keyword
https://read.qxmd.com/read/36294316/practical-recommendations-for-optimal-thromboprophylaxis-in-patients-with-covid-19-a-consensus-statement-based-on-available-clinical-trials
#21
REVIEW
Konstantinos G Kyriakoulis, Evangelos Dimakakos, Ioannis G Kyriakoulis, Mariella Catalano, Alex C Spyropoulos, Sam Schulman, James Douketis, Anna Falanga, Anthony Maraveyas, Dan-Mircea Olinic, Jill Belch, Grigorios Gerotziafas, Konstantinos Syrigos, Anastasios Kollias
Coronavirus disease 2019 (COVID-19) has been shown to be strongly associated with increased risk for venous thromboembolism events (VTE) mainly in the inpatient but also in the outpatient setting. Pharmacologic thromboprophylaxis has been shown to offer significant benefits in terms of reducing not only VTE events but also mortality, especially in acutely ill patients with COVID-19. Although the main source of evidence is derived from observational studies with several limitations, thromboprophylaxis is currently recommended for all hospitalized patients with acceptable bleeding risk by all national and international guidelines...
October 11, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36217296/peri-procedure-management-of-antithrombotic-agents-and-thrombocytopenia-for-common-procedures-in-oncology-guidance-from-the-ssc-of-the-isth
#22
JOURNAL ARTICLE
Tzu-Fei Wang, Kristen M Sanfilippo, James Douketis, Anna Falanga, John Karageorgiou, Anthony Maraveyas, Thomas L Ortel, Gerald Soff, Suresh Vedantham, Jeffrey I Zwicker
Patients with cancer have an increased risk of thrombosis requiring anticoagulants and/or antiplatelet agents, and they can also encounter thrombocytopenia due to cancer itself or cancer therapies. They often undergo many procedures such as tissue or bone marrow biopsies, placement of central access lines, diagnostic or therapeutic draining procedures, lumbar puncture, and more. Management of antithrombotic agents or thrombocytopenia around the time of these procedures is highly variable. In this document, the Hemostasis and Malignancy Subcommittee of the International Society on Thrombosis and Haemostasis aims to provide useful practice guidance in the management of antithrombotic agents and thrombocytopenia around the time of common procedures in patients with cancer...
December 2022: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/36200348/coagulation-assays-and-direct-oral-anticoagulant-levels-among-patients-having-an-elective-surgery-or-procedure
#23
JOURNAL ARTICLE
Joseph R Shaw, Na Li, Joanne Nixon, Karen A Moffat, Alex C Spyropoulos, Sam Schulman, James D Douketis
BACKGROUND: The Perioperative Anticoagulation Use for Surgery Evaluation study prospectively evaluated a prespecified periprocedural interruption strategy of direct oral anticoagulants (DOACs) among patients with atrial fibrillation. Coagulation testing is widely available and frequently requested prior to invasive procedures. Coagulation assays display poor sensitivity to clinically relevant DOAC concentrations. OBJECTIVES: Determine the utility of routinely available coagulation testing at predicting a DOAC concentration of <30 ng/ml among patients in the preprocedural setting...
December 2022: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/36055679/the-2022-itac-evidence-based-clinical-practice-guidelines-new-update-from-the-international-initiative-on-thrombosis-and-cancer-to-improve-the-care-in-patients-with-cancer-associated-thrombosis
#24
EDITORIAL
C Frere, D Farge, J Douketis, J M Connors
No abstract text is available yet for this article.
July 2022: Journal de Médecine Vasculaire
https://read.qxmd.com/read/35964704/perioperative-management-of-antithrombotic-therapy-an-american-college-of-chest-physicians-clinical-practice-guideline
#25
James D Douketis, Alex C Spyropoulos, M Hassan Murad, Juan I Arcelus, William E Dager, Andrew S Dunn, Ramiz A Fargo, Jerrold H Levy, C Marc Samama, Sahrish H Shah, Matthew W Sherwood, Alfonso J Tafur, Liang V Tang, Lisa K Moores
BACKGROUND: The American College of Chest Physicians Clinical Practice Guideline on the Perioperative Management of Antithrombotic Therapy addresses 43 Patients-Interventions-Comparators-Outcomes (PICO) questions related to the perioperative management of patients who are receiving long-term oral anticoagulant or antiplatelet therapy and require an elective surgery/procedure. This guideline is separated into four broad categories, encompassing the management of patients who are receiving: (1) a vitamin K antagonist (VKA), mainly warfarin; (2) if receiving a VKA, the use of perioperative heparin bridging, typically with a low-molecular-weight heparin; (3) a direct oral anticoagulant (DOAC); and (4) an antiplatelet drug...
November 2022: Chest
https://read.qxmd.com/read/35964703/executive-summary-perioperative-management-of-antithrombotic-therapy-an-american-college-of-chest-physicians-clinical-practice-guideline
#26
JOURNAL ARTICLE
James D Douketis, Alex C Spyropoulos, M Hassan Murad, Juan I Arcelus, William E Dager, Andrew S Dunn, Ramiz A Fargo, Jerrold H Levy, C Marc Samama, Sahrish H Shah, Matthew W Sherwood, Alfonso J Tafur, Liang V Tang, Lisa K Moores
BACKGROUND: The American College of Chest Physicians Clinical Practice Guideline on the Perioperative Management of Antithrombotic Therapy addresses 43 Patients-Interventions-Comparators-Outcomes (PICO) questions related to the perioperative management of patients who are receiving long-term oral anticoagulant or antiplatelet therapy and require an elective surgery/procedure. This guideline is separated into four broad categories, encompassing the management of patients who are receiving: (1) a vitamin K antagonist (VKA), mainly warfarin; (2) if receiving a VKA, the use of perioperative heparin bridging, typically with a low-molecular-weight heparin; (3) a direct oral anticoagulant (DOAC); and (4) an antiplatelet drug...
November 2022: Chest
https://read.qxmd.com/read/35918731/coordination-of-oral-anticoagulant-care-at-hospital-discharge-coached-protocol-for-a-pilot-randomised-controlled-trial
#27
JOURNAL ARTICLE
Anne M Holbrook, Kristina Vidug, Lindsay Yoo, Sue Troyan, Sam Schulman, James Douketis, Lehana Thabane, Stephen Giilck, Yousery Koubaesh, Sylvia Hyland, Karim Keshavjee, Joanne Ho, Jean-Eric Tarride, Amna Ahmed, Marianne Talman, Blair Leonard, Khursheed Ahmed, Mohammad Refaei, Deborah M Siegal
BACKGROUND: Oral anticoagulants (OACs) are commonly prescribed, have well-documented benefits for important clinical outcomes but have serious harms as well. Rates of OAC-related adverse events including thromboembolic and hemorrhagic events are especially high shortly after hospital discharge. Expert OAC management involving virtual care is a research priority given its potential to reach remote communities in a more feasible, timely, and less costly way than in-person care. Our objective is to test whether a focused, expert medication management intervention using a mix of in-person consultation and virtual care follow-up, is feasible and effective in preventing anticoagulation-related adverse events, for patients transitioning from hospital to home...
August 2, 2022: Pilot and Feasibility Studies
https://read.qxmd.com/read/35906715/good-practice-statements-for-antithrombotic-therapy-in-the-management-of-covid-19-guidance-from-the-ssc-of-the-isth
#28
JOURNAL ARTICLE
Alex C Spyropoulos, Jean M Connors, James D Douketis, Mark Goldin, Beverley J Hunt, Taiwo R Kotila, Renato D Lopes, Sam Schulman
Despite the emergence of high quality randomized trial data with the use of antithrombotic agents to reduce the risk of thromboembolism, end-organ failure, and possibly mortality in patients with coronavirus disease 2019 (COVID-19), questions still remain as to optimal patient selection for these strategies, the use of antithrombotics in outpatient settings and in-hospital settings (including critical care units), thromboprophylaxis in special patient populations, and the management of acute thrombosis in hospitalized COVID-19 patients...
October 2022: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/35877546/recurrence-after-stopping-anticoagulants-in-women-with-combined-oral-contraceptive-associated-venous-thromboembolism-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Jameel Abdulrehman, Carolyne Elbaz, David Aziz, Sameer Parpia, Rouhi Fazelzad, Lisbeth Eischer, Marc A Rodger, Suzanne C Cannegieter, Arina Ten Cate-Hoek, Michael Nagler, Sam Schulman, Suely M Rezende, Valérie Olié, Gualtiero Palareti, Maura Marcucci, James Douketis, Daniela Poli, Michal Zabczyk, Diana Aguiar de Sousa, Bruno Miranda, Mary Cushman, Alberto Tosetto, Gregoire Le Gal, Clive Kearon, Leslie Skeith
The risk of recurrence after discontinuation of anticoagulation for a combined oral contraceptive (COC)-associated venous thromboembolism (VTE) is unclear. Therefore, we conducted a systematic review and meta-analysis to estimate the incidence of recurrent VTE among women with COC-associated VTE, unprovoked VTE and to compare the incidence of recurrent VTE between the two groups. The Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase Classic +Embase and Medline ALL to July 2020 and citations from included studies were searched...
October 2022: British Journal of Haematology
https://read.qxmd.com/read/35772465/2022-international-clinical-practice-guidelines-for-the-treatment-and-prophylaxis-of-venous-thromboembolism-in-patients-with-cancer-including-patients-with-covid-19
#30
REVIEW
Dominique Farge, Corinne Frere, Jean M Connors, Alok A Khorana, Ajay Kakkar, Cihan Ay, Andres Muñoz, Benjamin Brenner, Pedro H Prata, Dialina Brilhante, Darko Antic, Patricia Casais, María Cecilia Guillermo Esposito, Takayuki Ikezoe, Syed A Abutalib, Luis A Meillon-García, Henri Bounameaux, Ingrid Pabinger, James Douketis
The International Initiative on Thrombosis and Cancer is an independent academic working group of experts aimed at establishing global consensus for the treatment and prophylaxis of cancer-associated thrombosis. The 2013, 2016, and 2019 International Initiative on Thrombosis and Cancer clinical practice guidelines have been made available through a free, web-based mobile phone application. The 2022 clinical practice guidelines, which are based on a literature review up to Jan 1, 2022, include guidance for patients with cancer and with COVID-19...
July 2022: Lancet Oncology
https://read.qxmd.com/read/35657682/canadian-stroke-best-practice-recommendations-secondary-prevention-of-stroke-update-2020-addendum
#31
JOURNAL ARTICLE
David J Gladstone, M Patrice Lindsay, James Douketis, Eric E Smith, Dar Dowlatshahi, Theodore Wein, Aline Bourgoin, Jafna Cox, John B Falconer, Brett R Graham, Marilyn Labrie, Lena McDonald, Jennifer Mandzia, Daniel Ngui, Paul Pageau, Amanda Rodgerson, William Semchuk, Tammy Tebbutt, Carmen Tuchak, Stephen van Gaal, Karina Villaluna, Norine Foley, Shelagh Coutts, Anita Mountain, Gord Gubitz, Jacob A Udell, Rebecca McGuff, Manraj K S Heran, Pascale Lavoie, Alexandre Y Poppe
No abstract text is available yet for this article.
June 3, 2022: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/35657375/antithrombotic-drug-removal-from-whole-blood-using-haemoadsorption-with-a-porous-polymer-bead-sorbent
#32
JOURNAL ARTICLE
Ritu Tripathi, Jesus Morales, Victoria Lee, C Michael Gibson, Michael J Mack, David J Schneider, James Douketis, Frank W Sellke, E Magnus Ohman, Vinod H Thourani, Robert F Storey, Efthymios N Deliargyris
AIM: To evaluate the ability of the DrugSorb™-AntiThrombotic Removal (ATR) haemoadsorption device utilizing porous polymer bead sorbent technology to remove 3 commonly used antithrombotic drugs from whole blood. METHODS: We evaluated the removal of apixaban, rivaroxaban, and ticagrelor by the DrugSorb-ATR haemoadsorption device in a benchtop clinical scale model using bovine whole blood. Blood spiked at clinically relevant concentrations of an antithrombotic agent was continuously circulated through a 300-mL DrugSorb-ATR haemoadsorption device at a flow rate of 300 mL/min...
June 3, 2022: European Heart Journal. Cardiovascular Pharmacotherapy
https://read.qxmd.com/read/35483046/2021-canadian-surgery-forum-virtual-online-sept-21-24-2021
#33
JOURNAL ARTICLE
G Johnson, A Vergis, B Unger, J Park, L Gillman, K Hickey, D Pace, A Azin, K Guidolin, K Lam-Tin-Cheung, S Chadi, F Quereshy, K Guidolin, J Catton, B Rubin, J Bell, J Marangos, A Heesters, T Stuart-McEwan, F Quereshy, F Shariff, F Wright, N Ahmed, A Nadler, J Hallet, J Gentles, L Chen, H Hwang, M Parapini, D Hirpara, R Sidhu, T Scott, A Karimuddin, R Guo, A Nguyen, J Osborn, S Wiseman, K Nabata, E Ertel, H Hwang, T Lenet, L Baker, L Park, M Vered, A Zahrai, R Shorr, A Davis, D McIsaac, A Tinmouth, D Fergusson, G Martel, K Nabata, S Rummel, M Stefic-Cubic, A Karimuddin, M Stewart, A Melck, T McKechnie, T Anpalagan, S Ichhpuniani, Y Lee, K Ramji, C Eskicioglu, A Zhu, S Deng, B Greene, M Tsang, V Palter, S Jayaraman, T McKechnie, A Mann, J Tittley, M Cadeddu, M Nguyen, A Madani, J Pasternak, T McKechnie, K Ramji, D Hong, L Qu, A Istl, E Tang, D Gray, J Zuckerman, N Coburn, J Callum, R McLeod, E Pearsall, Y Lin, A Turgeon, G Martel, J Hallet, A Mahar, A Kammili, P Kriviraltcheva-Kaneva, L Lee, J Cools-Lartigue, L Ferri, C Mueller, J Zuckerman, B Haas, B Tillman, M Guttman, T Chesney, V Zuk, A Mahar, A Hsu, W Chan, R Vasdev, N Coburn, J Hallet, K D'Souza, C Huynh, L Cadili J Ling, R Warburton, H Hwang, M Hameed, L Glass, H Williamson, P Murphy, E Tang, K Leslie, J Hawel, L Kerr, S Zablotny, H Roldan, W He, X Jiang, B Zheng, L Lee, J Fiore, L Feldman, G Fried, C Mueller, S Valanci, S Balvardi, J Cipolla, P Kaneva, S Demyttenaere, M Boutros, L Lee, L Feldman, J Fiore, S Balvardi, M Alhashemi, J Cipolla, L Lee, J Fiore, L Feldman, A Miles, K Purich, K Verhoeff, J Shapiro, D Bigam, J Kung, A Fecso, T Chesney, J Mosko, D Skubleny, P Hamilton, S Ghosh, S Widder, D Schiller, U Do, C El Kefraoui, M Pook, N Barone, S Balvardi, H Montgomery, P Nguyen-Powanda, F Rajabiyazdi, H Elhaj, M Lapointe-Gagner, G Olleik, P Kaneva, A Antoun, N Safa, E Di Lena, S Meterissian, A Meguerditchian, G Fried, M Alhashemi, F Lee, G Baldini, L Feldman, J Fiore, P E Serrano Aybar, S Parpia, L Ruo, K Tywonek, S Lee, C O'Neill, N Faisal, A Alfayyadh, M Gundayao, B M Meyers, R Habashi, C Kruse, T McKechnie, M Levin, K Aldrich, T Grantcharov, A Langerman, H Forbes, R Anantha, V Fawcett, A Hetherington, V Pravong, M Gervais, G Rakovich, R Selvam, R Hu, R Musselman, I Raiche, H Moloo, R Liu, A Elnahas, N Alkhamesi, J Hawel, E Tang, A Alnumay, C Schlachta, E Walser, C Zhang, S Cristancho, M Ott, A Lee, B Niu, F Balaa, N Gawad, K Ren, Y Qiu, K Hamann, N How, C Leveille, A Davidson, A Eqbal, Y Sardiwalla, M Korostensky, T McKechnie, E Lee, I Yang, K Ren, H Muaddi, T Stukel, C de Mestral, A Nathens, P Karanicolas, J Frigault, S Lemieux, D Breton, P Bouchard, A Bouchard, R Grégoire, F Letarte, G Bouchard, S Drolet, J Frigault, S Avoine, S Drolet, F Letarte, A Bouchard, J Gagné, C Thibault, R Grégoire, N Jutras Bouthillette, M Gosselin, P Bouchard, A Rosenzveig, T Stuleanu, A Jarrar, N Kolozsvari, G Skelhorne-Gross, R Nenshi, A Jerath, D Gomez, K Singh, T Amir, E Liu, S Farquharson, R Mao, L Lan, J Yan, A Allard-Coutu, A Mierzwa, R Tin, R Brisebois, N Bradley, R Wigen, E Walser, L Hartford, J Van Koughnett, K Vogt, R Hilsden, N Parry, L Allen, K Leslie, R Raskin, J Jones, K Neumann, C Dwyer, M Strickland, N Bradley, D O'Dochartaigh, K Lobay, A Kabaroff, E Chang, S Widder, R Anantha, W Sun, J Beck, R Anantha, R Liu, J Davidson, S Jones, T Van Hooren, J Van Koughnett, M Ott, E Schmitz, I Raiche, W Sun, M El Hafid, J Dang, V Mocanu, G Lutzak, R Sultanian, C Wong, S Karmali, E Schmitz, M Petrera, M Pickell, R Auer, N Patro, B Li, Y Lee, H Wilson, V Mocanu, W Sun, J Dang, U Jogiat, J Kung, N Switzer, S Karmali, C Wong, C Li, A Al Hinai, A Cieply, H Hawes, E Joos, A Saleh, C Li, A Saleh, P Engels, J Drung, L Allen, K Leslie, G Pang, M Kwong, C Schlachta, N Alkhamesi, J Hawel, A Elnahas, K Guidolin, J Ellsmere, S Chadi, F Quereshy, D Chang, M Hutter, R Spence, M Abou Khalil, M Boutros, C Vasilevsky, N Morin, Y Longtin, S Liberman, S Demyttenaere, P Montpetit, M Poirier, K Mukherjee, H Sebajang, R Younan, F Schwenter, E De Broux, K Larsen, G Skelhorne-Gross, A Beckett, J Nantais, D Gomez, L Lan, R Mao, J Kay, R Lohre, O Ayeni, D Goel, D de Sa, R He, D Hylton, E Bedard, S Johnson, B Laing, A Valji, W Hanna, S Turner, G Akhtar-Danesh, N Akhtar-Danesh, Y Shargall, G Akhtar-Danesh, N Akhtar-Danesh, Y Shargall, D Hirpara, V Gupta, B Kidane, J Limbachia, K Sullivan, F Farrokhyar, G Leontiadis, Y Patel, I Churchill, D Hylton, F Xie, A Seely, J Spicer, B Kidane, S Turner, K Yasufuku, W Hanna, U Jogiat, W Sun, J Dang, V Mocanu, J Kung, S Karmali, S Turner, N Switzer, Y Patel, I Churchill, K Sullivan, M Beauchamp, J Wald, L Mbuagbaw, J Agzarian, Y Shargall, C Finley, C Fahim, W Hanna, M Abbas, O Olaiya, H Begum, L Mbuagbaw, C Finley, W Hanna, J Agzarian, Y Shargall, A Ednie, D Palma, A Warner, R Malthaner, D Fortin, M Qiabi, R Nayak, T Nguyen, A Louie, G Rodrigues, B Yaremko, J Laba, R Inculet, J Alaichi, Y Patel, W Hanna, S Turner, B Mador, H Lai, J White, M Kim, D Hirpara, B Kidane, A Louie, V Zuk, G Darling, M Rousseau, T Chesney, N Coburn, J Hallet, Y Lee, Y Samarasinghe, M Lee, L Thiru, Y Shargall, C Finley, W Hanna, O Levine, R Juergens, J Agzarian, R Nayak, S Brogly, W Li, D Lougheed, D Petsikas, N Mistry, A Gatti, I Churchill, Y Patel, W Hanna, S Abdul, C Anestee, S Gilbert, S Sundaresan, A Seely, P Villeneuve, D Maziak, R Razzak, A Ashrafi, N Tregobov, N Hassanzadeh, S Stone, A Panjwani, T Bong, R Bond, A Hafizi, M De Meo, R Rayes, S Milette, M Vagai, M Usatii, A Chandrasekaran, B Giannias, F Bourdeau, V Sangwan, N Bertos, C Moraes, S Huang, D Quail, L Walsh, S Camilleri-Broet, P Fiset, J Cools-Lartigue, L Ferri, J Spicer, A Kammili, E Bilgic, A Quaiattini, M Maurice-Ventouris, S Najmeh, C Mueller, L Esther, H Begum, J Agzarian, W Hanna, C Finley, Y Shargall, Y Lee, J Lu, R Malhan, Y Shargall, C Finley, W Hanna, J Agzarian, S Brophy, K Brennan, D French, V Resende, M Momtazi, O Solaja, S Gilbert, D Maziak, A Seely, S Sundaresan, P Villeneuve, D Sisson, L Donahoe, P Bedard, A Hansen, M De Perrot, A Alghamedi, A Simone, H Begum, W Hanna, Y Shargall, S Turner, J Huang, H Lai, E Bedard, Y Shargall, S Murthy, J Lin, G Darling, R Malthaner, B Kidane, A Seely, H Li, M Crowther, L Linkins, E Lau, L Schneider, W Hanna, C Finley, J Agzarian, J Douketis, B Greenberg, V Gupta, C Allen-Avodabo, L Davis, H Zhao, B Kidane, G Darling, N Coburn, C Huynh, J Cools-Lartigue, L Ferri, S Najmeh, C Sirois, D Mulder, J Spicer, A Al Rawahi, S Aftab Abdul, D Nguyen, C Anstee, E Delic, S Gilbert, D Maziak, P Villeneuve, A Seely, D Sisson, H Sasewich, T Islam, D Low, G Darling, S Turner, M Humer, S Abdul, D Nguyen, A Al Rawahi, C Anstee, E Delic, S Gilbert, P Villeneuve, D Maziak, A Seely, D Le Nguyen, S Aftab Abdul, A Al Rawahi, C Anstee, E Delic, S Gilbert, P Villeneuve, D Maziak, A Seely, Y Patel, M Kay, I Churchill, K Sullivan, Y Shargall, B Shayegan, A Adili, W Hanna, M Kaafarani, C Huynh, F Chouiali, N Muthukrishnan, F Maleki, K Ovens, M Gold, M Sorin, R Falutz, R Rayes, R Forghani, J Spicer, N Hunka, R Kennedy, R Bigsby, S Bharadwaj, S Gowing, I Churchill, A Gatti, D Hylton, K Sullivan, Y Patel, F Farrokhyar, G Leontiadis, W Hanna, C Finley, H Begum, K Pearce, J Agzarian, W Hanna, Y Shargall, N Akhtar-Danesh, D Jones, C Anstee, S Kumar, M Gingrich, A Simone, Z Ahmadzai, K Thavorn, A Seely, V Gupta, A Namavarian, A Mohammed, S Uddin, D Jones, A Behzadi, A Brar, L Qu, M Qiabi, R Nayak, R Malthaner, E Peters, G Buduhan, L Tan, R Liu, S Srinathan, B Kidane, V Gupta, J Levy, B Kidane, A Mahar, J Ringash, R Sutradhar, G Darling, N Coburn, M Robinson, L Bednarek, G Buduhan, R Liu, L Tan, S Srinathan, B Kidane, H Wang, D French, D MacDonald, K Graham, S Enns, G Buduhan, S Srinathan, R Liu, A Tan, B Kidane, A Bruinooge, E Poole, C Pascoe, T Karakach, G Buduhan, L Tan, S Srinathan, A Halayko, B Kidane, K Verhoeff, V Mocanu, B Fang, J Dang, J Kung, N Switzer, D Birch, S Karmali, G Johnson, H Singh, A Vergis, J Park, O Hershorn, D Hochman, R Helewa, G Johnson, R Robertson, A Vergis, G Johnson, A Vergis, H Singh, J Park, R Helewa, A Azin, C Cahill, M Lipson, A Afzal, A Maclean, C Wong, S Roen, W Buie, T McKechnie, T Anpalagan, M Chu, Y Lee, N Amin, D Hong, C Eskicioglu, T McKechnie, K Ramji, C Kruse, H Jaffer, R Rebello, N Amin, A Doumouras, D Hong, C Eskicioglu, R Hajjar, M Oliero, T Cuisiniere, G Fragoso, A Calvé, S Djediai, B Annabi, C Richard, M Santos, K Purich, Y Zhou, S Dodd, B Ring, Y Yuan, J White, R Garfinkle, S Dell'Aniello, S Bhatnagar, N Morin, G Ghitulescu, J Faria, C Vasilevsky, P Brassard, M Boutros, R Garfinkle, E Salama, A Amar-Zifkin, N Morin, G Ghitulescu, J Faria, C Vasilevsky, M Boutros, G Talwar, R Daniel, T McKechnie, O Levine, C Eskicioglu, H AlSulaim, M Alqahtani, R Garfinkle, S Al-Masrouri, C Vasilevsky, N Morin, M Boutros, T McKechnie, A Chen, A Patel, Y Lee, A Doumouras, D Hong, C Eskicioglu, V Brissette, N Al Busaidi, F Rajabiyazdi, J Moon, M Demian, C Vasilevsky, N Morin, M Boutros, R Selvam, H Moloo, H MacRae, F Alam, I Raiche, J Holland, M Cwintal, G Rigas, C Vasilevsky, N Morin, G Ghitulescu, J Faria, A Pang, M Boutros, J Holland, J Moon, D Marinescu, N Morin, G Ghitulescu, A Pang, C Vasilevsky, M Boutros, C Brown, A Karimuddin, M Raval, P Phang, A Ghuman, M Li, S Muncner, I Mihajlovic, M Dykstra, R Snelgrove, H Wang, O Monton, A Smith, J Moon, M Demian, R Garfinkle, C Vasilevsky, F Rajabiyazdi, M Boutros, O AlAamer, N AlSelaim, M AlMalki, A Al-Osail, R Ruxton, P Manuel, F Mohamed, M K Motamedi, S Serahati, L Rajendran, C Brown, M Raval, A Karimuddin, A Ghuman, T Phang, N Caminsky, J Moon, F Rajabiyazdi, S Chadi, K Alavi, I Paquette, T MacLean, S Wexner, S Liberman, S Steele, J Park, S Patel, L Bordeianou, R Auer, P Sylla, N Morin, A Ghuman, M Boutros, Z Bayat, E Kennedy, C Victor, A Govindarajan, J Liang, C Vasilevsky, A Pang, G Ghitulescu, J Faria, N Morin, M Boutros, D Marinescu, H Roy, Z Baig, A Karimmudin, M Raval, C Brown, T Phang, D Gill, N Ginther, J Moon, D Marinescu, A Pang, G Ghitulescu, J Faria, N Morin, C Vasilevsky, M Boutros, J Moon, A Pang, G Ghitulescu, J Faria, N Morin, C Vasilevsky, M Boutros, E Salama, F Alrashid, C Vasilevsky, G Ghitulescu, J Faria, N Morin, M Boutros, V Wiseman, L Zhang, P MacDonald, S M Merchant, K Wattie Barnett, A Caycedo-Marulanda, S V Patel, Z Harra, C Vasilevsky, G Ghitulescu, N Morin, M Boutros, A Pang, M Hegagi, M Alqahtani, N Morin, G Ghitulescu, C Vasilevsky, M Boutros, N Alghaithi, D Marinescu, S Al-Masrouri, A Pang, C Vasilevsky, M Boutros, E Papillon, N Kasteel, G Kaur, S Bindra, A Malhotra, C Graham, A MacLean, P Beck, H Jijon, J Ferraz, W Buie, R Szwimer, J Moon, M Demian, A Pang, N Morin, C Vasilevsky, F Rajabiyazdi, M Boutros, A Azin, S Merchant, W Kong, B Gyawali, T Hanna, W Chung, S Nanji, S Patel, C Booth, V Li, A Awan, P Serrano, M Jacobson, M Chanco, V Wen, N Singh, L Peiris, J Pasieka, P Ghatage, D Buie, T MacLean, A Bouchard-Fortier, L Mack, W Marini, W Zheng, C Swallow, M Reedijk, A DiPasquale, L Peiris, Z Prus-Czrnecka, L Delmar, N Gagnon, R Villiard, É Martel, A Cadrin-Chênevert, É Ledoux, C Racicot, S Mysuria, A Bazzarelli, J Pao, L Chen, M Zhang, E McKevitt, R Warburton, U Kuusk, N Van Laeken, E Bovill, K Isaac, C Dingee, A Hunter-Smith, C Cuthbert, K Fergus, L Barbera, Y Efegoma, D Howell, S Isherwood, N Levasseur, A Scheer, C Simmons, A Srikantham, C Temple-Orberle, Y Xu, K Metcalfe, M Quan, A Alqaydi, J la, S Merchant, G Digby, V Pravong, A Brind'Amour, L Sidéris, P Dubé, L De Guerke, S Fortin, M Auclair, B Trilling, J Tremblay, É Di Lena, B Hopkins, S Wong, S Meterissian, É Di Lena, N Barone, B Hopkins, S Dumitra, P Kaneva, J Fiore, S Meterissian, S Mysuria, E McKevitt, R Warburton, L Chen, A Bazzarelli, J Pao, E Bovill, M Zhang, U Kuusk, K Isaac, N Van Laeken, C Dingee, H Kapur, E McKevitt, R Warburton, J Pao, C Dingee, A Bazarelli, U Kuusk, L Chen, L Cadili, K DeGirolamo, E McKevitt, J Pao, C Dingee, A Bazzarelli, R Warburton, D Ng, A Ali, D Eymae, K Lee, S Brar, J Conner, M Magalhaes, C Swallow, K Allen, C Baliski, D Cyr, A Sari, D Messenger, D Driman, N Assarzadegan, A Juda, C Swallow, E Kennedy, M Brar, J Conner, R Kirsch, A Allard-Coutu, K Singh, A Lamontagne, Y Gamache, A Allard-Coutu, C Mardinger, C Lee, R Duckworth, M Brindle, F Fraulin, L Austen, J Kortbeek, M Hyndman, D Nguyen, G Jamjoum, A Meguerditchian, S Langer, Y Yuan Xu, S Kong, M Quan, D Lim, H Retrouvey, I Kerrebijn, K Butler, A O'Neill, T Cil, T Zhong, S Hofer, D McCready, K Metcalfe, D Lim, B Greene, N Look Hong, M Parapini, J Skipworth, A Mah, S Desai, S Chung, C Scudamore, M Segedi, E Vasilyeva, J Li, P Kim, K Verhoeff, A Deprato, K Purich, J Kung, D Bigam, K Dajani, T Lenet, R Gilbert, R Smoot, G Martel, C Tzeng, F Rocha, L Yohanathan, S Cleary, K Bertens, F Reyna-Sepulveda, D Badrudin, B Gala-Lopez, N Hanna, S Brogly, X Wei, C Booth, S Nanji, J Zuckerman, N Coburn, A Mahar, J Callum, Y Kaliwal, S Jayaraman, A Wei, G Martel, J Hallet, J Zuckerman, S Jayaraman, A Wei, A Mahar, Y Kaliwal, G Martel, N Coburn, J Hallet, D Henault, B Barrette, S Pelletier, P Thebault, E Beaudry-Simoneau, Z Rong, M Plasse, A Roy M Dagenais, R Létourneau, R Lapointe, F Vandenbroucke-Menu, B Nguyen, G Soucy, S Turcotte, M Lemke, E Waugh, K Leslie, D Quan, A Skaro, E Tang, M Lund, L Allen, J Glinka, G Jada, D Quan, A Skaro, E Tang, L Park, J Daza, V Li, H Msallak, B Zhang, A Workneh, S Faisal, R Faisal, M Fabbro, C Gu, M Claassen, V Zuk, J Hallet, G Martel, G Sapisochin, P Serrano, J Glinka, A Skaro, K Leslie, G Jada, D Quan, E Tang, E Waugh, M Lemke, J Glinka, A Skaro, K Leslie, E Tang, E Waugh, D Breadner, R Liu, E Tang, L Allen, S Welch, A Skaro, K Leslie, J Glinka, E Waugh, E Tang, G Jada, D Quan, A Skaro, A Webb, E Lester, A Shapiro, D Eurich, D Bigam, Y Essaji, H Shrader, A Nayyar, M Suraju, S Williams-Perez, P Ear, C Chan, V Smith, M Rivers-Bowerman, A Costa, A Stueck, N Campbell, S Allen, B Gala-Lopez, R Gilbert, T Lenet, S Cleary, R Smoot, C Tzeng, F Rocha, G Martel, K Bertens, Z Mir, H Golding, S McKeown, S Nanji, J Flemming, P Groome, Z Mir, M Djerboua, S Nanji, J Flemming, P Groome, S Elbekri, S Turcotte, E Girard, P Morency-Potvin, R Lapointe, F Vandenbroucke-Menu, M Dagenais, A Roy, R Letourneau, M Plasse, E Simoneau, Z Rong, N Zuker, M Oakley, G Chartrand, B Misheva, Y Bendavid, J Frigault, S Lemieux, D Breton, G Bouchard, S Drolet, M Melland-Smith, L Smith, J Tan, U Kahn, C McLean, V Mocanu, D Birch, S Karmali, N Switzer, M Fortin, X Paré, A Doyon, S Keshavjee, K Schwenger, J Yadav, S Fischer, T Jackson, J Allard, A Okrainec, Y Lee, S Anvari, M Chu, O Lovrics, I Aditya, R Malhan, A Khondker, M Walsh, A Doumouras, D Hong, W He, A Vergis, K Hardy, R Romanescu, F Deaninck, J Linton, M Fowler-Woods, A Fowler-Woods, G Shingoose, A Vergis, K Hardy, M Zmudzinski, Z Cloutier, T McKechnie, Y Lee, V Archer, A Doumouras, J Shiroky, J Abu Halimah, K Ramji, V Boudreau, A Mierzwa, V Mocanu, G Marcil, J Dang, N Switzer, D Birch, S Karmali, A Mierzwa, A Jarrar, A Hardy-Henry, N Kolozsvari, W Lin, J Hagen, M Connell, W Sun, J Dang, V Mocanu, J Kung, N Switzer, D Birch, S Karmali
No abstract text is available yet for this article.
2021: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://read.qxmd.com/read/35439353/pharmacokinetics-of-apixaban-and-tacrolimus-or-cyclosporine-in-kidney-and-lung-transplant-recipients
#34
JOURNAL ARTICLE
Holly Mansell, Ahmed Shoker, Jane Alcorn, Mark E Fenton, Julian S Tam, William Semchuk, Babar Bashir, Walter K Kraft, Shenzhen Yao, James D Douketis
Apixaban is frequently used off-label in transplant recipients. However, a potential drug interaction exists with the calcineurin inhibitors. We conducted an open-label drug-drug interaction study to determine the pharmacokinetics of apixaban in lung and kidney transplant recipients who were taking a calcineurin inhibitor. A single dose of apixaban 10 mg was administered orally to kidney and lung transplant recipients maintained on either tacrolimus or cyclosporine, and pharmacokinetic parameters were compared to a reference cohort of 12 healthy subjects who used the same apixaban dose and pharmacokinetic blood sampling...
July 2022: Clinical and Translational Science
https://read.qxmd.com/read/35368325/american-college-of-gastroenterology-canadian-association-of-gastroenterology-clinical-practice-guideline-management-of-anticoagulants-and-antiplatelets-during-acute-gastrointestinal-bleeding-and-the-periendoscopic-period
#35
REVIEW
Neena S Abraham, Alan N Barkun, Bryan G Sauer, James Douketis, Loren Laine, Peter A Noseworthy, Jennifer J Telford, Grigorios I Leontiadis
We conducted systematic reviews of predefined clinical questions and used the Grading of Recommendations, Assessment, Development and Evaluations approach to develop recommendations for the periendoscopic management of anticoagulant and antiplatelet drugs during acute gastrointestinal (GI) bleeding and the elective endoscopic setting. The following recommendations target patients presenting with acute GI bleeding: For patients on warfarin, we suggest against giving fresh frozen plasma or vitamin K; if needed, we suggest prothrombin complex concentrate (PCC) compared with fresh frozen plasma administration; for patients on direct oral anticoagulants (DOACs), we suggest against PCC administration; if on dabigatran, we suggest against the administration of idarucizumab, and if on rivaroxaban or apixaban, we suggest against andexanet alfa administration; for patients on antiplatelet agents, we suggest against platelet transfusions; and for patients on cardiac acetylsalicylic acid (ASA) for secondary prevention, we suggest against holding it, but if the ASA has been interrupted, we suggest resumption on the day hemostasis is endoscopically confirmed...
April 2022: Journal of the Canadian Association of Gastroenterology
https://read.qxmd.com/read/35354773/management-of-patients-on-anticoagulants-and-antiplatelets-during-acute-gastrointestinal-bleeding-and-the-peri-endoscopic-period-a-clinical-practice-guideline-dissemination-tool
#36
JOURNAL ARTICLE
Alan N Barkun, James Douketis, Peter A Noseworthy, Loren Laine, Jennifer J Telford, Neena S Abraham
No abstract text is available yet for this article.
April 1, 2022: American Journal of Gastroenterology
https://read.qxmd.com/read/34830648/immunomodulation-and-reduction-of-thromboembolic-risk-in-hospitalized-covid-19-patients-systematic-review-and-meta-analysis-of-randomized-trials
#37
REVIEW
Dimitrios Sagris, Matilda Florentin, Panagiotis Tasoudis, Eleni Korompoki, Nikolaos Gatselis, Evangelos J Giamarellos-Bourboulis, Haralampos Milionis, James Douketis, Alex C Spyropoulos, George Dalekos, George Ntaios
BACKGROUND: We aimed to investigate the potential beneficial effect of immunomodulation therapy on the thromboembolic risk in hospitalized COVID-19 patients. METHODS: We searched PubMed and Scopus for randomized trials reporting the outcomes of venous thromboembolism (VTE), ischemic stroke or systemic embolism, myocardial infarction, any thromboembolic event, and all-cause mortality in COVID-19 patients treated with immunomodulatory agents. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using the Mantel-Haenszel random effects method...
November 18, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34799234/anticoagulant-therapy-for-covid-19-what-we-have-learned-and-what-are-the-unanswered-questions
#38
EDITORIAL
Dimitrios Giannis, James D Douketis, Alex C Spyropoulos
No abstract text is available yet for this article.
February 2022: European Journal of Internal Medicine
https://read.qxmd.com/read/34652572/perioperative-management-of-antithrombotic-therapy-a-case-based-narrative-review
#39
REVIEW
Andrew Tiger Chen, Matthew Patel, James Demetrios Douketis
The periprocedural management of patients who are receiving vitamin K antagonists, direct oral anticoagulants and antiplatelet therapy is a common and challenging clinical scenario as the decision to interrupt or continue these medications is anchored on patient and procedure-related risks for bleeding and thrombosis. Adding to the complexity of clinical management is the fact that anticoagulants have varied pharmacokinetic and pharmacodynamic properties and indications for clinical use. In many minimal-bleed-risk procedures, anticoagulants can be safely continued, without interruption, whereas in cases where anticoagulants cannot be safely continued, the timing of interruption and resumption, as well as the need for heparin bridging requires consideration...
January 2022: Internal and Emergency Medicine
https://read.qxmd.com/read/34391064/derivation-and-validation-of-predictors-of-oral-anticoagulant-related-adverse-events-in-seniors-transitioning-from-hospital-to-home
#40
JOURNAL ARTICLE
Harsukh Benipal, Anne Holbrook, J Michael Paterson, James Douketis, Gary Foster, Jinhui Ma, Lehana Thabane
INTRODUCTION: Oral anticoagulant (OAC)-related adverse events are high post-hospitalization. We planned to develop and validate a prediction model for OAC-related harm within 30 days of hospitalization. METHODS: We undertook a population-based study of adults aged ≥66 years who were discharged from hospital on an OAC from September 2010 to March 2015 in Ontario, Canada. The primary outcome was a composite of time to first hospitalization or emergency department visit for a hemorrhagic or thromboembolic event, or mortality within 30 days of hospital discharge...
October 2021: Thrombosis Research
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