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https://www.readbyqxmd.com/read/27867985/transapical-beating-heart-mitral-valve-repair-using-a-cordal-implantation-device-are-we-ready-to-open-our-minds
#1
EDITORIAL
Talal Al-Atassi, Vinod H Thourani
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27862901/does-minimalist-transfemoral-transcatheter-aortic-valve-replacement-produce-better-survival-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#2
Jose F Condado, Moosa N Haider, Stamatios Lerakis, Patricia Keegan, Hope Caughron, Vinod H Thourani, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert Guyton, Jessica Forcillo, Ateet Patel, Amy Simone, Peter C Block, Vasilis Babaliaros
OBJECTIVES: To compare outcomes after minimalist and standard transfemoral transcatheter aortic valve replacement (TF-TAVR) in patients with severe chronic obstructive pulmonary disease (COPD). BACKGROUND: TF-TAVR is increasingly performed with conscious sedation and transthoracic echocardiography guidance (minimalist). The safety/efficacy of this technique in patients with severe COPD is unknown. METHODS: We compared demographics, 30-day outcomes and 1-year survival of patients with severe COPD (FEV1% ≤50) who underwent minimalist vs...
November 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27847042/the-society-of-thoracic-surgeons-national-database-2016-annual-report
#3
Jeffrey P Jacobs, David M Shahian, Richard L Prager, Fred H Edwards, Donna McDonald, Jane M Han, Richard S D'Agostino, Marshall L Jacobs, Benjamin D Kozower, Vinay Badhwar, Vinod H Thourani, Henning A Gaissert, Felix G Fernandez, Cameron D Wright, Gaetano Paone, Joseph C Cleveland, J Matthew Brennan, Rachel S Dokholyan, Leo Brothers, Sreekanth Vemulapalli, Robert H Habib, Sean M O'Brien, Eric D Peterson, Frederick L Grover, G Alexander Patterson, Joseph E Bavaria
The art and science of outcomes analysis, quality improvement, and patient safety continue to evolve, and cardiothoracic surgery leads many of these advances. The Society of Thoracic Surgeons (STS) National Database is one of the principal reasons for this leadership role, as it provides a platform for the generation of knowledge in all of these domains. Understanding these topics is a professional responsibility of all cardiothoracic surgeons. Therefore, beginning in January 2016, The Annals of Thoracic Surgery began publishing a monthly series of scholarly articles on outcomes analysis, quality improvement, and patient safety...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27815101/cerebral-embolic-protection-during-transcatheter-aortic-valve-replacement
#4
Samir R Kapadia, Susheel Kodali, Raj Makkar, Roxana Mehran, Ronald M Lazar, Robert Zivadinov, Michael G Dwyer, Hasan Jilaihawi, Renu Virmani, Saif Anwaruddin, Vinod H Thourani, Tamim Nazif, Norman Mangner, Felix Woitek, Amar Krishnaswamy, Stephanie Mick, Tarun Chakravarty, Mamoo Nakamura, James M McCabe, Lowell Satler, Alan Zajarias, Wilson Y Szeto, Lars Svensson, Maria C Alu, Roseann M White, Carlye Kraemer, Azin Parhizgar, Martin B Leon, Axel Linke
BACKGROUND: Neurological events and brain infarction after transcatheter aortic valve replacement (TAVR) are concerns which may be reduced with transcatheter embolic protection (TEP). OBJECTIVE: Evaluate the safety and efficacy of TEP during TAVR. METHODS: Nineteen centers randomized 363 patients undergoing TAVR to safety (n=123), device imaging (n=121), and control imaging (n=119). The primary safety endpoint was major adverse cardiac and cerebrovascular events (MACCE) at 30 days and the primary efficacy endpoint was reduction in new lesion volume in protected brain territories on MRI scans at 2-7 days...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27756797/sex-differences-in-the-epidemiology-of-new-onset-in-hospital-post-coronary-artery-bypass-graft-surgery-atrial-fibrillation-a-large-multicenter-study
#5
Giovanni Filardo, Gorav Ailawadi, Benjamin D Pollock, Briget da Graca, Danielle M Sass, Teresa K Phan, Debbie E Montenegro, Vinod Thourani, Ralph Damiano
BACKGROUND: New-onset atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) is associated with increased morbidity and poorer long-term survival. Although many studies show differences in outcome in women versus men after CABG, little is known about the sex-specific incidence and characteristics of post-CABG AF. METHODS AND RESULTS: Overall, 11 236 consecutive patients without preoperative AF underwent isolated CABG from 2002 to 2010 at 4 US academic medical centers and 1 high-volume specialty cardiac hospital...
October 18, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27732927/a-meta-analysis-and-meta-regression-of-long-term-outcomes-of-transcatheter-versus-surgical-aortic-valve-replacement-for-severe-aortic-stenosis
#6
Pedro A Villablanca, Verghese Mathew, Vinod H Thourani, Josep Rodés-Cabau, Sripal Bangalore, Mohammed Makkiya, Peter Vlismas, David F Briceno, David P Slovut, Cynthia C Taub, Patrick M McCarthy, John G Augoustides, Harish Ramakrishna
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has emerged as an alternative to surgical aortic-valve replacement (SAVR) for patients with severe symptomatic aortic stenosis (AS) who are at high operative risk. We sought to determine the long-term (≥1year follow-up) safety and efficacy TAVR compared with SAVR in patients with severe AS. METHODS: A comprehensive search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, conference proceedings, and relevant Web sites from inception through 10 April 2016...
December 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27717427/should-we-perform-carotid-doppler-screening-before-surgical-or-transcatheter-aortic-valve-replacement
#7
Jose F Condado, Hanna A Jensen, Aneel Maini, Yi-An Ko, Mohammad H Rajaei, Lillian L Tsai, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert A Guyton, Vasilis Babaliaros, Edward P Chen, Michael Halkos, Amy Simone, Patricia Keegan, Peter C Block, Vinod H Thourani
BACKGROUND: Screening for internal carotid artery stenosis (ICAS) with Doppler ultrasound is commonly used before cardiovascular surgery. Nevertheless, the relationship between ICAS and procedure-related stroke in isolated aortic valve replacement is unclear. METHODS: We retrospectively reviewed patients with artery stenosis who underwent ICAS screening before surgical (SAVR) or transcatheter aortic valve replacement (TAVR) between January 2007 and August 2014. Logistic regression models were used to determine the relation between post-procedure stroke and total (sum of left and right ICAS) and maximal unilateral ICAS...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27717426/the-racial-paradox-in-multiarterial-conduit-utilization-for-coronary-artery-bypass-grafting
#8
W Brent Keeling, Jose Binongo, Michael E Halkos, Bradley G Leshnower, Duc Q Nguyen, Edward P Chen, Eric L Sarin, Jeffrey S Miller, Steven Macheers, Omar M Lattouf, Robert A Guyton, Vinod H Thourani
BACKGROUND: It has been established that outcomes for black patients undergoing coronary artery bypass graft surgery (CABG) are inferior to those of their white counterparts. The purpose of this study was to determine (1) whether rates of multiarterial grafting are different among black patients and white patients, and (2) whether racial differences exist in postoperative outcomes after accounting for grafting strategy. METHODS: A retrospective review of black patients (n = 2,810) and white patients (n = 13,569) who underwent isolated, primary CABG from January 2002 to June 2014 at a US academic institution was performed...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27662477/transcatheter-aortic-valve-replacement-current-technology-and-future-directions
#9
Richard C Gilmore, Vinod H Thourani, Hanna A Jensen, Jose F Condado, Michael O Kayatta, Mohammad H Rajaei, Amjad O Syed, Vasilis C Babaliaros, Eric L Sarin, Bradley G Leshnower
Transcatheter aortic valve replacement as an alternative to open surgical repair is rapidly becoming more used in high-risk patients with aortic stenosis. Transcatheter aortic valve replacement offers the benefit of being much less invasive than traditional surgical repair and has evolved as a therapeutic option for patients with prohibitive surgical risk or those deemed surgically inoperable. Nevertheless, despite its potential to mitigate risk in this frail population, it comes with its own unique set of complications...
July 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27625404/variation-in-hospital-risk-adjusted-mortality-rates-following-transcatheter-aortic-valve-replacement-in-the-united-states-a-report-from-the-society-of-thoracic-surgeons-american-college-of-cardiology-transcatheter-valve-therapy-registry
#10
Sean M O'Brien, David J Cohen, John S Rumsfeld, J Matthew Brennan, David M Shahian, David Dai, David R Holmes, Rosemarie B Hakim, Vinod H Thourani, Eric D Peterson, Fred H Edwards
BACKGROUND: The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality risk model and used it to quantify variation in mortality rates across United States (US) TAVR centers. METHODS AND RESULTS: We analyzed data from 22 248 TAVR procedures performed at 318 sites participating in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry (November 2011 to October 2014)...
September 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27609257/the-future-of-transaortic-transcatheter-aortic-valve-replacement
#11
EDITORIAL
Vinod H Thourani, Jessica Forcillo
No abstract text is available yet for this article.
September 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27601428/insights-into-timing-risk-factors-and-outcomes-of-stroke-and-transient-ischemic-attack-after-transcatheter-aortic-valve-replacement-in-the-partner-trial-placement-of-aortic-transcatheter-valves
#12
Samir Kapadia, Shikhar Agarwal, D Craig Miller, John G Webb, Michael Mack, Stephen Ellis, Howard C Herrmann, Augusto D Pichard, E Murat Tuzcu, Lars G Svensson, Craig R Smith, Jeevanantham Rajeswaran, John Ehrlinger, Susheel Kodali, Raj Makkar, Vinod H Thourani, Eugene H Blackstone, Martin B Leon
BACKGROUND: Prior studies of stroke and transient ischemic attack (TIA) after transcatheter aortic valve replacement (TAVR) are limited by reporting and follow-up variability. This is a comprehensive analysis of time-related incidence, risk factors, and outcomes of these events. METHODS AND RESULTS: From April 2007 to February 2012, 2621 patients, aged 84±7.2 years, underwent transfemoral (TF; 1521) or transapical (TA; 1100) TAVR in the PARTNER trial (Placement of Aortic Transcatheter Valves; as-treated), including the continued access registry...
September 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27592092/impact-of-preoperative-chronic-kidney-disease-in-2-531-high-risk-and-inoperable-patients-undergoing-transcatheter-aortic-valve-replacement-in-the-partner-trial
#13
Vinod H Thourani, Jessica Forcillo, Nirat Beohar, Darshan Doshi, Rupa Parvataneni, Girma M Ayele, Ajay J Kirtane, Vasilis Babaliaros, Susheel Kodali, Chandan Devireddy, Wilson Szeto, Howard C Herrmann, Raj Makkar, Gorav Ailawadi, Scott Lim, Hersh S Maniar, Alan Zajarias, Rakesh Suri, E Murat Tuzcu, Samir Kapadia, Lars Svensson, Jose Condado, Hanna A Jensen, Michael J Mack, Martin B Leon
BACKGROUND: Although preoperative renal dysfunction (RD) is associated with increased mortality and morbidity after surgical aortic valve replacement, its impact on clinical outcomes after transcatheter aortic valve replacement (TAVR) is less defined. METHODS: TAVR patients in the PARTNER (Placement of Aortic Transcatheter Valves) trial with a calculable glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease equation were included. Patients were divided into three groups: GFR >60 mL/min (none/mild RD), GFR 31 to 60 mL/min (moderate RD), and GFR ≤30 mL/min (severe RD)...
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27544602/neutrophil-lymphocyte-ratio-nlr-and-platelet-lymphocyte-ratio-plr-can-risk-stratify-patients-in-transcatheter-aortic-valve-replacement-tavr
#14
Jose F Condado, Parichart Junpaparp, Jose N Binongo, Yi Lasanajak, Christian F Witzke-Sanz, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, James Stewart, Robert Guyton, David Wheeler, Jessica Forcillo, Ateet Patel, Peter C Block, Vinod Thourani, Janani Rangaswami, Vasilis Babaliaros
BACKGROUND: Neutrophil-lymphocyte (NLR) and platelet-lymphocyte ratios (PLR) mark systemic inflammation. Patients with high NLR and PLR have worse cardiovascular disease and outcomes. We assessed the role of these ratios in predicting outcomes after transcatheter aortic valve replacement (TAVR). METHODS: The association between NLR and PLR with baseline characteristics, 30-day outcomes, and 1-year readmission/survival was determined in patients that underwent TAVR between 2007 and 2014 and had baseline complete blood count with differential...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27538860/swine-sus-scrofa-as-a-model-of-postinfarction-mitral-regurgitation-and-techniques-to-accommodate-its-effects-during-surgical-repair
#15
Eric L Sarin, Weiwei Shi, Rajnish Duara, Todd A Melone, Kanika Kalra, Ashley Strong, Apoorva Girish, Bryant V McIver, Vinod H Thourani, Robert A Guyton, Muralidhar Padala
Mitral regurgitation (MR) is a common heart-valve lesion after myocardial infarction in humans. Because it is considered a risk factor for accelerated heart failure and death, various surgical approaches and catheter-based devices to correct it are in development. Lack of a reproducible animal model of MR after myocardial infarction and reliable techniques to perform open-heart surgery in these diseased models led to the use of healthy animals to test new devices. Thus, most devices that are deemed safe in healthy animals have shown poor results in human efficacy studies, hampering progress in this area of research...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27491613/valve-type-size-and-deployment-location-affect-hemodynamics-in-an%C3%A2-in%C3%A2-vitro-valve-in-valve-model
#16
Prem A Midha, Vrishank Raghav, Jose F Condado, Ikechukwu U Okafor, Stamatios Lerakis, Vinod H Thourani, Vasilis Babaliaros, Ajit P Yoganathan
OBJECTIVES: The purpose of this study was to optimize hemodynamic performance of valve-in-valve (VIV) according to transcatheter heart valve (THV) type (balloon vs. self-expandable), size, and deployment positions in an in vitro model. BACKGROUND: VIV transcatheter aortic valve replacement is increasingly used for the treatment of patients with a failing surgical bioprosthesis. However, there is a paucity in understanding the THV hemodynamic performance in this setting...
August 8, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27437665/evaluation-of-flow-after-transcatheter-aortic-valve-replacement-in-patients-with-low-flow-aortic-stenosis-a-secondary-analysis-of-the-partner-randomized-clinical-trial
#17
Venkatesh Y Anjan, Howard C Herrmann, Philippe Pibarot, William J Stewart, Samir Kapadia, E Murat Tuzcu, Vasilis Babaliaros, Vinod H Thourani, Wilson Y Szeto, Joseph E Bavaria, Susheel Kodali, Rebecca T Hahn, Mathew Williams, D Craig Miller, Pamela S Douglas, Martin B Leon
IMPORTANCE: Low-flow (LF) severe aortic stenosis (AS) is an independent predictor of mortality in patients undergoing aortic valve replacement (AVR). Little is known about improvement in flow after AVR and its effects on survival. OBJECTIVE: To determine whether higher flow (left-ventricular stroke volume index [LVSVI]) after transcatheter AVR (TAVR) would indicate better clinical outcomes in this at-risk population. DESIGN, SETTING, AND PARTICIPANTS: A substudy analysis of data from the Placement of Aortic Transcatheter Valves (PARTNER) randomized clinical trial and continued-access registry was conducted...
August 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27437653/development-and-validation-of-a-risk-prediction-model-for-in-hospital-mortality-after-transcatheter-aortic-valve-replacement
#18
Fred H Edwards, David J Cohen, Sean M O'Brien, Eric D Peterson, Michael J Mack, David M Shahian, Frederick L Grover, E Murat Tuzcu, Vinod H Thourani, John Carroll, J Matthew Brennan, Ralph G Brindis, John Rumsfeld, David R Holmes
IMPORTANCE: Patient selection for transcatheter aortic valve replacement (TAVR) should include assessment of the risks of TAVR compared with surgical aortic valve replacement (SAVR). Existing SAVR risk models accurately predict the risks for the population undergoing SAVR, but comparable models to predict risk for patients undergoing TAVR are currently not available and should be derived from a population that underwent TAVR. OBJECTIVE: To use a national population of patients undergoing TAVR to develop a statistical model that will predict in-hospital mortality after TAVR...
April 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27400898/one-year-clinical-outcomes-with-sapien-3-transcatheter-aortic-valve-replacement-in-high-risk-and-inoperable-patients-with-severe-aortic-stenosis
#19
Howard C Herrmann, Vinod H Thourani, Susheel K Kodali, Raj R Makkar, Wilson Y Szeto, Saif Anwaruddin, Nimesh Desai, Scott Lim, S Chris Malaisrie, Dean J Kereiakes, Steven Ramee, Kevin L Greason, Samir Kapadia, Vasilis Babaliaros, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, Jonathon Leipsic, Brian K Whisenant, John G Webb, Michael J Mack, Martin B Leon
BACKGROUND: In the initial PARTNER trial (Placement of Aortic Transcatheter Valves) of transcatheter aortic valve replacement for high-risk (HR) and inoperable patients, mortality at 1 year was 24% in HR and 31% in inoperable patients. A recent report of the 30-day outcomes with the low-profile SAPIEN 3 transcatheter aortic valve replacement system demonstrated very low rates of adverse events, but little is known about the longer-term outcomes with this device. METHODS: Between October 2013 and September 2014, 583 HR (65%) or inoperable (35%) patients were treated via the transfemoral (84%) or transapical/transaortic (16%) access route at 29 US sites...
July 12, 2016: Circulation
https://www.readbyqxmd.com/read/27262913/the-society-of-thoracic-surgeons-adult-cardiac-surgery-database-2016-update-on-research
#20
Vinay Badhwar, J Scott Rankin, Jeffrey P Jacobs, David M Shahian, Robert H Habib, Richard S D'Agostino, Vinod H Thourani, Rakesh M Suri, Richard L Prager, Fred H Edwards
The Society of Thoracic Surgeons Adult Cardiac Database (ACSD) is an international voluntary effort that is the foundation of our specialty's efforts in clinical performance assessment and quality improvement. Containing nearly 6,000,000 patient records, the ACSD is a robust resource for clinical research. Seven major original publications and four review articles were generated from the ACSD in 2015. The risk-adjusted outcome analyses and quality measures reported in these studies have made substantial contributions to inform daily clinical practice...
July 2016: Annals of Thoracic Surgery
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