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https://www.readbyqxmd.com/read/28812204/multivariable-adaptive-artificial-pancreas-system-in-type-1-diabetes
#1
REVIEW
Ali Cinar
PURPOSE OF REVIEW: The review summarizes the current state of the artificial pancreas (AP) systems and introduces various new modules that should be included in future AP systems. RECENT FINDINGS: A fully automated AP must be able to detect and mitigate the effects of meals, exercise, stress and sleep on blood glucose concentrations. This can only be achieved by using a multivariable approach that leverages information from wearable devices that provide real-time streaming data about various physiological variables that indicate imminent changes in blood glucose concentrations caused by meals, exercise, stress and sleep...
August 15, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28809824/creation-and-transplantation-of-an-adipose-derived-stem-cell-asc-sheet-in-a-diabetic-wound-healing-model
#2
Yuka Kato, Takanori Iwata, Kaoru Washio, Toshiyuki Yoshida, Hozue Kuroda, Shunichi Morikawa, Mariko Hamada, Kazuki Ikura, Nobuyuki Kaibuchi, Masayuki Yamato, Teruo Okano, Yasuko Uchigata
Artificial skin has achieved considerable therapeutic results in clinical practice. However, artificial skin treatments for wounds in diabetic patients with impeded blood flow or with large wounds might be prolonged. Cell-based therapies have appeared as a new technique for the treatment of diabetic ulcers, and cell-sheet engineering has improved the efficacy of cell transplantation. A number of reports have suggested that adipose-derived stem cells (ASCs), a type of mesenchymal stromal cell (MSC), exhibit therapeutic potential due to their relative abundance in adipose tissue and their accessibility for collection when compared to MSCs from other tissues...
August 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28806625/association-of-changes-among-body-condition-score-during-the-transition-period-with-nefa-and-bhba-concentrations-milk-production-fertility-and-health-of-holstein-cows
#3
R V Barletta, M Maturana Filho, P D Carvalho, T A Del Valle, A S Netto, F P Rennó, R D Mingoti, J R Gandra, G B Mourão, P M Fricke, R Sartori, E H Madureira, M C Wiltbank
Our objective was to evaluate the association between body condition score (BCS) change during the transition period with fertility, non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) concentrations, milk yield, and health problems of Holstein cows in a retrospective cohort study. Holstein cows (n = 232) were assessed for BCS (5 point scale; 0.25 point increments) and had blood collected at 21 and 7 d before, on the day of, and 7 and 21 d after calving. Blood samples were assayed for NEFA and BHBA concentrations...
July 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28804963/effect-of-housing-system-on-reproductive-behaviour-and-on-some-endocrinological-and-seminal-parameters-of-donkey-stallions
#4
A Rota, M Sgorbini, D Panzani, F Bonelli, P Baragli, N Ille, D Gatta, C Sighieri, L Casini, M M Maggiorelli, C Aurich, F Camillo
Reproductive management of male donkeys employed for artificial breeding has been poorly studied. The aim of this study was to evaluate the effect of housing system, with the animals grouped together in a paddock or kept in individual boxes, on sexual behaviour, cortisol and testosterone concentration and seminal characteristics of adult male donkeys. The study included four Amiata donkey jacks (stallions) from which ejaculates, saliva and blood were collected during two distinct 3 weeks periods, one in the group and one in the box housing system...
August 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28802989/do-polyethylene-microplastic-beads-alter-the-intestinal-uptake-of-ag-in-rainbow-trout-oncorhynchus-mykiss-analysis-of-the-mp-vector-effect-using-in%C3%A2-vitro-gut-sacs
#5
Farhan R Khan, David Boyle, Elisabeth Chang, Nicolas R Bury
Microplastic (MP) vector effects have been well described in the literature but surprisingly little is in known about the impact of MPs on the intestinal uptake of contaminants. The present study aimed to determine whether the intestinal fate of Ag was affected by the presence of polyethylene MP beads. Ag (added as (110m)Ag) was introduced into the lumen of rainbow trout (Oncorhynchus mykiss) anterior/mid-intestine gut sac preparations as Ag only, Ag and MPs (co-exposure) and Ag-incubated MPs (where Ag was adsorbed to the MP)...
August 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28802241/the-9-d-cidr-pg-protocol-ii-characterization-of-endocrine-parameters-ovarian-dynamics-and-pregnancy-rates-to-fixed-time-ai-following-use-of-long-term-cidr-based-estrus-synchronization-among-mature-beef-cows
#6
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, S E Poock, M F Smith, D J Patterson
An experiment was designed to evaluate endocrine parameters, ovarian dynamics, and pregnancy rates to fixed-time artificial insemination (FTAI) following the 9-d CIDR-PG protocol in comparison to the 14-d CIDR-PG protocol. While both are long-term protocols using CIDR treatment for presynchronization, the 9-d CIDR-PG protocol differs from the 14-d CIDR-PG protocol in that prostaglandin F2α (PG) is administered at CIDR insertion and removal to facilitate a decreased length of progestin treatment and potentially enhance response to the presynchronization treatment...
August 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/28801994/influence-of-feeding-hematocrit-and-perfusion-pressure-on-hematocrit-reduction-f%C3%A3-hraeus-effect-in-an-artificial-microvascular-network
#7
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: Hematocrit in narrow vessels is reduced due to concentration of fast flowing red blood cells (RBC) in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local hematocrit in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding hematocrit and perfusion pressure on the Fåhraeus effect in an artificial microvascular network (AMVN)...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28800323/platelet-activation-and-erythrocyte-lysis-during-brief-exposure-of-blood-to-pathophysiological-shear-stress-in-vitro
#8
Suvankar Majumdar, Chetan N Patil, Tammy Ladner-Threadgill, Erica Randolph, Greg W Burgreen, John C Kermode
BACKGROUND: Interaction of von Willebrand factor (VWF) with circulating platelets is the trigger for thrombosis in a region of arterial stenosis. These events are typically studied in vitro under conditions where platelets adhere to a VWF-coated surface. Our approach assesses platelet responses in the absence of adhesion. OBJECTIVE: To characterize extent of platelet activation and erythrocyte lysis in an artificial stenosis model. METHODS: Whole blood is perfused through a length of polyetheretherketone tubing that includes an artificial stenosis, comprising narrow-bore (89-381 μm) tubing...
August 11, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28798852/flow-reproducibility-of-whole-blood-and-other-bodily-fluids-in-simplified-no-reaction-lateral-flow-assay-devices
#9
H Li, D Han, M A Hegener, G M Pauletti, A J Steckl
The "no reaction" lateral flow assay (nrLFA) uses a simplified LFA structure with no conjugate pad and no stored reagents. In the nrLFA, the capillary-based transport time or distance is the key indicator, rather than the outcome of a biochemical reaction. Hence, the calibration and reproducibility of the nrLFA device are critical. The capillary flow properties of several membrane types (nitrocellulose, nylon, cellulose acetate, polyethersulfone, and polyvinylidene difluoride) are evaluated. Flow rate evaluations of MilliporeSigma Hi-Flow™ Plus (HF075, HF135 and HF180) nitrocellulose membranes on nrLFA are performed using bodily fluids (whole blood, blood plasma, and artificial sweat)...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28798849/a-small-scale-rolled-membrane-microfluidic-artificial-lung-designed-towards-future-large-area-manufacturing
#10
A J Thompson, L H Marks, M J Goudie, A Rojas-Pena, H Handa, J A Potkay
Artificial lungs have been used in the clinic for multiple decades to supplement patient pulmonary function. Recently, small-scale microfluidic artificial lungs (μAL) have been demonstrated with large surface area to blood volume ratios, biomimetic blood flow paths, and pressure drops compatible with pumpless operation. Initial small-scale microfluidic devices with blood flow rates in the μl/min to ml/min range have exhibited excellent gas transfer efficiencies; however, current manufacturing techniques may not be suitable for scaling up to human applications...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28796799/differential-outcomes-of-zika-virus-infection-in-aedes-aegypti-orally-challenged-with-infectious-blood-meals-and-infectious-protein-meals
#11
Yan-Jang S Huang, Amy C Lyons, Wei-Wen Hsu, So Lee Park, Stephen Higgs, Dana L Vanlandingham
BACKGROUND: Infection of mosquitoes is an essential step for the transmission of mosquito-borne arboviruses in nature. Engorgement of infectious blood meals from viremic infected vertebrate hosts allows the entry of viruses and initiates infection of midgut epithelial cells. Historically, the infection process of arboviruses in mosquitoes has been studied through the engorgement of mosquitoes from viremic laboratory animals or from artificial feeders containing blood mixed with viruses harvested from cell cultures...
2017: PloS One
https://www.readbyqxmd.com/read/28794227/the-metabolic-cost-of-carrying-a-sexually-selected-trait-in-the-male-fiddler-crab-uca-pugilator
#12
Alexa Tullis, Corinne H T Straube
Models proposed to explain sexually selected structures assume that these traits are costly. However, studies investigating the impact of such structures on locomotory costs have produced inconsistent results. Male fiddler crabs possess a large sexually selected claw and are ideal for assessing the impact of a sexually selected trait on the cost of locomotion. Here, we measure the energy expenditure of clawed, declawed, and artificially loaded crabs during sustained exercise by measuring oxygen consumption and blood lactate levels...
August 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28791547/data-based-prediction-of-blood-glucose-concentrations-using-evolutionary-methods
#13
J Ignacio Hidalgo, J Manuel Colmenar, Gabriel Kronberger, Stephan M Winkler, Oscar Garnica, Juan Lanchares
Predicting glucose values on the basis of insulin and food intakes is a difficult task that people with diabetes need to do daily. This is necessary as it is important to maintain glucose levels at appropriate values to avoid not only short-term, but also long-term complications of the illness. Artificial intelligence in general and machine learning techniques in particular have already lead to promising results in modeling and predicting glucose concentrations. In this work, several machine learning techniques are used for the modeling and prediction of glucose concentrations using as inputs the values measured by a continuous monitoring glucose system as well as also previous and estimated future carbohydrate intakes and insulin injections...
August 8, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28790213/-surgical-treatment-of-cervical-carotid-artery-aneurysm
#14
Ryo Hamasaki, Toshiharu Yanagisawa, Yusuke Takahashi, Hiroaki Shimizu
Cervical carotid aneurysms are rare, and surgical treatment should be planned for each patient. The authors report 9 cases of cervical carotid aneurysm in 9 patients(mean age, 53.7 years;5 men)who were treated surgically between 2005 and 2014. The aneurysm was located in the internal carotid artery in 6 patients, the common carotid artery in 2 patients, and the carotid bifurcation in 1 patient. Four aneurysms were recurrences after a previous endovascular intervention(parent artery coil embolization, covered stent placement, or stent with coil embolization)...
August 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28782637/synthesis-and-activity-of-opioid-peptidomimetics-with-%C3%AE-2-and-%C3%AE-3-amino-acids
#15
Katarzyna Gach-Janczak, Justyna Piekielna-Ciesielska, Anna Adamska-Bartłomiejczyk, Renata Perlikowska, Rafał Kruszyński, Alicja Kluczyk, Julia Krzywik, Jarosław Sukiennik, Maria Camilla Cerlesi, Girolamo Calo, Andrzej Wasilewski, Marta Zielińska, Anna Janecka
Morphiceptin (Tyr-Pro-Phe-Pro-NH2) is a selective ligand of the mu opioid receptor, an important target in pain regulation. In this study, morphiceptin was modified at positions 2 or 3 by introduction of β(2)- or β(3)-amino acids and additionally in position 1 by replacing Tyr by Dmt (2',6'-dimethyltyrosine), which resulted in obtaining enzymatically stable analogs with mixed opioid receptor affinity profiles. An analog of the sequence Dmt-d-Ala-(R)-β(2)-1-Nal-Pro-NH2 [Nal=3-(1-naphthyl)-alanine] showed very high activity at the mu and delta receptors in the calcium mobilization functional test but did not cross the artificial membrane imitating the blood-brain barrier...
August 3, 2017: Peptides
https://www.readbyqxmd.com/read/28782121/rift-valley-fever-virus-and-european-mosquitoes-vector-competence-of-culex-pipiens-and-stegomyia-albopicta-%C3%A2-aedes-albopictus
#16
M Brustolin, S Talavera, A Nuñez, C Santamaría, R Rivas, N Pujol, M Valle, M Verdún, A Brun, N Pagès, N Busquets
Rift Valley fever (RVF) is a mosquito-borne disease caused by the Rift Valley fever virus (RVFV). Rift Valley fever affects a large number of species, including human, and has severe impact on public health and the economy, especially in African countries. The present study examined the vector competence of three different European mosquito species, Culex pipiens (Linnaeus, 1758) form molestus (Diptera: Culicidae), Culex pipiens hybrid form and Stegomyia albopicta (= Aedes albopictus) (Skuse, 1894) (Diptera: Culicidae)...
August 7, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28782037/chemotactic-synthetic-vesicles-design-and-applications-in-blood-brain-barrier-crossing
#17
Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or microswimmers, capable of mimicking biological locomotion and taxis. This active diffusion enables the engineering of complex operations that so far have not been possible at the micro- and nanoscale. One of the most promising tasks is the ability to engineer nanocarriers that can autonomously navigate within tissues and organs, accessing nearly every site of the human body guided by endogenous chemical gradients...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28765227/determination-of-an-optimal-pharmacokinetic-model-of-18-f-fet-for-quantitative-applications-in-rat-brain-tumors
#18
Marie Anne Richard, Jérémie P Fouquet, Réjean Lebel, Martin Lepage
O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) is a radiolabeled artificial amino acid used in PET for tumor delineation and grading. The present study compares different kinetic models to determine which are more appropriate for (18)F-FET in rats. Methods: Rats were implanted with F98 glioblastoma cells in the right hemisphere and scanned 9-15 d later. PET data were acquired during 50 min after a 1-min bolus of (18)F-FET. Arterial blood samples were drawn for arterial input function determination. Two compartmental pharmacokinetic models were tested: the 2-tissue model and the 1-tissue model...
August 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28763898/-effect-of-single-lumen-endobronchial-tube-and-double-lumen-endobronchial-tube-on-ventilation-and-lung-injury-in-patients-with-esophageal-cancer-undergoing-combined-thoracoscopic-and-laparoscopic-esophagectomy
#19
Y L Sun, Y Bai, T K Li, S G Lü, L Wang, X H Lu
Objective: To investigate the effect of the single lumen endobronchial tube and the double lumen endobronchial tube on ventilation and lung injury in patients with esophageal cancer undergoing combined thoracoscopic and laparoscopic esophagectomy. Methods: Sixty patients with esophageal cancer undergoing combined thoracoscopic and laparoscopic esophagectomy were divided into single lumen endobronchial tube group (D group, n=30) and double lumen endobronchial tube group (S, n=30) according to the random number table...
July 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28761992/novel-technique-for-airless-connection-of-artificial-heart-to-vascular-conduits
#20
Jamshid H Karimov, Shengqiang Gao, Raymond Dessoffy, Gengo Sunagawa, Martin Sinkewich, Patrick Grady, Shiva Sale, Nader Moazami, Kiyotaka Fukamachi
Successful implantation of a total artificial heart relies on multiple standardized procedures, primarily the resection of the native heart, and exacting preparation of the atrial and vascular conduits for pump implant and activation. Achieving secure pump connections to inflow/outflow conduits is critical to a successful outcome. During the connection process, however, air may be introduced into the circulation, traveling to the brain and multiple organs. Such air emboli block blood flow to these areas and are detrimental to long-term survival...
July 31, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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