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Hailei Su, Fengchang Wu, Ruiqing Zhang, Xiaoli Zhao, Yunsong Mu, Chenglian Feng, John P Giesy
PCBs are typical of persistent, bioaccumulative and toxic compounds (PBTs) that are widely distributed in the environment and can biomagnify through aquatic food webs, because of their stability and lipophilic properties. Fish-eating birds are top predators in the aquatic food chain and may suffer adverse effects from exposure to PCB concentrations. In this review, we address the toxicity of PCBs to birds and have derived tissue residue guidelines (TRGs) and toxic reference values (TRVs) for PCBs for protecting birds in China...
2014: Reviews of Environmental Contamination and Toxicology
Z Zakeri, M Curto, D Hoover, K Wightman, J Engelhardt, F F Smith, A L Kierszenbaum, T Gleeson, M Tenniswood
Testosterone-repressed prostate message-2 (TRPM-2) was originally isolated and cloned from the regressing ventral prostate of the rat. In this tissue, and in other hormone-dependent tissues such as the mammary gland, this gene is induced in the absence of the appropriate trophic hormone. Sequence analysis of the cDNA and genomic clones of TRPM-2 have demonstrated that the coding sequence of this gene is identical to S35-S45 (also known as SGP-2 and clusterin), which is constitutively expressed by the Sertoli cells of the adult testis...
December 1992: Molecular Reproduction and Development
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