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https://www.readbyqxmd.com/read/29054031/mental-health-of-heroin-users-with-differing-injection-drug-use-histories-a-non-treatment-sample-of-mexican-american-young-adult-men
#1
Kathryn M Nowotny, Tasha Perdue, Alice Cepeda, Avelardo Valdez
BACKGROUND: While the comorbidity of mental health and injecting heroin has been documented, current research is limited by describing the mental health of people who inject drugs without a comparison group and by the lack of research on nontreatment samples in the United States, particularly among Hispanics. The purpose of this study was to examine the association of injecting history (never, former, occasional, and daily) and multiple outcomes of global and mental health using a sample of U...
October 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29053960/a-general-strategy-for-discovery-of-inhibitors-and-activators-of-ring-and-u-box-e3-ligases-with-ubiquitin-variants
#2
Mads Gabrielsen, Lori Buetow, Mark A Nakasone, Syed Feroj Ahmed, Gary J Sibbet, Brian O Smith, Wei Zhang, Sachdev S Sidhu, Danny T Huang
RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge. We report the development of three ubiquitin variants (UbVs), each binding selectively to the RING or U-box domain of a distinct E3 ligase: monomeric UBE4B, phosphorylated active CBL, or dimeric XIAP. Structural and biochemical analyses revealed that UbVs specifically inhibited the activity of UBE4B or phosphorylated CBL by blocking the E2∼Ub binding site...
October 19, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29053946/measurement-of-area-and-personal-breathing-zone-concentrations-of-diesel-particulate-matter-dpm-during-oil-and-gas-extraction-operations-including-hydraulic-fracturing
#3
Eric J Esswein, Marissa Alexander-Scott, John Snawder, Michael Breitenstein
Diesel engines serve many purposes in modern oil and gas extraction activities. Diesel particulate matter (DPM) emitted from diesel engines is a complex aerosol that may cause adverse health effects depending on exposure dose and duration. This study reports on personal breathing zone (PBZ) and area measurements for DPM (expressed as elemental carbon) during oil and gas extraction operations including drilling, completions (which includes hydraulic fracturing) and servicing work. Researchers at the National Institute for Occupational Safety and Health (NIOSH) collected 104 full-shift air samples (49 PBZ and 55 area) in Colorado, North Dakota, Texas, and New Mexico during a four year period from 2008-2012 The arithmetic mean (AM) of the full shift TWA PBZ samples was 10 µg/m(3); measurements ranged from 0...
October 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29053937/studies-with-herpes-zoster-vaccines-in-immune-compromised-patients
#4
Myron J Levin, Eddy Bresnitz, Zoran Popmihajlov, Adriana Weinberg, Kai-Li Liaw, English Willis, Jeffrey R Curtis
INTRODUCTION: The active component of the herpes zoster vaccine (ZVL), recommended for people ≥50 years of age, is a live attenuated varicella-zoster virus. ZVL is contraindicated for immune compromised individuals, with limited regard to the degree of immunosuppression. Areas covered: This review evaluates phase I and II, and observational studies for ZVL and published reports of the off-label use of ZVL, for conditions and therapies for which investigators considered the risk-benefit for using ZVL to be favorable...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053927/safety-of-pharmacotherapy-options-for-bulimia-nervosa-and-binge-eating-disorder
#5
Nicholas T Bello, Bryn L Yeomans
Eating disorders represent a set of psychiatric illnesses with lifelong complications and high relapse rates. Individuals with eating disorders are often stigmatized and clinicians have a limited set of treatments options. Pharmacotherapy has the potential to improve long term compliance and patient commitment to treatment for eating disorders. Areas Covered: This review will examine the efficacy and safety profile of the FDA-approved medications for the treatment of bulimia nervosa (BN) and binge eating disorder (BED)...
October 20, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29053911/investigating-the-minimal-clinically-important-difference-for-snot-22-symptom-domains-in-surgically-managed-chronic-rhinosinusitis
#6
Naweed I Chowdhury, Jess C Mace, Todd E Bodner, Jeremiah A Alt, Adam S Deconde, Joshua M Levy, Timothy L Smith
BACKGROUND: Prior work has described 5 domains within the 22-item Sino-Nasal Outcomes Test (SNOT-22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results. METHODS: This study was designed as a secondary analysis of a prospective, multi-institutional, observational cohort...
October 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29053776/who-bears-the-cost-of-nice-public-health-recommendations
#7
Sebastian Hinde, Anggie Wiyani, Susan Griffin, Simon Walker
Background: In the UK, NICE issues guidance on public health initiatives. Failure to report which sectors of the economy are affected by their implementation precludes the appropriate accounting for the full opportunity costs, and has the potential to result in erroneous decision making and inefficient budgetary planning. Sources of data: We reviewed all NICE public health guidances available at the time of research, categorizing the sector on which the cost burden of the public health initiatives fall and the extent to which this burden was estimated...
October 19, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29053742/are-current-chronic-fatigue-syndrome-criteria-diagnosing-different-disease-phenotypes
#8
Laura Maclachlan, Stuart Watson, Peter Gallagher, Andreas Finkelmeyer, Leonard A Jason, Madison Sunnquist, Julia L Newton
IMPORTANCE: Chronic fatigue syndrome (CFS) is characterised by a constellation of symptoms diagnosed with a number of different polythetic criteria. Heterogeneity across these diagnostic criteria is likely to be confounding research into the as-yet-unknown pathophysiology underlying this stigmatised and debilitating condition and may diagnose a disease spectrum with significant implications for clinical management. No studies to date have objectively investigated this possibility using a validated measure of CFS symptoms-the DePaul Symptom Questionnaire (DSQ)...
2017: PloS One
https://www.readbyqxmd.com/read/29053734/an-instrument-to-assess-the-statistical-intensity-of-medical-research-papers
#9
Pentti Nieminen, Jorma I Virtanen, Hannu Vähänikkilä
BACKGROUND: There is widespread evidence that statistical methods play an important role in original research articles, especially in medical research. The evaluation of statistical methods and reporting in journals suffers from a lack of standardized methods for assessing the use of statistics. The objective of this study was to develop and evaluate an instrument to assess the statistical intensity in research articles in a standardized way. METHODS: A checklist-type measure scale was developed by selecting and refining items from previous reports about the statistical contents of medical journal articles and from published guidelines for statistical reporting...
2017: PloS One
https://www.readbyqxmd.com/read/29053728/density-abundance-survival-and-ranging-patterns-of-common-bottlenose-dolphins-tursiops-truncatus-in-mississippi-sound-following-the-deepwater-horizon-oil-spill
#10
Keith D Mullin, Trent McDonald, Randall S Wells, Brian C Balmer, Todd Speakman, Carrie Sinclair, Eric S Zolman, Fawn Hornsby, Shauna M McBride, Krystan A Wilkinson, Lori H Schwacke
After the Deepwater Horizon (DWH) oil spill began in April 2010, studies were initiated on northern Gulf of Mexico common bottlenose dolphins (Tursiops truncatus) in Mississippi Sound (MSS) to determine density, abundance, and survival, during and after the oil spill, and to compare these results to previous research in this region. Seasonal boat-based photo-identification surveys (2010-2012) were conducted in a section of MSS to estimate dolphin density and survival, and satellite-linked telemetry (2013) was used to determine ranging patterns...
2017: PloS One
https://www.readbyqxmd.com/read/29053664/scientific-production-of-vice-chancellors-for-research-in-peruvian-universities-with-a-medical-school
#11
Percy Herrera-Añazco, Germán Valenzuela-Rodríguez, Josmel Pacheco-Mendoza, Germán Málaga
OBJECTIVES: To determine the scientific production of Research Vice-chancellors at Peruvian universities that have medical schools, as well as their academic degrees as an indirect way to evaluate their suitability for the position they hold. METHODS: We searched all Peruvian universities that register medical schools. Of these, the scientific production of the universities registered in SCOPUS was identified in September of the 2016. The scientific production of the vice chancellors of investigation of these faculties of medicine was determined through the search of its scientific publications registered in SCOPUS and those reported in the National Registry of Researchers in Science and Technology...
October 19, 2017: Medwave
https://www.readbyqxmd.com/read/29053626/a-systematic-review-of-computational-drug-discovery-development-and-repurposing-for-ebola-virus-disease-treatment
#12
REVIEW
James Schuler, Matthew L Hudson, Diane Schwartz, Ram Samudrala
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized and/or novel treatments are reported to have potential anti-Ebola activity. Approaches that utilize multi-targeting/polypharmacology have the most promise in treating EVD...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053618/the-application-of-ultra-high-performance-liquid-chromatography-coupled-with-a-ltq-orbitrap-mass-technique-to-reveal-the-dynamic-accumulation-of-secondary-metabolites-in-licorice-under-aba-stress
#13
Da Li, Guojie Xu, Guangxi Ren, Yufeng Sun, Ying Huang, Chunsheng Liu
The traditional medicine licorice is the most widely consumed herbal product in the world. Although much research work on studying the changes in the active compounds of licorice has been reported, there are still many areas, such as the dynamic accumulation of secondary metabolites in licorice, that need to be further studied. In this study, the secondary metabolites from licorice under two different methods of stress were investigated by ultra-high-performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS)...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053574/symptoms-during-adolescents-first-use-of-cigarettes-and-e-cigarettes-a-pilot-study
#14
May S Chen, Marissa G Hall, Humberto Parada, Kathryn Peebles, Kaitlyn E Brodar, Noel T Brewer
Symptoms adolescents experience during their first time using a cigarette predict their current use, but little is known regarding the symptoms experienced during first e-cigarette use. We conducted a pilot study to understand the symptoms adolescents experience when they first tried cigarettes and e-cigarettes and the associations between these symptoms and current use. Participants were 41 adolescents in two U.S. cities who had tried cigarettes or e-cigarettes. We asked adolescents to recall the symptoms they experienced during their first cigarette or e-cigarette and categorized symptoms as negative (felt bad, coughing/chest pain, bad taste, upset stomach, dizzy/lightheaded) or positive (felt relaxed, rush/buzz)...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29053443/enhancement-of-intercellular-electrical-synchronization-by-conductive-materials-in-cardiac-tissue-engineering
#15
Yu Wu, Liang Guo
OBJECTIVE: cardiac tissue regeneration for the treatment of cardiovascular diseases has been of great research interest. Under the hypothesis that electrical synchronization of cardiac cells can be aided by conductive materials, electrically conductive scaffolds have been frequently used to improve cardiac tissue regeneration. However, theoretical analysis is presently absent in examining the underlying mechanism and rationally guiding the design of these conductive scaffolds. METHODS: here, equivalent-circuit models are proposed, in which two adjacent groups of cardiomyocytes are grown either on a bulk conductive substrate or around conductive nanostructures...
October 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29053439/factors-influencing-indonesian-women-s-use-of-maternal-health-care-services
#16
Anna Kurniati, Ching-Min Chen, Ferry Efendi, Sarni Maniar Berliana
Employing the 2012 Indonesia Demographic and Health Survey data, we aimed to examine factors influencing married women to use maternity services. Data of married women who had given birth in the last five years before the survey were included in the analysis (n = 14,672). Factors of education, employment, women's age at first marriage, age at first birth, spousal education difference, contraceptive use, place of residence, and woman's attitude toward wife beating were associated with the use of antenatal care, institutional delivery, and postnatal care services...
October 20, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/29053392/mental-health-related-stigma-in-china
#17
Xiuying Xu, Xin-Min Li, Jinhui Zhang, Wenqiang Wang
OBJECTIVE: The past decade has been marked by a significant increase in information on stigma associated with mental disorders, but these findings have yet to be applied extensively to mental health services in China. The objective of this study was to conduct a narrative review of studies relating to stigma toward mental illness in China. METHODS: A critical search of scientific papers was conducted in the PubMed, CNKI, and WANFANG databases. The search included articles published from January 2001 to April 2016...
October 20, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29053391/drinking-refusal-self-efficacy-and-intended-alcohol-consumption-during-a-mass-attended-youth-event
#18
Michelle I Jongenelis, Simone Pettigrew, Nicole Biagioni
BACKGROUND: Mass-attended youth events represent a substantial public health challenge due to high levels of alcohol consumption and corresponding high rates of alcohol-related harm. Although previous research has documented the protective effect of high drinking refusal self-efficacy (DRSE) on alcohol consumption in general, there is a lack of research examining the role of DRSE in reducing consumption during mass-attended youth events and the factors associated with DRSE in these contexts...
October 20, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29053375/the-structure-of-challenging-parenting-behavior-and-associations-with-anxiety-in-dutch-and-australian-children
#19
Mirjana Majdandžić, Rebecca S Lazarus, Frans J Oort, Cathy van der Sluis, Helen F Dodd, Talia M Morris, Wieke de Vente, Yulisha Byrow, Jennifer L Hudson, Susan M Bögels
Challenging parenting behavior (CPB), a novel construct involving active physical and verbal behaviors that encourage children to push their limits, has been identified as a potential buffer against child anxiety. This study aimed to (a) evaluate the measurement invariance of the Challenging Parenting Behavior Questionnaire (CPBQ4-6) across Dutch and Australian mothers and fathers of preschoolers, (b) examine differences in levels of CPB across mothers and fathers and across countries, and (c) examine whether parents' CPB predicts less child anxiety symptoms and disorders...
October 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29053189/pilot-screening-study-of-targeted-genetic-polymorphisms-for-association-with-seasonal-influenza-hospital-admission
#20
Tonia C Carter, Scott J Hebbring, Jixia Liu, Jonathan D Mosley, Christian M Shaffer, Lynn C Ivacic, Sarah Kopitzke, Elisha L Stefanski, Rob Strenn, Maria E Sundaram, Jennifer Meece, Murray H Brilliant, Jill M Ferdinands, Edward A Belongia
Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune response genes were evaluated for association with seasonal influenza hospitalization in an adult study population with European ancestry. SNP allele and genotype frequencies were compared between hospitalized influenza patients (cases) and population controls in a case-control study that included a discovery group (26 cases and 993 controls) and two independent, validation groups (one with 84 cases and 4,076 controls; the other with 128 cases and 9,187 controls)...
October 20, 2017: Journal of Medical Virology
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