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https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#1
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909496/transplantation-of-macroencapsulated-insulin-producing-cells
#2
REVIEW
Albert J Hwa, Gordon C Weir
PURPOSE OF REVIEW: There is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This review aims to summarize recent advances, to highlight remaining challenges, and to provide recommendations for the field. RECENT FINDINGS: A variety of new device designs have been reported to improve biocompatibility and to provide protection for islet/beta cells from immune destruction while allowing continuous secretion of insulin...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909366/identification-of-complement-inhibitory-activities-of-two-chemotherapeutic-agents-using-a-high-throughput-cell-imaging-based-screening-assay
#3
Lingjun Zhang, Yuriy Fedorov, Drew Adams, Feng Lin
Excessive complement activation contributes significantly to the pathogeneses of various diseases. Currently, significant developmental research efforts aim to identify complement inhibitors with therapeutic uses have led to the approval of one inhibitor for clinical use. However, most existing complement inhibitors are based on monoclonal antibodies, which have many drawbacks such as high costs and limited administration options. With this report, we establish an inexpensive, cell imaging-based high-throughput assay for the large-scale screening of potential small molecule complement inhibitors...
June 14, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29909302/affective-styles-in-mood-and-anxiety-disorders-clinical-validation-of-the-affective-style-questionnaire-asq
#4
Christina Totzeck, Tobias Teismann, Stefan G Hofmann, Ruth von Brachel, Xiao Chi Zhang, Verena Pflug, Jürgen Margraf
BACKGROUND: Emotion regulation plays a critical role in the development and maintenance of psychological disorders. Less is known about the association of affective styles and psychopathology. The 20-item "Affective Style Questionnaire" (ASQ) has been validated in nonclinical samples. The American and German validation studies resulted in a three-factor structure (concealing, adjusting, and tolerating). The present study aimed to investigate three aspects: (1) the validation of the ASQ within a clinical sample, (2) the examination of possible differences in affective styles between patients suffering from affective versus anxiety disorders, and (3) the association of affective styles and anxiety, depression, and stress symptoms...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909223/chemotherapy-and-cognition-international-cognition-and-cancer-task-force-recommendations-for-harmonising-preclinical-research
#5
REVIEW
Gordon Winocur, Ian Johnston, Hélène Castel
Cancer survivors who undergo chemotherapy for non-CNS tumours often report substantial cognitive disturbances that adversely affect quality of life, during and after treatment. The neurotoxic effects of anti-cancer drugs have been confirmed in clinical and pre-clinical research. Work with animals has also identified a range of factors and underlying mechanisms that contribute to chemotherapy-induced cognitive impairment. However, there is a continuing need to develop standard cognitive testing procedures for validation and comparison purposes, broaden the search for biological and neurochemical mechanisms, and develop improved animal models for investigating the combined effects of treatment, the disease, and other potential factors (e...
June 1, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29909177/-18-f-fmpep-d-2-pet-imaging-shows-age-and-genotype-dependent-impairments-in-the-availability-of-cannabinoid-receptor-1-in-a-mouse-model-of-alzheimer-s-disease
#6
Jatta S Takkinen, Francisco R López-Picón, Anna K Kirjavainen, Rea Pihlaja, Anniina Snellman, Tamiko Ishizu, Eliisa Löyttyniemi, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
Contradictory findings on the role of the type 1 cannabinoid receptor (CB1 R) during the pathogenesis of Alzheimer's disease (AD) have been reported. Here, we evaluated the CB1 R brain profile in an AD mouse model using longitudinal positron emission tomography with an inverse agonist for CB1 R, [18 F]FMPEP-d2 . APP/PS1-21 and wild-type (n = 8 in each group) mice were repeatedly imaged between 6 to 15 months of age, accompanied by brain autoradiography, western blot, and CB1 R immunohistochemistry with additional mice...
May 18, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29909157/fullerenol-c-60-oh-36-at-relatively-high-concentrations-impairs-hippocampal-theta-oscillations-in-vivo-and-in-vitro-and-triggers-epilepsy-in-vitro-a-dose-response-study
#7
Paulina Kazmierska, Anna Kobrzycka, Renata Bocian, Tomasz Kowalczyk, Anita Krokosz, Jacek Grebowski
Since the first identification of fullerenes (C60 ) and their synthesis in 1985, those compounds have been extensively studied in the biomedical field. In particular, their water-soluble derivatives, fullerenols (C60 (OH)n, n = 2-48), have recently been the subject of numerous investigations concerning their antioxidant and prooxidant properties in biological systems. A small fraction of that research has focused on the possible use of C60 and C60 (OH)n in neuroscience and the therapy of pathologies such as dementia, amyloid-β (Aβ) formation, and Parkinson's disease...
June 14, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#8
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29909022/a-review-on-healthy-ageing-interventions-addressing-physical-mental-and-social-health-of-independent-community-dwelling-older-adults
#9
Betsy Seah, Yanika Kowitlawakul, Ying Jiang, Emily Ang, Srinivasan Chokkanathan, Wenru Wang
Healthy ageing is a multi-dimensional concept which appertains to all older adults. This study reviewed the intervention characteristics, intervention content and effectiveness of multi-dimensional healthy ageing interventions (MHAIs) addressing physical, mental and social health among independent community-dwelling older adults. A search was conducted in PubMed, CINAHL, Embase, Scopus, and PsycINFO for studies published from Jan 2007 to October 2016. 18 publications were included, accounting for 15 studies...
June 13, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29908994/accounting-for-radiation-induced-indirect-damage-on-dna-with-the-geant-4-dna-code
#10
Liset de la Fuente Rosales, Sebastien Incerti, Ziad Francis, Mario A Bernal
The use of Monte Carlo (MC) simulations remains a powerful tool to study the biological effects induced by ionizing radiation on living beings. Several MC codes are commonly used in research fields such as nanodosimetry, radiotherapy, radiation protection, and space radiation. This work presents an enhancement of an existing model [1] for radiobiological purposes, to account for the indirect DNA damage induced by ionizing particles. The Geant4-DNA simulation toolkit was used to simulate the physical, pre-chemical, and chemical stages of early DNA damage induced by protons and α-particles...
June 13, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29908939/delivery-system-for-budesonide-based-on-lipid-dna
#11
Yun Liu, I Sophie T Bos, Tjitske A Oenema, Herman Meurs, Harm Maarsingh, Anna K H Hirsch
Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC)...
June 14, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908894/microrna-499a-decelerates-glioma-cell-proliferation-while-accelerating-apoptosis-through-the-suppression-of-notch1-and-the-mapk-signaling-pathway
#12
Bang-Qing Wang, Bin Yang, Hua-Chao Yang, Jun-Yi Wang, Sen Hu, Yu-Shuai Gao, Xing-Yao Bu
As the most common and lethal of intracranial tumors, glioma accounts for 81% of all malignant brain tumors. Research data has identified the role of microRNAs (miRs) as functional suppressers in the progression of Glioma. The present study aimed to, ascertain as to whether microRNA-499a (miR-499a) influences cell proliferation and apoptosis through the MAPK signaling pathway by targeting Notch1 in glioma. Both glioma and adjacent tissues between 2012~2016, were obtained from People's Hospital of Zhengzhou University (Henan Provincial People's Hospital)...
June 14, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29908876/prostate-imaging-reporting-and-data-system-steering-committee-pi-rads-v2-status-update-and-future-directions
#13
Anwar R Padhani, Jeffrey Weinreb, Andrew B Rosenkrantsz, Geert Villeirs, Baris Turkbey, Jelle Barentsz
CONTEXT: The Prostate Imaging-Reporting and Data System (PI-RADS) v2 analysis system for multiparametric magnetic resonance imaging (mpMRI) detection of prostate cancer (PCa) is based on PI-RADS v1, accumulated scientific evidence, and expert consensus opinion. OBJECTIVE: To summarize the accuracy, strengths and weaknesses of PI-RADS v2, discuss pathway implications of its use and outline opportunities for improvements and future developments. EVIDENCE ACQUISITION: For this consensus expert opinion from the PI-RADS steering committee, clinical studies, systematic reviews, and professional guidelines for mpMRI PCa detection were evaluated...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29908865/surgeons-perspective-on-shared-decision-making-in-trauma-surgery-a-national-survey
#14
Sarah Woltz, Pieta Krijnen, Arwen H Pieterse, Inger B Schipper
OBJECTIVE: This study aimed to answer the following research question: What is the knowledge, opinion, and experience of trauma surgeons with respect to shared decision making (SDM)? METHODS: An online survey was sent out in September 2016 to all 257 surgeons registered as a trauma surgeon with the Dutch Association of Trauma Surgery, to gather demographic, knowledge, and practice based information regarding their use of SDM. Results were presented according to the Checklist for Reporting Results of Internet E-Surveys (CHERRIES)...
June 6, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29908831/a-new-method-for-neonatal-rat-ventricular-myocyte-purification-using-superparamagnetic-iron-oxide-particles
#15
Duomeng Yang, Junmin Xi, Yun Xing, Xiangxu Tang, Xiaomeng Dai, Kaiying Li, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang
BACKGROUND: Neonatal rat ventricular myocytes (NRVMs) have proven to be an ideal research model for cardiac disease. However, the current methods to purify NRVMs have a limitation to obtain high purity. The purpose of this study was to develop a NRVM purification method by using superparamagnetic iron oxide particles (SIOP). METHODS: NRVMs were purified by using SIOP (SIOP group). The differential attachment with or without bromodeoxyuridine (BrdU) treatment served as control and BrdU groups, respectively...
June 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29908784/screening-for-psychiatric-disorders-with-self-administered-questionnaires
#16
Mark Zimmerman, Carolina Guzman Holst
Given the time demands of clinical practice it is not surprising that diagnoses are sometimes missed. To improve diagnostic recognition, self-administered screening scales have been recommended. A problem with much of the research effort on screening scales is the confusion between diagnostic testing and screening. It is important for a screening test to have high sensitivity because the more time intensive/expensive follow-up diagnostic inquiry will presumably only occur in patients who are positive on the initial screen...
May 16, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29908672/changing-the-neurology-policy-landscape-in-the-united-states-misconceptions-and-facts-about-epilepsy
#17
David C Grabowski, Jesse Fishman, Imane Wild, Bruce Lavin
Epilepsy has a relatively high prevalence, and diagnosis and treatment are often challenging. Seizure freedom without significant side effects is the ultimate goal for both physicians and patients, but not always achievable. In those cases, the treatment goals of patients and providers may differ. In the United States, many clinicians continue to prescribe older AEDs, even though newer AEDs have a more desirable safety and tolerability profile, fewer drug-drug interactions, and are associated with lower epilepsy-related hospital visits...
May 26, 2018: Health Policy
https://www.readbyqxmd.com/read/29908572/medicinal-plants-with-traditional-use-ethnobotany-in-the-indian-subcontinent
#18
Reena Rupani, Afton Chavez
Traditional medicine uses cultural knowledge and practices to promote health maintenance as well as diagnose and treat disease. In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported. We review the current understanding and research behind traditional therapies prevalent in the Indian subcontinent, including mind-body and energy-based healing, botanical medicine, and herbal remedies. Topics covered include Ayurveda, yoga, naturopathy, Unani, Siddha, Sowa-Rigpa, homeopathy, and medicinal plants such as neem, guggul, tulsi, amla, and turmeric...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29908487/dynamic-properties-of-hydrogels-and-fiber-reinforced-hydrogels
#19
Nicholas Martin, George Youssef
Hydrophilic polymers, or hydrogels, are used for a wide variety of biomedical applications, due to their inherent ability to withhold a high-water content. In recent years, a large effort has been focused on tailoring the mechanical properties of these hydrogels to become more appropriate materials for use as anatomical and physiological structural supports. A few of these such methods include using diverse types of polymers, both natural and synthetic, varying the type of molecular cross-linking, as well as combining these efforts to form interpenetrating polymer network hydrogels...
June 7, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29908450/cervical-sympathetic-chain-schwannoma-masquerading-as-a-vagus-nerve-schwannoma-complicated-by-postoperative-horner-s-syndrome-and-facial-pain-a-case-report
#20
Austin T Baker, Tyler J Homewood, Terry R Baker
INTRODUCTION: Cervical Sympathetic Chain Schwannomas (CSCS) of the carotid sheath are rare neoplasms that can be misdiagnosed on imaging. The following case documents a rare incident of a misdiagnosed CSCS with unusual outcomes of permanent Horner's syndrome and facial pain. PRESENTATION OF CASE: A 36-year-old female presented with a slow-growing neck mass. CT and MRI led to a preoperative diagnosis of vagus nerve schwannoma (VNS). However, surgical treatment revealed the mass to be involved with the cervical sympathetic chain rather than the vagus nerve...
June 9, 2018: International Journal of Surgery Case Reports
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