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https://www.readbyqxmd.com/read/27913886/influence-of-vessel-stenosis-on-indocyanine-green-fluorescence-intensity-assessed-by-near-infrared-fluorescence-angiography
#1
Masaki Yamamoto, Hideaki Nishimori, Takashi Fukutomi, Takemi Handa, Kazuki Kihara, Miwa Tashiro, Takayuki Sato, Kazumasa Orihashi
PURPOSE: Although useful for visualizing blood flow during revascularization surgery, the permeability of near-infrared fluorescence (NIR) angiography using indocyanine green (ICG) does not allow for vessel stenosis visualization. We hypothesized that changes in ICG fluorescence intensity reflect vessel stenosis, and evaluated the influence of stenosis on blood flow by ex vivo experimentation. METHODS: The vessel stenosis model comprised a silicon tube, a graft occluder, and artificial blood...
December 2, 2016: Surgery Today
https://www.readbyqxmd.com/read/27908752/n-propargylpiperidines-with-naphthalene-2-carboxamide-or-naphthalene-2-sulfonamide-moieties-potential-multifunctional-anti-alzheimer-s-agents
#2
Urban Košak, Damijan Knez, Nicolas Coquelle, Boris Brus, Anja Pišlar, Florian Nachon, Xavier Brazzolotto, Janko Kos, Jacques-Philippe Colletier, Stanislav Gobec
In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased. While BChE is a viable therapeutic target for alleviation of symptoms caused by cholinergic hypofunction, MAO-B is a potential therapeutic target for prevention of neurodegeneration in Alzheimer's disease. Starting with piperidine-based selective human (h)BChE inhibitors and propargylamine-based MAO inhibitors, we have designed, synthesized and biochemically evaluated a series of N-propargylpiperidines...
November 19, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27906423/analysis-of-factors-influenced-by-the-effectiveness-of-non-invasive-ventilation-in-the-treatment-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-with-different-severities
#3
J-J Zhu, L-J Liu
OBJECTIVE: To investigate the correlation of levels of procalcitonin (PCT) and blood lactic acid with the effectiveness of the non-invasive ventilation (NIV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with different severities. PATIENTS AND METHODS: We used a case-control method to study patients who were admitted for AECOPD to the ICU at the Second Affiliated Hospital of Soochow University from January 1, 2012, to December 31, 2014...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27902880/monoamine-oxidase-inhibitory-activity-methyl-versus-chlorochalcone-derivatives
#4
Bijo Mathew, Gülberk Uçar, Githa Elizabeth Mathew, Sincy Mathew, Praseedha Kalatharakkal Purapurath, Fasil Moolayil, Smrithy Mohan, Sheeba Varghese Gupta
Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors. As a continuation of our ongoing research into the development of reversible human MAO-B (hMAO-B) inhibitors, two series of twenty chalcones containing electron-donating and electron-withdrawing substituents were synthesized. All compounds were found to be competitive, selective, and reversible inhibitors of hMAO-B except (2E)-1-(4-methylphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (P7) and (2E)-1-(4-chlorophenyl)-3-(4-nitrophenyl)prop-2-en-1-one (P17), which were found to be selective inhibitors of hMAO-A...
November 30, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27898968/post-artificial-insemination-supplementation-with-calcium-salts-of-soybean-oil-influences-pregnancy-establishment-factors-in-beef-cows
#5
R S Cipriano, R F Cooke, A D Rodrigues, L G T Silva, D W Bohnert, R S Marques, J L M Vasconcelos, A V Pires, R L A Cerri
The objective of this experiment was to compare hormonal, uterine, and conceptus factors associated with pregnancy establishment in beef cows supplemented or not with Ca salts of soybean oil (CSSO) for 21 d beginning after timed AI. One hundred lactating multiparous Nelore cows were allocated to 20 groups of 5 cows/group and timed inseminated on d 0 of the experiment. After AI, groups were randomly assigned to receive (as-fed basis) 100 g of protein-mineral mix + 100 g of ground corn per cow per day, in addition to 1) 100 g/cow daily of CSSO ( = 10) or 2) 100 g/cow daily of kaolin (CON; rumen-inert indigestible substance; = 10)...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898921/using-estrus-detection-patches-to-optimally-time-insemination-improved-pregnancy-risk-in-suckled-beef-cows-enrolled-in-a-fixed-time-artificial-insemination-program
#6
S L Hill, D M Grieger, K C Olson, J R Jaeger, C R Dahlen, G A Bridges, F Dantas, J E Larson, A M Muth-Spurlock, J K Ahola, M C Fischer, G A Perry, E L Larimore, T L Steckler, W D Whittier, J F Currin, J S Stevenson
A multilocation study examined pregnancy risk (PR) after delaying AI in suckled beef cows from 60 to 75 h when estrus had not been detected by 60 h in response to a 7-d CO-Synch + progesterone insert (CIDR) timed AI (TAI) program (d -7: CIDR insert concurrent with an injection of GnRH; d 0: PGF injection and removal of CIDR insert; and GnRH injection at TAI [60 or 75 h after CIDR removal]). A total of 1,611 suckled beef cows at 15 locations in 9 states (CO, IL, KS, MN, MS, MT, ND, SD, and VA) were enrolled...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27892505/in-vivo-measurement-of-hemodynamic-information-in-stenosed-rat-blood-vessels-using-x-ray-piv
#7
Hanwook Park, Jun Hong Park, Sang Joon Lee
Measurements of the hemodynamic information of blood flows, especially wall shear stress (WSS), in animal models with circulatory vascular diseases (CVDs) are important to understand the pathological mechanism of CVDs. In this study, X-ray particle image velocimetry (PIV) with high spatial resolution was applied to obtain velocity field information in stenosed blood vessels with high WSS. 3D clips fabricated with a 3D printer were applied to the abdominal aorta of a rat cadaver to induce artificial stenosis in the real blood vessel of an animal model...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890022/continuous-light-after-2-months-of-long-days-stimulates-ram-testis-volume-and-increases-fertility-in-spring
#8
D Chesneau, D Guillaume, P Chemineau, B Malpaux
Seasonal reproduction is one of the major biotechnical and economic constraints of sheep production in temperate latitudes. Treatments using extra light followed by melatonin implants have been used satisfactorily in open barns, farms and artificial insemination centres to produce out-of-season sexual activity in rams. The aim of the present study is to explore the possibility of replacing melatonin implants with continuous light (LL), which was recently shown to increase LH secretion similar to melatonin and/or pinealectomy...
November 28, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#9
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27886350/design-of-artificial-red-blood-cells-using-polymeric-hydrogel-microcapsules-hydrogel-stability-improvement-and-polymer-selection
#10
Wujie Zhang, Matthew J Bissen, Emily S Savela, Joshua N Clausen, Samantha J Fredricks, Xiaoru Guo, Zachary R Paquin, Ryan P Dohn, Ian J Pavelich, Alec L Polovchak, Michael J Wedemeyer, Brock E Shilling, Emily N Dufner, Anna C O'Donnell, Gerardo Rubio, Logan R Readnour, Tyler F Brown, Jung C Lee, Matey G Kaltchev, Junhong Chen, Charles S Tritt
PURPOSE: To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions. METHODS: Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied. RESULTS AND CONCLUSIONS: It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability...
November 16, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27875902/nuisance-regression-of-high-frequency-fmri-data-de-noising-can-be-noisy
#11
Jingyuan E Chen, Gary Glover, Hesamoddin Jahanian
Recently, emerging studies have demonstrated the existence of brain resting state (RS) spontaneous activity at frequencies higher than the conventional 0.1 Hz. A few groups utilizing accelerated acquisitions have reported persisting signals beyond 1 Hz, which seems too high to be accommodated by the sluggish hemodynamic process underpinning blood-oxygen-level dependent contrasts (the upper limit of the canonical model is ~ 0.3 Hz). It is thus questionable whether the observed high-frequency (HF) functional connectivity (FC) originates from alternative mechanisms (e...
November 22, 2016: Brain Connectivity
https://www.readbyqxmd.com/read/27872723/a-human-reproductive-approach-to-the-study-of-infertility-in-chimpanzees-an-experience-at-leon-s-zoological-park-mexico
#12
Raul Eduardo Piña-Aguilar, Janet López-Saucedo, Lilia Ivone Ruiz-Galaz, José de Jesús Barroso-Padilla, Mayra Celina Gallegos-Rivas, Claudia González-Ortega, Antonio Martin Gutiérrez-Gutiérrez
Great apes are mammals close to humans in their genetic, behavioral, social and evolutionary characteristics and new genomic information is revolutionizing our understanding of evolution in primates. However, all these species are endangered. While there are many global programs to protect these species, the International Union for Conservation of Nature (IUCN) projects that in a near future the wild populations will decrease significantly. Nowadays, the relevance of captive populations of great apes is becoming critical for research and understanding of pathophysiology of diseases...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27870812/does-breastfeeding-protect-young-infants-from-pertussis-case-control-study-and-immunologic-evaluation
#13
Elisabetta Pandolfi, Francesco Gesualdo, Emanuela Carloni, Alberto Villani, Fabio Midulla, Rita Carsetti, Paola Stefanelli, Giorgio Fedele, Alberto Eugenio Tozzi
BACKGROUND: Pertussis infection can be severe in unvaccinated infants. A case control study was conducted to investigate the potential role of breastfeeding in protecting young, unvaccinated infants from pertussis. METHODS: Hospitalized infants < 6 months with positive RT-PCR for pertussis on nasopharyngeal aspirate were enrolled as cases; healthy controls were enrolled among patients admitted for ultrasound screening. Vaccinated infants were excluded. Sociodemographic, clinical and feeding information were collected...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27869129/reprogramming-mouse-fibroblasts-into-engraftable-myeloerythroid-and-lymphoid-progenitors
#14
Hui Cheng, Heather Yin-Kuan Ang, Chadi A El Farran, Pin Li, Hai Tong Fang, Tong Ming Liu, Say Li Kong, Michael Lingzi Chin, Wei Yin Ling, Edwin Kok Hao Lim, Hu Li, Tara Huber, Kyle M Loh, Yuin-Han Loh, Bing Lim
Recent efforts have attempted to convert non-blood cells into hematopoietic stem cells (HSCs) with the goal of generating blood lineages de novo. Here we show that hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can convert a developmentally distant lineage (fibroblasts) into 'induced hematopoietic progenitors' (iHPs). Functionally, iHPs generate acetylcholinesterase(+) megakaryocytes and phagocytic myeloid cells in vitro and can also engraft immunodeficient mice, generating myeloerythoid and B-lymphoid cells for up to 4 months in vivo...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27867245/diamond-coated-artificial-cardiovascular-devices
#15
Hongjun Zeng, Robert Jarvik, Grace Catausan, Nicolaie Moldovan, John Carlisle
Ultrananocrystalline diamond (UNCD), an extremely smooth, low cost diamond coating was successfully developed herein for antithrombogenic application which requires high biocompatibility, low wear, low friction, and chemical inertness. The substrate materials utilized in the Jarvik 2000 ventricular assist device (VAD), silicon carbide and titanium alloy, provide an excellent substrate match for UNCD integration. The paper addresses the development of medical-quality UNCD films to significantly improve the knowledge base regarding the defect mechanisms of UNCD films, to reduce or eliminate known wear-inducing imperfections in the film, and to thoroughly characterize and test the films as well as assembled UNCD-coated VADs...
September 25, 2016: Surface & Coatings Technology
https://www.readbyqxmd.com/read/27866686/size-loading-efficiency-and-cytotoxicity-of-albumin-loaded-chitosan-nanoparticles-an-artificial-neural-networks-study
#16
Hadi Baharifar, Amir Amani
When designing nanoparticles for drug delivery, many variables such as size, loading efficiency, and cytotoxicity should be considered. Usually, smaller particles are preferred in drug delivery because of longer blood circulation time and their ability to escape from immune system, whereas smaller nanoparticles often show increased toxicity. Determination of parameters which affect size of particles and factors such as loading efficiency and cytotoxicity could be very helpful in designing drug delivery systems...
November 17, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27862028/peripheral-cellular-and-humoral-responses-to-infestation-with-the-cattle-tick-rhipicephalus-microplus-in-santa-gertrudis-cattle
#17
Emily K Piper, Nicholas N Jonsson, Cedric Gondro, Megan E Vance, Alicja Lew-Tabor, Louise A Jackson
Resistance to cattle tick infestation in single-host ticks is primarily manifested against the larval stage and results in the immature tick failing to attach successfully and obtain a meal. The present study was conducted to identify immune responses that characterise the tick-resistant phenotype in cattle. Thirty-five tick-naïve Santa-Gertrudis heifers were used in this study, thirty of which were artificially infested for thirteen weeks with tick larvae while five animals remained at a tick-free quarantine property to serve as a control group...
November 12, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27861431/pediatric-artificial-lung-a-low-resistance-pumpless-artificial-lung-alleviates-an-acute-lamb-model-of-increased-right-ventricle-afterload
#18
Fares Alghanem, Benjamin S Bryner, Emilia M Jahangir, Uditha P Fernando, John M Trahanas, Hayley R Hoffman, Robert H Bartlett, Alvaro Rojas-Peña, Ronald B Hirschl
Lung disease in children often results in pulmonary hypertension and right heart failure. The availability of a pediatric artificial lung (PAL) would open new approaches to the management of these conditions by bridging to recovery in acute disease or transplantation in chronic disease. This study investigates the efficacy of a novel PAL in alleviating an animal model of pulmonary hypertension and increased right ventricle afterload.Five juvenile lambs (20-30 Kg) underwent PAL implantation in a pulmonary artery to left atrium configuration...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27859378/mechanical-circulatory-support-devices-for-pediatric-patients-with-congenital-heart-disease
#19
REVIEW
Steven G Chopski, William B Moskowitz, Randy M Stevens, Amy L Throckmorton
The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations...
November 8, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27855959/assessment-of-the-blood-brain-barrier-permeability-of-potential-neuroprotective-aurones-in-parallel-artificial-membrane-permeability-assay-and-porcine-brain-endothelial-cell-models
#20
Kok-Fui Liew, Nur Aziah Hanapi, Kit-Lam Chan, Siti R Yusof, Chong-Yew Lee
Previously, several aurone derivatives were identified with promising neuroprotective activities. In developing these compounds to target the central nervous system (CNS), an assessment of their blood-brain barrier (BBB) permeability was performed using in vitro BBB models: parallel artificial membrane permeability assay-BBB which measures passive permeability and primary porcine brain endothelial cell model which enables determination of the involvement of active transport mechanism. Parallel artificial membrane permeability assay-BBB identified most compounds with high passive permeability, with 3 aurones having exceptional Pe values highlighting the importance of basic amine moieties and optimal lipophilicity for good passive permeability...
November 14, 2016: Journal of Pharmaceutical Sciences
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