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https://www.readbyqxmd.com/read/29775720/diagnosing-human-blood-clotting-deficiency
#1
REVIEW
Chong Cheen Ong, Subash C B Gopinath, Leong Wei Xian Rebecca, Veeradasan Perumal, Thangavel Lakshmipriya, Mohamed Shuaib Mohamed Saheed
There are different clotting factors present in blood, carries the clotting cascade and excessive bleeding may cause a deficiency in the clotting. Diagnosis of deficiency in clotting reduces the potential fatality. For enabling a sensor to detect the clotting factors, suitable probes such as antibody and aptamer have been used to capture the clotting factors on the sensing surface. Two major clotting factors were widely studied in detail for the diagnosis of clotting deficiency, which includes factor IX and thrombin...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29773185/kinetics-and-tissue-distribution-of-bismuth-tin-and-lead-after-implantation-of-miniature-shotgun-alloy-pellets-in-rats
#2
Vidar Skaug, Einar Eilertsen, Asbjørn Skogstad, Finn E S Levy, Balázs Berlinger, Yngvar Thomassen, Dag G Ellingsen
INTRODUCTION: Shotgun pellets containing bismuth (Bi) as substitute for lead (Pb) are increasingly being used due to environmental concerns. Information on toxicokinetics of Bi is lacking for the assessment of humans accidentally shot by Bi-containing shotgun alloy pellets. METHODS: Male Wistar rats were exposed to miniature alloy pellets containing Bi, tin (Sn) and minor amounts of Pb by implantation in muscle tissues of the hind legs. RESULTS: The concentrations of Bi in whole blood and urine increased up to 53 weeks after implantation...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29771450/effects-of-intense-aerobic-exercise-and-or-antihypertensive-medication-in-individuals-with-metabolic-syndrome
#3
M Ramirez-Jimenez, F Morales-Palomo, J F Ortega, R Mora-Rodriguez
We studied the blood pressure lowering effects of a bout of exercise and/or antihypertensive medicine with the goal of studying if exercise could substitute or enhance pharmacologic hypertension treatment. Twenty-three hypertensive metabolic syndrome patients chronically medicated with angiotensin II receptor 1 blockade antihypertensive medicine underwent 24-hr monitoring in four separated days in a randomized order; a) after taking their habitual dose of antihypertensive medicine (AHM trial), b) substituting their medicine by placebo medicine (PLAC trial), c) placebo medicine with a morning bout of intense aerobic exercise (PLAC+EXER trial) and d) combining the exercise and antihypertensive medicine (AHM+EXER trial)...
May 17, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29770739/-express-novel-ntrk1-mutations-in-chinese-patients-with-congenital-insensitivity-to-pain-with-anhidrosis
#4
Xingzhu Geng, Yanshan Liu, Xiuzhi Ren, Yun Guan, Yanzhou Wang, Bin Mao, Xiuli Zhao, Xue Zhang
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder, characterized by loss of algesthesis and inability to sweat. CIPA is known to be caused by mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1). However, the details of NTRK1 mutations in Chinese CIPA patients remain unclear. In the present study, we recruited 36 CIPA patients from 34 unrelated families in mainland China. Blood samples from these patients and their available familial members were collected and subjected to genetic analysis...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29769802/who-height-charts-can-be-safely-substituted-when-calculating-bp-z-scores-in-a-north-american-clinic-setting
#5
Celia J Rodd, Daniel L Metzger, Atul K Sharma
Objectives: The Public Health Agency of Canada has officially adopted growth charts from the World Health Organization (WHO); nevertheless, North American blood pressure (BP) Z-scores and percentiles still depend on height Z-scores based on growth charts from the US Centers for Disease Control (CDC), which may differ significantly, particularly in toddlers. Since many practitioners simply replace CDC height scores with WHO equivalents for diagnosing hypertension, we explore the impact of this substitution on BP Z-scores in real-world BPs measured on more than 22,000 children aged 2 to 18 years...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29768545/hcmv-ul97-phosphotransferase-gene-mutations-may-be-associated-with-antiviral-resistance-in-immunocompromised-patients-in-bel%C3%A3-m-pa-northern-brazil
#6
Dorotéa de Fátima Lobato da Silva, Jedson Ferreira Cardoso, Sandro Patroca da Silva, Leda Mani França Arruda, Renato Lopes Fernandes de Medeiros, Marluce Matos Moraes, Rita Catarina Medeiros Sousa
INTRODUCTION: Human cytomegalovirus is one of the causes of opportunist infections in immunocompromised patients, and is triggered by factors such as state of viral latency, weakened immune responses, and development of antiviral resistance to ganciclovir, the only drug offered by the public health system in Brazil to treat the infection. The goal of this study was to identify mutations that may be associated with antiviral resistance in immunocompromised patients. METHODS: Molecular analysis was performed in 82 blood samples and subjected to genomic DNA extraction by a silica-based method...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768387/optimal-reconstruction-methods-after-distal-gastrectomy-for-gastric-cancer-a-systematic-review-and-network-meta-analysis
#7
Zhaolun Cai, Ye Zhou, Chenxiao Wang, Yiqiong Yin, Yuan Yin, Chaoyong Shen, Xiaonan Yin, Zhixin Chen, Bo Zhang
BACKGROUND: The choice of anastomosis methods including Billroth I, Billroth II, and Roux-en-Y after a distal gastrectomy is still controversial. The conventional meta-analyses assessing 2 alternative treatments were not powered to compare differences in clinical outcomes. To guide treatment decisions in patients with gastric cancer (GC) after distal gastrectomy, we did a systematic review and network meta-analysis to identify the best reconstruction method. METHODS: We systematically searched PubMed, EMBASE, the Cochrane Library for randomized controlled trials comparing the outcomes of Billroth I, Billroth II, or Roux-en-Y reconstruction after distal subtotal gastrectomy for patients with GC, then we performed a direct meta-analysis and Bayesian network meta-analysis to pooled odds ratios (OR) or weighted mean differences (WMD) with 95% credible intervals (CrI) with random effects model...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29763982/bone-graft-in-posterior-spine-fusion-for-adolescent-idiopathic-scoliosis-a-meta-analysis
#8
REVIEW
Nathan Kirzner, Luke Hilliard, Catherine Martin, Gerald Quan, Susan Liew, Ali Humadi
BACKGROUNDS: The aim of this study was to systematically analyse and perform a meta-analysis on the current available literature comparing the fusion rates and complications associated with use of autograft, allograft and bone substitutes to supplement posterior spinal fusion for adolescent idiopathic scoliosis (AIS). METHODS: The electronic databases including Embase, PubMed, Medline, Cinahl and Cochrane Library were searched to identify relevant studies. A total of 12 studies with 2389 patients were included for meta-analysis...
May 15, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29763883/impact-of-common-environmental-chemicals-bisphenol-a-and-bisphenol-s-on-the-physiology-of-lumbriculus-variegatus
#9
Victoria Vought, Hong-Sheng Wang
Bisphenol A (BPA) is a component of polycarbonate plastics and a near ubiquitous environmental endocrine disrupting chemical. Bisphenol S (BPS), a substitute of BPA, is also hormonally active. This study examines the effects of aqueous exposure to BPA and BPS on the freshwater annelids Lumbriculus variegatus, a keystone species in shallow water ecosystems. Both BPA and BPS, at both low dose (10-9 M) and high dose (10-6 M), retarded the initial phase of body regrowth after cutting/fragmentation, which is the main mode of reproduction of L...
May 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29763549/development-of-positron-emission-tomography-pet-radiotracers-for-the-gaba-transporter-1-gat-1
#10
Alexandra R Sowa, Allen F Brooks, Xia Shao, Bradford D Henderson, Phillip S Sherman, Janna Arteaga, Jenelle Stauff, Adam C Lee, Robert A Koeppe, Peter J H Scott, Michael R Kilbourn
In vivo PET imaging of the γ-aminobutyric acid (GABA) receptor complex has been accomplished using radiolabeled benzodiazepine derivatives, but development of specific presynaptic radioligands targeting the neuronal membrane GABA transporter type 1 (GAT-1) has been less successful. The availability of new structure-activity studies of GAT-1 inhibitors and the introduction of a GAT-1 inhibitor (tiagabine, Gabatril® ) into clinical use prompted us to reinvestigate the syntheses of PET ligands for this transporter...
May 15, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29761919/serologic-evidence-for-schmallenberg-virus-circulation-at-high-altitude-central-portugal-2015-2016
#11
F Esteves, R Cruz, C Vasconcelos-Nóbrega, C Santos, A S Ferreira, T Petrovic, L Cardoso, A C Coelho, H Vala, M S J Nascimento, J R Mesquita
A few years after the initial 2011 large scale Schmallenberg virus (SBV) epidemic that affected Europe, a subsequent decrease in new SBV infections was observed presumably associated with natural substitution of previously exposed animals. In the present work, a 2-year prospective serosurvey was performed to evaluate SBV circulation in a population of sheep living at high altitude in the central region of Portugal and with restricted movement. Blood from a representative sample of 168 autochthonous sheep was collected in 2015 and again in 2016, and tested for the presence of anti-SBV IgG by ELISA...
May 15, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29761250/sarcoma-in-neurofibromatosis-2-case-report-and-review-of-the-literature
#12
C Linder, M J Smith, M Bulman, A Wallace, A J Freemont, D C Mangham, D G R Evans
Neurofibromatosis type 2 (NF2) is associated with the development of several types of benign nervous system tumours, while malignancies are rare. We report a 22-year-old man who presented with retroperitoneal and spinal high-grade sarcomas with epithelial features. Samples showed a mixed epithelioid and spindled cell content with little associated matrix and inconclusive immunochemistry. Genetic analysis of a schwannoma and matched blood samples demonstrated a constitutional de novo substitution at the splice donor site of intron 8 of the NF2 gene and aa acquired large deletion of the entire NF2 gene as a second hit, with some loss of SMARCB1...
May 14, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29757413/evaluation-of-iron-stores-by-zinc-protoporphyrin-analysis-in-blood-donors
#13
Richard R Gammon, Tania Kozel, Patrick Morel, Christopher Kendrick
Background: Zinc protoporphyrin (ZPP) testing has been studied previously as a substitute for ferritin (fer) testing of blood donors in determining iron stores. Objective: To determine whether ZPP testing could be performed using specimens collected via the capillary (cap) finger-stick (FS) method, similar to predonation hemoglobin (HB) testing. Also, we evaluated the correlation among FS HB, venous (ven) ZZP, FS ZPP, and ven fer levels as predictors of iron depletion...
May 11, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29756282/acute-arthritis-predictive-factors-and-current-practice-in-the-approach-to-diagnosis-and-management-across-two-hospitals-in-sydney
#14
Katrina Pavic, Jay Pandya, Sophie Sebak, Amith Shetty, David Spencer, N Nicholas Manolios
BACKGROUND: Literature pertaining to the predictive factors for septic arthritis is limited. AIMS: The primary objective was to investigate the predictive factors for septic arthritis. The secondary objectives were to investigate the predictive factors for crystal arthritis and to explore current practises in the management of acute arthritis. METHODS: A retrospective analysis was undertaken. All patients with an acute arthritis who underwent a joint aspiration for diagnostic and management purposes were considered for inclusion...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#15
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29755531/adjunctive-platelet-rich-plasma-prp-in-infrabony-regenerative-treatment-a-systematic-review-and-rct-s-meta-analysis
#16
REVIEW
Mubashir Saleem, Flavio Pisani, Faisal Maqbool Zahid, Ioannis Georgakopoulos, Teuta Pustina-Krasniqi, Edit Xhajanka, Maher Almasri
Background and Objective: The purpose of this study was to highlight the clinical performance of platelet-rich plasma (PRP) used as an adjunctive tool for regeneration in infrabony periodontal defects using different biomaterials or performing different surgical flap approaches. Comparative evaluation of main clinical outcomes as probing pocket depth reduction, clinical attachment gain, and recession reduction with and without the use of PRP has been analysed. Materials and Methods: According to the focused question, an electronic and hand searching has been performed up to December 2016...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29754506/hirsutella-sinensis-inhibits-lewis-lung-cancer-via-tumor-microenvironment-effector-t-cells-in-mice
#17
Huiying Fu, Lu Jin, Xia Shao, Yuanyuan Li, Fangming Chen, Zhiqiang Shou, Xiaofang Tang, Bing Ji, Qiyang Shou
Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8[Formula: see text] T cells...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29753503/novel-esophageal-reconstruction-technique-via-transmediastinal-route-from-posterior-to-anterior-mediastinum-after-esophagectomy
#18
Takushi Yasuda, Osamu Shiraishi, Mitsuru Iwama, Tomoki Makino, Hiroaki Kato, Yutaka Kimura
BACKGROUND: The incidence of metachronous esophageal squamous cell cancer (ESCC) after head and neck cancer (HNC) and in elderly patients has increased. Both elderly ESCC patients and ESCC patients after HNC surgery are at potential risk for dysphagia, and for the latter, surgery in the neck is difficult. An intrathoracic anastomosis that bypasses the cervical procedure is preferable to preserve swallowing function and reduce surgical risk. In gastrectomized patients, because the stomach cannot be used as a substitute, securing graft blood supply is critical, but microvascular anastomosis cannot be easily added in procedures for intrathoracic posterior mediastinal reconstruction...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29748216/intrinsic-anti-inflammatory-properties-in-the-serum-of-two-species-of-deep-diving-seal
#19
Aranya Bagchi, Annabelle J Batten, Milton Levin, Kaitlin N Allen, Michael L Fitzgerald, Luis A Hückstädt, Daniel P Costa, Emmanuel S Buys, Allyson G Hindle
Weddell and elephant seals are deep diving mammals, which rely on lung collapse to limit nitrogen absorption and prevent decompression injury. Repeated collapse and re-expansion exposes the lungs to multiple stressors, including ischemia/reperfusion, alveolar shear stress, and inflammation. There is no evidence, however, that diving damages pulmonary function in these species. To investigate potential protective strategies in deep-diving seals, we examined the inflammatory response of seal whole blood exposed to lipopolysaccharide (LPS), a potent endotoxin...
May 10, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29747438/novel-substituted-heterocyclic-gaba-analogues-enzymatic-activity-against-the-gaba-at-enzyme-from-pseudomonas-fluorescens-and-in-silico-molecular-modeling
#20
Erika Tovar-Gudiño, Juan Alberto Guevara-Salazar, José Raúl Bahena-Herrera, José Guadalupe Trujillo-Ferrara, Zuleyma Martínez-Campos, Rodrigo Said Razo-Hernández, Ángel Santiago, Nina Pastor, Mario Fernández-Zertuche
&gamma;-Aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the central nervous system, and a deficiency of GABA is associated with serious neurological disorders. Due to its low lipophilicity, there has been an intensive search for new molecules with increased lipophilicity to cross the blood-brain barrier to raise GABA concentrations. We have designed and evaluated in vitro and in silico some new analogues of GABA, where the nitrogen atom at the &gamma;-position is embedded in heterocyclic scaffolds and determined their inhibitory potential over the GABA-AT enzyme from Pseudomonas fluorescens ...
May 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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