Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Evgeny G Chulkov, Emery Smith, Louis Scampavia, Timothy P Spicer, Simone Haeberlein, Jonathan S Marchant
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases - for example, the parasitic blood fluke infection, schistosomiasis - are treated with the drug praziquantel (PZQ). However, PZQ is ineffective against disease caused by liver flukes from the genus Fasciola . This is due to a single amino acid change within the target of PZQ, a transient receptor potential ion channel (TRPM PZQ ), in Fasciola species. Here we identify benzamidoquinazolinone analogs that are active against Fasciola TRPM PZQ ...
September 22, 2023: bioRxiv