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https://www.readbyqxmd.com/read/28333983/alterations-in-amino-acid-status-in-cats-with-feline-dysautonomia
#1
Bruce C McGorum, Herb W Symonds, Clare Knottenbelt, Tom A Cave, Susan J MacDonald, Joanna Stratton, Irene Leon, Judith A Turner, R Scott Pirie
Feline dysautonomia (FD) is a multiple system neuropathy of unknown aetiology. An apparently identical disease occurs in horses (equine grass sickness, EGS), dogs, rabbits, hares, sheep, alpacas and llamas. Horses with acute EGS have a marked reduction in plasma concentrations of the sulphur amino acids (SAA) cyst(e)ine and methionine, which may reflect exposure to a neurotoxic xenobiotic. The aim of this study was to determine whether FD cats have alterations in amino acid profiles similar to those of EGS horses...
2017: PloS One
https://www.readbyqxmd.com/read/28330130/isolation-and-characterization-of-bacterial-endophytes-of-curcuma-longa-l
#2
Ajay Kumar, Ritu Singh, Akhilesh Yadav, D D Giri, P K Singh, Kapil D Pandey
Fourteen endophytic bacterial isolates were isolated from the rhizome of Curcuma longa L. were characterized on the basis of morphology, biochemical characteristics and 16S rRNA gene sequence analysis. The isolates were identified to six strains namely Bacillus cereus (ECL1), Bacillus thuringiensis (ECL2), Bacillus sp. (ECL3), Bacillus pumilis (ECL4), Pseudomonas putida (ECL5), and Clavibacter michiganensis (ECL6). All the strains produced IAA and solubilized phosphate and only two strains produced siderophore (ECL3 and ECL5) during plant growth promoting trait analysis...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330112/feather-degradation-potential-of-stenotrophomonas-maltophilia-kb13-and-feather-protein-hydrolysate-fph-mediated-reduction-of-hexavalent-chromium
#3
Khushboo Bhange, Venkatesh Chaturvedi, Renu Bhatt
An efficient keratinolytic strain of Stenorophomonas maltophilia KB13 was isolated from feather disposal site of Bilaspur, Chhattisgarh, India. The strain could metabolize 10 g/l chicken feathers as sole source of carbon and nitrogen. Soluble protein, amino acid, and cysteine content were found to be maximum (690.6 ± 8.7, 688.9 ± 9.12 and 21 ± 0.36 µg/ml, respectively) at late logarithmic phase of growth. Protease and keratinase activity reached its maximum level (103.26 ± 7.09 and 178.5 ± 9...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325728/corneal-cystine-crystals-in-cystinosis
#4
Chen Ling, Xiaorong Liu, Zhi Chen, Yeping Jiang, Jianfeng Fan, Qun Meng, Qian Fu, Jifeng Yu
No abstract text is available yet for this article.
March 21, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28323099/nanohydrogel-with-n-n-bis-acryloyl-cystine-crosslinker-for-high-drug-loading
#5
Marcin Mackiewicz, Jan Romanski, Ewa Drozd, Beata Gruber-Bzura, Piotr Fiedor, Zbigniew Stojek, Marcin Karbarz
Substantially improved hydrogel particles based on poly(N-isopropylacrylamide) (pNIPA) have been obtained. First, as a result of replacing commercially available N,N'-bis(acryloyl)cystamine (BAC), the crosslinker, with acryloyl derivative of cystine containing a carboxylic group (BISS), the hydrogel particles acquired improved stability vs. ionic strength and allowed further chemical modification of the chains, including the attachment of drug molecules. Next, a redox-initiated aqueous precipitation polymerization via the semi-batch method was used...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28320941/potent-neuroprotection-after-stroke-afforded-by-a-double-knot-spider-venom-peptide-that-inhibits-acid-sensing-ion-channel-1a
#6
Irène R Chassagnon, Claudia A McCarthy, Yanni K-Y Chin, Sandy S Pineda, Angelo Keramidas, Mehdi Mobli, Vi Pham, T Michael De Silva, Joseph W Lynch, Robert E Widdop, Lachlan D Rash, Glenn F King
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and a key mediator of acidosis-induced neuronal damage following cerebral ischemia. Genetic ablation and selective pharmacologic inhibition of ASIC1a reduces neuronal death following ischemic stroke in rodents. Here, we demonstrate that Hi1a, a disulfide-rich spider venom peptide, is highly neuroprotective in a focal model of ischemic stroke...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28317703/detection-of-l-cysteine-in-wheat-flour-by-raman-microspectroscopy-combined-chemometrics-of-hca-and-pca
#7
Nur Cebi, Canan Ekinci Dogan, Ayşen Develioglu, Mediha Esra Altuntop Yayla, Osman Sagdic
l-Cysteine is deliberately added to various flour types since l-Cysteine has enabled favorable baking conditions such as low viscosity, increased elasticity and rise during baking. In Turkey, usage of l-Cysteine as a food additive isn't allowed in wheat flour according to the Turkish Food Codex Regulation on food additives. There is an urgent need for effective methods to detect l-Cysteine in wheat flour. In this study, for the first time, a new, rapid, effective, non-destructive and cost-effective method was developed for detection of l-Cysteine in wheat flour using Raman microscopy...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28300660/mechanistic-understanding-of-the-cysteine-capping-modifications-of-antibodies-enables-selective-chemical-engineering-in-live-mammalian-cells
#8
Xiaotian Zhong, Tao He, Amar S Prashad, Wenge Wang, Justin Cohen, Darren Ferguson, Amy S Tam, Eric Sousa, Laura Lin, Lioudmila Tchistiakova, Scott Gatto, Aaron D'Antona, Yen-Tung Luan, Weijun Ma, Richard Zollner, Jing Zhou, Bo Arve, Will Somers, Ronald Kriz
Protein modifications by intricate cellular machineries often redesign the structure and function of existing proteins to impact biological networks. Disulfide bond formation between cysteine (Cys) pairs is one of the most common modifications found in extracellularly-destined proteins, key to maintaining protein structure. Unpaired surface cysteines on secreted mammalian proteins are also frequently found disulfide-bonded with free Cys or glutathione (GSH) in circulation or culture, the mechanism for which remains unknown...
March 11, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28297659/oncogene-selective-sensitivity-to-synchronous-cell-death-following-modulation-of-the-amino-acid-nutrient-cystine
#9
Ioannis Poursaitidis, Xiaomeng Wang, Thomas Crighton, Christiaan Labuschagne, David Mason, Shira L Cramer, Kendra Triplett, Rajat Roy, Olivier E Pardo, Michael J Seckl, Scott W Rowlinson, Everett Stone, Richard F Lamb
Cancer cells reprogram their metabolism, altering both uptake and utilization of extracellular nutrients. We individually depleted amino acid nutrients from isogenic cells expressing commonly activated oncogenes to identify correspondences between nutrient supply and viability. In HME (human mammary epithelial) cells, deprivation of cystine led to increased cell death in cells expressing an activated epidermal growth factor receptor (EGFR) mutant. Cell death occurred via synchronous ferroptosis, with generation of reactive oxygen species (ROS)...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28292198/prospective-analysis-of-a-complete-retrograde-ureteroscopic-technique-with-holmium-laser-stent-cutting-for-management-of-encrusted-ureteral-stents
#10
Alexandre Thomas, Jonathan Cloutier, Luca Villa, Julien Letendre, Achilles Ploumidis, Olivier Traxer
PURPOSE: To propose and evaluate a new endoscopic technique using only a retrograde ureteroscopic approach for the removal of heavily encrusted ureteral stents. METHODS: Data from 51 consecutive patients with encrusted and retained ureteral stents were prospectively collected. Description of the successive steps of surgery is detailed. The Holmium-YAG laser properties offer the opportunity for fragmentation of stent-attached encrustation and the ability to cut the stent itself...
March 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28289330/the-heterogeneity-of-cancer-stem-like-cells-at-the-invasive-front
#11
Go J Yoshida
Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid malignant tumors which highly express CD44v8-10, the variant isoform of CD44 generated by alternative splicing, has a resistance to redox stress by the robust production of glutathione mediated by ESRP1-CD44v-xCT (cystine/glutamate antiporter) axis. It has been reported that CD44v and c-Myc tend to show the inversed expression pattern at the invasive front of the aggressive tumors...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28288221/intracellular-synthesis-of-d-aminoluciferin-for-bioluminescence-generation
#12
Zhen Zheng, Gongyu Li, Chengfan Wu, Miaomiao Zhang, Yue Zhao, Gaolin Liang
d-Luciferin is the most widely used substrate for bioluminescence (BL) applications but its low chemical stability always affects its performance. Herein, we rationally designed two chemically stable precursor molecules CBT-d-cystine-CBT (d-1) and CBT-l-cystine-CBT (l-1), and subjected them to reduction-controlled condensation to form 1-oligomer and subsequent proteolysis to yield d-aminoluciferin for BL generation in cells and in vivo. We envision that our precursor molecules might serve as d-luciferin alternatives for a wide range of BL applications in the near future...
March 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28285261/catalase-as-a-sulfide-sulfur-oxido-reductase-an-ancient-and-modern-regulator-of-reactive-sulfur-species-rss
#13
Kenneth R Olson, Yan Gao, Eric R DeLeon, Maaz Arif, Faihaan Arif, Nitin Arora, Karl D Straub
Catalase is well-known as an antioxidant dismutating H2O2 to O2 and H2O. However, catalases evolved when metabolism was largely sulfur-based, long before O2 and reactive oxygen species (ROS) became abundant, suggesting catalase metabolizes reactive sulfide species (RSS). Here we examine catalase metabolism of H2Sn, the sulfur analog of H2O2, hydrogen sulfide (H2S) and other sulfur-bearing molecules using H2S-specific amperometric electrodes and fluorophores to measure polysulfides (H2Sn; SSP4) and ROS (dichlorofluorescein, DCF)...
March 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28279790/peritoneal-bacterial-infection-repressed-the-expression-of-il17d-in-siberia-sturgeon-a-chondrostean-fish-in-the-early-immune-response
#14
Hua Zhu, Ruxing Song, Xiaowen Wang, Hongxia Hu, Zuobing Zhang
IL17s are pro-inflammatory cytokines that play important roles in host fighting against extracellular bacteria and auto-immune and allergic diseases. IL17D is believed to be the most ancient IL17 member and its functions are far from clarity. Although it has been found in invertebrates, jawless fish, teleosts, and tetrapods, it has not been described in chondrostean fish. Moreover, there are discrepancies concerning its expression pattern in these animals. In this study, we cloned and characterized the cDNA of il17d in Siberia sturgeon (Acipenser baerii), a chondrostean fish and commercially important species in aquaculture...
March 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28273808/role-of-ul3-in-multidrug-resistance-in-p53-mutated-lung-cancer-cells
#15
Annapina Russo, Assunta Saide, Silvia Smaldone, Raffaella Faraonio, Giulia Russo
Cancer is one of the most common causes of death among adults. Chemotherapy is crucial in determining patient survival and quality of life. However, the development of multidrug resistance (MDR) continues to pose a significant challenge in the management of cancer. In this study, we analyzed the role of human ribosomal protein uL3 (formerly rpL3) in multidrug resistance. Our studies revealed that uL3 is a key determinant of multidrug resistance in p53-mutated lung cancer cells by controlling the cell redox status...
March 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28270646/a-novel-mutation-in-slc7a9-gene-in-cystinuria
#16
Saeedeh Fazaeli, Saeideh Ashouri, Majid Kheirollahi, Mehrdad Mohammadi, Mohammad Fazilati
INTRODUCTION: Cystinuria is an inherited disorder affecting luminal transport of cystine and dibasic amino acids. Because of the poor solubility of cystine in urine, stone formation in the kidney occurs frequently. Cystinuria is associated with mutations in the SLC3A1 and SLC7A9 genes. Despite the population-specific distribution of mutations in the SLC7A9 genes, there are few genetic data reported for cystinuric patients from the Middle East. MATERIALS AND METHODS: Exon 4 of the SLC7A9 gene was sequenced in 21 patients with cystinuria, using the polymerase chain reaction and sequencing methods...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28262541/retrograde-intrarenal-surgery-in-the-management-of-pediatric-cystine-stones
#17
E Yuruk, M Tuken, S Gonultas, A Colakerol, O O Cakir, M Binbay, K Sarica, A Y Muslumanoglu
OBJECTIVE: To investigate the efficacy and safety of retrograde intrarenal surgery (RIRS) in the treatment of pediatric cystine stones. STUDY DESIGN: Data of the pediatric patients who underwent RIRS for kidney stones were retrospectively evaluated. A total of 14 children with cystine stones managed with RIRS were identified. In addition to the patient demographics and stone characteristics, all retrospectively obtained operative data were evaluated and discussed in detail, with an emphasis on the success and complication rates...
February 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28249194/cyclotides-as-drug-design-scaffolds
#18
REVIEW
David J Craik, Junqiao Du
Cyclotides are ultra-stable peptides derived from plants. They are around 30 amino acids in size and are characterized by their head-to-tail cyclic backbone and cystine knot. Their exceptional stability and tolerance to sequence substitutions has led to their use as frameworks in drug design. This article describes recent developments in this field, particularly developments over the last two years relating to the grafting of bioactive peptide sequences into the cyclic cystine knot framework of cyclotides to stabilize the sequences...
February 26, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28247719/-cystine-as-a-risk-factor-of-the-stone-formation-in-kidney-the-reference-value-range-of-urinary-excretion-the-stage-diagnosis-of-cystine-metabolism-disorder
#19
A A Gres, D M Nitkin, T M Juraha, A A Sivakow
OBJECTIVE: to define the reference value ranges of cystine, lysine and arginine urinary excretion relative to creatinine in the morning urine samples for the metabolic disorders diagnosis leading to the formation of urinary stones. MATERIALS AND METHODS: the study involved 695 healthy individuals aged 1-17 and 1564 patients with urolithiasis aged 7-45. The content of cystine in the urine samples was determined by high performance liquid chromatography. The chemical composition of urinary stones was investigated by methods of the qualitative chemical reaction and the crystals microscopy...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28245769/macrocyclic-antimicrobial-peptides-engineered-from-%C3%AF-conotoxin
#20
Xinya Hemu, James Tam
The potent calcium channel blocker ω-conotoxin MVIIA is a linear cystine-knot peptide with multiple basic amino acids at both termini. This work shows that macrocyclization of MVIIA linking two positive-charge terminal clusters as a contiguous segment converts a conotoxin into an antimicrobial peptide. In addition, conversion of disulfide bonds to amino butyric acids improved the antimicrobial activity of the cyclic analogs. Ten macrocyclic analogs, with or without disulfide bonds, were prepared by both Boc and Fmoc chemistry using native chemical ligation...
October 27, 2016: Current Pharmaceutical Design
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