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O Lattouf

D Makhija, M Rock, Y Xiong, J D Epstein, M R Arnold, O M Lattouf, D Calcaterra
BACKGROUND: A recent retrospective comparative effectiveness study found that use of the FLOSEAL Hemostatic Matrix in cardiac surgery was associated with significantly lower risks of complications, blood transfusions, surgical revisions, and shorter length of surgery than use of SURGIFLO Hemostatic Matrix. These outcome improvements in cardiac surgery procedures may translate to economic savings for hospitals and payers. OBJECTIVE: The objective of this study was to estimate the cost-consequence of two flowable hemostatic matrices (FLOSEAL or SURGIFLO) in cardiac surgeries for US hospitals...
June 2017: Journal of Medical Economics
Vinod H Thourani, Seyed Amirhossein Razavi, Tom C Nguyen, Patrick D Kilgo, John D Puskas, Robert A Guyton, Omar M Lattouf, Bradley G Leshnower, Edward P Chen, Eric L Sarin, Michael E Halkos
BACKGROUND: Atherosclerotic disease of the ascending aorta during coronary artery bypass graft surgery (CABG) increases the risk for postoperative stroke. The objective of this study was to examine the incidence of postoperative stroke in CABG utilizing the Heartstring (Maquet Cardiovascular, San Jose, CA) proximal anastomotic device. METHODS: Intraoperative epiaortic ultrasonography was used to grade atherosclerosis in CABG patients at Emory University from April 2003 to December 2012...
June 2014: Annals of Thoracic Surgery
Mikhael F El-Chami, Fadi J Sawaya, Patrick Kilgo, William Stein, Michael Halkos, Vinod Thourani, Omar M Lattouf, David B Delurgio, Robert A Guyton, John D Puskas, Angel R Leon
OBJECTIVES: This study sought to investigate the prevalence, predictors, and outcomes of patients with post-operative ventricular arrhythmia (POVA) in a large cohort of patients. BACKGROUND: New-onset POVA after cardiac surgery (CS) is uncommon and has controversial prognostic value. METHODS: A total of 14,720 consecutive patients undergoing CS at Emory University between January 2004 and July 2010 were included in the study. Data on all-cause mortality were obtained from Social Security Administration death records...
December 25, 2012: Journal of the American College of Cardiology
Michael Capron, Sergio Díaz-Tendero, Sylvain Maclot, Alicja Domaracka, Elie Lattouf, Arkadiusz Ławicki, Rémi Maisonny, Jean-Yves Chesnel, Alain Méry, Jean-Christophe Poully, Jimmy Rangama, Lamri Adoui, Fernando Martín, Manuel Alcamí, Patrick Rousseau, Bernd A Huber
Fragmentation of the γ-aminobutyric acid molecule (GABA, NH(2)(CH(2))(3)COOH) following collisions with slow O(6+) ions (v≈0.3 a.u.) was studied in the gas phase by a combined experimental and theoretical approach. In the experiments, a multicoincidence detection method was used to deduce the charge state of the GABA molecule before fragmentation. This is essential to unambiguously unravel the different fragmentation pathways. It was found that the molecular cations resulting from the collisions hardly survive the interaction and that the main dissociation channels correspond to formation of NH(2)CH(2)(+), HCNH(+), CH(2)CH(2)(+), and COOH(+) fragments...
July 23, 2012: Chemistry: a European Journal
Eric L Sarin, Michael O Kayatta, Patrick Kilgo, Ameesh Dara, John D Puskas, Omar M Lattouf, Edward P Chen, Michael E Halkos, Robert A Guyton, Vinod H Thourani
OBJECTIVE: : Coronary artery bypass grafting (CAB) on elderly patients presenting with multivessel coronary artery disease has become routine in modern day operating rooms. The aim of our study was to compare short- and long-term outcomes in octogenarian patients undergoing off-pump CAB (OPCAB) versus on-pump CAB (ONCAB). METHODS: : A propensity-adjusted, retrospective review of patients older than 80 years who underwent primary CAB from January 1996 to September 2008 at our institution's hospitals was performed...
March 2011: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
M Bishr, J B Lattouf, P O Gannon, F Saad
Prostate cancer (PCa) is the most commonly diagnosed noncutaneous cancer in men accounting for 28% of all newly diagnosed cancer cases and it is the second to third most common cause of cancer death in the Western world. Nearly all patients with metastatic disease will eventually experience disease progression despite castration as the median duration of response is between 18-24 months. Hence, development of castration-resistant prostate cancer (CRPC) is only a matter of time in these patients. CRPC is defined by disease progression despite androgen-deprivation therapy...
June 2011: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Jessica Godin-Ethier, Sandy Pelletier, Laïla-Aïcha Hanafi, Philippe O Gannon, Marie-Andrée Forget, Jean-Pierre Routy, Mohamed-Rachid Boulassel, Urszula Krzemien, Simon Tanguay, Jean-Baptiste Lattouf, Nathalie Arbour, Réjean Lapointe
Previous cancer vaccination approaches have shown some efficiency in generating measurable immune responses, but they have rarely led to tumor regression. It is therefore possible that tumors emerge with the capacity to down-regulate immune counterparts, through the local production of immunosuppressive molecules, such as IDO. Although it is known that IDO exerts suppressive effects on T cell functions, the mechanisms of IDO regulation in tumor cells remain to be characterized. Here, we demonstrate that activated T cells can induce functional IDO expression in breast and kidney tumor cell lines, and that this is partly attributable to IFN-gamma...
December 15, 2009: Journal of Immunology: Official Journal of the American Association of Immunologists
Stephen O Bader, Omar M Lattouf, Roman M Sniecinski
No abstract text is available yet for this article.
November 2007: Anesthesia and Analgesia
J N Kauffman, T Walker, O Lattouf, B Letson, R A Guyton
A simplified system was developed for administration of blood cardioplegia with reperfusion modification. This system utilizes a single pass stainless steel coil to eliminate the need for a separate heat exchanger circuit. This system was compared with an oxygenated crystalloid cardioplegia system which was utilized in a manner which allowed warm blood perfusion of the heart for the last three minutes of the crossclamp interval. Both of these systems were compared with regard to mortality, spontaneous defibrillation, myocardial temperature, blood usage and peak CK-MB levels...
1991: Journal of Extra-corporeal Technology
E L Bradley, J R Hall, J Lutz, L Hamner, O Lattouf
Fifteen patients with severe pancreatitis underwent cardiovascular monitoring in an intensive care unit. The principal findings were a high cardiac index and a decrease in systemic vascular resistance. A significant negative correlation was found to exist between these two parameters (p less than 0.001). Severe pancreatitis apparently results in hemodynamic changes similar to those observed in sepsis. The mechanisms responsible for these observations are not known, although circulating vasoactive compounds resulting from pancreatic necrosis remain a strong possibility...
August 1983: Annals of Surgery
O M Lattouf, R R Ricketts
Pediatric renal failure patients can be restored to health with peritoneal dialysis more easily, more comfortably, and more safely than with hemodialysis. During the past 3.5 years, we have treated 22 children with either acute (less than 30 days) or chronic (greater than 30 days) peritoneal dialysis (PD) at Henrietta Egleston Hospital for Children. They ranged in age from 2 weeks to 15 1/6 years, mean 5.2 years. The indications for acute dialysis were renal failure following cardiac surgery (4); hemolytic-uremic syndrome (4); and renal failure associated with bromide intoxication (1), congenital urethral stricture (1), or bronchopulmonary dysplasia (1)...
February 1986: American Surgeon
E L Jones, O Lattouf, J F Lutz, S B King
One or more internal mammary artery (IMA) anastomoses were performed in 87% of 692 consecutive coronary artery bypass operations performed over a 20-month period. One IMA was used in 68% (N = 469) and both IMAs were used in 19% (N = 130). Only saphenous vein grafts were used in 13% (N = 93). The mean number of anastomoses (all types) was 3.5. Fifty-seven patients were having a reoperation; bilateral IMA grafting was performed in 23% (N = 13). In 60 patients, 3 or more IMA anastomoses were performed: 3 IMA anastomoses, 50 patients; 4, 9 patients; and 5, 1 patient...
May 1987: Annals of Thoracic Surgery
E L Jones, O M Lattouf, W S Weintraub
Inappropriate use of the internal mammary artery for complex coronary artery bypass operations may have disastrous yet avoidable consequences. In 712 consecutive coronary artery bypass operations performed between January 1985 and September 1986, five patients had an intraoperative course suggesting internal mammary artery hypoperfusion. In three, coronary artery bypass was performed as a reoperative procedure. The following similarities were noted in all five patients: a technically satisfactory internal mammary artery anastomosis, a left anterior descending coronary artery having critical proximal stenosis (greater than or equal to 90%), a distal artery at least 2...
November 1989: Journal of Thoracic and Cardiovascular Surgery
P A Baciewicz, C del Rio, M A Goncalves, O M Lattouf, R A Guyton, D C Morris
Hemodynamically critical thrombotic stenosis of porcine bioprosthetic valves in the aortic position without thrombotic predisposition is rare. Two patients at our institution abruptly manifested thrombotic stenosis of porcine bioprosthetic valves in the aortic position within 3 months of implantation without apparent predisposing factors. Clinicians should consider this rare but catastrophic complication in the appropriate setting.
November 1990: Annals of Thoracic Surgery
Y C Wang, A Herskowitz, L B Gu, K Kanter, O Lattouf, K W Sell, A Ahmed-Ansari
Human cardiac myocytes do not express detectable levels of major histocompatibility complex (MHC) class II antigens and express low levels, if any, of MHC class I antigens. During rejection episodes, cardiac biopsies show massive increases of MHC antigens, which are thought to be induced by cytokines released by donor-sensitized recipient mononuclear cells. In efforts to determine the nature of the cytokines that induce MHC expression on cardiac myocytes, human fetal cardiac myocyte cultures were established...
June 1991: Human Immunology
Y C Wang, K Kanter, O Lattouf, G E Rodey, K W Sell, A A Ansari
CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cells. Two of the 14 cloned T-cell lines were examined in detail for their ability to proliferate in vitro. Clones 7E4 and 8G2 proliferated (as determined by primed lymphocyte testing) only when cocultured with a series of distinct autologous cloned T-cell lines from previous biopsies that were specific for donor-specific HLA-DR3 and HLA-DR4, respectively...
June 1990: Human Immunology
D S Sgoutas, O M Lattouf, D C Finlayson, R V Clark
Plasma lipid, lipoprotein and apolipoprotein levels are known to decrease after major surgery. Coronary artery bypass surgery additionally involves use of extracorporeal circulation by use of a cardiopulmonary bypass pump, which necessitates hemodilution due to saline dextrose infusion to prime the pump. To investigate changes in lipids, lipoproteins and apolipoproteins as well as changes in C-reactive protein and albumin we conducted a study on 22 patients undergoing cardiac surgery involving cardiopulmonary bypass...
November 1992: Atherosclerosis
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