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https://www.readbyqxmd.com/read/29245188/the-unmet-needs-of-aboriginal-australians-with-musculoskeletal-pain-a-mixed-method-systematic-review
#1
Ivan B Lin, Samantha Bunzli, Donna B Mak, Charmaine Green, Roger Goucke, Juli Coffin, Peter B O'Sullivan
OBJECTIVE: Musculoskeletal pain (MSP) conditions are the biggest cause of disability and internationally, Indigenous peoples experience a higher burden. There are conflicting reports about Aboriginal Australians and MSP. We conducted a systematic review to describe the prevalence, associated factors, impacts, care access, health care experiences, and factors associated with MSP among Aboriginal Australians. METHODS: A systematic search of quantitative and qualitative scientific and grey literature (PROSPERO number: CRD42016038342)...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245187/news-on-relapsing-polychondritis-the-patients-experience
#2
EDITORIAL
Jean-Charles Piette, Jérémie Dion, Nathalie Costedoat-Chalumeau
In this issue of Arthritis Care & Research, the authors of Patient-Perception of Disease-Related Symptoms and Complications in Relapsing Polychondritis report for the first time the patient's view over the disease (1). Thanks go to them for this important step forward. The method used however, carries some limitations, as indicated very honestly by the authors. This article is protected by copyright. All rights reserved.
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245177/microplastics-as-an-emerging-threat-to-terrestrial-ecosystems
#3
Anderson Abel de Souza Machado, Werner Kloas, Christiane Zarfl, Stefan Hempel, Matthias C Rillig
Microplastics (plastics < 5 mm, including nanoplastics which are < 0.1 μm) originate from the fragmentation of large plastic litter or from direct environmental emission. Their potential impacts in terrestrial ecosystems remain largely unexplored despite numerous reported effects on marine organisms. Most plastics arriving in the oceans were produced, used, and often disposed on land. Hence, it is within terrestrial systems that microplastics might first interact with biota eliciting ecologically relevant impacts...
December 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29245169/-mistakes-and-drawbacks-in-german-newspaper-articles-on-epidemiologic-studies-meat-consumption-and-colorectal-cancer-as-an-example
#4
Bernd Kowall, Andreas Stang
Background Results of epidemiologic studies are often reported in the media because they are of vital interest for many people. Using the example of meat consumption and colorectal cancer, we investigated whether results of epidemiologic studies are reported in an understandable and correct manner in German newspapers and magazines. Methods We gathered all articles published in 13 selected German newspapers and magazines that referred to a press release on meat consumption and colorectal cancer issued by the International Agency for Research on Cancer (IARC) on October 26th 2015...
December 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29245147/levels-of-trace-elements-methylmercury-and-polybrominated-diphenyl-ethers-in-foraging-green-turtles-in-the-south-china-region-and-their-conservation-implications
#5
Connie Ka Yan Ng, James Chung Wah Lam, Xiao Hua Zhang, He Xiang Gu, Tsung Hsien Li, Min Bin Ye, Zhong Rong Xia, Fei Yan Zhang, Jin Xia Duan, Wen Xiong Wang, Isaac Kam Sum Lam, George H Balazs, Paul K S Lam, Margaret B Murphy
Sea turtles are globally endangered and face daily anthropogenic threats, including pollution. However, there is a lack of ecotoxicological information on sea turtles, especially in the Asia-Pacific region. This study aims to determine pollutant levels of foraging green turtles (Chelonia mydas) in South China, including Hong Kong, Guangdong and Taiwan, as a basis for their conservation. Scute, liver and muscle tissues of stranded green turtles were analysed for levels of 17 trace elements and methylmercury (MeHg) (n = 86 for scute and n = 14 for liver) and polybrominated diphenyl ethers (PBDEs) (n = 11 for muscle and n = 13 for liver)...
December 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29245141/a-systematic-review-of-the-state-of-the-literature-on-sexually-exploited-boys-internationally
#6
Melissa Moynihan, Katherine Mitchell, Claire Pitcher, Farinaz Havaei, Max Ferguson, Elizabeth Saewyc
This systematic review assessed the current state of the literature on sexually exploited boys internationally. We aimed to describe what is known about sexual exploitation of boys, identify gaps in the literature, provide implications for practice, and make recommendations for future research. Multiple database searches were conducted using a combination of controlled vocabulary and keywords to capture child and adolescent sexual exploitation. Our search identified 11,099 unique references and excluded studies that did not include male participants less than 18 years old or disaggregate results by relevant age groups and/or by sex...
December 12, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29245108/learning-and-transfer-of-working-memory-gating-policies
#7
Apoorva Bhandari, David Badre
knowledge about the tasks we encounter enables us to rapidly and flexibly adapt to novel task contexts. Previous research has focused primarily on abstract rules that leverage shared structure in stimulus-response (S-R) mappings as the basis of such task knowledge. Here we provide evidence that working memory (WM) gating policies - a type of control policy required for internal control of WM during a task - constitute a form of abstract task knowledge that can be transferred across contexts. In two experiments, we report specific evidence for the transfer of selective WM gating policies across changes of task context...
December 12, 2017: Cognition
https://www.readbyqxmd.com/read/29245102/random-responses-inflate-statistical-estimates-in-heavily-skewed-addictions-data
#8
Kevin M King, Dale S Kim, Connor J McCabe
BACKGROUND: Some respondents may respond at random to self-report surveys, rather than responding conscientiously (Meade and Craig, 2012), and this has only recently come to the attention of researchers in the addictions field (Godinho et al., 2016). Almost no research in the published addictions literature has reported screening for random responses. We illustrate how random responses can bias statistical estimates using simulated and real data, and how this is especially problematic in skewed data, as is common with substance use outcomes...
December 9, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29245090/psychological-distress-and-risk-for-suicidal-behavior-among-university-students-in-contemporary-china
#9
Fang Tang, Majella Byrne, Ping Qin
BACKGROUND: Psychological distress and suicidal behavior are important mental health problems among university students and warrant research to inform strategies for effective prevention in this young population. The present study aimed to assess psychological distress and suicidal behavior and to unravel their associations among university students. METHODS: A total of 5972 undergraduate students, randomly selected from six universities in central China, comprised the sample...
December 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#10
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245083/concordance-between-the-wada-test-and-neuroimaging-lateralization-influence-of-imaging-modality-fmri-and-meg-and-patient-experience
#11
Steven Kemp, Garreth Prendergast, Theodoros Karapanagiotidis, Gus Baker, Thomas P Kelly, Tufail Patankar, Simon S Keller
The Wada test remains the traditional test for lateralizing language and memory function prior to epilepsy surgery. Functional imaging, particularly functional MRI (fMRI), has made progress in the language domain, but less so in the memory domain. Magnetoencephalography (MEG) has received less research attention, but shows promise, particularly for language lateralization. We recruited a consecutive sample of 19 patients with epilepsy who had completed presurgical work-up, including the Wada test, and compared fMRI (memory) and MEG (language and memory) with Wada test results...
December 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29245079/what-technologies-do-people-engage-with-while-driving-and-why
#12
Katie J Parnell, Neville A Stanton, Katherine L Plant
This paper presents the findings of a semi-structured interview study that was conducted to identify drivers' self-reported likelihood of engaging with technologies that are now commonly found in modern automobiles. Previous research has focused on the effect these technological tasks have on driving performance, but there has been less focus on how, why and when drivers choose to engage with them. As distraction remains a significant contributor to road accidents, an understanding of why it occurs will give important insights into how it can be prevented...
December 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29244997/beliefs-and-determinants-of-use-of-traditional-complementary-alternative-medicine-in-pediatric-patients-who-undergo-treatment-for-cancer-in-south-america
#13
Valeria Rocha, Elena J Ladas, Meiko Lin, Walter Cacciavillano, Elizabeth Ginn, Kara M Kelly, Guillermo Chantada, Luis Castillo
Purpose The use of traditional complementary/alternative medicine (TCAM) among children with cancer has been well documented. South America has a rich history of traditional healers and medicinal resources; however, little is known about the use of TCAM among children with cancer. We sought to investigate patterns, beliefs, and determinants of TCAM use among South American children with cancer. Methods A cross-sectional survey was administered to 199 children treated for cancer at institutions located in Buenos Aires, Argentina, and Montevideo, Uruguay...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#14
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244908/changes-in-coping-and-social-motives-for-drinking-and-alcohol-consumption-across-the-menstrual-cycle
#15
Kayla M Joyce, Amanda Hudson, Roisin O'Connor, Kara Thompson, Megan Hodgin, Tara Perrot, Sherry H Stewart
BACKGROUND: Alcohol use has been reported to fluctuate over women's menstrual cycles (MCs), with increased intake occurring premenstrually/menstrually (phases characterized by heightened negative affect) and during the ovulatory phase (a phase characterized by positive affect). This suggests women may drink for particular emotion-focused reasons at specific points in their cycles. However, no research had yet examined MC variability in drinking motives, or links between cycle-related changes in drinking motives and alcohol consumption...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244874/maximum-walking-speed-in-multiple-sclerosis-assessed-with-visual-perceptive-computing
#16
Anuschka Grobelny, Janina R Behrens, Sebastian Mertens, Karen Otte, Sebastian Mansow-Model, Theresa Krüger, Elona Gusho, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Tanja Schmitz-Hübsch
BACKGROUND: Gait is often impaired in people with multiple sclerosis (PwMS), but detailed assessment of gait impairment in research and care remains challenging. In a previous pilot study we reported the feasibility of visual perceptive computing (VPC) for gait assessment in PwMS using the Short Maximum Speed Walk (SMSW), which assesses gait on recording distances confined to less than 4 meters. OBJECTIVE: To investigate the equivalence of SMSW to rater-based timed 25ft...
2017: PloS One
https://www.readbyqxmd.com/read/29244799/prenatal-and-early-postnatal-measures-of-brain-development-and-childhood-sleep-patterns
#17
Desana Kocevska, Maria E Verhoeff, Selma Meinderts, Vincent W Jaddoe, Frank C Verhulst, Sabine J Roza, Maartje P C M Luijk, Henning Tiemeier
BACKGROUND: Brain development underlies maturation of sleep patterns throughout childhood. Intrauterine head growth -marker of early neurodevelopment- has not been associated with childhood sleep characteristics. We explored associations between ultrasonographic measures of prenatal and early postnatal neurodevelopment and childhood sleep. METHODS: Six-thousand-five-hundred-twenty-eight children from a population-based birth cohort (Generation R) were included. Head circumference (HC) and lateral ventricles size were assessed with mid- and late-pregnancy fetal ultrasounds, and with cranial ultrasound 3-20 weeks postnatally...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244791/management-and-outcomes-of-childhood-goodpasture-s-disease
#18
Carmela P Menzi, Barbara S Bucher, Mario G Bianchetti, Gianluigi Ardissino, Giacomo D Simonetti
BACKGROUND: In an attempt to improve knowledge about childhood Goodpasture's disease, we performed a retrospective analysis of patients with Goodpasture's disease from several pediatric nephrology centers. METHODS: We analyzed the responses to 27 questions that elicited information about the following: incidence, demographics, patient history and clinical presentation, diagnostics performed, acute and chronic therapy, course of disease and outcome. RESULTS: Goodpasture's disease, which is extremely rare in this age group, may manifest in 2-year-old toddlers and does not typically present with pulmonary findings before puberty...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244610/inhibition-of-exosome-release-by-ketotifen-enhances-sensitivity-of-cancer-cells-to-doxorubicin
#19
Farman Matloob Khan, Ekram Saleh, Hussain Alawadhi, Rania Harati, Wolfram-Hubertus Zimmermann, Raafat El-Awady
Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy. Therapeutic targeting of exosomes is a promising area in cancer research. Our aim is to test the effect of the mast cell stabilizer ketotifen on exosomes release from cancer cells and how this can modify their response to doxorubicin. Exosomes release from three cancer cell lines (MCF7, HeLa and BT549) was assessed by scan electron microscope and exosomes quantification kit. Doxorubicin export within exosomes was monitored flurometrically and cellular sensitivity to doxorubicin ± ketotifen was measured by sulphorhodamine-B and colony formation assays...
December 15, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29244527/motivations-for-extradyadic-infidelity-revisited
#20
Dylan Selterman, Justin R Garcia, Irene Tsapelas
Relationship infidelities are motivated by many distinct factors, with previous research indicating motivations of dissatisfaction, neglect, anger, and sexual desire (Barta & Kiene, 2005). We expand on this by demonstrating additional, empirically distinct motivations for infidelity. Using an Internet-based questionnaire, participants (N = 495), most of whom were young adults, self-reported their infidelities. In addition to evidence for previously studied motivations, our data demonstrate additional factors, including lack of love ("I had 'fallen out of love with' my primary partner"), low commitment ("I was not very committed to my primary partner"), esteem ("I wanted to enhance my popularity"), gaining sexual variety ("I wanted a greater variety of sexual partners"), and situational factors ("I was drunk and not thinking clearly")...
December 15, 2017: Journal of Sex Research
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