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Intratympanic steroid

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https://www.readbyqxmd.com/read/27921520/a-comparison-between-systemic-and-intratympanic-steroid-therapies-as-initial-therapy-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#1
Qingfen Qiang, Xuewen Wu, Tao Yang, Chunguang Yang, Hong Sun
CONCLUSIONS: Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE: This article was aimed at evaluating whether intratympanic steroid (ITS) treatment would provide benefits over systemic steroid therapy (SST) as initial therapy in patients with idiopathic sudden sensorineural hearing loss (ISSHL)...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27898607/effects-of-intratympanic-dexamethasone-on-high-dose-radiation-ototoxicity-in-vivo
#2
Christine T Dinh, Si Chen, John Dinh, Stefania Goncalves, Esperanza Bas, Kyle Padgett, Perry Johnson, Nagy Elsayyad, Fred Telischi, Thomas Van De Water
BACKGROUND: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. HYPOTHESIS: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. METHODS: Seven rats received radiation (12 Gy) to both cochleae...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27894374/autologous-intratympanic-blood-patch-for-presumed-perilymphatic-fistulas
#3
P K Foster
OBJECTIVE: To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections. METHOD: A review was conducted of patients' history, physical and audiometric data, before and after treatment by intratympanic blood injections performed from 2009 to 2015. RESULTS: Twelve ears were identified, with trauma associated with air travel, water sports or nose blowing. Ten of these cases had hearing loss, six had vestibular symptoms...
November 29, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27861924/intratympanic-dexamethasone-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#4
REVIEW
Nagi G El Sabbagh, Maida J Sewitch, Aren Bezdjian, Sam J Daniel
OBJECTIVE: Systemic dexamethasone has demonstrated conclusive benefits in reversing sudden sensorineural hearing loss (SSNHL) despite considerable number of potential side effects. In contrast, the intratympanic route of steroid administration averts several possible complications. This study aims to examine the literature to delineate the efficacy and side effect of intratympanic dexamethasone (ITD) injection for the treatment of SSNHL. DATA SOURCE: Cochrane, Embase, and MEDLINE electronic databases from January 1950 to August 2014, with an update performed on November 10, 2014...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27821219/effects-of-two-different-local-anaesthetic-methods-vs-no-anaesthesia-on-pain-scores-for-intratympanic-injections
#5
N Ata, O Erdur, M H Görgülü, E Yilmaz
OBJECTIVE: This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes...
November 8, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27779563/hearing-changes-after-intratympanically-applied-steroids-for-primary-therapy-of-sudden-hearing-loss-a-meta-analysis-using-mathematical-simulations-of-drug-delivery-protocols
#6
Arne Liebau, Olivia Pogorzelski, Alec N Salt, Stefan K Plontke
OBJECTIVE: Controlled and uncontrolled studies with primary intratympanic or combined intratympanic and systemic application of glucocorticosteroids for idiopathic sudden hearing loss were analyzed by means of a meta-analysis in an attempt to establish optimal local drug delivery protocols. STUDY DESIGN: A total of 25 studies with 28 treatment groups between January 2000 and June 2014 were selected that adequately described drug delivery protocols. Cochlear drug levels were calculated by a validated computer model of drug dispersion in the inner ear fluids based on the concentration and volume of glucocorticoids applied, the time the drug remained in the middle ear, and the specific timing of injections...
October 21, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27751619/rate-of-tympanic-membrane-perforation-after-intratympanic-steroid-injection
#7
Michael C Topf, David W Hsu, Douglas R Adams, Tingting Zhan, Stanley Pelosi, Thomas O Willcox, Brian McGettigan, Kyle W Fisher
PURPOSE: To determine the rate of persistent tympanic membrane perforation after intratympanic steroid injection. To determine which comorbid conditions and risk factors are associated with prolonged time to perforation closure following intratympanic steroid injection. MATERIALS AND METHODS: Clinical data were gathered for patients who had undergone intratympanic steroid injection to treat sudden sensorineural hearing loss or Ménière's disease. Primary outcomes analysis included rate of persistent tympanic membrane perforation, defined as perforation at least 90days following last injection, and time to perforation healing...
January 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27638077/meni%C3%A3-re-s-disease
#8
J M Espinosa-Sanchez, J A Lopez-Escamez
Menière's disease (MD) is a chronic multifactorial disorder of the inner ear characterized by episodic vestibular symptoms associated with sensorineural hearing loss, tinnitus, and aural pressure. Epidemiologic and genomic evidence supports a genetic susceptibility with multiple biochemical pathways involved, including the endocrine system, innate immune response, and autonomic nervous system. Allergens, infectious agents, vascular events, or genetic factors could modify inner-ear homeostasis and trigger MD...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27552828/successful-continual-intratympanic-steroid-injection-therapy-in-a-patient-with-refractory-sensorineural-hearing-loss-accompanied-by-relapsing-polychondritis
#9
Koichiro Wasano, Shuta Tomisato, Sayuri Yamamoto, Noriomi Suzuki, Taiji Kawasaki, Kaoru Ogawa
OBJECTIVE: To report the treatment efficacy of continual intratympanic steroid injection (ITSI) therapy in a patient with refractory sensorineural hearing loss accompanied by relapsing polychondritis. PATIENT: A 49-year-old female diagnosed with relapsing polychondritis at the age of 45 years and who had been treated with corticosteroids and immunosuppressants developed sensorineural hearing loss in the left ear. INTERVENTION: Her unilateral hearing loss did not recover despite receiving one cyclophosphamide pulse treatment, one methylprednisolone pulse treatment, and weekly leukapheresis...
August 20, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27497416/pediatric-sudden-sensorineural-hearing-loss-etiology-diagnosis-and-treatment-in-20-children
#10
Kavita Dedhia, David H Chi
OBJECTIVES: 1. To report our experience in children with sudden-onset sensorineural hearing loss (SSNHL). 2. To describe the etiology and management of children with SSNHL. METHODS: Retrospective review of 20 children with SSNHL, from 2000 to 2013 at a tertiary pediatric facility. Patients had the following inclusion criteria: history of normal hearing, hearing loss occurring in less than 3 days, and audiogram documentation. RESULTS: The average age of patients presenting with SSNHL is 11 years 3 months (22months-18years)...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27413407/the-efficacy-of-adjuvant-intratympanic-steroid-treatment-for-otitis-media-with-effusion-in-children
#11
Hazem Saeed Amer, Mohammad Waheed El-Anwar, Alaa Eldin Elfeky
INTRODUCTION: Otitis media with effusion (OME) is a leading cause of hearing impairment in children. Therefore, early and proper management is essential. OBJECTIVES: The objective of this research is to assess the efficacy of intratympanic (IT) steroids injection for management of otitis media with effusion (OME). METHODS: This study involved 42 children (84 ears) with bilateral OME. We used tympanometry to confirm the childreńs middle ear effusion and pure tone audiometry to determine hearing threshold...
July 2016: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/27403406/intratympanic-dexamethasone-injection-vs-methylprednisolone-for-the-treatment-of-refractory-sudden-sensorineural-hearing-loss
#12
Nezamoddin Berjis, Saeed Soheilipour, Alireza Musavi, Seyed Mostafa Hashemi
BACKGROUND: During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL) treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there are still debates about the optimal dosage, preferred drug, and the route of administration...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27392835/about-the-pathophysiology-of-acute-unilateral-vestibular-deficit-vestibular-neuritis-vn-or-peripheral-vestibulopathy-pvp
#13
Denis S Uffer, Stefan C A Hegemann
OBJECTIVE: To determine whether patients with acute unilateral peripheral vestibulopathy (PVP), often called "vestibular neuritis/neuronitis or neuropathy" (VN) have a vestibular lesion pattern consistent with the distribution of the neurological afferents. BACKGROUND: Much is known about the clinical nature of PVP, however less so about its etiology and pathogenesis. Due to the frequency with which VN is used to describe the syndrome, an inflammation of the vestibular nerve or of one of its branches is often assumed to be the cause of PVP, though there is insufficient data so far to support this assumption...
July 2, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27379548/management-of-sudden-sensorineural-hearing-loss
#14
Aaron M Metrailer, Seilesh C Babu
PURPOSE OF REVIEW: Sudden sensorineural hearing loss (SNHL) is an otologic emergency and should be managed quickly and effectively. This review focuses on the management of sudden SNHL, primarily idiopathic sudden SNHL as it is the most common cause. RECENT FINDINGS: Management options include observation, oral steroids, intratympanic steroids, or combined oral/intratympanic steroids. One-third to two-thirds of patients will achieve spontaneous recovery, most likely within the first 2 weeks...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27379547/primary-treatment-of-idiopathic-sudden-sensorineural-hearing-loss-with-intratympanic-dexamethasone
#15
Candace E Hobson, Thomas H Alexander, Jeffrey P Harris
PURPOSE OF REVIEW: Systemic corticosteroids have been the mainstay of treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) for over 30 years. Recently, intratympanic steroids have risen in popularity; however, there is no consensus regarding the details of their application. The purpose of this article is to review the current literature and share our opinion that intratympanic dexamethasone (alone or with systemic steroids) should be offered as primary treatment of ISSNHL...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27348351/current-concepts-in-the-management-of-idiopathic-sudden-sensorineural-hearing-loss
#16
Brendan P O'Connell, Jacob B Hunter, David S Haynes
PURPOSE OF REVIEW: The purpose of this manuscript is to review the initial management strategies for idiopathic sudden sensorineural hearing loss, with an emphasis on the role that steroids play in treatment of this condition, and discuss options for auditory rehabilitation of persistent unilateral hearing loss. RECENT FINDINGS: Recent data suggest that hearing improvement may be greater for patients initially treated with both systemic and intratympanic steroid when compared with those treated with systemic steroids alone...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27223677/sudden-pediatric-hearing-loss-comparing-the-results-of-combined-treatment-intratympanic-dexamethasone-and-systemic-steroids-with-systemic-steroid-treatment-alone
#17
Gültekin Övet, Necat Alataş, Fatih Güzelkara
OBJECTIVE: The aim of the present study was to compare hearing improvements obtained with combined intratympanic and systemic steroid therapy, and systemic steroid therapy alone in pediatric patients with idiopathic sudden sensorineural hearing loss (SSHL). STUDY DESIGN: Retrospective. SETTING: Tertiary referral hospital. PATIENTS: Pediatric patients with SSHL. INTERVENTIONS: The patients were divided into two groups, based on the method of steroid administration: Group 1 (systemic therapy group, n = 23) was treated with oral methylprednisolone alone whereas Group 2 (combination therapy group, n = 26) was treated with combination of oral methylprednisolone and intratympanic dexamethasone injections...
July 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27087111/effect-of-intratympanic-steroid-administration-on-sensorineural-hearing-loss-associated-with-acute-otitis-media
#18
R L Heywood, S N Ifeacho, A A Narula
OBJECTIVE: To evaluate a small cohort of patients who presented with symptoms and signs consistent with acute infective sensorineural hearing loss who were treated with intratympanic steroids. METHOD: Seven patients received a 7-day course of oral antibiotics and oral prednisolone followed by 3 intratympanic injections of methylprednisolone and 1 week of topical dexamethasone drops. RESULTS: Hearing improved in 57 per cent of patients (four out of seven)...
June 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27077389/the-short-and-long-term-outcome-of-intratympanic-steroid-therapy-as-a-salvage-treatment-for-acute-low-tone-sensorineural-hearing-loss-without-episodes-of-vertigo
#19
Shinya Morita, Yuji Nakamaru, Keishi Fujiwara, Keiji Iizuka, Masayori Masuya, Akihiro Homma, Atsushi Fukuda, Satoshi Fukuda
OBJECTIVES: To evaluate the hearing outcomes of intratympanic steroid (ITS) treatment for patients with acute low-tone sensorineural hearing loss (ALHL) after failure of initial therapy and to investigate the recurrence and progression to definite Ménière's disease (MD) during a long-term follow-up. METHODS: We retrospectively reviewed the medical records of 90 patients with refractory ALHL who were followed up for at least 1 year between January 2000 and April 2014...
2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27071771/combined-intratympanic-and-systemic-use-of-steroids-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#20
Yang Gao, Dong Liu
The main objective of the meta-analysis was to investigate whether intratympanic steroid injections in combination with systemic steroids would provide an additional advantage over systemic steroid therapy (SST) alone in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). The results will provide a meaningful suggestion in clinical therapy of ISSNHL. The electronic database search was based on the database in OVID Medline, Embase and PubMed up to December 15, 2015 with the goal of identifying all available observational studies examining the effects of combination therapy and SST in ISSNHL patients...
November 2016: European Archives of Oto-rhino-laryngology
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