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Lorete Kotze

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https://www.readbyqxmd.com/read/27933472/tumor-necrosis-factor-alpha-inhibitors-did-not-influence-postoperative-morbidity-after-elective-surgical-resections-in-crohn-s-disease
#1
Paulo Gustavo Kotze, Mansur Paulo Saab, Bárbara Saab, Lorete Maria da Silva Kotze, Marcia Olandoski, Lilian Vital Pinheiro, Carlos Augusto Real Martinez, Maria de Lourdes Setsuko Ayrizono, Daniela de Oliveira Magro, Claudio Saddy Rodrigues Coy
BACKGROUND: The real impact of anti-tumor necrosis alpha (TNF) therapy in postoperative complications after intestinal resections in Crohn's disease (CD) still needs to be determined. AIMS: To compare the postoperative complication rates after elective intestinal resections in CD patients, with or without previous exposure to anti-TNF therapy. METHODS: This was a retrospective and observational study, with elective intestinal resections for CD (emergency procedures were excluded)...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27556094/endoscopic-evaluation-of-celiac-disease-severity-and-its-correlation-with-histopathological-aspects-of-the-duodenal-mucosa
#2
Mauro W Bonatto, Luiz Kotze, Marcia Orlandoski, Ricardo Tsuchyia, Carlos A de Carvalho, Doryane Lima, Gustavo Kurachi, Ivan R B Orso, Lorete Kotze
BACKGROUND AND STUDY AIMS: Celiac disease (CD) is a chronic systemic autoimmune disorder affecting genetically predisposed individuals, triggered and maintained by the ingestion of gluten. Triggered and maintained by the ingestion of gluten, celiac disease is a chronic systemic autoimmune disorder affecting genetically predisposed individuals. Persistent related inflammation of the duodenal mucosa causes atrophy architecture detectable on esophagogastroduodenoscopy (EGD) and histopathology...
July 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/26838490/impact-of-a-gluten-free-diet-on-bone-mineral-density-in-celiac-patients
#3
Lorete M S Kotze, Thelma Skare, Antonella Vinholi, Leandro Jurkonis, Renato Nisihara
BACKGROUND: Osteoporosis (OP) is a metabolic bone illness that may complicate celiac disease (CD). It can lead to devastating consequences because of low bone mass and fragility fractures. PURPOSE: To study the OP prevalence in a group of Brazilian patients with CD and the value of a gluten free diet (GFD). METHODS: Retrospective study of celiac female patients from a single University Center followed with bone densitometries. Results from densitometry made at first visit were compared with a second study after a median time of 5 years...
February 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26653030/impact-of-a-gluten-free-diet-on-bone-mineral-density-in-celiac-patients
#4
Lorete M S Kotze, Thelma Skare, Antonella Vinholi, Leandro Jurkonis, Renato Nisihara
BACKGROUND: Osteoporosis (OP) is a metabolic bone illness that may complicate celiac disease (CD). It can lead to devastating consequences because of low bone mass and fragility fractures. PURPOSE: To study the OP prevalence in a group of Brazilian patients with CD and the value of a gluten free diet (GFD). METHODS: Retrospective study of celiac female patients from a single University Center followed with bone densitometries. Results from densitometry made at first visit were compared with a second study after a median time of 5 years...
December 10, 2015: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26131001/conventional-versus-biological-therapy-for-prevention-of-postoperative-endoscopic-recurrence-in-patients-with-crohn-s-disease-an-international-multicenter-and-observational-study
#5
Paulo Gustavo Kotze, Antonino Spinelli, Rodolff Nunes da Silva, Ivan Folchini de Barcelos, Fábio Vieira Teixeira, Rogério Saad-Hossne, Idblan Carvalho de Albuquerque, Marcia Olandoski, Lorete Maria da Silva Kotze, Yasuo Suzuki, Akihiro Yamada, Ken Takeuchi, Matteo Sacchi, Takayuki Yamamoto
BACKGROUND/AIMS: Postoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn's disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice. METHODS: The MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecal resection, from 7 referral centers in 3 different countries...
July 2015: Intestinal Research
https://www.readbyqxmd.com/read/26017083/fecal-calprotectin-levels-for-the-ethiological-diagnosis-in-brazilian-patients-with-gastrointestinal-symptoms
#6
Lorete Maria da Silva Kotze, Renato Mitsunori Nisihara, Sandra Beatriz Marion, Murilo Franco Cavassani, Paulo Gustavo Kotze
BACKGROUND: Determination of fecal calprotectin can provide an important guidance for the physician, also in primary care, in the differential diagnosis of gastrointestinal disorders, meanly between inflammatory bowel diseases and irritable bowel syndrome. Objectives The aims of the present study were to prospectively investigate, in Brazilian adults with gastrointestinal complaints, the value of fecal calprotectin as a biomarker for the differential diagnosis between functional and organic disorders and to correlate the concentrations with the activity of inflammatory bowel diseases...
January 2015: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/25925094/anti-ccp-antibodies-and-rheumatological-findings-in-brazilian-patients-with-crohn-s-disease
#7
Valmir Mocelin, Renato Mitsunori Nisihara, Shirley R R Utiyama, Lorete M S Kotze, Odery Ramos, Iara Messias-Reason
BACKGROUND/AIMS: Arthropathy is the most common extraintestinal manifestation observed in patients with Crohn's disease (CD). The present study aimed to screen rheumatoid arthritis (RA) using anti-CCP antibodies and rheumatoid factor (RF) in CD patients from Southern Brazil. Additionally, the presence of arthralgia and spondyloarthritis (SpA) was evaluated. CD patients, previously diagnosed using clinical data, imaging tests, endoscopic and histological findings, were included consecutively...
2015: Digestion
https://www.readbyqxmd.com/read/25820017/direct-retrospective-comparison-of-adalimumab-and-infliximab-in-preventing-early-postoperative-endoscopic-recurrence-after-ileocaecal-resection-for-crohn-s-disease-results-from-the-multiper-database
#8
MULTICENTER STUDY
Paulo Gustavo Kotze, Takayuki Yamamoto, Silvio Danese, Yasuo Suzuki, Fabio Vieira Teixeira, Idblan Carvalho de Albuquerque, Rogerio Saad-Hossne, Ivan Folchini de Barcelos, Rodolff Nunes da Silva, Lorete Maria da Silva Kotze, Márcia Olandoski, Matteo Sacchi, Akihiro Yamada, Ken Takeuchi, Antonino Spinelli
BACKGROUND AND AIMS: Both adalimumab [ADA] and infliximab [IFX] seem to be effective in the prevention of early postoperative endoscopic recurrence [EPER] after ileocaecal resection in Crohn's disease [CD] patients. There is lack of data with direct comparison between the two agents in the postoperative scenario. The aim of this study was to compare the rates of EPER in patients treated with ADA and IFX after ileocaecal resection for CD. METHODS: This was a multicentre retrospective analysis of EPER rates in CD patients after ileocaecal resections, from seven referral centres in three countries...
July 2015: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/25721295/disease-duration-did-not-influence-the-rates-of-loss-of-efficacy-of-the-anti-tnf-therapy-in-latin-american-crohn%C3%A2-s-disease-patients
#9
MULTICENTER STUDY
Paulo Gustavo Kotze, Juliano Coelho Ludvig, Fábio Vieira Teixeira, Everson Fernando Malluta, Eron Fábio Miranda, Marcelo Raisweiler Hardt, Márcia Olandoski, Lorete Maria da Silva Kotze, Harry Kleinubing
BACKGROUND/AIMS: The efficacy of both Infliximab (IFX) and Adalimumab (ADA) can be reduced over time. The aim of this study was to analyze the incidence of loss of efficacy (LOE) of both IFX and ADA, and outline the influence of disease duration on its occurrence. METHODS: Retrospective, multicenter, observational cohort study, with CD patients treated with anti-TNF therapy. LOE was defined as the need for steroids, occurrence of major abdominal surgery during treatment, dose increase, interval shortening or switching of the anti- TNF agent...
2015: Digestion
https://www.readbyqxmd.com/read/24760063/adalimumab-for-maintenance-therapy-for-one-year-in-crohn-s-disease-results-of-a-latin-american-single-center-observational-study
#10
Paulo Gustavo Kotze, Vinícius Rezende Abou-Rejaile, Luciana Aparecida Uiema, Marcia Olandoski, Maria Cristina Sartor, Eron Fábio Miranda, Lorete Maria da Silva Kotze, Rogério Saad-Hossne
CONTEXT: Adalimumab is a fully-human antibody that inhibits TNF alpha, with a significant efficacy for long-term maintenance of remission. Studies with this agent in Latin American Crohn's disease patients are scarce. OBJECTIVES: The objective of this study was to outline clinical remission rates after 12 months of adalimumab therapy for Crohn's disease patients. METHODS: Retrospective, single-center, observational study of a Brazilian case series of Crohn's disease patients under adalimumab therapy...
January 2014: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/24322197/dermatitis-herpetiformis-the-celiac-disease-of-the-skin
#11
REVIEW
Lorete Maria da Silva Kotze
No abstract text is available yet for this article.
July 2013: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/23329745/celiac-disease-and-dermatitis-herpetiformis-in-brazilian-twins-a-long-term-follow-up-and-screening-of-their-relatives
#12
Lorete Maria da Silva Kotze, Renato Nisihara, Luiz Roberto Kotze, Shirley Ramos da Rosa Utiyama
OBJECTIVES: To investigate three pairs of twins with celiac disease (CD) concerning clinical presentation, diagnostic procedures, and long-follow-up, besides screening CD in their first-degree relatives. PATIENTS/METHODS: CD was diagnosed in childhood by endoscopic duodenal biopsy in two monozygotic (MZ) female pairs (A1 and A2, B1 and B2) and one dizygotic (DZ) pair, in which the male (C1) had CD and the female (C2) was negative. The patients had periodic evaluations after a gluten-free diet (GFD) for 16 to 21 years...
2013: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/23011242/autoantibodies-in-relatives-of-celiac-disease-patients-a-follow-up-of-6-10-years
#13
Flávia Raphaela Nass, Lorete Maria Kotze, Renato M Nisihara, Iara Taborda de Messias-Reason, Shirley R da Rosa Utiyama
CONTEXT: Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. OBJECTIVE: To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. METHODS: Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997-2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006-2007)...
July 2012: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/22624128/celiac-disease-in-native-indians-from-brazil-a-clinical-and-epidemiological-survey
#14
Shirley Ramos da Rosa Utiyama, João Luis Coelho Ribas, Renato Mitsunori Nisihara, Lorete Maria da Silva Kotze, Iara José de Messias-Reason
BACKGROUND: Celiac disease has been described in populations from around the world, with recent data emphasizing the occurrence of the disease in ethnic minorities. There are only a few studies evaluating celiac disease in native Indians. AIMS: This study aimed to screen the anti-endomysial antibody (IgA-EmA) in Kaingang and Guarani Indians from southern Brazil, in order to establish a clinical serological evaluation of celiac disease in these individuals. MATERIAL AND METHODS: Serum samples from 321 individuals (125 male and 196 female; 4-86 years old) from Mangueirinha Indigenous Reserve, State of Parana, Brazil, and 180 non-Indigenous healthy individuals (62 male and 118 female; 2-81 years old) were analysed to the presence of anti-endomysial antibody class IgA by indirect immunofluorescence assay...
March 2010: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/21140083/antibodies-anti-saccharomyces-cerevisiae-asca-do-not-differentiate-crohn-s-disease-from-celiac-disease
#15
Lorete Maria da Silva Kotze, Renato Mitsunori Nisihara, Shirley Ramos da Rosa Utiyama, Paulo Gustavo Kotze, Petra Mirella Theiss, Márcia Olandoski
CONTEXT: Anti-Saccharomyces cerevisiae antibodies (ASCA), considered serologic markers for Crohn's disease, were described in patients with celiac disease, disappearing after a gluten-free diet. OBJECTIVES: Evaluation of ASCA positivity in patients with Crohn's disease and celiac disease in relation to healthy individuals. METHODS: A total of 145 individuals were studied: 36 with Crohn's disease and 52 with celiac disease, that fulfilled the diagnostic criteria for both affections, and 57 healthy individuals for control...
July 2010: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/21042020/serological-and-clinical-follow-up-of-relatives-of-celiac-disease-patients-from-southern-brazil
#16
Flávia Raphaela Nass, Lorete Maria da Silva Kotze, Renato Mitsunori Nisihara, Iara José de Messias-Reason, Shirley Ramos da Rosa Utiyama
BACKGROUND/AIMS: In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METHODS: Serum samples of 233 relatives, 186 recruited between 1997 and 2000 (phase I) and 138 between 2006 and 2007 (phase II: 91 of the follow-up group and 47 newly tested), were analyzed...
2011: Digestion
https://www.readbyqxmd.com/read/20232004/celiac-disease-in-brazilian-patients-associations-complications-and-causes-of-death-forty-years-of-clinical-experience
#17
Lorete Maria da Silva Kotze
CONTEXT: Celiac disease is a multisystem auto-immune disorder and may start at any age in genetically predisposed individuals. OBJECTIVE: To identify associations, complications, and cause of death in Brazilian patients. METHODS: One hundred and fifty-seven patients were studied: 23 adolescents and 134 adults, 79.6% females, 20.4% males, 75.8% at the time of diagnosis and 24.2% on a gluten-free diet, follow-up between 1 and 40 years. The diagnosis of celiac disease was based on histologic findings and the presence of serologic auto-antibodies markers for celiac disease...
October 2009: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/19764094/a-brazilian-experience-of-the-self-transglutaminase-based-test-for-celiac-disease-case-finding-and-diet-monitoring
#18
Lorete Maria da Silva Kotze, Ana Paula Brambila Rodrigues, Luiz Roberto Kotze, Renato Mitsunori Nisihara
AIM: To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring. METHODS: Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea...
September 21, 2009: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/18478332/mannan-binding-lectin-levels-related-to-spontaneous-abortion-in-brazilian-patients-with-celiac-disease
#19
Lorete Maria da Silva Kotze, Elisandra Grangeiro de Carvalho, Shirley Ramos da Rosa Utiyama, Renato Mitsunori Nisihara, Iara Messias-Reason
Low concentration of mannan-binding lectin (MBL) has been related to unexplained spontaneous abortion (SA), which has also been observed in an increased frequency in patients with celiac disease (CD). In this study, plasma levels of MBL were determined in patients with CD and irritable bowel syndrome (IBS) in order to investigate whether there is an association of MBL levels and the occurrence of SA in these patients. MBL concentration was determined in 46 patients with CD (28 without and 18 with report of SA) and 38 patients with IBS (25 without and 13 with report of SA)...
December 2008: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/17962863/-serological-screening-of-relatives-of-celiac-disease-patients-antiendomysium-antibodies-anti-tissue-transglutaminase-or-both
#20
Shirley Ramos da Rosa Utiyama, Flávia Raphaela Nass, Lorete Maria da Silva Kotze, Renato Mitsunori Nisihara, Altair Rogério Ambrosio, Iara Taborda de Messias-Reason
BACKGROUND: Celiac disease is the most common intestinal disorder of caucasian populations and presents a prevalence of 8% to 18% between the relatives of patients. The anti-endomysial (IgA-EmA) and anti-tissue transglutaminase antibodies (IgA-tTG) have represented an important non invasive and sensitivity method of screening and diagnosis of celiac disease in risk groups and populations. AIM: To investigate the prevalence of IgA-EmA and IgA-tTG antibodies in relatives of celiac patients and verify the degree of concordance between them...
April 2007: Arquivos de Gastroenterologia
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