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Program development and evaluation

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https://www.readbyqxmd.com/read/28735360/navigating-the-future-of-cardiovascular-drug-development-leveraging-novel-approaches-to-drive-innovation-and-drug-discovery-summary-of-findings-from-the-novel-cardiovascular-therapeutics-conference
#1
REVIEW
Thomas J Povsic, Rob Scott, Kenneth W Mahaffey, Robert Blaustein, Jay M Edelberg, Martin P Lefkowitz, Scott D Solomon, Jonathan C Fox, Kevin E Healy, Aarif Y Khakoo, Douglas W Losordo, Fady I Malik, Brett P Monia, Rusty L Montgomery, Jeffrey Riesmeyer, Gregory G Schwartz, Steven L Zelenkofske, Joseph C Wu, Scott M Wasserman, Matthew T Roe
PURPOSE: The need for novel approaches to cardiovascular drug development served as the impetus to convene an open meeting of experts from the pharmaceutical industry and academia to assess the challenges and develop solutions for drug discovery in cardiovascular disease. METHODS: The Novel Cardiovascular Therapeutics Summit first reviewed recent examples of ongoing or recently completed programs translating basic science observations to targeted drug development, highlighting successes (protein convertase sutilisin/kexin type 9 [PCSK9] and neprilysin inhibition) and targets still under evaluation (cholesteryl ester transfer protein [CETP] inhibition), with the hope of gleaning key lessons to successful drug development in the current era...
July 22, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28734949/the-program-evaluation-committee-in-action-lessons-learned-from-a-general-surgery-residency-s-experience
#2
Shanley B Deal, Heather Seabott, Lily Chang, Adnan A Alseidi
OBJECTIVE: To evaluate the success of the annual program evaluation process and describe the experience of a Program Evaluation Committee for a General Surgery residency program. DESIGN: We conducted a retrospective review of the Program Evaluation Committee's meeting minutes, data inputs, and outcomes from 2014 to 2016. We identified top priorities by year, characterized supporting data, summarized the improvement plans and outcome measures, and evaluated whether the outcomes were achieved at 1 year...
July 19, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28734773/epico-4-0-total-quality-in-the-management-of-invasive-candidiasis-in-critically-ill-patients-by-analysing-the-integrated-process
#3
Rafael Zaragoza, Ricard Ferrer, Pedro Llinares, Emilio Maseda, Alejandro Rodríguez, Santiago Grau, Guillermo Quindós
BACKGROUND: A high quality integrated process in the clinical setting of non-neutropenic critically ill patients at risk for invasive candidiasis is a necessary tool to improve the management of these patients. AIMS: To identify the key points on invasive candidiasis in order to develop a set of recommendations with a high level of consensus required for the creation of a total quality integrated process for the management of non-neutropenic critically ill patients at risk of invasive candidiasis...
July 19, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28734679/assessment-of-biodistribution-using-mesenchymal-stromal-cells-algorithm-for-study-design-and-challenges-in-detection-methodologies
#4
Blanca Reyes, Maria Isabel Coca, Margarita Codinach, María Dolores López-Lucas, Anna Del Mazo-Barbara, Marta Caminal, Irene Oliver-Vila, Valentín Cabañas, Silvia Lope-Piedrafita, Joan García-López, José M Moraleda, Cesar G Fontecha, Joaquim Vives
BACKGROUND AIMS: Biodistribution of candidate cell-based therapeutics is a critical safety concern that must be addressed in the preclinical development program. We aimed to design a decision tree based on a series of studies included in actual dossiers approved by competent regulatory authorities, noting that the design, execution and interpretation of pharmacokinetics studies using this type of therapy is not straightforward and presents a challenge for both developers and regulators...
July 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28733270/evaluating-a-web-based-coaching-program-using-electronic-health-records-for-patients-with-chronic-obstructive-pulmonary-disease-in-china-randomized-controlled-trial
#5
Lan Wang, Lin He, Yanxia Tao, Li Sun, Hong Zheng, Yashu Zheng, Yuehao Shen, Suyan Liu, Yue Zhao, Yaogang Wang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is now the fourth leading cause of death in the world, and it continues to increase in developing countries. The World Health Organization expects COPD to be the third most common cause of death in the world by 2020. Effective and continuous postdischarge care can help patients to maintain good health. The use of electronic health records (EHRs) as an element of community health care is new technology in China. OBJECTIVE: The aim of this study was to develop and evaluate a Web-based coaching program using EHRs for physical function and health-related quality of life for patients with COPD in China...
July 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28733221/incidence-predictors-and-outcomes-of-acute-on-chronic-liver-failure-in-outpatients-with-cirrhosis
#6
Salvatore Piano, Marta Tonon, Elia Vettore, Marialuisa Stanco, Chiara Pilutti, Antonietta Romano, Sara Mareso, Carmine Gambino, Alessandra Brocca, Antonietta Sticca, Silvano Fasolato, Paolo Angeli
BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) is the most life-threatening complication of cirrhosis. Prevalence and outcomes of ACLF have been recently described in hospitalized patients with cirrhosis. However, no data is currently available on the prevalence and the risk factors of ACLF in outpatients with cirrhosis. The aim of this study was to evaluate incidence, predictors and outcomes of ACLF in a large cohort of outpatients with cirrhosis. METHODS: 466 patients with cirrhosis consecutively evaluated in a tertiary hospital outpatient clinic were included and followed up until death and/or liver transplantation for a mean of 45±44 months...
July 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28733189/systematic-review-of-serum-steroid-reference-intervals-developed-using-mass-spectrometry
#7
REVIEW
Nevada Tavita, Ronda F Greaves
The aim of this study was to perform a systematic review of the published literature to determine the available serum/plasma steroid reference intervals generated by mass spectrometry (MS) methods across all age groups in healthy subjects and to suggest recommendations to achieve common MS based reference intervals for serum steroids. MEDLINE, EMBASE and PubMed databases were used to conduct a comprehensive search for English language, MS-based reference interval studies for serum/plasma steroids. Selection of steroids to include was based on those listed in the Royal College of Pathologists of Australasia Quality Assurance Programs, Chemical Pathology, Endocrine Program...
July 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28733128/dance-for-health-an-intergenerational-program-to-increase-access-to-physical-activity
#8
Krista Schroeder, Sarah J Ratcliffe, Adriana Perez, David Earley, Cory Bowman, Terri H Lipman
PURPOSE: The purpose of this study was to evaluate Dance for Health, an intergenerational program to increase access to physical activity in an underserved, high risk urban community. DESIGN AND METHODS: Dance for Health was developed using community-based participatory research methods and evaluated using an observational study design. The program entailed two hour line dancing sessions delivered by trained dance instructors in the neighborhood recreation center...
July 18, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28732323/evaluation-of-an-online-training-for-improving-self-reported-evidence-based-decision-making-skills-in-cancer-control-among-public-health-professionals
#9
A B Morshed, P Ballew, M B Elliott, D Haire-Joshu, M W Kreuter, R C Brownson
OBJECTIVES: The purpose of this evaluation was to assess the effect of the online evidence-based cancer control (EBCC) training on improving the self-reported evidence-based decision-making (EBDM) skills in cancer control among Nebraska public health professionals. STUDY DESIGN: Cross-sectional group comparison. METHODS: Previously developed EBDM measures were administered via online surveys to 201 public health professionals at baseline (comparison group) and 123 professionals who took part in the training...
July 18, 2017: Public Health
https://www.readbyqxmd.com/read/28731883/the-effects-on-children-s-anxiety-and-quality-of-life-of-a-psychoeducational-program-for-families-living-with-parental-cancer-and-their-network-a-randomized-controlled-trial-study
#10
May Aasebø Hauken, Mariana Pereira, Mette Senneseth
BACKGROUND: Families living with parental cancer report lack of social support. The Cancer PEPSONE Program (CPP) was developed to bridge the gap between the families and their network. OBJECTIVE: The aims of this study were to study the effect of the CPP on children's anxiety and quality of life (QOL) and examine the association between the CPP's effect on their well parents' received social support, QOL, and psychological distress and the children's anxiety and QOL...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28731607/process-evaluation-of-a-patient-centred-patient-directed-group-based-education-program-for-the-management-of-type-2-diabetes-mellitus
#11
Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger
AIM: The present study developed and evaluated a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus. METHODS: Two frameworks, the Medical Research Council (MRC) framework for developing and evaluating complex interventions and the RE-AIM framework were followed. Data to develop the intervention were sourced from scoping of the literature and formative evaluation. Program evaluation comprised analysis of primary recruitment of participants through general practitioners, baseline and end-point measures of anthropometry, four validated questionnaires, contemporaneous facilitator notes and telephone interviews with participants...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731526/drug-discovery-and-development-for-rare-genetic-disorders
#12
REVIEW
Wei Sun, Wei Zheng, Anton Simeonov
Approximately 7,000 rare diseases affect millions of individuals in the United States. Although rare diseases taken together have an enormous impact, there is a significant gap between basic research and clinical interventions. Opportunities now exist to accelerate drug development for the treatment of rare diseases. Disease foundations and research centers worldwide focus on better understanding rare disorders. Here, the state-of-the-art drug discovery strategies for small molecules and biological approaches for orphan diseases are reviewed...
July 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28730508/quality-improvement-initiatives-in-inflammatory-bowel-disease
#13
REVIEW
Sameer K Berry, Corey A Siegel, Gil Y Melmed
PURPOSE OF REVIEW: This article serves as an overview of several quality improvement initiatives in inflammatory bowel disease (IBD). RECENT FINDINGS: IBD is associated with significant variation in care, suggesting poor quality of care. There have been several efforts to improve the quality of care for patients with IBD. Quality improvement (QI) initiatives in IBD are intended to be patient-centric, improve outcomes for individuals and populations, and reduce costs-all consistent with "the triple aim" put forth by the Institute for Healthcare Improvement (IHI)...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28730459/fetal-programming-as-a-predictor-of-adult-health-or-disease-the-need-to-reevaluate-fetal-heart-function
#14
REVIEW
Joana O Miranda, Carla Ramalho, Tiago Henriques-Coelho, José Carlos Areias
Epidemiologic and experimental evidence suggests that adverse stimuli during critical periods in utero permanently alters organ structure and function and may have persistent consequences for the long-term health of the offspring. Fetal hypoxia, maternal malnutrition, or ventricular overloading are among the major adverse conditions that can compromise cardiovascular development in early life. With the heart as a central organ in fetal adaptive mechanisms, a deeper understanding of the fetal cardiovascular physiology and of the echocardiographic tools to assess both normal and stressed pregnancies would give precious information on fetal well-being and hopefully may help in early identification of special risk groups for cardiovascular diseases later in life...
July 20, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28729780/best-practices-for-robotic-surgery-programs
#15
Stephanie J Estes, David Goldenberg, Joshua S Winder, Ryan M Juza, Jerome R Lyn-Sue
BACKGROUND AND OBJECTIVES: Robotic surgical programs are increasing in number. Efficient methods by which to monitor and evaluate robotic surgery teams are needed. METHODS: Best practices for an academic university medical center were created and instituted in 2009 and continue to the present. These practices have led to programmatic development that has resulted in a process that effectively monitors leadership team members; attending, resident, fellow, and staff training; credentialing; safety metrics; efficiency; and case volume recommendations...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28729188/assessing-interest-and-barriers-for-resident-and-faculty-involvement-in-global-surgery
#16
Maija Cheung, James M Healy, Michael R Hall, Doruk Ozgediz
BACKGROUND: Multiple institutions have developed international electives and sustainable global surgery initiatives to facilitate clinical, research, and outreach opportunities with hospitals in resource-poor areas. Despite increasing interest among programs, many institutions have not successfully reached potential involvement. OBJECTIVE: This study evaluates the experiences of Yale residents and faculty, measures interest in the development of an international surgical elective, and enumerates barriers to developing or participating in these opportunities...
July 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#17
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28728763/implementation-of-a-school-nurse-led-intervention-for-children-with-severe-obesity-in-new-york-city-schools
#18
Krista Schroeder, Haomiao Jia, Y Claire Wang, Arlene Smaldone
PURPOSE: The Healthy Options and Physical Activity Program (HOP) is a school nurse-led intervention for children with severe obesity. HOP was developed by experts at the New York City Department of Health and Mental Hygiene and implemented in New York City schools beginning in 2012. The purpose of this study was to evaluate HOP implementation with the goal of informing HOP refinement and potential future HOP dissemination. DESIGN AND METHODS: This study entailed a retrospective analysis of secondary data...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28728552/study-protocol-for-a-comparative-effectiveness-trial-of-two-models-of-perinatal-integrated-psychosocial-assessment-the-pipa-project
#19
Nicole Reilly, Emma Black, Georgina M Chambers, Virginia Schmied, Stephen Matthey, Josephine Farrell, Dawn Kingston, Andrew Bisits, Marie-Paule Austin
BACKGROUND: Studies examining psychosocial and depression assessment programs in maternity settings have not adequately considered the context in which psychosocial assessment occurs or how broader components of integrated care, including clinician decision-making aids, may optimise program delivery and its cost-effectiveness. There is also limited evidence relating to the diagnostic accuracy of symptom-based screening measures used in this context. The Perinatal Integrated Psychosocial Assessment (PIPA) Project was developed to address these knowledge gaps...
July 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28727808/automatic-mouse-ultrasound-detector-a-mud-a-new-tool-for-processing-rodent-vocalizations
#20
Sarah M Zala, Doris Reitschmidt, Anton Noll, Peter Balazs, Dustin J Penn
House mice (Mus musculus) emit complex ultrasonic vocalizations (USVs) during social and sexual interactions, which have features similar to bird song (i.e., they are composed of several different types of syllables, uttered in succession over time to form a pattern of sequences). Manually processing complex vocalization data is time-consuming and potentially subjective, and therefore, we developed an algorithm that automatically detects mouse ultrasonic vocalizations (Automatic Mouse Ultrasound Detector or A-MUD)...
2017: PloS One
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