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Fresh osteochondral allograft

Raffy Mirzayan, Michael J Lim
BACKGROUND: Osteochondritis dissecans (OCD) of the capitellum is a rare yet debilitating injury seen in young athletes. This is the first report in the literature describing fresh osteochondral allograft transplantation (FOCAT) to treat OCD of the capitellum. METHODS: Nine male baseball players (mean age, 15.3; range, 14-18 years), with OCD of the capitellum were treated with FOCAT. There were 6 pitchers and 3 position players. A ligament-sparing, mini-open approach was used...
November 2016: Journal of Shoulder and Elbow Surgery
Justin D Orr, John C Dunn, Kenneth A Heida, Nicholas A Kusnezov, Brian R Waterman, Philip J Belmont
INTRODUCTION: Structural fresh osteochondral allograft transfer is an appropriate treatment option for large osteochondral lesions of the talus (OLTs), specifically lesions involving the shoulder of the talus. Sparse literature exists regarding functional outcome following this surgery in high-demand populations. MATERIALS AND METHODS: Over a 2-year period, a single surgeon performed 8 structural allograft transfers for treatment of large OLTs in an active duty US military population...
September 13, 2016: Foot & Ankle Specialist
Richard J VanTienderen, John C Dunn, Nicholas Kusnezov, Justin D Orr
PURPOSE: The purpose of this study is to present a systematic review of the literature regarding the use of fresh bulk osteochondral allograft transfer for treatment of large osteochondral lesions of the talus (OCLT) in an effort to characterize the functional outcomes, complications, and reoperation rates. METHODS: A search of the PubMed, CINAHL, Embase, and Cochrane Databases was performed between January 1, 1990, and March 1, 2016, and included all articles related to outcomes after fresh talar allograft transplantation for OCLT...
August 18, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Kamran N Sadr, Pamela A Pulido, Julie C McCauley, William D Bugbee
BACKGROUND: Osteochondritis dissecans (OCD) of the knee can be difficult to treat. Cartilage restoration techniques are often indicated when the lesion or fragment cannot be salvaged and the patient remains symptomatic. Fresh osteochondral allograft (OCA) transplantation can restore both bone and cartilage defects characteristic of OCD. HYPOTHESIS: We hypothesized that osteochondral allografting is a successful method for treating OCD of the knee. STUDY DESIGN: Case series; Level of evidence, 4...
August 5, 2016: American Journal of Sports Medicine
Luís Eduardo Passarelli Tírico, Marco Kawamura Demange, Luiz Augusto Ubirajara Santos, Márcia Uchoa de Rezende, Camilo Partezani Helito, Riccardo Gomes Gobbi, José Ricardo Pécora, Alberto Tesconi Croci, William Dick Bugbee
OBJECTIVE: To standardize and to develop a fresh osteochondral allograft protocol of procurement, processing and surgical utilization in Brazil. This study describes the steps recommended to make fresh osteochondral allografts a viable treatment option in a country without previous fresh allograft availability. DESIGN: The process involves regulatory process modification, developing and establishing procurement, and processing and surgical protocols. RESULTS: Legislation: Fresh osteochondral allografts were not feasible in Brazil until 2009 because the law prohibited preservation of fresh grafts at tissue banks...
July 2016: Cartilage
Eric C McCarty, Ryan R Fader, Justin J Mitchell, R Edward Glenn, Hollis G Potter, Kurt P Spindler
BACKGROUND: Osteochondral autografts and allografts have been widely used in the treatment of isolated grade 4 articular cartilage lesions of the knee. However, there is a paucity of literature regarding the basic science investigating the direct comparison between fresh osteochondral allografts to autografts. HYPOTHESIS: At 12 months, fresh osteochondral allografts are equal to autografts with respect to function, bony incorporation into host bone, and chondrocyte viability...
September 2016: American Journal of Sports Medicine
Dimitrios S Mastrokalos, Georgios N Panagopoulos, Ioannis P Galanopoulos, Panayiotis J Papagelopoulos
: Management of a posterior shoulder dislocation with an associated reverse Hill-Sachs lesion is challenging, both diagnostically and therapeutically. Diagnosis is frequently delayed or missed, whereas the resulting humeral head defect is often larger and more difficult to salvage than in anterior shoulder dislocations. This report presents the case of a 29-year-old male with a recurrent posterior shoulder dislocation associated with a large reverse Hill-Sachs defect, treated with bone augmentation of the lesion with a combination of fresh femoral head allograft and a locally harvested humeral head autograft transfer, with a successful outcome...
June 23, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Chase S Dean, Jorge Chahla, Raphael Serra Cruz, Robert F LaPrade
Articular cartilage damage of the knee can cause severe morbidity. Owing to its avascular nature, articular cartilage has limited potential for self-healing and increased propensity to progress to osteoarthritis. Treatment of large, full-thickness cartilage defects is still a challenge for orthopaedic surgeons but has recently achieved high success rates with the use of osteochondral allografts. This article details our technique of osteochondral allograft transplantation for the treatment of articular cartilage defects of the knee...
February 2016: Arthroscopy Techniques
Ryan Joseph Pomajzl, Erin Ann Baker, Kevin Charles Baker, Mackenzie Marie Fleischer, Meagan R Salisbury, Dylan M Phillips, Paul Thomas Fortin
BACKGROUND: Fresh osteochondral allografting of the talus is one treatment option for large chondral defects. Following positive early term results, failure rates of up to 35% have been reported. A retrieval study was performed to characterize failed talar allografts. METHODS: Failed fresh osteochondral allografts of the talus were retrieved on revision. Cases of deep infection were excluded. After tissue fixation, samples were decalcified, embedded, and stained with Safranin-O/Fast Green, osteocalcin, tumor necrosis factor alpha (TNF-α), CD4, CD8, and CD68...
September 2016: Foot & Ankle International
Alexander D Cigan, Brendan L Roach, Robert J Nims, Andrea R Tan, Michael B Albro, Aaron M Stoker, James L Cook, Gordana Vunjak-Novakovic, Clark T Hung, Gerard A Ateshian
Animal cells have served as highly controllable model systems for furthering cartilage tissue engineering practices in pursuit of treating osteoarthritis. Although successful strategies for animal cells must ultimately be adapted to human cells to be clinically relevant, human chondrocytes are rarely employed in such studies. In this study, we evaluated the applicability of culture techniques established for juvenile bovine and adult canine chondrocytes to human chondrocytes obtained from fresh or expired osteochondral allografts...
June 14, 2016: Journal of Biomechanics
Jack Farr, Guilherme C Gracitelli, Nehal Shah, Eric Y Chang, Andreas H Gomoll
BACKGROUND: Widespread adoption of fresh allograft transplantation remains limited, predominantly by supply issues. To overcome these limitations, a preshaped, cylindrical sterilized and decellularized osteochondral allograft (SDOCA) implant was recently introduced as a clinical treatment option. PURPOSE: To evaluate functional outcomes and graft survivorship among patients treated with the SDOCA implant for knee cartilage injuries. STUDY DESIGN: Case series; Level of evidence, 4...
August 2016: American Journal of Sports Medicine
Ioannis C Zouzias, William D Bugbee
The technique of osteochondral allograft (OCA) transplantation has been used to treat a wide spectrum of cartilage deficiencies in the knee. Its use has been supported by basic science and clinical studies that show it is a safe and effective treatment option. What sets fresh OCA transplantation apart from other cartilage procedures in the knee, is the ability to treat large defects with mature hyaline cartilage. Studies looking at transplantation of fresh OCAs in the general population have shown reliable pain relief and return to activities of daily living...
June 2016: Sports Medicine and Arthroscopy Review
Christopher E Gross, Samuel B Adams, Mark E Easley, James A Nunley
Osteochondral lesions of the talus, large or small, are challenging for the treating orthopaedic surgeon. These cartilage and bony defects can cause substantial pain and functional disability. Surgical treatment of small osteochondral lesions of the talus has been thoroughly explored and includes retrograde drilling, arthroscopic débridement and marrow stimulation, osteochondral autografting from cartilage/bone unit harvested from the ipsilateral knee (mosaicplasty), and autologous chondrocyte implantation...
2016: Instructional Course Lectures
Erik Hohmann, Kevin Tetsworth
BACKGROUND: The purpose of this study was to review the clinical results of irradiated fresh frozen osteochondral allografts for large osteochondral defects of the knee using the Mega-OATS technique. METHODS: Nine patients with a mean age of 32.1±6.6 (18 to 44) underwent Mega-OATS transplantation with irradiated (2.5Mrad), fresh frozen distal femur allograft. Three patients also underwent ACL-reconstruction; one patient a high tibial osteotomy. The underlying indication was osteochondrosis dissecans in four and trauma in five patients...
June 2016: Knee
Yang Lin, Eric A Lewallen, Emily T Camilleri, Carolina A Bonin, Dakota L Jones, Amel Dudakovic, Catalina Galeano-Garces, Wei Wang, Marcel J Karperien, A Noelle Larson, Diane L Dahm, Michael J Stuart, Bruce A Levy, Jay Smith, Daniel B Ryssman, Jennifer J Westendorf, Hee-Jeong Im, Andre J van Wijnen, Scott M Riester, Aaron J Krych
Preservation of osteochondral allografts used for transplantation is critical to ensure favorable outcomes for patients after surgical treatment of cartilage defects. To study the biological effects of protocols currently used for cartilage storage, we investigated differences in gene expression between stored allograft cartilage and fresh cartilage from living donors using high throughput molecular screening strategies. We applied next generation RNA sequencing (RNA-seq) and real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) to assess genome-wide differences in mRNA expression between stored allograft cartilage and fresh cartilage tissue from living donors...
February 22, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
E W Yates, R A Boden, K Suvarna, I Stockley
No abstract text is available yet for this article.
February 2016: Annals of the Royal College of Surgeons of England
Abdulaziz Z Alomar, Ali Mohammed Somily, Thamer M Alraiyes, Ahmad S Bin Nasser, Fawzi F Aljassir
BACKGROUND: Inadvertent contamination of osteochondral (OC) autografts during harvesting and preparation can lead to significant complications and can cause the operating team to weigh the infection risk after reimplantation against discarding the OC fragment. The most commonly reported contamination mechanism is the accidental dropping of an OC fragment; however, associated contamination levels remain unclear. The rate and level of contamination during standard harvesting and preparation are also unknown...
March 2016: American Journal of Sports Medicine
Amanda Pinheiro, Avery Cooley, Jun Liao, Rajkumar Prabhu, Steven Elder
Osteochondral xenografts are potentially inexpensive, widely available alternatives to fresh allografts. However, antigen removal from xenogenic cartilage may damage the extracellular matrix and reduce compressive stiffness. Non-crosslinked xenogenic cartilage may also undergo rapid enzymatic degradation in vivo. We hypothesized that natural crosslinking agents could be used in place of glutaraldehyde to improve the mechanical properties and enzymatic resistance of decellularized cartilage. This study compared the effects of genipin (GNP), proanthocyanidin (PA), and epigallocatechin gallate (EGCG), on the physical and mechanical properties of decellularized porcine cartilage...
June 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Susanna Chubinskaya, Dominik Haudenschild, Seth Gasser, James Stannard, Christian Krettek, Joseph Borrelli
Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain, and often causes significant disability and loss of productivity. Osteoarthritis is believed to occur as a result of ordinary "wear and tear" on joints during the course of normal activities of daily living. Posttraumatic osteoarthritis is a particular subset of osteoarthritis that occurs after a joint injury. Developing clinically relevant animal models will allow investigators to delineate the causes of posttraumatic osteoarthritis and develop means to slow or prevent its development after joint injury...
December 2015: Journal of Orthopaedic Trauma
Jin Park, Whan Yong Chung
Talar body fractures are rare and associated with a high rate of morbidity due to poor vascularity and the frequent occurrence of posttraumatic osteoarthritis. If talar body fractures are combined with a large bone defect, the situation becomes even more challenging due to difficult joint reconstruction. Only few reports have described the use of whole-bone fresh-frozen allografts for the treatment of foot trauma. Osteochondral bulk allografts can be used as an alternative to tibiotalar arthrodesis for the treatment of talar body fractures with large bone defects, especially in young patients...
January 2016: Archives of Orthopaedic and Trauma Surgery
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