keyword
MENU ▼
Read by QxMD icon Read
search

Research report

keyword
https://www.readbyqxmd.com/read/29475213/modified-multivisceral-transplantation-with-native-spleen-removal-in-rats
#1
Pablo Stringa, Nidia Monserrat Arreola, Ane M Andres Moreno, Carlota Largo, Martín Rumbo, Francisco Hernandez
BACKGROUND:  Modified multivisceral transplantation (MMVTx) refers to the use of a graft that includes all abdominal organs except the liver. The use of this type of transplant in children and adults expanded over the last years with good results. However, long-term survival in experimental models has not been reported. Our aim is to describe in detail some technical modifications of MMVTx to obtain long-term survival. MATERIALS AND METHODS:  Syngeneic (Lewis-Lewis) heterotopic MMVTx was performed in 16 male rats (180-250 g)...
February 23, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29475198/willingness-to-use-drug-checking-within-future-supervised-injection-services-among-people-who-inject-drugs-in-a-mid-sized-canadian-city
#2
Mary Clare Kennedy, Ayden Scheim, Beth Rachlis, Sanjana Mitra, Geoff Bardwell, Sean Rourke, Thomas Kerr
BACKGROUND: Esclating epidemics of fatal overdose are affecting communities across Canada. In many instances, the unanticipated presence of powerful opioids, such as fentanyl, in street drugs is a contributing factor. Drug checking offered within supervised injection services (SIS) is being considered as a potential measure for reducing overdose and related harms. We therefore sought to characterize the willingness of people who inject drugs (PWID) to use drug checking within SIS. METHODS: Data were derived from a cross-sectional survey examining the feasibility of SIS in London, Canada, a mid-sized city...
February 15, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29475174/early-maltreatment-is-associated-with-greater-risk-of-conduct-problems-and-lack-of-guilt-in-adolescence
#3
Meagan Docherty, Joanna Kubik, Carolina M Herrera, Paul Boxer
Previous research indicates a link between childhood maltreatment and elevated conduct problems. Yet the literature is less clear on associations between maltreatment and callousness (e.g., lack of empathy or guilt). This is a critical gap given that callousness is a robust predictor of serious aggressive and violent behavior. We examine the association between substantiated maltreatment events in childhood and adolescence (up to age 13) and conduct problems and lack of guilt at age 14. We analyze self- and parent-report data along with official maltreatment records on 557 youth (50% female; 69% non-white) from a larger dataset (Longitudinal Studies on Childhood Abuse and Neglect; N = 1354)...
February 20, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29475118/kockdown-of-oip5-as1-expression-inhibits-proliferation-metastasis-and-emt-progress-in-hepatoblastoma-cells-through-up-regulating-mir-186a-5p-and-down-regulating-zeb1
#4
Ze Zhang, Feng Liu, Fan Yang, Yahui Liu
Long non-coding RNA OIP5-AS1 has been studied in human diseases, including several kinds of cancers. It was not studied or reported in hepatoblastoma, so we chose it to do our research in hepatoblastoma. We thought OIP5-AS1 was oncogenic in hepatoblastoma for the high expression of it in hepatoblastoma tissues and cells. OIP5-AS1 knockdown was carried out in cancer cells. Unsurprisingly, this action was verified to be able to inhibit cell proliferation, metastasis and EMT progress in hepatoblastoma. We then measured the low expression level of miR-186a-5p and the high expression level of ZEB1 in hepatoblastoma tissues and cells...
February 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29475104/distress-and-sleep-quality-in-young-amphetamine-type-stimulant-users-with-an-affective-or-psychotic-illness
#5
Jacob J Crouse, Rico S C Lee, Django White, Ahmed A Moustafa, Ian B Hickie, Daniel F Hermens
Misuse of amphetamine-type stimulant (ATS) drugs may disrupt key neurodevelopmental processes in young people and confer protracted neurocognitive and psychopathological harm. ATS users with a co-occurring psychiatric illness are typically excluded from research, reducing generalisability of findings. Accordingly, we conducted a cross-sectional examination of key clinical, sleep, socio-occupational and neurocognitive measures in current, past and never users of ATS drugs who were accessing a youth mental health service (headspace) for affective- or psychotic-spectrum illnesses...
February 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29475084/full-length-myocilin-protein-is-purified-from-mammalian-cells-as-a-dimer
#6
Parvaneh Katoli, Adarsh Godbole, Michael J Romanowski, Kirk Clark, Erik Meredith, Veronica Saenz-Vash, Y Karen Wang, Nancy Lewicki, Andrew A Nguyen, Jeffrey M Lynch
Myocilin (MYOC) is a secreted protein found in human aqueous humor (AH) and mutations in the MYOC gene are the most common mutation observed in glaucoma patients. Human AH analyzed under non-reducing conditions suggests that MYOC is not normally found in a monomeric form, but rather is predominantly dimeric. Although MYOC was first reported almost 20 years ago, a technical challenge still faced by researchers is an inability to isolate full-length MYOC protein for experimental purposes. Herein we describe two methods by which to isolate sufficient quantities of human full-length MYOC protein from mammalian cells...
February 20, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29475040/metabo-devo-a-metabolic-perspective-of-development
#7
REVIEW
Lautaro Gándara, Pablo Wappner
In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus, current developmental biology has begun to describe different ways by which the metabolic profile of the cell and developmental programs of the organism can crosstalk. In this review, we discuss mechanisms by which metabolism impacts on processes governing development...
February 20, 2018: Mechanisms of Development
https://www.readbyqxmd.com/read/29475001/regulation-of-tak1-alternative-splicing-by-splice-switching-oligonucleotides
#8
Donghu Zhou, Qianqian Shao, Xu Fan, Peng Wu, Weiran Lin, Handong Wei, Fuchu He, Ying Jiang
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result in genetic disorders or cancer. In recent years, splice-switching oligonucleotides (SSOs) have emerged as a promising therapeutic strategy for several neurological diseases, but the efficacy of this strategy in other organs is less reported. In this study, we designed and synthesized SSOs targeting the splicing regulators of exon 12 of the Tak1 gene, inducing variant switching between Tak1-A and Tak1-B...
February 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29474932/profiling-g-protein-coupled-receptors-of-fasciola-hepatica-identifies-orphan-rhodopsins-unique-to-phylum-platyhelminthes
#9
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J Marks, Aaron G Maule
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-targeted anti-parasite drugs. This study facilitates GPCR research in the liver fluke, Fasciola hepatica, by generating the first profile of GPCRs from the F. hepatica genome. Our dataset describes 147 high confidence GPCRs, representing the largest cohort of GPCRs, and the largest set of in silico ligand-receptor predictions, yet reported in any parasitic helminth...
February 5, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29474797/maternal-health-in-india-a-survey-of-birth-attendant-competency-through-completeness-of-prescribed-care-during-perinatal-visits-in-12-randomly-chosen-districts-of-uttar-pradesh-india
#10
Adiya Jaffari, Stephen Alexander Benjamin Troxel
We assessed the completeness of care provided during perinatal visits at public institutions in Uttar Pradesh (UP), India. Self-reported data from 53 interviews with birth attendants throughout 12 districts in UP showed that 52% of the items from a procedural checklist were covered during visits. Routine visits were found to be incomplete, provider training related to pharmaceuticals and counseling were suggested to be low, and the monitoring of vitals to be infrequent and inconsistent. We suggest further grassroots research be conducted in developing nations so that strategic and precise reform can be made to lower global maternal mortality...
February 23, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29474737/association-between-reported-aetiology-of-central-nervous-system-infections-and-the-speciality-of-study-investigators-a-bias-compartmental-syndrome
#11
Tehmina Bharucha, Serena Vickers, Damien Ming, Sue J Lee, Audrey Dubot-Pérès, Xavier de Lamballerie, Paul N Newton
Background: Conventional descriptions of central nervous system (CNS) infections are variably categorized into clinical syndromes for patient investigation, management and research. Aetiologies of the most commonly recognized syndromes, encephalitis and meningitis, tend to be attributed predominantly to viruses and bacteria, respectively. Methods: A systematic review was performed of aetiological studies of CNS syndromes and data extracted on reported author specialities...
February 21, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29474729/the-science-of-peer-support-as-applied-to-behavioral-medicine-and-the-care-of-individuals-surviving-with-cancer-a-commentary-on-peer-mentors-delivering-a-physical-activity-intervention-for-cancer-survivors-effects-among-mentors-by-pinto-et-al
#12
Christine Rini, Kristi D Graves, Suzanne C O'Neill, Kenneth P Tercyak
There is a critical gap between the resources available to promote health and wellness after cancer and services that address these public health goals. Researchers, policy makers, healthcare providers, and community stakeholders increasingly recognize the benefits of filling this gap with trained peer mentors who can provide health-promotion services to fellow cancer survivors. This commentary addresses a mixed-method study by Pinto and colleagues that investigated the responses and experiences of trained peer mentors who delivered their telephone-based physical activity intervention for breast cancer survivors...
February 21, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29474454/the-impact-of-poverty-reduction-and-development-interventions-on-non-communicable-diseases-and-their-behavioural-risk-factors-in-low-and-lower-middle-income-countries-a-systematic-review
#13
Jessie Pullar, Luke Allen, Nick Townsend, Julianne Williams, Charlie Foster, Nia Roberts, Mike Rayner, Bente Mikkelsen, Francesco Branca, Kremlin Wickramasinghe
INTRODUCTION: Non-communicable diseases (NCDs) disproportionately affect low- and lower-middle income countries (LLMICs) where 80% of global NCD related deaths occur. LLMICs are the primary focus of interventions to address development and poverty indicators. We aimed to synthesise the evidence of these interventions' impact on the four primary NCDs (cardiovascular disease, diabetes, chronic respiratory disease and cancer) and their common behavioural risk factors (unhealthy diets, physical inactivity, tobacco and alcohol use)...
2018: PloS One
https://www.readbyqxmd.com/read/29474416/primate-social-attention-species-differences-and-effects-of-individual-experience-in-humans-great-apes-and-macaques
#14
Fumihiro Kano, Stephen V Shepherd, Satoshi Hirata, Josep Call
When viewing social scenes, humans and nonhuman primates focus on particular features, such as the models' eyes, mouth, and action targets. Previous studies reported that such viewing patterns vary significantly across individuals in humans, and also across closely-related primate species. However, the nature of these individual and species differences remains unclear, particularly among nonhuman primates. In large samples of human and nonhuman primates, we examined species differences and the effects of experience on patterns of gaze toward social movies...
2018: PloS One
https://www.readbyqxmd.com/read/29474267/perspectives-on-integrated-hiv-and-hcv-testing-among-persons-entering-a-northern-california-jail-a-pilot-study
#15
Wilson Ly, Jennifer Cocohoba, Alexander Chyorny, Jodi Halpern, Colette Auerswald, Janet Myers
BACKGROUND: Providing HIV and HCV testing on an 'opt-out' basis is often considered the 'gold standard' because it contributes to higher testing rates when compared to 'opt-in' strategies. While rates are crucial, an individual's testing preferences are also important, especially in correctional settings where legal and social factors influence a person's capacity to freely decide whether or not to test. Our study explored factors influencing HIV and HCV testing decisions and individuals' preferences and concerns regarding opt-in versus opt-out testing at the time of jail entry...
February 22, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29474264/migrant-and-ethnic-minority-status-as-risk-indicators-for-schizophrenia-new-findings
#16
Els van der Ven, Jean-Paul Selten
PURPOSE OF REVIEW: Arguably, the strongest evidence of an environmental contribution to the cause of psychosis is the increased risk for certain groups of migrants and ethnic minorities. This article summarizes findings published since 2016. RECENT FINDINGS: Two studies suggested that migration or minority status are proxies for exposure to an inferior social status. A study from Bologna, Italy, showed that the psychosis risk for internal migrants from Southern Italy was as much increased as that for international migrants...
February 22, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29474216/anesthesia-and-analgesia-for-gynecological-surgery
#17
Allana Munro, Ana Sjaus, Ronald B George
PURPOSE OF REVIEW: High-quality analgesia has been linked to improved patient satisfaction as well as improved short-term and long-term postoperative outcomes. Acute surgical pain is a modifiable risk factor for development of chronic postoperative pain, which is reported by up to 26% of gynecologic surgical patients. In other surgical populations, multimodal analgesia has shown improved pain control and decreased reliance on opioids. This review examines recent evidence for various analgesic modalities applied specifically to the gynecologic surgical population...
February 22, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29474173/possibility-of-database-research-as-a-means-of-pharmacovigilance-in-japan-based-on-a-comparison-with-sertraline-postmarketing-surveillance
#18
Yoko Hirano, Yuko Asami, Kazuhiko Kuribayashi, Shigeru Kitazaki, Yuji Yamamoto, Yoko Fujimoto
BACKGROUND: Many pharmacoepidemiologic studies using large-scale databases have recently been utilized to evaluate the safety and effectiveness of drugs in Western countries. In Japan, however, conventional methodology has been applied to postmarketing surveillance (PMS) to collect safety and effectiveness information on new drugs to meet regulatory requirements. Conventional PMS entails enormous costs and resources despite being an uncontrolled observational study method. This study is aimed at examining the possibility of database research as a more efficient pharmacovigilance approach by comparing a health care claims database and PMS with regard to the characteristics and safety profiles of sertraline-prescribed patients...
June 20, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474153/consumers-use-of-personal-electronic-devices-in-the-kitchen
#19
Amy M Lando, Michael C Bazaco, Yi Chen
Smartphones, tablets, and other personal electronic devices have become ubiquitous in Americans' daily lives. These devices are used by people throughout the day, including while preparing food. For example, a device may be used to look at recipes and therefore be touched multiple times during food preparation. Previous research has indicated that cell phones can harbor bacteria, including opportunistic human pathogens such as Staphylococcus and Klebsiella spp. This investigation was conducted with data from the 2016 Food Safety Survey (FSS) and from subsequent focus groups to determine the frequency with which consumers use personal electronic devices in the kitchen while preparing food, the types of devices used, and hand washing behaviors after handling these devices...
February 23, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29474132/who-s-the-target-mother-or-baby
#20
Alisa Kachikis, Linda O Eckert, Janet Englund
Maternal immunization for prevention of morbidity and mortality of pregnant women and their neonates due to infectious diseases is ongoing worldwide. The complexity of vaccine research and development in this population is challenging. Not only do vaccines for pregnant women require evidence of immunogenicity, potency, stability, and limited reactogenicity, they must also provide efficacy in decreasing morbidity for the pregnant woman, her fetus, and the neonate, demonstrate safety or lack of evidence of harm, and offer benefit or potential benefit of vaccination during pregnancy...
February 23, 2018: Viral Immunology
keyword
keyword
58765
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"