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JOURNAL ARTICLE
Jonas L Isaksen, Jonas Ghouse, Morten W Skov, Morten S Olesen, Anders G Holst, Adrian Pietersen, Jonas B Nielsen, Anja Maier, Claus Graff, Thomas A Gerds, Ruth Frikke-Schmidt, Jørgen K Kanters
OBJECTIVE: The association between common electrocardiogram (ECG) markers and Alzheimer's disease has been scarcely investigated, and it is unknown if ECG markers can improve risk prediction. Thus, we aimed to examine the association between common ECG markers and Alzheimer's disease in a large population. METHODS: We studied the association between ECG markers and Alzheimer's disease using Cox models with adjustment for age, sex, and comorbidities using a large primary care population of patients aged 60 years or more...
February 9, 2023: Journal of the Neurological Sciences
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JOURNAL ARTICLE
Patrick J Kato, Arielle E Kanters, Samantha J Rivard, Samantha Hendren, Carole Ramm, Jeremy Albright, Kate E Schumaker, Robert K Cleary
BACKGROUND: A Michigan Surgical Quality Collaborative Colorectal Cancer Project initiative sought to increase adoption of surgeon total mesorectal excision (TME) grading through standardized education and synoptic operative reporting. Our study aim was to assess initiative impact and level of agreement between surgeon and pathologist-determined TME grades. METHODS: This is a retrospective comparison of surgeon and pathologist TME grades before and after initiative implementation using a prospectively maintained enhanced recovery colorectal surgery database...
February 15, 2023: Journal of Surgical Oncology
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JOURNAL ARTICLE
Astrid N L Hermans, Jonas L Isaksen, Monika Gawalko, Nikki A H A Pluymaekers, Rachel M J van der Velden, Hilco Snippe, Stijn Evens, Glenn De Witte, Justin G L M Luermans, Martin Manninger, Joost Lumens, Jørgen K Kanters, Dominik Linz
AIMS: Although mobile health tools using photoplethysmography (PPG) technology have been validated for the detection of atrial fibrillation (AF), their utility for heart rate assessment during AF remains unclear. Therefore, we aimed to evaluate the accuracy of continuous PPG-based 1 min mean heart rate assessment during AF. METHODS AND RESULTS: Persistent AF patients were provided with Holter electrocardiography (ECG) (for ≥24 h) simultaneously with a PPG-equipped smartwatch...
February 7, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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JOURNAL ARTICLE
Victoria E de Knegt, Paula L Hedley, Anna K Eltvedt, Sophie Placing, Karen Wøjdemann, Anne-Cathrine Shalmi, Line Rode, Jørgen K Kanters, Karin Sundberg, Ann Tabor, Ulrik Lausten-Thomsen, Michael Christiansen
The serum adiponectin/leptin ratio (A/L ratio) is a surrogate marker of insulin sensitivity. Pre-eclampsia (PE) is associated with maternal metabolic syndrome and occasionally impaired fetal growth. We assessed whether the A/L ratio in first-trimester maternal serum was associated with PE and/or birth weight. Adiponectin and leptin were quantitated in first-trimester blood samples (gestational week 10+3 -13+6 ) from 126 women who later developed PE with proteinuria (98 mild PE; 21 severe PE; 7 HELLP syndrome), and 297 controls, recruited from the Copenhagen First-Trimester Screening Study...
January 3, 2023: Life
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JOURNAL ARTICLE
Mary Eapen, Ruta Brazauskas, David A Williams, Mark C Walters, Andrew St Martin, Benjamin L Jacobs, Joseph H Antin, Kira Bona, Sonali Chaudhury, Victoria H Coleman-Cowger, Nancy L DiFronzo, Erica B Esrick, Joshua J Field, Courtney D Fitzhugh, Julie Kanter, Neena Kapoor, Donald B Kohn, Lakshmanan Krishnamurti, Wendy B London, Michael A Pulsipher, Sohel Talib, Alexis A Thompson, Edmund K Waller, Ted Wun, Mary M Horowitz
PURPOSE: To report the incidence and risk factors for secondary neoplasm after transplantation for sickle cell disease. METHODS: Included are 1,096 transplants for sickle cell disease between 1991 and 2016. There were 22 secondary neoplasms. Types included leukemia/myelodysplastic syndrome (MDS; n = 15) and solid tumor (n = 7). Fine-Gray regression models examined for risk factors for leukemia/MDS and any secondary neoplasm. RESULTS: The 10-year incidence of leukemia/MDS was 1...
April 20, 2023: Journal of Clinical Oncology
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JOURNAL ARTICLE
Srinath Adusumalli, Genevieve P Kanter, Dylan S Small, David A Asch, Kevin G Volpp, Sae-Hwan Park, Yevgeniy Gitelman, David Do, Damien Leri, Corinne Rhodes, Christine VanZandbergen, John T Howell, Mika Epps, Ann M Cavella, Michael Wenger, Tory O Harrington, Kayla Clark, Julie E Westover, Christopher K Snider, Mitesh S Patel
IMPORTANCE: Statins reduce the risk of major adverse cardiovascular events, but less than one-half of individuals in America who meet guideline criteria for a statin are actively prescribed this medication. OBJECTIVE: To evaluate whether nudges to clinicians, patients, or both increase initiation of statin prescribing during primary care visits. DESIGN, SETTING, AND PARTICIPANTS: This cluster randomized clinical trial evaluated statin prescribing of 158 clinicians from 28 primary care practices including 4131 patients...
November 30, 2022: JAMA Cardiology
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JOURNAL ARTICLE
Julie Kanter, R Clark Brown, Cynthia Norris, Santosh M Nair, Abdullah Kutlar, Deepa Manwani, Nirmish Shah, Chiaki Tanaka, Shankaranand Bodla, Gessami Sanchez-Olle, Urs Albers, Darla Liles
Crizanlizumab is an anti-P-selectin monoclonal antibody indicated to reduce the frequency/prevent recurrence of vaso-occlusive crises (VOCs) in patients with sickle cell disease (SCD) aged ≥16 years. This analysis of an ongoing phase 2, nonrandomized, open-label study reports the pharmacokinetics (PK), pharmacodynamics (PD), safety, and efficacy of crizanlizumab 5.0 mg/kg (N = 45) and 7.5 mg/kg (N = 12) in patients with SCD with a history of VOCs. The median treatment duration was 104.7 and 85...
March 28, 2023: Blood Advances
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JOURNAL ARTICLE
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K de Kanter, Yannick P Kok, Marieke Everts, H Rudolf de Boer, Anastasia Audrey, Femke J Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C J Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M Lansdorp, Marcel A T M van Vugt
Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are considered to form through homologous recombination (HR). Indeed, SCE induction upon irradiation requires the canonical HR factors BRCA1, BRCA2 and RAD51. In contrast, replication-blocking agents, including PARP inhibitors, induce SCEs independently of BRCA1, BRCA2 and RAD51. PARP inhibitor-induced SCEs are enriched at difficult-to-replicate genomic regions, including common fragile sites (CFSs). PARP inhibitor-induced replication lesions are transmitted into mitosis, suggesting that SCEs can originate from mitotic processing of under-replicated DNA...
November 7, 2022: Nature Communications
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JOURNAL ARTICLE
Christine K Fox, Liza Leykina, Nancy K Hills, Janet L Kwiatkowski, Julie Kanter, John J Strouse, Jenifer H Voeks, Heather J Fullerton, Robert J Adams
BACKGROUND: Hemorrhagic stroke in young patients with sickle cell anemia remains poorly characterized. METHODS: The Post-STOP (Stroke Prevention Trial in Sickle Cell Anemia) retrospective study collected follow-up data on STOP and STOP II clinical trial cohorts. From January 2012 to May 2014, a team of analysts abstracted data from medical records of prior participants (all with sickle cell anemia). Two vascular neurologists reviewed data to confirm hemorrhagic strokes defined as spontaneous intracerebral, subarachnoid, or intraventricular hemorrhage...
November 2022: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Benjamin Neely, Mohammad Shahsahebi, Caitlin E Marks, Steve Power, Andrew Kanter, Claire Howell, Terry Hyslop, Jennifer K Plichta
PURPOSE: Outcomes for patients with metastatic breast cancer (MBC) are continually improving as more effective treatments become available. Granular data sets of this unique population are lacking, and the standard method for data collection relies largely on chart review. Therefore, using electronic health records (EHR) collected at a tertiary hospital system, we developed and evaluated a computational phenotype designed to identify all patients with MBC, and we compared the effectiveness of this algorithm against the gold standard, clinical chart review...
September 2022: JCO Clinical Cancer Informatics
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RANDOMIZED CONTROLLED TRIAL
Christian R Juhl, Josephine Burgdorf, Cecilie Knudsen, Anniek F Lubberding, Simon Veedfald, Jonas L Isaksen, Bolette Hartmann, Ruth Frikke-Schmidt, Thomas Mandrup-Poulsen, Jens J Holst, Jørgen K Kanters, Signe S Torekov
AIM: The voltage-gated potassium channel Kv 11.1 is important for repolarizing the membrane potential in excitable cells such as myocytes, pancreatic α- and β-cells. Moxifloxacin blocks the Kv 11.1 channel and increases the risk of hypoglycaemia in patients with diabetes. We investigated glucose regulation and secretion of glucoregulatory hormones in young people with and without moxifloxacin, a drug known to block the Kv 11.1 channel. MATERIALS AND METHODS: The effect of moxifloxacin (800 mg/day for 4 days) or placebo on glucose regulation was assessed in a randomized, double-blind, crossover study of young men and women (age 20-40 years and body mass index 18...
January 2023: Diabetes, Obesity & Metabolism
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JOURNAL ARTICLE
William J Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Linda Repetto, Maria Pina Concas, Marten E van den Berg, Stefan Weiss, Antoine R Baldassari, Traci M Bartz, James P Cook, Daniel S Evans, Rebecca Freudling, Oliver Hines, Jonas L Isaksen, Honghuang Lin, Hao Mei, Arden Moscati, Martina Müller-Nurasyid, Casia Nursyifa, Yong Qian, Anne Richmond, Carolina Roselli, Kathleen A Ryan, Eduardo Tarazona-Santos, Sébastien Thériault, Stefan van Duijvenboden, Helen R Warren, Jie Yao, Dania Raza, Stefanie Aeschbacher, Gustav Ahlberg, Alvaro Alonso, Laura Andreasen, Joshua C Bis, Eric Boerwinkle, Archie Campbell, Eulalia Catamo, Massimiliano Cocca, Michael J Cutler, Dawood Darbar, Alessandro De Grandi, Antonio De Luca, Jun Ding, Christina Ellervik, Patrick T Ellinor, Stephan B Felix, Philippe Froguel, Christian Fuchsberger, Martin Gögele, Claus Graff, Mariaelisa Graff, Xiuqing Guo, Torben Hansen, Susan R Heckbert, Paul L Huang, Heikki V Huikuri, Nina Hutri-Kähönen, M Arfan Ikram, Rebecca D Jackson, Juhani Junttila, Maryam Kavousi, Jan A Kors, Thiago P Leal, Rozenn N Lemaitre, Henry J Lin, Lars Lind, Allan Linneberg, Simin Liu, Peter W MacFarlane, Massimo Mangino, Thomas Meitinger, Massimo Mezzavilla, Pashupati P Mishra, Rebecca N Mitchell, Nina Mononen, May E Montasser, Alanna C Morrison, Matthias Nauck, Victor Nauffal, Pau Navarro, Kjell Nikus, Guillaume Pare, Kristen K Patton, Giulia Pelliccione, Alan Pittman, David J Porteous, Peter P Pramstaller, Michael H Preuss, Olli T Raitakari, Alexander P Reiner, Antonio Luiz P Ribeiro, Kenneth M Rice, Lorenz Risch, David Schlessinger, Ulrich Schotten, Claudia Schurmann, Xia Shen, M Benjamin Shoemaker, Gianfranco Sinagra, Moritz F Sinner, Elsayed Z Soliman, Monika Stoll, Konstantin Strauch, Kirill Tarasov, Kent D Taylor, Andrew Tinker, Stella Trompet, André Uitterlinden, Uwe Völker, Henry Völzke, Melanie Waldenberger, Lu-Chen Weng, Eric A Whitsel, James G Wilson, Christy L Avery, David Conen, Adolfo Correa, Francesco Cucca, Marcus Dörr, Sina A Gharib, Giorgia Girotto, Niels Grarup, Caroline Hayward, Yalda Jamshidi, Marjo-Riitta Järvelin, J Wouter Jukema, Stefan Kääb, Mika Kähönen, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Maria Fernanda Lima-Costa, Yongmei Liu, Ruth J F Loos, Steven A Lubitz, Dennis O Mook-Kanamori, Andrew P Morris, Jeffrey R O'Connell, Morten Salling Olesen, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Bruce M Psaty, Jerome I Rotter, Bruno Stricker, Pim van der Harst, Cornelia M van Duijn, Niek Verweij, James F Wilson, Dan E Arking, Julia Ramirez, Pier D Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B Munroe
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes...
September 1, 2022: Nature Communications
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JOURNAL ARTICLE
Astrid N L Hermans, Monika Gawalko, Daniek P J Slegers, Nora Andelfinger, Nikki A H A Pluymaekers, Dominique V M Verhaert, Rachel M J van der Velden, Konstanze Betz, Stijn Evens, Justin G L M Luermans, Dennis W den Uijl, Mathias Baumert, Hien L Nguyen, Jonas L Isaksen, Jørgen K Kanters, Michiel Rienstra, Kevin Vernooy, Isabelle C Van Gelder, Jeroen M Hendriks, Dominik Linz
BACKGROUND: The assessment of symptom-rhythm correlation (SRC) in patients with persistent atrial fibrillation (AF) is challenging. Therefore, we performed a novel mobile app-based approach to assess SRC in persistent AF. METHODS: Consecutive persistent AF patients planned for electrical cardioversion (ECV) used a mobile app to record a 60-s photoplethysmogram (PPG) and report symptoms once daily and in case of symptoms for four weeks prior and three weeks after ECV...
August 10, 2022: International Journal of Cardiology
#34
JOURNAL ARTICLE
Jonas L Isaksen, Jonas Ghouse, Morten W Skov, Morten S Olesen, Anders G Holst, Adrian Pietersen, Jonas B Nielsen, Anja Maier, Claus Graff, Ruth Frikke-Schmidt, Jørgen K Kanters
OBJECTIVES: To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD. MATERIALS AND METHODS: We retrospectively included 170,605 primary care patients aged 60 years or older referred for an ECG by their general practitioner and followed them for a median of 7.6 years. Using Cox regression, we reported hazard ratios (HRs) for electrocardiogram markers...
September 2022: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#35
JOURNAL ARTICLE
Stephen R Chen, Clarissa M LeVasseur, Samuel Pitcairn, Maria A Munsch, Brandon K Couch, Adam S Kanter, David O Okonkwo, Jeremy D Shaw, William F Donaldson, Joon Y Lee, William J Anderst
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To identify patient factors that affect adjacent segment kinematics after anterior cervical discectomy and fusion (ACDF) as measured by biplane radiography. SUMMARY OF BACKGROUND DATA: The etiology of adjacent segment disease (ASD) may be multifactorial. Previous studies have investigated associations between patient factors and ASD, although few attempted to link patient factors with mechanical changes in the spine that may explain ASD development...
June 29, 2022: Spine
#36
JOURNAL ARTICLE
Camilla H B Jespersen, Jawad Haider Butt, Johanna Krøll, Bo Gregers Winkel, Jørgen K Kanters, Gunnar Gislason, Christian Torp-Pedersen, Henning Bundgaard, Henrik Kjærulf Jensen, Lars Køber, Jacob Tfelt-Hansen, Peter E Weeke
OBJECTIVE: To examine workforce attachment among patients with congenital long QT syndrome (cLQTS) following diagnosis and identify factors associated with workforce attachment. METHODS AND RESULTS: In this nationwide cohort study, all patients diagnosed with cLQTS in Denmark between 1996 and 2016 aged 18-60 years at diagnosis were identified using nationwide registries. Patients attached to the workforce at diagnosis were included. Attachment to the workforce 1 year after cLQTS diagnosis was examined and compared with a background population matched 1:4 on age, sex and employment status...
July 2022: Open Heart
#37
JOURNAL ARTICLE
Alp Ozpinar, Jennifer L Perez, Emily Hacker, Nima Alan, Nitin Agarwal, Hansen Deng, David O Okonkwo, Adam S Kanter, D K Hamilton
BACKGROUND: Cervical diffuse idiopathic skeletal hyperostosis (DISH) fractures are frequently unstable and carry significant risk of neurologic injury and death. Most patients with DISH fractures are elderly (>70 years) with significant comorbidities. We assessed factors that contribute to outcomes in elderly patients with cervical DISH fractures. METHODS: Elderly patients with cervical DISH fractures from 2008 to 2017 were included in this retrospective multi-institutional cohort study...
June 2022: International Journal of Spine Surgery
#38
JOURNAL ARTICLE
The Zwolle experience with left bundle branch area pacing using stylet-driven active fixation leads.
F Daniëls, A Adiyaman, K M Aarnink, F J Oosterwerff, J R A Verbakel, A Ghani, J J J Smit, M A Kanters, P P H M Delnoy, A Elvan
AIMS: Left bundle branch area pacing (LBBAP) is a novel physiological pacing modality and is regarded as a viable alternative to His bundle pacing. LBBAP has mostly been performed with the lumen-less permanent pacing lead (SelectSecure™ Model 3830, Medtronic, Inc.) with a fixed helix. The aim of this study was to compare the non-stylet driven lumen-less lead (LLL) (Medtronic 3830) with a standard stylet-driven active fixation lead (SDL) (Tendril™ STS Model 2088TC-38, Abbott Laboratories) in terms of lead parameters, procedural success and complication rates...
June 18, 2022: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#39
JOURNAL ARTICLE
Eline J M Bertrums, Axel K M Rosendahl Huber, Jurrian K de Kanter, Arianne M Brandsma, Anaïs J C N van Leeuwen, Mark Verheul, Marry M van den Heuvel-Eibrink, Rurika Oka, Markus J van Roosmalen, Hester A de Groot-Kruseman, C Michel Zwaan, Bianca F Goemans, Ruben van Boxtel
Childhood cancer survivors are confronted with various chronic health conditions like therapy-related malignancies. However, it is unclear how exposure to chemotherapy contributes to the mutation burden and clonal composition of healthy tissues early in life. Here, we studied mutation accumulation in hematopoietic stem and progenitor cells (HSPC) before and after cancer treatment of 24 children. Of these children, 19 developed therapy-related myeloid neoplasms (t-MN). Posttreatment HSPCs had an average mutation burden increase comparable to what treatment-naïve cells accumulate during 16 years of life, with excesses up to 80 years...
August 5, 2022: Cancer Discovery
#40
JOURNAL ARTICLE
Juan S Uribe, Robert M Koffie, Michael Y Wang, Gregory M Mundis, Adam S Kanter, Robert K Eastlack, Neel Anand, Paul Park, Justin S Smith, Douglas C Burton, Dean Chou, Michael P Kelly, Han Jo Kim, Shay Bess, Christopher I Shaffrey, Frank J Schwab, Lawrence G Lenke, Praveen V Mummaneni
OBJECTIVE: Spine surgeons have a heuristic sense of how to surgically restore alignment and address adult spinal deformity (ASD) symptoms, but consensus on the extent of treatment remains unclear. We sought to determine the variability of surgical approaches in treating ASD. METHODS: Sixteen spine surgeons were surveyed on treatment approaches in 10 select ASD cases. We repeated the survey with the same surgeons 4 weeks later, with cases ordered differently. We examined the variability in length of construct, use of interbody spacers, osteotomies, and pelvic fixation frequency...
September 2022: World Neurosurgery
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