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Vitamin d adipocyte

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https://www.readbyqxmd.com/read/29339180/leptin-blocks-the-inhibitory-effect-of-vitamin-d-on-adipogenesis-and-cell-proliferation-in-3t3-l1-adipocytes
#1
Jessica Lopes Nobre, Patricia Cristina Lisboa, Janaine Cavalcanti Carvalho, Mariana Renovato Martins, Simone Vargas, Cristina Barja-Fidalgo, Egberto Gaspar de Moura, Elaine de Oliveira
Recently, we demonstrated high serum leptin and 25(OH)D (calcidiol) in obese animals, with high C/EBPβ and PPARγ expression in adipose tissue. Since the role of vitamin D in adipogenesis remains controversial and hyperleptinemia is found in obesity, we asked if leptin could interfere in vitamin D action on adipocytes. Here, we studied the direct effect of these two hormones upon 3T3L1 preadipocytes incubated with or without 1,25(OH)2D (100 nM, 24 h) and with leptin (10-7M, 4 h later). RT-PCR (VDR and Cyp27b1/1α-hydroxylase), western blotting (VDR, Cyp27b1/1α-hydroxylase, ObR-b, C/EBPβ, PPARγ and Bax content), a cell proliferation assay and an Annexin V-FITC binding assay were performed...
January 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29321608/the-effect-of-maternal-vitamin-d-deficiency-during-pregnancy-on-body-fat-and-adipogenesis-in-rat-offspring
#2
Juan Wen, Qin Hong, Xingyun Wang, Lijun Zhu, Tianqi Wu, Pengfei Xu, Ziyi Fu, Lianghui You, Xing Wang, Chenbo Ji, Xirong Guo
To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, and explore the potential mechanism, we constructed a vitamin D deficient rat model and performed metabolic activity evaluation, body fat monitoring, biochemical analysis, adipogenesis assay, methylation microarray and RNA-seq for their offspring rats. We found the weight of vitamin D deficient (VDD) offspring was gradually higher than that of control (CLT) offspring, and the difference was significant since 10 weeks old...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29205876/vitamin-d-does-not-play-a-functional-role-in-adipose-tissue-development-in-rodent-models
#3
Alexandra Schutkowski, Daniela Max, Markus Bönn, Corinna Brandsch, Sarah M Grundmann, Frank Hirche, Martin S Staege, Gabriele I Stangl
SCOPE: Several studies have proposed a role of vitamin D in adipogenesis. Here, we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size in young and old mice and the effect of maternal vitamin D deficiency on fetal adipogenesis. METHODS AND RESULTS: Histological analysis of adipose tissues showed that Vdr knockout (KO) mice had smaller adipocytes than wild-type (WT) mice. Next, we compared young and old Vdr-KO and WT mice and found no differences in adipocyte sizes between weaned Vdr-KO mice and WT mice...
December 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29186386/gene-expression-pattern-in-response-to-cholecalciferol-supplementation-highlights-cubilin-as-a-major-protein-of-25-oh-d-uptake-in-adipocytes-and-male-mice-white-adipose-tissue
#4
Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Julien Astier, Julie Dalifard, Catherine Defoort, Ljubica Svilar, Jean-Charles Martin, Franck Tourniaire, Jean-François Landrier
It is well established that the active form of vitamin D, i.e. 1,25(OH)2D, regulates the expression of genes involved in its own metabolism and transport in the kidney, and possibly in the liver. However, little is known about the transcriptional impact of cholecalciferol supplementation on white adipose tissue (WAT) and adipocytes, which are a major site of vitamin D and 25(OH)D storage in the organism. To fill this gap, we investigated the impact of cholecalciferol supplementation in WAT via a panel of genes coding for enzymes and proteins involved in vitamin D metabolism and uptake...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29182958/vitamin-a-and-marbling-attributes-intramuscular-fat-hyperplasia-effects-in-cattle
#5
Z A Kruk, M J Bottema, L Reyes-Veliz, R E A Forder, W S Pitchford, C D K Bottema
Twenty Angus steers were fed a diet low in β-carotene and vitamin A for 10months. Ten steers were supplemented with vitamin A weekly, while the other ten steers did not receive any additional vitamin A. The results demonstrated that the restriction of vitamin A intake increased intramuscular fat (IMF) by 46%. This was a function of the total number of marbling flecks increasing by 22% and the average marbling fleck size increasing by 14%. Vitamin A restriction resulted in marbling flecks that were less branched (22%) and slightly more round (4%) with an increased minor axis length (7%)...
November 21, 2017: Meat Science
https://www.readbyqxmd.com/read/29180820/subcutaneous-white-adipocytes-express-a-light-sensitive-signaling-pathway-mediated-via-a-melanopsin-trpc-channel-axis
#6
Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y Lee, Peter E Light
Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin may regulate scWAT function. In this regard, we discovered a novel blue light-sensitive current in human scWAT that is mediated by melanopsin coupled to transient receptor potential canonical cation channels...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112142/igfbp-3-interacts-with-the-vitamin-d-receptor-in-insulin-signaling-associated-with-obesity-in-visceral-adipose-tissue
#7
Inmaculada Moreno-Santos, Daniel Castellano-Castillo, María Fernanda Lara, Jose Carlos Fernandez-Garcia, Francisco Jose Tinahones, Manuel Macias-Gonzalez
Adipose tissue has traditionally only been considered as an energy storage organ. Nevertheless, the importance of this tissue in systemic physiology and, especially, in systemic inflammation has been highlighted in recent years. Adipose tissue expresses proteins related to vitamin D (VD) metabolism, and it has been proposed that it can act as a VD storage tissue. The active form of VD, 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃), is able to modify adipocyte and adipose tissue physiology via the VD receptor (VDR), decreasing the expression of pro-inflammatory cytokines in adipose tissue...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29037825/vitamin-d-prevents-lipid-accumulation-in-murine-muscle-through-regulation-of-ppar%C3%AE-and-perilipin-2-expression
#8
Jiarong Li, Milton Mihalcioiu, Lifeng Li, Mahvash Zakikhani, Anne Camirand, Richard Kremer
Vitamin D plays an important role in regulation of skeletal muscle tone and contraction. Serum vitamin D status is linked to muscle power and force in adolescent girls, and vitamin D deficiency is associated with myopathies in children and poorer physical performance in the elderly. We previously reported that vitamin D deficiency is linked to a significant increase in muscle fatty infiltration in healthy young women, and studies in patients with neuromuscular disorders also associate muscle weakening and lipid content...
October 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28676524/in-utero-vitamin-d-deficiency-predisposes-offspring-to-long-term-adverse-adipose-tissue-effects
#9
Anthony M Belenchia, Sarah A Johnson, Mark R Ellersieck, Cheryl S Rosenfeld, Catherine A Peterson
The fetal period represents an important window of susceptibility for later obesity and metabolic disease. Maternal vitamin D deficiency (VDD) during pregnancy is a global concern that may have long-lasting consequences on offspring metabolic health. We sought to determine whether a VDD in utero environment affects fetal adipose tissue development and offspring metabolic disease predisposition in adulthood. Furthermore, we sought to explore the extent to which the VDD intrauterine environment interacts with genetic background or postnatal environment to influence metabolic health...
September 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28670298/in-vitro-differentiation-of-preosteoblast-like-cells-mc3t3-e1-to-adipocytes-is-enhanced-by-1-25-oh-2-vitamin-d3
#10
Elisha Pendleton, Nalini Chandar
Osteoblasts and adipocytes originate from common mesenchymal progenitor cells and are controlled by specific transcription factors. While 1,25-dihydroxyvitamin D3 (vitamin D) is known to be an important factor for osteoblast differentiation, there are conflicting reports regarding its effect on adipogenesis. In this study, we attempted to understand the effect of exposure of preosteoblasts (MC3T3-E1) to adipogenic media with and without vitamin D and determined the expression of adipogenic genes during this process...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28617856/the-associations-between-vdr-bsmi-polymorphisms-and-risk-of-vitamin-d-deficiency-obesity-and-insulin-resistance-in-adolescents-residing-in-a-tropical-country
#11
Rayinda Rahmadhani, Nur Lisa Zaharan, Zahurin Mohamed, Foong Ming Moy, Muhammad Yazid Jalaludin
BACKGROUND: The vitamin D receptor (VDR) gene is expressed abundantly in different tissues; including adipocytes and pancreatic beta cells. The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance. AIMS: This study was aimed to examine the association between BsmI polymorphism and risk of vitamin D deficiency, obesity and insulin resistance in adolescents living in a tropical country...
2017: PloS One
https://www.readbyqxmd.com/read/28501775/vitamin-d-correlation-with-biochemical-and-body-composition-changes-in-a-southern-brazilian-population-and-induction-of-cytotoxicity-in-mesenchymal-stem-cells-derived-from-human-adipose-tissue
#12
João Renato Pesarini, Rodrigo Juliano Oliveira, Lucas Roberto Pessatto, Andréia Conceição Milan Brochado Antoniolli-Silva, Ingrid Felicidade, Nance Beyer Nardi, Melissa Camassola, Mário Sérgio Mantovani, Lúcia Regina Ribeiro
Studies have shown that metabolic disorders, serum inflammatory markers and weight gain (obesity) are correlated with vitamin D deficiency. Therefore, the present study correlated the serum calcidiol (s25(OH)D3) levels in a sample of individuals from southern Brazil with variables related to metabolic disorders, obesity and lifestyle habits and assessed the cytotoxic effect of calcitriol on adipose tissue-derived mesenchymal stem cells (ADSCs). The results showed a 79.23% prevalence of hypovitaminosis D in the study population and a correlation (p<0...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28475114/melatonin-and-vitamin-d-interfere-with-the-adipogenic-fate-of-adipose-derived-stem-cells
#13
Valentina Basoli, Sara Santaniello, Sara Cruciani, Giorgio Carlo Ginesu, Maria Laura Cossu, Alessandro Palmerio Delitala, Pier Andrea Serra, Carlo Ventura, Margherita Maioli
Adipose-derived stem cells (ADSCs) represent one of the cellular populations resident in adipose tissue. They can be recruited under certain stimuli and committed to become preadipocytes, and then mature adipocytes. Controlling stem cell differentiation towards the adipogenic phenotype could have a great impact on future drug development aimed at counteracting fat depots. Stem cell commitment can be influenced by different molecules, such as melatonin, which we have previously shown to be an osteogenic inducer...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28353634/vitamin-d-insufficiency-exacerbates-adipose-tissue-macrophage-infiltration-and-decreases-ampk-sirt1-activity-in-obese-rats
#14
Eugene Chang, Yangha Kim
Obesity is recognized as a state of chronic low-grade systemic inflammation due to adipose tissue macrophage infiltration and production of proinflammatory adipokines. Decreased vitamin D status is associated with obesity. The specific aim of the present study is to investigate the effects of vitamin D on obesity-induced adipose tissue inflammation. Male Sprague-Dawley rats were randomized and fed a normal diet (NOR, 1000 IU vitamin D/kg diet), a 45% high-fat diet (HF, 1000 IU vitamin D/kg diet), or a 45% high-fat diet containing 25 IU vitamin D/kg diet (HF+LVD) for 12 weeks...
March 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28229265/low-vitamin-d-status-and-obesity-role-of-nutritionist
#15
REVIEW
Silvia Savastano, Luigi Barrea, Maria Cristina Savanelli, Francesca Nappi, Carolina Di Somma, Francesco Orio, Annamaria Colao
Low vitamin D status and obesity have concomitantly reached epidemic levels worldwide. Up to now the direction of the association between low vitamin D status and obesity, the exact mechanisms responsible for this association and the clinical usefulness to increase vitamin D status for reducing adiposity still warrant further evaluation. The aim of the present review was to examine the current evidence linking low vitamin D status and obesity in relation to the role of the nutritionist. On the one side, considering obesity as a causal factor, low sun exposure in obese individuals due to their sedentary lifestyle and less outdoor activity, vitamin D sequestration in adipose tissue, and volumetric dilution of ingested or cutaneously synthesized vitamin D3 in the large fat mass of obese patients, might represent some of the factors playing a major role in the pathogenesis of the low vitamin D status...
June 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28100914/tet-mediated-hydroxymethylcytosine-at-the-ppar%C3%AE-locus-is-required-for-initiation-of-adipogenic-differentiation
#16
Y Yoo, J H Park, C Weigel, D B Liesenfeld, D Weichenhan, C Plass, D-G Seo, A M Lindroth, Y J Park
BACKGROUND/OBJECTIVES: Adipose tissue is one of the main organs regulating energy homeostasis via energy storage as well as endocrine function. The adipocyte cell number is largely determined by adipogenesis. While the molecular mechanism of adipogenesis has been extensively studied, its role in dynamic DNA methylation plasticity remains unclear. Recently, it has been shown that Tet methylcytosine dioxygenase (TET) is catalytically capable of oxidizing DNA 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) toward a complete removal of the methylated cytosine...
April 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28091892/bariatric-roux-en-y-gastric-bypass-surgery-adipocyte-proteins-involved-in-increased-bone-remodeling-in-humans
#17
Maria Fernanda G Biagioni, Adriana L Mendes, Célia Regina Nogueira, Celso V Leite, Loraine Gollino, Gláucia Mfs Mazeto
PURPOSE: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. MATERIALS AND METHODS: This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB)...
July 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28063949/vitamin-d-supplementation-inhibits-oxidative-stress-and-upregulate-sirt1-ampk-glut4-cascade-in-high-glucose-treated-3t3l1-adipocytes-and-in-adipose-tissue-of-high-fat-diet-fed-diabetic-mice
#18
Prasenjit Manna, Arunkumar E Achari, Sushil K Jain
This study examined the hypothesis that vitamin-D prevents oxidative stress and upregulates glucose metabolism via activating insulin-independent signaling molecules in 3T3-L1 adipocytes and in high fat diet (HFD)-fed mice. To investigate the mechanism 3T3L1 adipocytes were treated with high glucose (HG, 25 mM) and 1,25(OH)2D3 (1,25-dihydroxyvitamin D3) (0-50 nM). Results showed that 1,25(OH)2D3 supplementation decreased NOX4 expression, ROS production, NF-κB phosphorylation, and increased the expression of Nrf2 and Trx in HG-treated cells...
February 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28055298/vitamin-d-limits-inflammation-linked-microrna-expression-in-adipocytes-in-vitro-and-in-vivo-a-new-mechanism-for-the-regulation-of-inflammation-by-vitamin-d
#19
Esma Karkeni, Lauriane Bonnet, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Jianping Ye, Jean-François Landrier
Inflammation of adipose tissue is believed to be a contributing factor to many chronic diseases associated with obesity. Vitamin D (VD) is now known to limit this metabolic inflammation by decreasing inflammatory marker expression and leukocyte infiltration in adipose tissue. In this study, we investigated the impact of VD on microRNA (miR) expression in inflammatory conditions in human and mouse adipocytes, using high-throughput methodology (miRNA PCR arrays). Firstly, we identified three miRs (miR-146a, miR-150, and miR-155) positively regulated by TNFα in human adipocytes...
January 5, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28004271/maternal-vitamin-d-deficiency-during-pregnancy-affects-expression-of-adipogenic-regulating-genes-peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-and-vitamin-d-receptor-vdr-in-lean-male-mice-offspring
#20
Anthony M Belenchia, Karen L Jones, Matthew Will, David Q Beversdorf, Victoria Vieira-Potter, Cheryl S Rosenfeld, Catherine A Peterson
PURPOSE: Maternal vitamin D deficiency during pregnancy is a widespread issue that may have long-lasting consequences on offspring adiposity. We sought to determine how maternal vitamin D deficiency during the perinatal period would affect offspring adipose tissue development and gene expression. METHODS: Female C57BL/6 J mice were fed either a vitamin D deficient (VDD) or control diet from 4 weeks before pregnancy (periconception) until 7 days postparturition...
December 21, 2016: European Journal of Nutrition
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