Cecilie Skarstad Norevik, Aleksi M Huuha, Ragnhild N Røsbjørgen, Linda Bergersen, Kamilla Jacobsen, Rodrigo Miguel-Dos-Santos, Liv Ryan, Belma Skender, Jose Bianco N Moreira, Asgeir Kobro-Flatmoen, Menno P Witter, Nathan Scrimgeour, Atefe R Tari
BACKGROUND: Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. Here we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability, and an in vivo rat model of AD to test whether such plasma impacts cognitive function, amyloid pathology, and neurogenesis. METHODS: Mouse hippocampal neuronal cells (HT22) were exposed to AD-like stress using Amyloid-β and treated with plasma collected from human male donors 3 h after a single bout of high-intensity exercise...
July 25, 2023: Journal of Sport and Health Science