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https://www.readbyqxmd.com/read/29163195/members-of-bitter-taste-receptor-cluster-tas2r143-tas2r135-tas2r126-are-expressed-in-the-epithelium-of-murine-airways-and-other-non-gustatory-tissues
#1
Shuya Liu, Shun Lu, Rui Xu, Ann Atzberger, Stefan Günther, Nina Wettschureck, Stefan Offermanns
The mouse bitter taste receptors Tas2r143, Tas2r135, and Tas2r126 are encoded by genes that cluster on chromosome 6 and have been suggested to be expressed under common regulatory elements. Previous studies indicated that the Tas2r143/Tas2r135/Tas2r126 cluster is expressed in the heart, but other organs had not been systematically analyzed. In order to investigate the expression of this bitter taste receptor gene cluster in non-gustatory tissues, we generated a BAC (bacterial artificial chromosome) based transgenic mouse line, expressing CreERT2 under the control of the Tas2r143 promoter...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29160509/sympatry-influence-in-the-interaction-of-trypanosoma-cruzi-with-triatomine
#2
Elaine Schultz Dworak, Silvana Marques de Araújo, Mônica Lúcia Gomes, Miyoko Massago, Érika Cristina Ferreira, Max Jean de Ornelas Toledo
INTRODUCTION: Trypanosoma cruzi, the etiologic agent of Chagas disease, is widely distributed in nature, circulating between triatomine bugs and sylvatic mammals, and has large genetic diversity. Both the vector species and the genetic lineages of T. cruzi present a varied geographical distribution. This study aimed to verify the influence of sympatry in the interaction of T. cruzi with triatomines. Methods: The behavior of the strains PR2256 (T. cruzi II) and AM14 (T. cruzi IV) was studied in Triatoma sordida (TS) and Rhodnius robustus (RR)...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29158992/hrv-derived-data-similarity-and-distribution-index-based-on-ensemble-neural-network-for-measuring-depth-of-anaesthesia
#3
Quan Liu, Li Ma, Ren-Chun Chiu, Shou-Zen Fan, Maysam F Abbod, Jiann-Shing Shieh
Evaluation of depth of anaesthesia (DoA) is critical in clinical surgery. Indices derived from electroencephalogram (EEG) are currently widely used to quantify DoA. However, there are known to be inaccurate under certain conditions; therefore, experienced anaesthesiologists rely on the monitoring of vital signs such as body temperature, pulse rate, respiration rate, and blood pressure to control the procedure. Because of the lack of an ideal approach for quantifying level of consciousness, studies have been conducted to develop improved methods of measuring DoA...
2017: PeerJ
https://www.readbyqxmd.com/read/29157979/artificial-apolipoprotein-corona-enables-nanoparticle-brain-targeting
#4
Roberta Dal Magro, Barbara Albertini, Silvia Beretta, Roberta Rigolio, Elisabetta Donzelli, Alessia Chiorazzi, Maurizio Ricci, Paolo Blasi, Giulio Sancini
Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate(®) 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium...
November 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29157454/developing-a-new-intelligent-system-for-the-diagnosis-of-tuberculous-pleural-effusion
#5
Chengye Li, Lingxian Hou, Bishundat Yanesh Sharma, Huaizhong Li, ChengShui Chen, Yuping Li, Xuehua Zhao, Hui Huang, Zhennao Cai, Huiling Chen
BACKGROUND AND OBJECTIVE: In countries with high prevalence of tuberculosis (TB), clinicians often diagnose tuberculous pleural effusion (TPE) by using diagnostic tests, which have not only poor sensitivity, but poor availability as well. The aim of our study is to develop a new artificial intelligence based diagnostic model that is accurate, fast, non-invasive and cost effective to diagnose TPE. It is expected that a tool derived based on the model be installed on simple computer devices (such as smart phones and tablets) and be used by clinicians widely...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29155557/wearable-nanoplasmonic-patch-detecting-sun-uv-exposure
#6
Jessica G Barajas-Carmona, Leydi Francisco-Aldana, Eden Morales-Narváez
Sun exposure is known to yield beneficial health outcomes, including synthesis of adequate levels of vitamin D, beneficial modulation of blood pressure and is a valuable factor in mental health care. However, the increasing incidence of sun/UV exposure-related illness, such as skin cancer, is seriously concerning public health authorities as well as the scientific community. Consequently, moderate sun/UV exposure is strongly recommended. A wearable nanoplasmonic patch whose original color changes upon sun exposure due to its UV-responsive capabilities that are visually detectable has been engineered...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29149993/label-free-determination-of-prostate-specific-membrane-antigen-in-human-whole-blood-at-nanomolar-levels-by-magnetically-assisted-surface-enhanced-raman-spectroscopy
#7
Zuzana Chaloupková, Anna Balzerová, Jitka Bařinková, Zdenka Medříková, Pavel Šácha, Petr Beneš, Václav Ranc, Jan Konvalinka, Radek Zbořil
Prostate cancer is one of the most common cancers among men and can in its later stages cause serious medical problems. Due to the limited suitability of current diagnostic biochemical markers, new biomarkers for the detection of prostate cancer are highly sought after. An ideal biomarker should serve as a reliable prognostic marker, be applicable for early diagnosis, and be applicable for monitoring of therapeutic response. One potential candidate is glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), which has a promising role for direct imaging...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29146940/development-and-physiological-effects-of-an-artificial-diet-for-wolbachia-infected-aedes-aegypti
#8
Heverton Leandro Carneiro Dutra, Silvia Lomeu Rodrigues, Simone Brutman Mansur, Sofia Pimenta de Oliveira, Eric Pearce Caragata, Luciano Andrade Moreira
The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there is a dearth of mass rearing infrastructure specific to Wolbachia-infected mosquitoes. One example is the lack of a blood meal substitute, which accounts for the Wolbachia-specific physiological changes in infected mosquitoes, that allows the bacterium to spread, and block viral infections...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145859/singapore-s-anopheles-sinensis-form-a-is-susceptible-to-plasmodium-vivax-isolates-from-the-western-thailand-myanmar-border
#9
Sook-Cheng Pang, Chiara Andolina, Benoit Malleret, Peter R Christensen, Sai-Gek Lam-Phua, Muhammad Aliff Bin Abdul Razak, Chee-Seng Chong, Daiqin Li, Cindy S Chu, Bruce Russell, Laurent Rénia, Lee-Ching Ng, Francois Nosten
BACKGROUND: Singapore has been certified malaria-free by the World Health Organization since November 1982. However, sporadic autochthonous malaria outbreaks do occur. In one of the most recent outbreaks of vivax malaria, an entomological investigation identified Anopheles sinensis as the most probable vector. As metaphase karyotype studies divided An. sinensis into two forms, A and B, with different vector competence: the investigation of vector competence of An. sinensis found in Singapore was thus pursued using Plasmodium vivax field isolates from the Thailand-Myanmar border...
November 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29144729/an-optical-nanoantenna-for-single-molecule-based-detection-of-zika-virus-nucleic-acids-without-molecular-multiplication
#10
Sarah Elisabeth Ochmann, Carolin Vietz, Kateryna Trofymchuk, Guillermo P Acuna, Birka Lalkens, Philip Tinnefeld
Due to the limited signal-to-background ratio, molecular diagnostics requires molecular amplification of the target molecules or molecular signal amplification after target recognition. For direct molecular detection, we demonstrate a purely physical fluorescence enhancement process which can elevate the fluorescence signal of single fluorescent dyes by several orders of magnitude. To this end, DNA origami-based optical antennas with a height of around 125 nm are used, which utilize metallic nanoparticles to create a hotspot where fluorescence signals are enhanced by plasmonic effects...
November 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29144384/mediator-preference-of-two-different-fad-dependent-glucose-dehydrogenases-employed-in-disposable-enzyme-glucose-sensors
#11
Noya Loew, Wakako Tsugawa, Daichi Nagae, Katsuhiro Kojima, Koji Sode
Most commercially available electrochemical enzyme sensor strips for the measurement of blood glucose use an artificial electron mediator to transfer electrons from the active side of the enzyme to the electrode. One mediator recently gaining attention for commercial sensor strips is hexaammineruthenium(III) chloride. In this study, we investigate and compare the preference of enzyme electrodes with two different FAD-dependent glucose dehydrogenases (FADGDHs) for the mediators hexaammineruthenium(III) chloride, potassium ferricyanide (the most common mediator in commercial sensor strips), and methoxy phenazine methosulfate (mPMS)...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144171/circadian-gene-methylation-in-rotating-shift-nurses-a-cross-sectional-study
#12
Edyta Reszka, Edyta Wieczorek, Monika Przybek, Ewa Jabłońska, Paweł Kałużny, Agnieszka Bukowska-Damska, Shanbeh Zienolddiny, Beata Pepłońska
Investigating the methylation status of the circadian genes may contribute to a better understanding of the shift work-related circadian disruption in individuals exposed to artificial light at night. In the present study, we determined the methylation status of the circadian genes associated with a shift work pattern among nurses and midwives participating in a cross-sectional study in Lodz, Poland. Quantitative methylation polymerase chain reaction assays were used to assess promoter CpG methylation in PER1, PER2, PER3, CRY1, CRY2, BMAL1, CLOCK, and NPAS2 in genomic DNA from whole blood of 347 women having a rotating-shift work schedule and 363 women working days only...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29137394/measuring-plasma-levels-of-three-micrornas-can-improve-the-accuracy-for-identification-of-malignant-breast-lesions-in-women-with-bi-rads-4-mammography
#13
Julia Alejandra Pezuk, Thiago Luiz Araujo Miller, José Luiz Barbosa Bevilacqua, Alfredo Carlos Simões Dornellas de Barros, Felipe Eduardo Martins de Andrade, Luiza Freire de Andrade E Macedo, Vera Aguilar, Amanda Natasha Menardo Claro, Anamaria Aranha Camargo, Pedro Alexandre Favoretto Galante, Luiz F L Reis
A BI-RADS category of 4 from a mammogram indicates suspicious breast lesions, which require core biopsies for diagnosis and have an approximately one third chance of being malignant. Human plasma contains many circulating microRNAs, and variations in their circulating levels have been associated with pathologies, including cancer. Here, we present a novel methodology to identify malignant breast lesions in women with BI-RADS 4 mammography. First, we used the miRNome array and qRT-PCR to define circulating microRNAs that were differentially represented in blood samples from women with breast tumor (BI-RADS 5 or 6) in comparison to controls (BI-RADS 1 or 2)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131276/the-expression-of-mmp-7-in-serum-and-aneurysm-tissues-of-patients-with-abdominal-aortic-aneurysm-associated-with-hypertension-and-the-clinical-efficacy-of-endovascular-exclusion
#14
W-H Zhang, C-H Qiao, X Zhang, H Luo, X-K Sun
OBJECTIVE: To investigate the expression of matrix metalloproteinase-7 (MMP-7) in abdominal aortic aneurysm (AAA) with hypertension, and the clinical efficacy of endovascular exclusion. PATIENTS AND METHODS: Seventy-two cases of AAA with hypertension were retrospectively analyzed. Patients were divided into the observation group (34 cases) and control group (38 cases). The control group was treated by AAA incision with artificial vascular replacement, while the observation group was treated by endovascular graft exclusion...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29131241/insulin-like-growth-factor-i-reduces-the-occurrence-of-necrotizing-enterocolitis-by-reducing-inflammatory-response-and-protecting-intestinal-mucosal-barrier-in-neonatal-rats-model
#15
F Tian, G-R Liu, N Li, G Yuan
OBJECTIVE: To observe the effect of enteral supplement of insulin-like growth factor I (IGF-1) on dynamic changes of TLR4, NF-κB, IL-6, SIgA and MUC2 in intestinal tissues of neonatal rats, and to investigate the protective effects and possible mechanisms of IGF-1 on necrotizing enterocolitis (NEC). MATERIALS AND METHODS: Specific pathogen free (SPF) neonatal Sprague Dawley (SD) rats aged 3 days old were randomly divided into 3 groups, namely, normal control group, NEC model group and IGF-1 intervention group...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29130393/wound-healing-effects-of-human-dermal-components-with-gelatin-dressing
#16
Hyun-Jun Jang, Yu-Mi Kim, Bo-Young Yoo, Young-Kwon Seo
There have been numerous investigations regarding various types of dressings and artificial dermis of solid form, yet limited research and development on paste types, such as hydrogels with dermal powder, have ensued. In this study, we compared the in vivo wound healing effects of gelatin paste containing dermal powder to a collagen type I/chondroitin 6-sulfate (coll/chondroitin) sponge and gelatin alone, after 48 days post grafting, in a skin wound rat model. In the dermis powder/gelatin paste-treated group, wound area contraction was minimized 50%, while in the gelatin and coll/chondroitin sponge groups, the initial area contracted 83-85% and 79-85%, respectively...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29127352/margination-of-stiffened-red-blood-cells-regulated-by-vessel-geometry
#17
Yuanyuan Chen, Donghai Li, Yongjian Li, Jiandi Wan, Jiang Li, Haosheng Chen
Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication.
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123846/two-cases-of-cryptogenic-life-threatening-hemoptysis-identification-and-management-of-bleeding-point
#18
Kazunori Okuda, Jun Tanaka, Jun Okamoto, Fumihisa Kishi, Junichiro Nakagawa, Hiroshi Hino, Satoru Chujoh, Kazuhisa Shimadzu, Masafumi Kishimoto, Noboru Kato, Shigeru Shiono
Cases: Case 1: A 63-year-old woman was referred for coughing blood. Although cardiorespiratory dynamics were stabilized by artificial respiration under sedation, severely poor ventilation developed from asphyxia associated with massive respiratory tract hemorrhage. One-lung ventilation was temporarily secured by endotracheal tube insertion into the left main bronchus just prior to cardiopulmonary arrest.Case 2: A 72-year-old man was referred for massive hemoptysis after coughing, then intubated and placed on a respirator...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122949/the-effects-of-extended-crawling-on-the-physiology-and-swim-performance-of-loggerhead-and-green-sea-turtle-hatchlings
#19
Karen Pankaew, Sarah L Milton
Following emergence from the nest, sea turtle hatchling dispersal can be disrupted by artificial lights or skyglow from urban areas. Mis- or disorientation may increase exposure to predation, thermal stress, and dehydration, and consume valuable energy, thus decreasing the likelihood of survival. In this study hatchlings were run on a treadmill for 200m or 500m to investigate the physiological impacts of disorientation crawling on loggerhead (Caretta caretta) and green (Chelonia mydas) sea turtle hatchlings...
November 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29121658/risk-factors-for-postoperative-deep-infection-in-bone-tumors
#20
Shinji Miwa, Toshiharu Shirai, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kaoru Tada, Yoshitomo Kajino, Hiroyuki Inatani, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hiroyuki Tsuchiya
BACKGROUND: Postoperative deep infection after bone tumor surgery remains a serious complication. Although there are numerous reports about risk factors for postoperative deep infection in general surgery, there is only a small number of reports about those for bone tumor surgery. This retrospective study aimed to identify risk factors for postoperative deep infection after bone tumor resection. METHODS: We reviewed data of 681 patients (844 bone tumors) who underwent surgery...
2017: PloS One
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