constriction-injury
#12
Naoya Hirosawa, Kentaro Uchida, Kazuki Kuniyoshi, Kenichi Murakami, Gen Inoue, Masayuki Miyagi, Yusuke Matsuura, Sumihisa Orita, Kazuhide Inage, Takane Suzuki, Masashi Takaso, Seiji Ohtori
The clinical efficacy of autologous vein wrapping for recurrent compressive neuropathy has been demonstrated; however, the underlying mechanisms of this technique remain unclear. Rats were divided into chronic constriction injury (CCI) and CCI + vein wrapping (CCI + VW) groups. Mechanical allodynia was evaluated using von Frey filaments. To identify the neuroprotective factors released from veins, basic fibroblast growth factor (bFGF) mRNA expression in veins was compared to that in the sciatic nerve...
August 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28768536/a-novel-composite-formulation-of-palmitoylethanolamide-and-quercetin-decreases-inflammation-and-relieves-pain-in-inflammatory-and-osteoarthritic-pain-models
#13
Domenico Britti, Rosalia Crupi, Daniela Impellizzeri, Enrico Gugliandolo, Roberta Fusco, Carlo Schievano, Valeria Maria Morittu, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea
BACKGROUND: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the cornerstone of treatment for OA pain, but side effects with long-term use pose important challenges to veterinary practitioners when dealing with OA pain. Palmitoylethanolamide (PEA) is a naturally-occurring fatty acid amide, locally produced on demand by tissues in response to stress...
August 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28768437/clinical-descriptors-for-the-recognition-of-central-sensitization-pain-in-patients-with-knee-osteoarthritis
#14
Enrique Lluch, Jo Nijs, Carol A Courtney, Trudy Rebbeck, Vikki Wylde, Isabel Baert, Timothy H Wideman, Nick Howells, Søren T Skou
BACKGROUND: Despite growing awareness of the contribution of central pain mechanisms to knee osteoarthritis pain in a subgroup of patients, routine evaluation of central sensitization is yet to be incorporated into clinical practice. AIM: The objective of this perspective is to design a set of clinical descriptors for the recognition of central sensitization in patients with knee osteoarthritis that can be implemented in clinical practice. METHODS: A narrative review of original research papers was conducted by nine clinicians and researchers from seven different countries to reach agreement on clinically relevant descriptors...
August 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28767433/association-of-myelinated-primary-afferents-impairment-with-mechanical-allodynia-in-diabetic-peripheral-neuropathy-an-experimental-study-in-rats
#15
Chenlong Liao, Min Yang, Wenxiang Zhong, Pengfei Liu, Wenchuan Zhang
To investigate the mechanisms underlying the efficacy of surgical treatment for painful diabetic peripheral neuropathy. Rats were initially divided into 3 groups (I, control rats, II, streptozotocin-induced diabetic rats, III, streptozotocin-induced diabetic rats with latex tube encircling the sciatic nerve without compression). When mechanical allodynia (MA) became stable in the third week, one third of group III rats were sacrificed and the remainder were further divided into subgroups depending on whether the latex tube was removed...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28761433/mild-closed-head-traumatic-brain-injury-induced-changes-in-monoamine-neurotransmitters-in-the-trigeminal-subnuclei-of-a-rat-model-mechanisms-underlying-orofacial-allodynias-and-headache
#16
Golam Mustafa, Jiamei Hou, Rachel Nelson, Shigeharu Tsuda, Mansura Jahan, Naweed S Mohammad, Joseph V Watts, Floyd J Thompson, Prodip Bose
Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28761369/capsaicin-8-patch-treatment-for-amputation-stump-and-phantom-limb-pain-a-clinical-and-functional-mri-study
#17
Rosario Privitera, Rolfe Birch, Marco Sinisi, Iordan R Mihaylov, Robert Leech, Praveen Anand
PURPOSE: The aim of this study was to measure the efficacy of a single 60 min application of capsaicin 8% patch in reducing chronic amputation stump and phantom limb pain, associated hypersensitivity with quantitative sensory testing, and changes in brain cortical maps using functional MRI (fMRI) scans. METHODS: A capsaicin 8% patch (Qutenza) treatment study was conducted on 14 patients with single limb amputation, who reported pain intensity on the Numerical Pain Rating Scale ≥4/10 for chronic stump or phantom limb pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28760650/grip-strength-in-mice-with-joint-inflammation-a-rheumatology-function-test-sensitive-to-pain-and-analgesia
#18
Ángeles Montilla-García, Miguel Á Tejada, Gloria Perazzoli, José M Entrena, Enrique Portillo-Salido, Eduardo Fernández-Segura, Francisco J Cañizares, Enrique J Cobos
Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms. Mice with periarticular injections of complete Freund's adjuvant (CFA) in the ankles showed periarticular immune infiltration and synovial membrane alterations, together with pronounced grip strength deficits and tactile allodynia measured with von Frey hairs...
July 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28758232/administrations-of-thalidomide-into-the-rostral-ventromedial-medulla-produce-antinociceptive-effects-in-a-rat-model-of-postoperative-pain
#19
Tieying Song, Xiaojing Ma, Pengyu Ma, Kunfeng Gu, Jianhui Zhao, Yunliang Yang, Bo Jiang, Yuxia Li, Chunping Wang
The rostral ventromedial medulla (RVM) is highly involved in pain signal transmissions. Previous studies have shown that thalidomide is anti-nociceptive. Thus, we evaluated the neurobiological mechanisms of thalidomide in the RVM in the regulation of postoperative pain. We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons...
July 31, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28757391/systemic-dexmedetomidine-attenuates-mechanical-allodynia-through-extracellular-sign-db-type-2-diabetic-mice
#20
Hui Chen, Xiang Xu, Xiao-Yu Yang, Bing-Yu Ling, He-Ping Sun, Chao Liu, Yu Qiu Zhang, Hong Cao, Lan Xu
Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus. However, the treatment for PDN is limited in clinical practice. In the present study, we investigated the effect of systemic administration dexmedetomidine (DEX), a selective alpha 2 adrenergic receptor (α2AR) agonist, on mechanical allodynia and its underlying mechanism in db/db mice, an animal model of type 2 diabetes mellitus. Our data demonstrated that db/db mice develop mechanical allodynia at the early stage of diabetes...
July 28, 2017: Neuroscience Letters
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