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https://www.readbyqxmd.com/read/29334511/evaluation-of-recombinant-factor-viia-tranexamic-acid-and-desmopressin-to-reduce-prasugrel-related-bleeding-a-randomised-placebo-controlled-study-in-a-rabbit-model
#1
Fanny Bonhomme, Thomas Lecompte, Charles M Samama, Anne Godier, Pierre Fontana
BACKGROUND: Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE: The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs - recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) - to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects...
January 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29332864/associations-of-periparturient-plasma-biochemical-parameters-endometrial-leukocyte-esterase-and-myeloperoxidase-and-bacterial-detection-with-clinical-and-subclinical-endometritis-in-postpartum-dairy-cows
#2
Sayed Ahmad Nazhat, Go Kitahara, Nobutoshi Kozuka, Shogo Mido, Mohammed Sadawy, Hossam El-Sheikh Ali, Takeshi Osawa
This study was aimed at demonstrating associations between peripheral biochemical parameters, endometrial leukocyte esterase (LE) and myeloperoxidase (MPO), and bacterial detection with the degree of endometrial inflammation, and determining the best time postpartum for diagnosing endometritis to predict subsequent fertility in dairy cows. Plasma albumin, blood urea nitrogen (BUN), total cholesterol (T-cho), NEFA, and BHBA concentrations were analyzed in 43 Holstein cows at 3, 5 and 7 weeks postpartum (W3, W5 and W7)...
January 12, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29331829/additional-small-dose-of-prostaglandin-f2%C3%AE-at-timed-artificial-insemination-failed-to-improve-pregnancy-risk-of-lactating-dairy-cows
#3
J A Sauls, B E Voelz, L G D Mendonça, J S Stevenson
Two experiments were performed to test the hypothesis that administering PGF2α concurrent with timed artificial insemination (AI) in lactating dairy cows would enhance pregnancy per AI (P/AI). In experiment 1, lactating Holstein cows (n = 289) in one herd were enrolled after a non-pregnancy diagnosis (30-36 d after AI) to synchronize subsequent ovulation before AI. Cows were assigned randomly to receive (im) 10 mg of PGF2α concurrent with timed AI (Day 0; treatment) or no injection (control). Blood samples were collected on Days -3, 0, and 13 to determine serum concentrations of progesterone...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29323533/comparison-of-repair-characteristics-of-artificial-dermis-composite-tissue-with-traditional-prefabricated-flap
#4
Yuchong Wang, Mengyan Sun, Haiying Dai, Chuan Lv, Jianguo Xu, Ji Zhu, Ran Tao, Kai Wu, Xinwei Wang, Chunyu Xue
BACKGROUND: We compared the application of artificial dermis composite tissue and the traditional prefabricated flap in a rat model of an exposed bone and tendon injury. METHODS: Sprague Dawley rats were randomly divided into two groups (A and B, n = 40). Group A rats received artificial dermis composite tissue flaps while group B rats received traditional prefabricated flaps. Flap appearance, range of motion, degree of swelling, tissue histology, and imaging were compared between groups at 7, 14, 21, and 28 days...
January 11, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29321454/paper-like-surface-microstructure-fabricated-on-a-polymer-surface-by-femtosecond-laser-machining
#5
Kenji Goya, Yusuke Fuchiwaki
In this study, we demonstrate the precise control of fluid flow using femtosecond (FS) laser-induced microstructures. A microgroove structure inscribed on a poly(methyl methacrylate) (PMMA) substrate functions as a superhydrophilic membrane similar to paper. We first estimated the flow rate for pure water on microgrooves fabricated at various laser fluences in the range from 9.2 to 100.8 J/cm2. The results showed that the flow rate could be tuned in the range from 0.30 to 12.07 μL/s by varying the laser irradiation parameters...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29320155/transparent-and-waterproof-ionic-liquids-based-fibers-for-highly-durable-multifunctional-sensors-and-strain-insensitive-stretchable-conductors
#6
Song Chen, Haizhou Liu, Shuqi Liu, Pingping Wang, Songshan Zeng, Luyi Sun, Lan Liu
Ionic liquids (ILs) are regarded as ideal components in the next generation of strain sensors because their ultralow modulus can commendably circumvent or manage the mechanical mismatch in traditional strain sensors. In addition to strain sensors, stretchable conductors with strain-insensitive conductance are also indispensable in artificial systems for connecting and transporting electrons, similar to the function of blood vessels in the human body. In this work, two types of ILs-based conductive fibers were fabricated by developing hollow fibers with specific micro-scale channels which were then filled with ILs...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29314633/leucocyte-and-platelet-rich-fibrin-a-carrier-of-autologous-multipotent-cells-for-regenerative-medicine
#7
Rosa Di Liddo, Thomas Bertalot, Alessio Borean, Ivan Pirola, Alberto Argentoni, Sandra Schrenk, Carola Cenzi, Stefano Capelli, Maria Teresa Conconi, Pier Paolo Parnigotto
The wound healing is a complex process wherein inflammation, proliferation and regeneration evolve according to a spatio-temporal pattern from the activation of coagulation cascade to the formation of a plug clot including fibrin matrix, blood-borne cells and cytokines/growth factors. Creating environments conducive to tissue repair, the haemoderivatives are commonly proposed for the treatment of hard-to-heal wounds. Here, we explored in vitro the intrinsic regenerative potentialities of a leucocyte- and platelet-rich fibrin product, known as CPL-MB, defining the stemness grade of cells sprouting from the haemoderivative...
January 5, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29310847/effects-of-long-term-near-term-and-real-time-energy-balance-and-blood-progesterone-concentrations-on-the-pregnancy-rate-of-contemporary-dairy-cows
#8
N A Gomez, A J Conley, P H Robinson
This study aimed to contribute to understanding the interface between reproductive and nutritional energetic physiology in contemporary dairy cattle. Multiparous Holstein cows (n = 32) between 70 and 180 days in milk were used in a study starting 10 d prior to the artificial insemination (AI) date and were estrous synchronized using a hormonal regimen. Fourteen cows were determined pregnant on day 39 post-AI. Coccygeal blood samples of all cows were collected on d -10 and -3 prior to AI to determine estrous cyclicity, as well as at AI and at 6, 13 and 20 d post-AI...
January 4, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29310400/clinical-analysis-of-hyperkalemia-after-esophagectomy-a-case-report
#9
Qiang Chen, Wei-Guo Zhang, Shu-Chang Chen
RATIONALE: The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid loss and physiological consumption lead to the deficiency of potassium, even hypokalemia. Patients often require the addition of a large amount of potassium after operation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304411/rapid-screening-of-brain-penetrable-antioxidants-from-natural-products-by-blood-brain-barrier-specific-permeability-assay-combined-with-dpph-recognition
#10
Junfeng Zhu, Xiaojiao Yi, Jinghui Zhang, Shuqing Chen, Yongjiang Wu
Screening brain-penetrable antioxidants from natural products is a promising way for neuroprotective drug discovery. However, there is no screening methodology enables simultaneous investigation of antioxidant activity and blood-brain barrier (BBB) permeability of compounds from complex samples. Here we propose a novel strategy by combining BBB specific parallel artificial membrane permeability assay with 1,1-diphenyl-2-picrylhydrazyl recognition (BBB-PAMPA-DPPH) to achieve rapid multicomponent screening. First, BBB specific artificial membrane was constructed to separate the compounds with high BBB permeability in herbal extracts...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29303467/prospective-randomized-multicenter-study-of-cervical-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-5-year-results-with-a-metal-on-metal-artificial-disc
#11
Domagoj Coric, Richard D Guyer, Pierce D Nunley, David Musante, Cameron Carmody, Charles Gordon, Carl Lauryssen, Margaret O Boltes, Donna D Ohnmeiss
OBJECTIVE Seven cervical total disc replacement (TDR) devices have received FDA approval since 2006. These devices represent a heterogeneous assortment of implants made from various biomaterials with different biomechanical properties. The majority of these devices are composed of metallic endplates with a polymer core. In this prospective, randomized multicenter study, the authors evaluate the safety and efficacy of a metal-on-metal (MoM) TDR (Kineflex|C) versus anterior cervical discectomy and fusion (ACDF) in the treatment of single-level spondylosis with radiculopathy through a long-term (5-year) follow-up...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29302141/use-of-an-intra-arterial-catheter-as-a-provisional-conduit-for-regulated-outflow-management-in-the-setting-of-artery-only-digital-replantation
#12
Michael V DeFazio, Kevin D Han, Ebrahim Paryavi
Successful replantation of distal digital segments necessitates the establishment of sufficient outflow to minimize congestion and progressive tissue necrosis. In cases where only arterial anastomosis is feasible, an artificial outlet must be provided to maintain physiological requirements until microvenous circulation regenerates. This can be accomplished using any number of "exsanguination techniques" designed to facilitate egress through ongoing passive blood loss. Although reportedly effective, these measures are imprecise and carry a substantial risk of infection, scarring, and/or uncontrolled hemorrhage...
December 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29300089/monodisperse-micro-shell-structured-gelatin-microparticles-for-temporary-chemoembolization
#13
Bohyun Kim, Sang Woo Han, Song-Ee Choi, DaBin Yim, Jong-Ho Kim, Hans M Wyss, Jin Woong Kim
Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a micro-shell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively crosslink them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets...
January 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29299659/ex-vivo-expanded-nk-cells-from-blood-and-ascites-of-ovarian-cancer-patients-are-cytotoxic-against-autologous-primary-ovarian-cancer-cells
#14
Tina Nham, Sophie M Poznanski, Isabella Y Fan, Mira M Shenouda, Marianne V Chew, Amanda J Lee, Fatemeh Vahedi, Yalda Karimi, Martin Butcher, Dean A Lee, Hal Hirte, Ali A Ashkar
Ovarian cancer (OC) is the leading cause of gynecological cancer-related death in North America. Most ovarian cancer patients (OCPs) experience disease recurrence after first-line surgery and chemotherapy; thus, there is a need for novel second-line treatments to improve the prognosis of OC. Although peripheral blood-derived NK cells are known for their ability to spontaneously lyse tumour cells without prior sensitization, ascites-derived NK cells (ascites-NK cells) isolated from OCPs exhibit inhibitory phenotypes, impaired cytotoxicity and may play a pro-tumourigenic role in cancer progression...
January 3, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29297094/evaluation-of-a-semi-automated-in-vitro-feeding-system-for-dermacentor-reticulatus-and-ixodes-ricinus-adults
#15
Bettina Böhme, Christoph Krull, Peter-Henning Clausen, Ard M Nijhof
The long feeding duration of ixodid ticks and need for regular blood changes turns the artificial feeding of ticks into a tedious process. To reduce the number of blood changes, a semi-automated system (SAS) for the artificial feeding of hard ticks was developed and evaluated. It consisted of a glass feeding reservoir that can accommodate six tick feeding chambers. A peristaltic pump was used to pump blood through the feeding reservoir, which was changed once daily. Groups of Dermacentor reticulatus and Ixodes ricinus adults were fed simultaneously in both the SAS and a conventional in vitro feeding system...
January 3, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29296087/examining-hemodialyzer-membrane-performance-using-proteomic-technologies
#16
REVIEW
Mario Bonomini, Luisa Pieroni, Lorenzo Di Liberato, Vittorio Sirolli, Andrea Urbani
The success and the quality of hemodialysis therapy are mainly related to both clearance and biocompatibility properties of the artificial membrane packed in the hemodialyzer. Performance of a membrane is strongly influenced by its interaction with the plasma protein repertoire during the extracorporeal procedure. Recognition that a number of medium-high molecular weight solutes, including proteins and protein-bound molecules, are potentially toxic has prompted the development of more permeable membranes. Such membrane engineering, however, may cause loss of vital proteins, with membrane removal being nonspecific...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29290542/identification-of-novel-allosteric-inhibitors-of-mutant-isocitrate-dehydrogenase-1-by-cross-docking-based-virtual-screening
#17
Fangxia Zou, Stefan Pusch, Jie Hua, Tianfang Ma, Lijun Yang, Qihua Zhu, Yungen Xu, Yueqing Gu, Andreas von Deimling, Xiaoming Zha
IDH1 mutation (mIDH1) occurs in 20-30% of gliomas and is a promising target for the cancer therapy. In this article, a cross docking-based virtual screening was employed to identify seven small molecules for the allosteric site of mIDH1. Compounds ZX01, ZX05 and ZX06 exhibited the potent inhibitory activity and the high selectivity against WT-IDH1, providing a good starting point for the further development of highly selective mIDH1 inhibitors. Importantly, the parallel artificial membrane permeation assay of the blood-brain barrier (PAMPA-BBB) identified ZX06 with a good ability to penetrate BBB...
December 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29287980/development-of-radiopaque-biocompatible-antimicrobial-micro-particle-fillers-for-micro-ct-imaging-of-simulated-periodontal-pockets
#18
M Elashiry, M M Meghil, S Kalathingal, A Buchanan, M Rajendran, R Elrefai, M Ochieng, A Elawady, R M Arce, K H Sandhage, C W Cutler
OBJECTIVES: Approximately 109 bacteria can be harbored within periodontal pockets (PP) along with inflammatory byproducts implicated in the pathophysiology of systemic diseases linked to periodontitis (PD). Calculation of this inflammatory burden has involved estimation of total pocket surface area using analog data from conventional periodontal probing which is unable to determine the three-dimensional (3-D) nature of PP. The goals of this study are to determine the radiopacity, biocompatibility, and antimicrobial activity of transient micro-particle fillers in vitro and demonstrate their capability for 3-D imaging of artificial PP (U...
December 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29287072/a-highly-stable-blood-meal-alternative-for-rearing-aedes-and-anopheles-mosquitoes
#19
Ted Baughman, Chelsea Peterson, Corrie Ortega, Sarah R Preston, Christopher Paton, Jessica Williams, Amy Guy, Gavin Omodei, Brian Johnson, Helen Williams, Scott L O'Neill, Scott A Ritchie, Stephen L Dobson, Damian Madan
We investigated alternatives to whole blood for blood feeding of mosquitoes with a focus on improved stability and compatibility with mass rearing programs. In contrast to whole blood, an artificial blood diet of ATP-supplemented plasma was effective in maintaining mosquito populations and was compatible with storage for extended periods refrigerated, frozen, and as a lyophilized powder. The plasma ATP diet supported rearing of both Anopheles and Aedes mosquitoes. It was also effective in rearing Wolbachia-infected Aedes mosquitoes, suggesting compatibility with vector control efforts...
December 29, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29285107/n-n-dimethylformamide-induced-acute-hepatic-failure-a-case-report-and-literature-review
#20
Yuanli Lei, Shasha Xiao, Shouquan Chen, Haiyan Zhang, Huiping Li, Yingru Lu
N,N-dimethylformamide (DMF) is a major solvent predominantly used in the chemical industry. The main toxic effects following exposure to DMF are gastric irritation, skin eruption and hepatotoxicity. However, hepatic failure induced by DMF is rare. In this report, we present a case of acute hepatic failure following exposure to a toxic dose of DMF via respiratory tract inhalation and skin absorption with detailed abdominal computed tomography scan, sequential laboratory data and polymorphisms. The patient recovered satisfactorily following artificial liver support therapy and pharmacological agents to protect the liver in addition to plasma, blood platelet and albumin transfusions...
December 2017: Experimental and Therapeutic Medicine
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