keyword
https://read.qxmd.com/read/38535476/study-on-the-anti-mycobacterium-marinum-activity-of-a-series-of-marine-derived-14-membered-resorcylic-acid-lactone-derivatives
#1
JOURNAL ARTICLE
Qian-Qian Jing, Jun-Na Yin, Ya-Jie Cheng, Qun Zhang, Xi-Zhen Cao, Wei-Feng Xu, Chang-Lun Shao, Mei-Yan Wei
With the emergence of drug-resistant strains, the treatment of tuberculosis (TB) is becoming more difficult and there is an urgent need to find new anti-TB drugs. Mycobacterium marinum , as a model organism of Mycobacterium tuberculosis , can be used for the rapid and efficient screening of bioactive compounds. The 14-membered resorcylic acid lactones (RALs) have a wide range of bioactivities such as antibacterial, antifouling and antimalarial activity. In order to further study their bioactivities, we initially constructed a 14-membered RALs library, which contains 16 new derivatives...
March 16, 2024: Marine Drugs
https://read.qxmd.com/read/38535318/unravel-the-supremacy-of-klebsiella-variicola-over-native-microbial-strains-for-aroma-enhancing-compound-production-in-reconstituted-tobacco-concentrate-through-metagenomic-analysis
#2
JOURNAL ARTICLE
Shen Huang, Li Zhu, Ke Wang, Xinlong Zhang, Duobin Mao, Aamir Rasool
Sensory attributes strongly influence consumers' preferences for products. The inoculation of the Klebsiella variicola H8 strain in a reconstituted tobacco leaf concentrate (RTLC) solution increased neutral aroma-enhancing compound (NAEC) production by 45%, decreased the nicotine level by 25%, decreased the water-soluble total sugar content by ~36%, and improved the sensory quality by 5.71%. The production of NAECs such as dihydrokiwi lactone (DHKL: 192.86%), 1,2,3,4-tetrahydro-1,1,6-trimethylnaphthalene (THTMN: 177...
March 8, 2024: Metabolites
https://read.qxmd.com/read/38535199/structures-and-biological-activities-of-secondary-metabolites-from-xylaria-spp
#3
REVIEW
Weikang Chen, Miao Yu, Shiji Chen, Tianmi Gong, Linlin Xie, Jinqin Liu, Chang Bian, Guolei Huang, Caijuan Zheng
The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review...
February 29, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38532596/potential-of-the-quorum-quenching-and-plant-growth-promoting-halotolerant-bacillus-toyonensis-aa1ec1-as-biocontrol-agent
#4
JOURNAL ARTICLE
Amalia Roca, Mónica Cabeo, Carlos Enguidanos, Fernando Martínez-Checa, Inmaculada Sampedro, Inmaculada Llamas
The use of fertilizers and pesticides to control plant diseases is widespread in intensive farming causing adverse effects together with the development of antimicrobial resistance pathogens. As the virulence of many Gram-negative phytopathogens is controlled by N-acyl-homoserine lactones (AHLs), the enzymatic disruption of this type of quorum-sensing (QS) signal molecules, mechanism known as quorum quenching (QQ), has been proposed as a promising alternative antivirulence therapy. In this study, a novel strain of Bacillus toyonensis isolated from the halophyte plant Arthrocaulon sp...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38529937/total-synthesis-of-cyclotripeptidic-natural-products-anacine-aurantiomide-c-polonimides-a-and-c-and-verrucine-f
#5
JOURNAL ARTICLE
Guanghui Han, Wei Zhang, Emmanuelle Acs, Alexis Paquin, Quentin Ronzon, Nicolas Casaretto, Bastien Nay
The total synthesis of cyclotripeptidic natural products possessing a central piperazino[2,1- b ]quinazolin-3,6-dione core is described through an original strategy involving the pivotal cyclocondensation of an electrophilic homoserine lactone intermediate. The alkylidene group was spontaneously installed by autoxidation during the cyclocondensation process, while the propionamide side chain was introduced through the nickel-catalyzed aminocarbonylation of a bromoethyl intermediate. This last reaction is unprecedented on such highly functionalized intermediates...
March 26, 2024: Organic Letters
https://read.qxmd.com/read/38529189/sesquiterpene-lactones-as-emerging-biomolecules-to-cease-cancer-by-targeting-apoptosis
#6
REVIEW
Chou-Yi Hsu, Sadegh Rajabi, Maryam Hamzeloo-Moghadam, Abhinav Kumar, Marc Maresca, Pallavi Ghildiyal
Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy response of different cancer types, making it an effective target for treating cancer. Cancer has been considered a challenging issue in global health. Cancer cells possess six biological characteristics during their developmental process known as cancer hallmarks. Hallmarks of cancer include continuous growth signals, unlimited proliferation, resistance to proliferation inhibitors, apoptosis escaping, active angiogenesis, and metastasis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38527851/effects-of-matrix-structure-on-protein-digestibility-and-antioxidant-property-of-different-soybean-curds-during-in-vitro-digestion
#7
JOURNAL ARTICLE
Feifei Hu, Lin Wang, Loraine Bainto-Ancheta, Yukiharu Ogawa
This study compared the three most common types of tofu (soybean curd), which were prepared by using magnesium chloride (MgCl2 tofu), calcium sulfate (CaSO4 tofu), and glucono-δ-lactone (GDL tofu) coagulants. The results showed that GDL tofu had a higher water holding capacity than MgCl2 tofu and CaSO4 tofu, which was attributed to its high surface hydrophobicity and disulfide bond content. GDL tofu possessed the lowest firmness, gumminess, and chewiness, along with a uniform network structure and a thin protein matrix...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38527380/synthesis-and-biological-activity-of-thiophene-bioisosteres-of-natural-styryl-lactone-goniofufurone-and-related-compounds
#8
JOURNAL ARTICLE
Mirjana Popsavin, Sanja Djokić, Ivana Kovačević, Slađana M Stanisavljević, Vesna Kojić, Marko V Rodić, Lidija Aleksić, Jelena Kesić, Bojana Srećo Zelenović, Velimir Popsavin, Dimitar S Jakimov
Ten new thiophene derivatives related to goniofufurone have been obtained by multistep synthesis starting from d-glucose. The critical step of the synthesis was the Grignard reaction of 2-thienyl magnesium bromide with a protected dialdose, yielding the C-5 epimeric thiophene derivatives 9 and 10. The mixture was oxidized to the 5-keto derivative 11, which after deprotection was converted to the corresponding keto-lactone 14. Stereoselective reduction of 14 afforded the thiophene mimic of goniofufurone 3. Esterification of 3 with cinnamic or 4-fluorocinnamic acid gave hybrids 5-7...
March 21, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38526035/expanding-the-scope-of-the-successive-ring-expansion-strategy-for-macrocycle-and-medium-sized-ring-synthesis-unreactive-and-reactive-lactams
#9
JOURNAL ARTICLE
Zhongzhen Yang, Marion Arnoux, Damien Hazelard, Owen R Hughes, Joe Nabarro, Adrian C Whitwood, Martin A Fascione, Christopher D Spicer, Philippe Compain, William P Unsworth
New methods are described that expand the scope of the Successive Ring Expansion (SuRE) with respect to synthetically challenging lactams. A protocol has been developed for use with 'unreactive' lactams, enabling SuRE reactions to be performed on subsrates that fail under previously established conditions. Ring expansion is also demonstarted on 'reactive' lactams derived from iminosugars for the first time. The new SuRE methods were used to prepare a diverse array of medium-sized and macrocyclic lactams and lactones, which were evaluted in an anti-bacterial assay against E...
March 25, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38525814/withaferin-a-alters-the-expression-of-micrornas-146a-5p-and-34a-5p-and-associated-hub-genes-in-mda-mb-231-cells
#10
JOURNAL ARTICLE
Mohd Shuaib, Smriti Chaudhri, Shashank Kumar
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes ( CDKN3 , TRAF6 , CCND1 , JAK1 , MET , AXIN2 , JAG1 , VEGFA , BRCA1 , E2F3 , WNT1 , CDK6 , KRAS , MYB , MYCN , TGFβR2 , NOTCH1 , SIRT1 , MYCN , NOTCH2 , WNT3A ) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein-protein interaction network analysis...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38524670/quorum-sensing-facilitates-interpopulation-signaling-by-vibrio-fischeri-within-the-light-organ-of-euprymna-scolopes
#11
JOURNAL ARTICLE
Taylor A Yount, Andrew N Murtha, Andrew G Cecere, Tim I Miyashiro
Quorum sensing is an intercellular signaling mechanism that enables bacterial cells to coordinate population-level behaviors. How quorum sensing functions in natural habitats remains poorly understood. Vibrio fischeri is a bacterial symbiont of the Hawaiian bobtail squid Euprymna scolopes and depends on LuxI/LuxR quorum sensing to produce the symbiotic trait of bioluminescence. A previous study demonstrated that animals emit light when co-colonized by a Δ lux mutant, which lacks several genes within the lux operon that are necessary for bioluminescence production, and a LuxI- mutant, which cannot synthesize the quorum signaling molecule N -3-oxohexanoyl-homoserine lactone...
June 2023: Israel Journal of Chemistry
https://read.qxmd.com/read/38523180/development-and-characterization-of-liposomal-formulations-containing-sesquiterpene-lactones-for-the-treatment-of-chronic-gout
#12
JOURNAL ARTICLE
Rafaela Cunha Matosinhos, Frédéric Frézard, Sabrina Mendes Silva Araújo, Andressa Magalhães Barbosa, Isabela Fernanda de Souza, José Dias de Souza Filho, Jacqueline de Souza, Ana Paula Corrêa Oliveira Bahia, Francesca Ietta, Agnese Magnani, Dênia Antunes Saúde-Guimarães
Gout and hyperuricemia are characterized by high uric acid levels, and their treatment involves medications that have adverse effects. In this study, we evaluated oral liposomal formulations with eremantholide C and goyazensolide as a novel approach to reduce the toxicity associated with these substances while maintaining their anti-hyperuricemic activity. We characterized the formulations and evaluated them based on encapsulation efficiency and stability over 12 months and under simulated physiological environments...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38520282/engineering-quorum-quenching-acylases-with-improved-kinetic-and-biochemical-properties
#13
JOURNAL ARTICLE
Kitty Sompiyachoke, Mikael H Elias
Many Gram-negative bacteria use N-acyl-L-homoserine lactone (AHL) signals to coordinate phenotypes such as biofilm formation and virulence factor production. Quorum-quenching enzymes, such as AHL acylases, chemically degrade these molecules which prevents signal reception by bacteria and inhibits undesirable biofilm-related traits. These capabilities make acylases appealing candidates for controlling microbes, yet candidates with high activity levels and substrate specificity and that are capable of being formulated into materials are needed...
April 2024: Protein Science
https://read.qxmd.com/read/38518649/dehydrocostus-lactone-alleviates-irinotecan-induced-intestinal-mucositis-by-blocking-tlr4-md2-complex-formation
#14
JOURNAL ARTICLE
Miaomiao Sun, Honghong Zhan, Xiaoliang Long, Ali M Alsayed, Zhe Wang, Fancheng Meng, Guowei Wang, Jingxin Mao, Zhihua Liao, Min Chen
BACKGROUND: Irinotecan (CPT-11) is used as chemotherapeutic drug for treatment of colorectal cancer. However, without satisfactory treatments, its gastrointestinal toxicities such as diarrhea and intestinal inflammation severely restrained its clinical application. Roots of Aucklandia lappa Decne. are used as traditional Chinese medicine to relieve gastrointestinal dysfunction and dehydrocostus lactone (DHL) is one of its main active components. Nevertheless, the efficacy and mechanism of DHL against intestinal mucositis remains unclear...
February 3, 2024: Phytomedicine
https://read.qxmd.com/read/38517949/topology-accelerated-and-selective-cascade-depolymerization-of-architecturally-complex-polyesters
#15
JOURNAL ARTICLE
Changxia Shi, Nicholas A Rorrer, Alexander L Shaw, Ryan W Clarke, Bonnie L Buss, Gregg T Beckham, Linda J Broadbelt, Eugene Y-X Chen
Despite considerable recent advances already made in developing chemically circular polymers (CPs), the current framework predominantly focuses on CPs with linear-chain structures of different monomer types. As polymer properties are determined by not only composition but also topology, manipulating the topology of the single-monomer-based CP systems from linear-chain structures to architecturally complex polymers could potentially modulate the resulting polymer properties without changing the chemical composition, thereby advancing the concept of monomaterial product design...
March 22, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38516998/-pantoea-ananatis-a-plant-growth-stimulating-bacterium-and-its-metabolites-isolated-from-hydrocotyle-umbellata-dollarweed
#16
JOURNAL ARTICLE
Kumudini M Meepagala, Caleb M Anderson, Natascha Techen, Stephen O Duke
A bacterium growing on infected leaves of Hydrocotyle umbellata , commonly known as dollarweed, was isolated and identified as Pantoea ananatis . An ethyl acetate extract of tryptic soy broth (TSB) liquid culture filtrate of the bacterium was subjected to silica gel chromatography to isolate bioactive molecules. Indole was isolated as the major compound that gave a distinct, foul odor to the extract, together with phenethyl alcohol, phenol, tryptophol, N -acyl-homoserine lactone, 3-(methylthio)-1-propanol, cyclo(L-pro-L-tyr), and cyclo(dehydroAla-L-Leu)...
December 31, 2024: Plant Signaling & Behavior
https://read.qxmd.com/read/38516805/phosphine-catalyzed-synthesis-and-cytotoxic-evaluation-of-michael-adducts-of-the-sesquiterpene-lactone-arglabin
#17
JOURNAL ARTICLE
Alexey Valeryevich Salin, Andrey A Shabanov, Khasan R Khayarov, Daut R Islamov, Alexandra D Voloshina, Syumbelya K Amerhanova, Anna P Lyubina
A general method for chemo- and diastereoselective modification of anticancer natural product arglabin with nitrogen- and carbon-centered pronucleophiles under the influence of nucleophilic phosphine catalysts was developed. The locked s-cis-geometry of α-methylene-γ-butyrolactone moiety of arglabin favors for the additional stabilization of zwitterionic intermediate by electrostatic interaction between phosphonium and enolate oxygen centers, leading to the unprecedentedly efficient phosphine-catalyzed Michael additions to this sesquiterpene lactone...
March 22, 2024: ChemMedChem
https://read.qxmd.com/read/38515542/evaluation-of-antioxidant-and-antibacterial-properties-of-dehydrocostus-lactone%C3%A2-isolated-from-echinops-kebericho-root
#18
JOURNAL ARTICLE
Sisay Awoke Endalew, Minbale Gashu Taddese, Meseret Muhammed
BACKGROUND AND AIM: Echinops kebericho , an endemic plant to Ethiopia, traditionally used to treat infectious as well as noninfectious diseases. The primary objective of this study was isolating dehydrocostus lactone (DHCL) from E. kebericho and evaluating antibacterial activities on selected human pathogenic bacteria. METHODS: Extraction method used in this study was maceration. Based on the bioassay information methanol extract of the root of E. kebericho was subjected to column chromatography on silica gel by increasing solvent gradients to isolate DHCL...
March 2024: Health Science Reports
https://read.qxmd.com/read/38514642/a-concise-and-scalable-chemoenzymatic-synthesis-of-prostaglandins
#19
JOURNAL ARTICLE
Yunpeng Yin, Jinxin Wang, Jian Li
Prostaglandins have garnered significant attention from synthetic chemists due to their exceptional biological activities. In this report, we present a concise chemoenzymatic synthesis method for several representative prostaglandins, achieved in 5 to 7 steps. Notably, the common intermediate bromohydrin, a radical equivalent of Corey lactone, is chemoenzymatically synthesized in only two steps, which allows us to complete the synthesis of prostaglandin F2α in five steps on a 10-gram scale. The chiral cyclopentane core is introduced with high enantioselectivity, while the lipid chains are sequentially incorporated through a cost-effective process involving bromohydrin formation, nickel-catalyzed cross-couplings, and Wittig reactions...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38513913/isolation-identification-and-characterisation-of-pseudomonas-koreensis-cm-01-isolated-from-diseased-malaysian-mahseer-tor-tambroides
#20
JOURNAL ARTICLE
Melinda Mei Lin Lau, Cindy Jia Yung Kho, Hung Hui Chung, Azham Zulkharnain
Pseudomonas species are one of the most threatening fish pathogens which reside a wide range of environments. In this study, the dominant bacteria were isolated from diseased Malaysian mahseer (Tor tambroides) and tentatively named CM-01. It was identified as Pseudomonas koreensis based on its biochemical, morphological, genetic and physiological information. Its pathogenicity was found to be correlated with twelve virulence genes identified including iron uptake, protease, acylhomoserine lactone synthase gacS/gacA component regulation system, type IV secretion system, hydrogen cyanide production, exolysin, alginate biosynthesis, flagella and pili...
March 19, 2024: Fish & Shellfish Immunology
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