Mohd Shuaib, Smriti Chaudhri, Shashank Kumar
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes ( CDKN3 , TRAF6 , CCND1 , JAK1 , MET , AXIN2 , JAG1 , VEGFA , BRCA1 , E2F3 , WNT1 , CDK6 , KRAS , MYB , MYCN , TGFβR2 , NOTCH1 , SIRT1 , MYCN , NOTCH2 , WNT3A ) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein-protein interaction network analysis...
January 1, 2024: Biomolecular Concepts