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https://www.readbyqxmd.com/read/27151913/age-dependent-effect-of-pediatric-cardiac-progenitor-cells-after-juvenile-heart-failure
#1
Udit Agarwal, Amanda W Smith, Kristin M French, Archana V Boopathy, Alex George, David Trac, Milton E Brown, Ming Shen, Rong Jiang, Janet D Fernandez, Brian E Kogon, Kirk R Kanter, Baahaldin Alsoufi, Mary B Wagner, Manu O Platt, Michael E Davis
UNLABELLED: Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years)...
July 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26520007/selective-management-strategy-of-interrupted-aortic-arch-mitigates-left-ventricular-outflow-tract-obstruction-risk
#2
Bahaaldin Alsoufi, Brian Schlosser, Courtney McCracken, Ritu Sachdeva, Brian Kogon, William Border, William T Mahle, Kirk Kanter
BACKGROUND: Left ventricular outflow tract obstruction (LVOTO) is an important problem after interrupted aortic arch (IAA) repair, especially when early reoperation is required during infancy. Several anatomic factors have been identified that increase LVOTO risk; surgical strategies such as concomitant resection of the conal septum or left ventricular outflow tract (LVOT) bypass (single-stage Yasui operation, or staged Norwood procedure, followed by the Rastelli procedure) have been proposed for such patients...
February 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26505290/depressive-symptoms-in-children-with-chronic-kidney-disease
#3
Amy J Kogon, Matthew B Matheson, Joseph T Flynn, Arlene C Gerson, Bradley A Warady, Susan L Furth, Stephen R Hooper
OBJECTIVE: To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). STUDY DESIGN: Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4...
January 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/24048375/nephrotic-range-proteinuria-is-strongly-associated-with-poor-blood-pressure-control-in-pediatric-chronic-kidney-disease
#4
Amy J Kogon, Christopher B Pierce, Christopher Cox, Tammy M Brady, Mark M Mitsnefes, Bradley A Warady, Susan L Furth, Joseph T Flynn
Despite the importance of blood pressure (BP) control in chronic kidney disease (CKD), few longitudinal studies on its trends exist for pediatric patients with CKD. Here we longitudinally analyzed casual data in 578 children with CKD and annual BP measurements standardized for age, gender, and height. At baseline, 124 children were normotensive, 211 had elevated BP, and 243 had controlled hypertension. Linear mixed-effects models accounting for informative dropout determined factors associated with BP changes over time and relative sub-hazards (RSH) identified factors associated with the achievement of controlled BP in children with baseline elevated BP...
April 2014: Kidney International
https://www.readbyqxmd.com/read/23350927/predicting-functional-capacity-in-patients-with-a-systemic-right-ventricle-subjective-patient-self-assessment-is-better-than-b-type-natriuretic-peptide-levels-and-right-ventricular-systolic-function
#5
COMPARATIVE STUDY
Wendy Book, Michael McConnell, Matthew Oster, Teresa Lyle, Brian Kogon
BACKGROUND: Many adults with transposition of the great arteries have an anatomic right ventricle functioning as the systemic ventricle and are known to develop congestive heart failure, premature cardiac death, and need for cardiac transplantation. Predictors of poor clinical outcome and functional status in patients with left ventricular failure do not always apply to these patients. We aimed to identify predictors of poor functional status in those patients with a systemic right ventricle...
November 2013: Congenital Heart Disease
https://www.readbyqxmd.com/read/19559217/one-thousand-repeat-sternotomies-for-congenital-cardiac-surgery-risk-factors-for-reentry-injury
#6
Paul M Kirshbom, Richard J Myung, Janet M Simsic, Zachary B Kramer, Traci Leong, Brian E Kogon, Kirk R Kanter
BACKGROUND: Reentry injury is a risk associated with repeat sternotomy for cardiac surgery. This risk has been well defined for adults, but there is less information available for patients with congenital heart disease. The goal of this review was to identify the incidence, risk factors, and outcomes for reentry injury in patients with congenital heart disease. METHODS: Eight hundred two patients with congenital heart disease had 1,000 consecutive repeat sternotomies between August 2000 and November 2007...
July 2009: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/19379889/perioperative-risks-and-outcomes-of-atrioventricular-valve-surgery-in-conjunction-with-fontan-procedure
#7
Faraz Kerendi, Zachary B Kramer, William T Mahle, Brian E Kogon, Kirk R Kanter, Paul M Kirshbom
BACKGROUND: Long-term outcomes of staged single-ventricle palliation can be impaired by atrioventricular valve (AVV) regurgitation. Atrioventricular valve repair or replacement has been shown to improve late outcomes, but little data exist regarding the associated perioperative morbidity. This study aimed to evaluate the additional perioperative risks associated with single-ventricle AVV surgery. METHODS: Two hundred thirty-six consecutive Fontan procedures were retrospectively reviewed...
May 2009: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/19356811/pulmonary-arterial-hypertension-in-patients-with-prior-atrial-switch-procedure-for-d-transposition-of-great-arteries-dtga
#8
Amin Yehya, Teresa Lyle, Maria A Pernetz, M E McConnell, B Kogon, Wendy M Book
UNLABELLED: Pulmonary arterial hypertension (PAH) is an uncommon complication of atrial switch repair (Mustard or Senning) for d-transposition of the great arteries (dTGA), often difficult to diagnose by trans-thoracic echocardiography. This patient population is unique in that heart failure and elevated filling pressures are common after atrial switch repairs. Most studies evaluating the use of PAH therapies have excluded this group of patients. METHODS: Our echocardiography database was reviewed for patients with a diagnosis of dTGA status post-atrial switch operation treated with pulmonary vasodilator therapy (monotherapy or combination)...
September 3, 2010: International Journal of Cardiology
https://www.readbyqxmd.com/read/19127223/force-frequency-relationship-of-the-human-ventricle-increases-during-early-postnatal-development
#9
COMPARATIVE STUDY
Rob F Wiegerinck, Anca Cojoc, Carlo M Zeidenweber, Guoliang Ding, Ming Shen, Ronald W Joyner, Janet D Fernandez, Kirk R Kanter, Paul M Kirshbom, Brian E Kogon, Mary B Wagner
Understanding developmental changes in contractility is critical to improving therapies for young cardiac patients. Isometric developed force was measured in human ventricular muscle strips from two age groups: newborns (<2 wk) and infants (3-14 mo) undergoing repair for congenital heart defects. Muscle strips were paced at several cycle lengths (CLs) to determine the force frequency response (FFR). Changes in Na/Ca exchanger (NCX), sarcoplasmic reticulum Ca-ATPase (SERCA), and phospholamban (PLB) were characterized...
April 2009: Pediatric Research
https://www.readbyqxmd.com/read/17786375/prehospital-discharge-car-safety-seat-testing-of-infants-after-congenital-heart-surgery
#10
J M Simsic, K Masterson, B E Kogon, P M Kirshbom, K Kanter
BACKGROUND: This study aimed to expand the American Academy of Pediatrics (AAP) car safety seat testing recommendation to include high-risk infants after cardiac surgery. METHODS: Car safety seat testing (< or =4 days before discharge), performed according to AAP guidelines, was retrospectively reviewed for 66 postoperative infants. Failure was defined as apnea, bradycardia, or oxygen desaturation. RESULTS: The average birth weight of the study infants was 3...
January 2008: Pediatric Cardiology
https://www.readbyqxmd.com/read/17676370/closure-of-symptomatic-ventricular-septal-defects-how-early-is-too-early
#11
COMPARATIVE STUDY
B Kogon, H Butler, P Kirshbom, K Kanter, M McConnell
With improvements in technology and surgical technique, pediatric cardiologists are challenging surgeons to close symptomatic ventricular septal defects (VSDs) in ever smaller patients. Although delaying surgery may facilitate operative repair, early intervention decreases the period of time these patients require therapy to prevent heart failure, maintains growth, and minimizes exposure to increased pulmonary pressures. To evaluate early intervention, we compare the outcomes of VSD closure in different-sized children...
January 2008: Pediatric Cardiology
https://www.readbyqxmd.com/read/17674082/right-pulmonary-agenesis-converts-an-incomplete-vascular-ring-into-a-near-complete-vascular-ring
#12
B Kogon, G Lee, C Villari, J Parks, D Sallee, R Campbell
A unique combination of pulmonary agenesis and anatomic left aortic arch with aberrant right subclavian artery was identified in two patients. Because of the right pulmonary agenesis, there is rotation of mediastinal contents, especially the aortic arch, into the right chest, converting an incomplete vascular ring to a near-complete vascular ring. The anterior portion of the ring is formed by the ascending aorta and aortic arch, whereas the posterior portion is formed by the aberrant right subclavian artery...
January 2008: Pediatric Cardiology
https://www.readbyqxmd.com/read/17674081/pre-hospital-discharge-car-safety-seat-testing-in-infants-following-congenital-heart-surgery
#13
COMPARATIVE STUDY
J M Simsic, K Masterson, B E Kogon, P M Kirshbom, K R Kanter
The purpose of this study was to expand the American Academy of Pediatrics' (AAP) car safety seat testing recommendation to include high-risk infants following cardiac surgery. Car safety seat testing (< or =4 days prior to discharge) was retrospectively reviewed for 66 postoperative infants. Car safety seat testing was performed according to AAP guidelines. Failure of the test was defined as the occurrence of apnea, bradycardia, or oxygen desaturation. Average birth weight was 3.1 +/- 0.5 kg. Two patients were born <37 weeks of gestation...
March 2008: Pediatric Cardiology
https://www.readbyqxmd.com/read/16450061/partial-pericardial-defect-with-left-atrial-herniation
#14
B E Kogon, H Butler, K R Kanter
No abstract text is available yet for this article.
January 2006: Pediatric Cardiology
https://www.readbyqxmd.com/read/16450060/anomalous-drainage-of-the-inferior-vena-cava-into-the-left-atrium
#15
B E Kogon, D Fyfe, H Butler, K R Kanter
No abstract text is available yet for this article.
January 2006: Pediatric Cardiology
https://www.readbyqxmd.com/read/11819201/gastric-tonometry-and-direct-intraabdominal-pressure-monitoring-in-abdominal-compartment-syndrome
#16
S A Engum, B Kogon, E Jensen, J Isch, C Balanoff, J L Grosfeld
BACKGROUND/PURPOSE: Abdominal compartment syndrome (ACS) may complicate abdominal closure in patients with abdominal wall defects, abdominal trauma, intraperitoneal bleeding, and infection. Increased intraabdominal pressure (IAP) leads to respiratory compromise, organ hypoperfusion, and a high mortality rate. This study evaluates the efficacy of continuous direct monitoring of IAP and gastric tissue pH in detecting impending ACS. METHODS: Ten mongrel puppies weighing 2...
February 2002: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/11352431/treatment-of-ischemic-wounds-using-cultured-dermal-fibroblasts-transduced-retrovirally-with-pdgf-b-and-vegf121-genes
#17
A S Breitbart, D A Grande, J Laser, M Barcia, D Porti, S Malhotra, A Kogon, R T Grant, J M Mason
The healing of ischemic wounds is a particularly difficult clinical challenge. In this study, rabbit dermal fibroblasts transduced retrovirally with human platelet-derived growth factor B (PDGF-B) and human vascular endothelial growth factor 121 (VEGF121) genes were used to treat wounds in a rabbit ischemic ear model. The PDGF-B and VEGF121 genes were obtained from human umbilical vein endothelial cells (HUVECs) by reverse transcription-polymerase chain reaction, cloned into retroviral vectors under control of the beta-actin promoter, and introduced into primary rabbit dermal fibroblast cells...
May 2001: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/10946865/leptin-production-in-adipocytes-from-morbidly-obese-subjects-stimulation-by-dexamethasone-inhibition-with-troglitazone-and-influence-of-gender
#18
L B Williams, R L Fawcett, A S Waechter, P Zhang, B E Kogon, R Jones, M Inman, J Huse, R V Considine
This study examined the regulation of leptin production by dexamethasone and troglitazone. Subcutaneous and omental adipose tissue was obtained during bariatric surgical procedures (30 women and 16 men; body mass index, 52.5 +/- 1.7 kg/m2, age, 39 +/- 2 yr), and adipocytes were cultured in suspension. Subcutaneous adipocytes from females released significantly more leptin than did omental cells from the same subject (P < 0.05), but basal leptin release was not different in adipocytes from these depots in males...
August 2000: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/10022165/evaluation-of-small-intestine-submucosa-and-acellular-dermis-as-diaphragmatic-prostheses
#19
L Dalla Vecchia, S Engum, B Kogon, E Jensen, M Davis, J Grosfeld
BACKGROUND/PURPOSE: The repair of large congenital diaphragmatic defects in the neonate continues to be a challenge. Polytetrafluoroethylene (PTFE) is the synthetic material most widely used for reconstruction in instances of partial and complete diaphragmatic agenesis. Recurrent hernia is a frequent complication, because this material does not grow with the infant. This study evaluates two novel materials; small intestine submucosa (SIS; Cook Biotech, Lafayette, IN), and acellular dermis (AlloDerm; Lifecell Corp, The Woodland, TX) for diaphragm reconstruction in growing animals...
January 1999: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/9620152/angiosarcoma-presenting-as-an-occluded-popliteal-artery-pseudoaneurysm
#20
B Kogon, M Kabeer, A P Sawchuk, M Dalsing, S Billings
No abstract text is available yet for this article.
May 1998: Journal of Vascular Surgery
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