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https://www.readbyqxmd.com/read/28636179/discontinuation-and-non-publication-of-neurodegenerative-disease-trials-a-cross-sectional-analysis
#1
J D Stefaniak, T C H Lam, N E Sim, R Al-Shahi Salman, D P Breen
BACKGROUND AND PURPOSE: Trial discontinuation and non-publication represent major sources of research waste in clinical medicine. No previous studies have investigated non-dissemination bias in clinical trials of neurodegenerative diseases. METHODS: ClinicalTrials.gov was searched for all randomized, interventional, phase II-IV trials that were registered between 1 January 2000 and 31 December 2009 and included adults with Alzheimer's disease, motor neurone disease, multiple sclerosis or Parkinson's disease...
June 21, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28634537/a-meta-analysis-of-antibacterial-envelope-use-in-prevention-of-cardiovascular-implantable-electronic-device-infection
#2
Sajid Ali, Yousuf Kanjwal, Steven R Bruhl, Mohammed Alo, Mohammed Taleb, Syed S Ali, Ameer Kabour, Owais Khawaja
OBJECTIVES: Cardiac implantable electronic device (CIED) infection has been a major clinical problem in addition to being a major financial burden. In spite of antimicrobial prophylaxis, CIED infection rates have been increasing disproportionately. We therefore conducted this meta-analysis to assess the role of TYRX antibiotic envelope for the prevention of CIED infection. METHODS: Using extensive online search, we conducted a meta-analysis of studies reporting CIED infections with versus without the use of TYRX antibiotic envelope...
May 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28632035/a-comprehensive-study-of-worldwide-selfie-related-accidental-mortality-a-growing-problem-of-the-modern-society
#3
Mohit J Jain, Kinjal J Mavani
Since Oxford dictionary has described 'Selfie', selfie deaths have received a fair amount of coverage but the extent of the problem and the data behind it have not been appropriately explored. The aim of our study is to obtain epidemiological characteristics of selfie-related mortality worldwide with the objective of providing an insight to 'Why selfie', 'Why risky', 'Psychological basis' and 'measures of control.' Despite thousands of web pages, very few scientific articles are available in medical journals...
February 14, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/28631984/effect-of-exercise-interventions-on-perceived-fatigue-in-people-with-multiple-sclerosis-synthesis-of-meta-analytic-reviews
#4
Reza Safari, Marietta L Van der Linden, Tom H Mercer
Although exercise training has been advocated as a nonpharmacological treatment for multiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To address this, we collated meta-analytic reviews that explored the effectiveness of exercise training for the treatment of MS-related fatigue. We searched five online databases for relevant reviews, published since 2005, and identified 172 records. Five reviews were retained for systematic extraction of information and evidence quality analysis...
June 20, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28631816/cognitive-rehabilitation-for-adults-with-traumatic-brain-injury-to-improve-occupational-outcomes
#5
REVIEW
K Suresh Kumar, Selvaraj Samuelkamaleshkumar, Anand Viswanathan, Ashish S Macaden
BACKGROUND: Cognitive impairment in people with traumatic brain injury (TBI) could affect multiple facets of their daily functioning. Cognitive rehabilitation brings about clinically significant improvement in certain cognitive skills. However, it is uncertain if these improved cognitive skills lead to betterments in other key aspects of daily living. We evaluated whether cognitive rehabilitation for people with TBI improves return to work, independence in daily activities, community integration and quality of life...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28630942/antimalarial-drugs-and-the-prevalence-of-mental-and-neurological-manifestations-a-systematic-review-and-meta-analysis
#6
Mary A Bitta, Symon M Kariuki, Clifford Mwita, Samson Gwer, Leah Mwai, Charles R J C Newton
Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association between anti-malarial drugs and mental and neurological impairment in humans.  Methods: We systematically searched online databases, including Medline/PubMed, PsychoInfo, and Embase, for articles published up to 14th July 2016. Pooled prevalence, heterogeneity and factors associated with prevalence of mental and neurological manifestations were determined using meta-analytic techniques...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28630750/tips-and-tricks-for-using-the-internet-for-professional-purposes
#7
Hasan Huseyin Ceylan, Nurdan Güngören, Fatih Küçükdurmaz
Online resources provide access to large amounts of information which is expanding every day. Using search engines for reaching the relevant, updated and complete literature that is indexed in various bibliographical databases has already become part of the medical professionals' everyday life.However, most researchers often fail to conduct a efficient literature search on the internet. The right techniques in literature search save time and improve the quality of the retrieved data.Efficient literature search is not a talent but a learnable skill, which should be a formal part of medical education...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28630510/current-practices-of-awarding-graduation-honors-within-doctor-of-pharmacy-degree-programs
#8
Paul A DiPietro, Stacy L Longo, Beth E Welch, Daniel R Kennedy, Eric C Nemec
Objective. To survey the practices of awarding honors upon graduation with a doctor of pharmacy degree. Methods. College and school of pharmacy websites were systematically searched to identify if, and then how, graduation honors are awarded. Programs that offer graduation honors were categorized and quantified based upon grade point average (GPA) cutoffs, honors enrollment, research project completion, faculty vote, course failure considerations, and ethics code violations. Results. Of the 132 doctor of pharmacy programs reviewed, 86% (n=114) had accessible online resources and were included in data analysis...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28629871/a-review-of-patterns-of-practice-and-clinical-guidelines-in-the-palliative-radiation-treatment-of-uncomplicated-bone-metastases
#9
REVIEW
Vithusha Ganesh, Stephanie Chan, Srinivas Raman, Ronald Chow, Peter Hoskin, Henry Lam, Bo Angela Wan, Leah Drost, Carlo DeAngelis, Edward Chow
BACKGROUND AND PURPOSE: Single fraction radiation treatment (SFRT) is recommended for its equivalence to multiple-fraction (MF) RT in the palliation of uncomplicated bone metastases (BM). However, adoption of SFRT has been slow. MATERIALS AND METHODS: Literature searches for studies published following 2014 were conducted using online repositories of gray literature, Ovid MEDLINE, Embase and Embase Classic, and the Cochrane Central Register of Controlled Trials databases...
June 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28629816/tinospora-species-an-overview-of-their-modulating-effects-on-the-immune-system
#10
REVIEW
Areeful Haque, Ibrahim Jantan, Syed Nasir Abbas Bukhari
ETHNOPHARMACOLOGICAL RELEVANCE: Studies on the effects of natural immunomodulators to heal various diseases related to the immune system have been a growing interest in recent years. Amongst the medicinal plants, Tinospora species (family; Menispermaceae) have been one of the widely investigated plants for their modulating effects on the immune system due to their wide use in ethnomedicine to treat various ailments related to immune-related diseases. However, their ethnopharmacological uses are mainly with limited or without scientific basis...
June 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28629764/oral-versus-topical-calcium-channel-blockers-for-chronic-anal-fissure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Shaheel M Sahebally, Khalid Ahmed, Raminta Cerneveciute, Asif Iqbal, Stewart R Walsh, Myles R Joyce
BACKGROUND: Chemical sphincterotomy with pharmacological agents is recommended as first line therapy for chronic anal fissures (CAF). Calcium channel blockers (CCB) are associated with similar efficacy but fewer side effects compared to nitrates. However, the optimal formulation (oral versus topical) is unknown. We aimed to perform a systematic review and meta-analysis to compare the effectiveness of oral and topical CCB in the treatment of CAF. METHODS: PubMed and Embase online databases were searched for relevant articles...
June 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28629370/pharmacogenetic-testing-through-the-direct-to-consumer-genetic-testing-company-23andme
#12
Mengfei Lu, Cathryn M Lewis, Matthew Traylor
BACKGROUND: Rapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer (DTC) genetic testing companies, such as 23andMe, allow consumers to access their genetic information directly through an online service without the involvement of healthcare professionals. Here, we evaluate the clinical relevance of pharmacogenetic tests reported by 23andMe in their UK tests. METHODS: The research papers listed under each 23andMe report were evaluated, extracting information on effect size, sample size and ethnicity...
June 19, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28629131/a-hybrid-scheme-for-fine-grained-search-and-access-authorization-in-fog-computing-environment
#13
Min Xiao, Jing Zhou, Xuejiao Liu, Mingda Jiang
In the fog computing environment, the encrypted sensitive data may be transferred to multiple fog nodes on the edge of a network for low latency; thus, fog nodes need to implement a search over encrypted data as a cloud server. Since the fog nodes tend to provide service for IoT applications often running on resource-constrained end devices, it is necessary to design lightweight solutions. At present, there is little research on this issue. In this paper, we propose a fine-grained owner-forced data search and access authorization scheme spanning user-fog-cloud for resource constrained end users...
June 17, 2017: Sensors
https://www.readbyqxmd.com/read/28628562/robotic-versus-video-assisted-lobectomy-segmentectomy-for-lung-cancer-a-meta-analysis
#14
Hengrui Liang, Wenhua Liang, Lei Zhao, Difei Chen, Jianrong Zhang, Yiyin Zhang, Shiyan Tang, Jianxing He
: Objective: To compare the safety/efficacy of the robotic-assisted lobectomy/segmentectomy (RAL/S) with the video-assisted lobectomy/segmentectomy (VAL/S) for radical lung cancer resection. BACKGROUND: It remains uncertain whether the newly developed RAL/S is comparable with the VAL/S. METHODS: A comprehensive search of online databases was performed. Perioperative outcomes were synthesized. Cumulative meta-analysis was performed to evaluate the temporal trend of pooled outcomes...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28628360/genetic-risk-factors-for-folate-responsive-neural-tube-defects
#15
Anne M Molloy, Faith Pangilinan, Lawrence C Brody
Neural tube defects (NTDs) are the most severe congenital malformations of the central nervous system. The etiology is complex, with both genetic and environmental factors having important contributions. Researchers have known for the past two decades that maternal periconceptional use of the B vitamin folic acid can prevent many NTDs. Though this finding is arguably one of the most important recent discoveries in birth defect research, the mechanism by which folic acid exerts this benefit remains unknown. Research to date has focused on the hypothesis that an underlying genetic susceptibility interacts with folate-sensitive metabolic processes at the time of neural tube closure...
June 19, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28628346/physician-review-portals-do-not-favor-highly-cited-us-ophthalmologists
#16
Janusz Skrzypecki, Joanna Przybek
PURPOSE: Physician review portals are becoming increasingly popular among patients and often serve as a primary advisory tool during the search for a doctor. However, it has not been established whether these platforms favor leaders of the field; i.e., physicians with high academic rank. Here, we assessed online ratings of US ophthalmologists, selected for their outstanding scientific performance. METHODS: This cross-sectional, Internet-based study was performed in September 2016...
June 19, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28627394/novel-non-canonical-genetic-rearrangements-termed-complex-structural-variations-in-hbv-genome
#17
Kei Fujiwara, Kayoko Matsunami, Etsuko Iio, Shunsuke Nojiri, Takashi Joh
BACKGROUNDS AND AIMS: Chronic hepatitis B virus (HBV) infection is an important worldwide public health issue. Further knowledge on the characteristics of HBV will facilitate its eradication. Genome structural variations (SVs) are defined by its canonical form such as duplication, deletion, and insertion. However, recent studies have reported complex SVs that cannot be explained by those canonical SVs. A HBV strain (UK2) with an unusual genome structure rearrangement that was completely different from known mutations or rearrangements was previously reported...
June 13, 2017: Virus Research
https://www.readbyqxmd.com/read/28625077/microbiome-and-microbial-biofilm-profiles-of-peri-implantitis-a-systematic-review
#18
Gloria Inés Lafaurie, María Alejandra Sabogal, Diana Marcela Castillo, María Victoria Rincón, Luz Amparo Gómez, Yamil Augusto Lesmes, Leandro Chambrone
BACKGROUND: This systematic review assesses the microbiological profiles of peri-implantitis, periodontitis and healthy implants based on studies that evaluated microbial biofilms and entire microbiomes to establish their similarities and differences. METHODS: The Medical Literature Analysis and Retrieval System Online, via PubMed, EMBASE (Excerpta Medica Database) and Cochrane Central Register of Controlled Trials (CENTRAL) were searched without language restrictions through July 30, 2016...
June 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28625076/the-one-abutment-one-time-protocol-a-systematic-review-and-meta-analysis
#19
Momen A Atieh, Andrew Tawse-Smith, Nabeel H M Alsabeeha, Sunyoung Ma, Warwick J Duncan
BACKGROUND: The use of definitive abutments (DAs) at the time of implant placement has been introduced to overcome the limitations of dis/reconnection of healing / provisional abutments (PAs). With little and inconsistent information in the literature regarding the effectiveness of using DAs, the aim of this systematic review was to examine marginal bone and soft tissue level changes, technical and biological complications and implant failure associated with the use of DAs and PAs. METHODS: This systematic review was prepared according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
June 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28624758/prevalence-incidence-and-aetiologies-of-pulmonary-hypertension-in-africa-a-systematic-review-and-meta-analysis-protocol
#20
Jean Joel Bigna, Jean Jacques Noubiap, Jobert Richie Nansseu, Leopold Ndemnge Aminde
INTRODUCTION: There are no data summarising the epidemiology of pulmonary hypertension (PH) among adults residing in Africa. Establishment of accurate epidemiological data on PH in this region may guide decision-making toward interventions to curb the burden of PH in Africa. The aim of this systematic review is to determine the prevalence, incidence and aetiologies of PH among people residing in Africa. METHODS AND ANALYSIS: This systematic review and meta-analysis will follow the MOOSE guidelines for reporting...
June 16, 2017: BMJ Open
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