Piotr J Czernik, Rachel M Golonka, Saroj Chakraborty, Beng San Yeoh, Ahmed A Abokor, Piu Saha, Ji-Youn Yeo, Blair Mell, Xi Cheng, Sudipta Baroi, Yuan Tian, Andrew D Patterson, Bina Joe, Matam Vijay-Kumar, Beata Lecka-Czernik
Integration of microbiota in a host begins at birth and progresses during adolescence, forming a multidirectional system of physiological interactions. Here, we present an instantaneous effect of natural, bacterial gut colonization on the acceleration of longitudinal and radial bone growth in germ-free born, 7-wk-old male rats. Changes in bone mass and structure were analyzed after 10 days following the onset of colonization through cohousing with conventional rats and revealed unprecedented acceleration of bone accrual in cortical and trabecular compartments, increased bone tissue mineral density, improved proliferation and hypertrophy of growth plate chondrocytes, bone lengthening, and preferential deposition of periosteal bone in the tibia diaphysis...
December 1, 2021: Physiological Genomics