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follicular adenoma

Paula Boaventura, Rui Batista, Ana Pestana, Marta Reis, Adélia Mendes, Catarina Eloy, Manuel Sobrinho-Simoes, Paula Soares
Objective - The aim of this study is to evaluate the frequency and molecular characteristics of TERTp mutations in thyroid adenomas and carcinomas occurring in the low dose radiation exposure tinea capitis setting. Design and methods - Twenty seven patients with 34 well differentiated thyroid carcinomas and 28 patients with 29 follicular adenomas diagnosed in a Portuguese tinea capitis cohort of 1375 patients, were studied. Blood samples were obtained from all the patients. Screening for TERTp mutations was performed by PCR amplification followed by Sanger sequencing...
October 19, 2016: European Journal of Endocrinology
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
Seung-Hyun Jung, Min Sung Kim, Chan Kwon Jung, Hyun-Chun Park, So Youn Kim, Jieying Liu, Ja-Seong Bae, Sung Hak Lee, Tae-Min Kim, Sug Hyung Lee, Yeun-Jun Chung
Follicular thyroid adenoma (FTA) precedes follicular thyroid carcinoma (FTC) by definition with a favorable prognosis compared to FTC. However, the genetic mechanism of FTA to FTC progression remains unknown. For this, it is required to disclose FTA and FTC genomes in mutational and evolutionary perspectives. We performed whole-exome sequencing and copy number profiling of 14 FTAs and 13 FTCs, which exhibited previously-known gene mutations (NRAS, HRAS, BRAF, TSHR and EIF1AX) and copy number alterations (CNAs) (22q loss and 1q gain) in follicular tumors...
September 9, 2016: Oncotarget
Nicla Borrelli, Maria Denaro, Clara Ugolini, Anello Marcello Poma, Mario Miccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Follicular variants of papillary thyroid carcinoma include encapsulated (with or without capsular/vascular invasion) and infiltrative forms, which have different clinical behaviors. The encapsulated forms that lack capsular invasion have an indolent clinical behavior that is similar to benign lesions; therefore, they were recently reclassified as 'noninvasive follicular thyroid neoplasms with papillary-like nuclear features' (NIFTPs). Because NIFTPs have nuclear features of papillary carcinomas, distinguishing between NIFTPs and infiltrative follicular variant of papillary thyroid carcinoma is almost impossible with cytological examination...
September 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
J A Ramos-Vara, C B Frank, D DuSold, M A Miller
Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81 follicular tumours expressed thyroglobulin and were negative for calcitonin; 79/81 (98%) of these tumours expressed TTF-1 and Pax8 and 60/81 (74%) expressed napsin A...
August 24, 2016: Journal of Comparative Pathology
Kaori Isobe, Sydney Mukaratirwa, Claudio Petterino, Alys Bradley
The incidence and range of spontaneous thyroid and parathyroid glands findings were determined in control Han-Wistar and Sprague-Dawley rats, and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the thyroid or parathyroid glands were generally uncommon apart from some findings in CD-1 mice such as ultimobranchial duct/cyst (5.72%), follicular distension/dilatation (3.84%), and cystic follicles (3...
July 2016: Journal of Toxicologic Pathology
Daniel Maya-Pulgarin, María S Gonzalez-Dominguez, Diego Aranzazu-Taborda, Natalia Mendoza, Juan G Maldonado-Estrada
Ovariohysterectomy (OHE) of bitches is a matter of conflict depending on the region and country in the world. In a descriptive, prospective cross-sectional study uterine tracts and ovaries exhibiting gross pathologic findings (n = 76) were collected post-surgery from a reference population of 3600 bitches (2,11% incidence) undergoing elective ovariohysterectomy during the warm-humid season (September-to-November 2013, average 26ºC) and were evaluated by histopathology examination. Data were evaluated by descriptive statistics and Chi-Squared test...
August 10, 2016: Journal of Veterinary Science
Sayed Mahmoud Mirhosaini, Soroush Amani, Rana Fereidani
Ectopic parathyroid adenoma can be seen in various locations. Sometimes ultrasound and even fine needle aspiration studies cannot distinguish this lesion from thyroid lesions. A 29-year-old woman with a prominent nodule of left thyroid lobe was referred to surgical department. Thyroid function test were normal. She had no family history of parathyroid disease, other endocrine disease, and any other malignancies and had received no radiation. Ultrasonography revealed a solid and hypoechoic mass, 25x20 mm in size, with a regular shape and contour without calcification in the inferior of left lobe of the thyroid gland...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Seong-Keun Yoo, Seungbok Lee, Su-Jin Kim, Hyeon-Gun Jee, Byoung-Ae Kim, Hyesun Cho, Young Shin Song, Sun Wook Cho, Jae-Kyung Won, Jong-Yeon Shin, Do Joon Park, Jong-Il Kim, Kyu Eun Lee, Young Joo Park, Jeong-Sun Seo
Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable by preoperative diagnosis due to their similar histological features. Here we report the first RNA sequencing study of these tumors, with data for 30 minimally invasive FTCs (miFTCs) and 25 FAs. We also compared 77 classical papillary thyroid carcinomas (cPTCs) and 48 follicular variant of PTCs (FVPTCs) to observe the differences in their molecular properties. Mutations in H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, and SPOP were identified in miFTC or FA...
August 2016: PLoS Genetics
Tomasz Stokowy, Bartosz Wojtas, Barbara Jarzab, Knut Krohn, David Fredman, Henning Dralle, Thomas Musholt, Steffen Hauptmann, Dariusz Lange, László Hegedüs, Ralf Paschke, Markus Eszlinger
Diagnosis of thyroid by fine needle aspiration is challenging for the "indeterminate" category and can be supported by molecular testing. We set out to identify miRNA markers that could be used in a diagnostic setting to improve the discrimination of mutation-negative indeterminate fine needle aspirations. miRNA high-throughput sequencing was performed for freshly frozen tissue samples of 19 RAS and PAX8/PPARG mutation-negative follicular thyroid carcinomas, and 23 RAS and PAX8/PPARG mutation-negative follicular adenomas...
July 29, 2016: Endocrine
Yasuhiro Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Minoru Kihara, Tomonori Yabuta, Hiroo Masuoka, Mitsuhiro Fukushima, Takuya Higashiyama, Kaoru Kobayashi, Akihiro Miya
Oxyphilic cell carcinoma is a relatively rare type of differentiated thyroid carcinoma. We investigated the diagnosis of oxyphilic cell carcinoma based on surgical specimens and cytology to elucidate the indications for surgery for oxyphilic tumors. Among 330 patients pathologically diagnosed as having an oxyphilic cell carcinoma or adenoma, the incidence of carcinoma was 21%. The pathological diagnosis of oxyphilic cell carcinoma was related to tumor size (>4 cm). On cytology, 79% of the tumors were classified as category IV or greater by the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), but no significant difference was established between category IV or greater and categories I-III regarding the incidence of carcinoma...
July 26, 2016: Endocrine Journal
Kyle C Strickland, Marina Vivero, Vickie Y Jo, Alarice C Lowe, Monica Hollowell, Xiaohua Qian, Tad J Wieczorek, Christopher A French, Lisa A Teot, Peter M Sadow, Erik K Alexander, Edmund S Cibas, Justine A Barletta, Jeffrey F Krane
BACKGROUND: The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) in recognition of the indolent behavior of this tumor. The ability to differentiate NIFTP from classical papillary thyroid carcinoma (cPTC) by fine-needle aspiration (FNA) would facilitate conservative management for NIFTP. The aim of this study was to determine if NIFTP can be distinguished prospectively from cPTC...
October 2016: Thyroid: Official Journal of the American Thyroid Association
Hye Min Kim, Yu Kyung Lee, Ja Seung Koo
PURPOSE: This study aimed to investigate the expression of glutamine metabolism-related protein in tumor and stromal compartments among the histologic subtypes of thyroid cancer. RESULTS: GLS1 and GDH expression in tumor and stromal compartments were the highest in AC than in other subtypes. Tumoral ASCT2 expression was higher in MC but lower in FC (p < 0.001). In PTC, tumoral GLS1 and tumoral GDH expression was higher in the conventional type than in the follicular variant (p = 0...
July 18, 2016: Oncotarget
Luciana Bueno Ferreira, Catarina Tavares, Ana Pestana, Catarina Leite Pereira, Catarina Eloy, Marta Teixeira Pinto, Patricia Castro, Rui Batista, Elisabete Rios, Manuel Sobrinho-Simões, Etel Rodrigues Pereira Gimba, Paula Soares
Osteopontin (OPN) is a matricellular protein overexpressed in cancer cells and modulates tumorigenesis and metastasis, including in thyroid cancer (TC). The contribution of each OPN splice variant (OPN-SV), named OPNa, OPNb and OPNc, in TC is currently unknown. This study evaluates the expression of total OPN (tOPN) and OPN-SV in TC tissues and cell lines, their correlation with clinicopathological, molecular features and their functional roles. We showed that tOPN and OPNa are overexpressed in classic papillary thyroid carcinoma (cPTC) in relation to adjacent thyroid, adenoma and follicular variant of papillary thyroid carcinoma (fvPTC) tissues...
July 7, 2016: Oncotarget
Jason Trahan, Abhita Reddy, Ellen Chang, Ricardo Gomez, Pinki Prasad, Anita Jeyakumar
OBJECTIVES: 1. Analyze our center's experience with thyroid nodules. 2. Evaluate the efficacy of fine needle biopsy. 3. Compare our experience with the 2015 ATA guidelines. METHODS: IRB approved retrospective chart review from July 1993-July 2014 at a tertiary pediatric institution. Patients under age 21 with documented thyroid nodules who underwent fine needle aspiration, and/or thyroidectomy were included. RESULTS: 126 patients were identified...
August 2016: International Journal of Pediatric Otorhinolaryngology
Abdelhamid Biyi, Soukaina Zaïmi, Abderrahim Doudouh
Functioning thyroid metastases are a rare cause of hyperthyroidism. Most of them are follicular carcinoma. Here, we report a case of 62 years old man with a past history of right sub total thyroidectomy for a benign adenoma. Recently, he complained of symptoms of hyperthyroidism associated with left arm pain. Biopsy of the humeral lesion was consistent with a papillary carcinoma of the thyroid metastasis. Postoperatively, he received a cumulative dose of 14.8 GBq of 131-I with a good control of hyperthyroidism but without eradication of the bone metastases...
June 30, 2016: Journal of Nuclear Medicine Technology
Jianlin Xu, Ding Zhang, Qian Niu, Yonggang Nan, Changbei Shi, Hua Zhao, Xiaoyan Liang
Current methods for diagnosing thyroid carcinoma are time consuming or expensive. Thus, alternative approaches are required. In the present study, microRNAs (miRNAs) with higher sensitivity and specificity were screened while distinguishing between differentiated thyroid carcinoma (DTC) and subtype papillary thyroid carcinoma (PTC). A total of 120 cases suspected of having thyroid carcinoma were selected and examined using clinical color Doppler ultrasound, and computed tomography scan at the same time. The tissue specimens were obtained with fine needle aspiration, multiphase biopsy and surgical resection...
July 2016: Oncology Letters
Anne-Marie Makhlouf, Zhanna Chitikova, Marc Pusztaszeri, Margaret Berczy, Celine Delucinge-Vivier, Frederic Triponez, Patrick Meyer, Jacques Philippe, Charna Dibner
The search for preoperative biomarkers for thyroid malignancies, in particular for follicular thyroid carcinoma (FTC) diagnostics, is of utmost clinical importance. We thus aimed at screening for potential biomarker candidates for FTC. To evaluate dynamic alterations in molecular patterns as a function of thyroid malignancy progression, a comparative analysis was conducted in clinically distinct subgroups of FTC and poorly differentiated thyroid carcinoma (PDTC) nodules. NanoString analysis of FFPE samples was performed in 22 follicular adenomas, 56 FTC and 25 PDTC nodules, including oncocytic and non-oncocytic subgroups...
June 18, 2016: Oncotarget
Alessandro Del Gobbo, Erika Peverelli, Donatella Treppiedi, Andrea Lania, Giovanna Mantovani, Stefano Ferrero
In this review, we discuss the molecular mechanisms and prognostic implications of the protein kinase A (PKA) signaling pathway in human tumors, with special emphasis on the malignant thyroid. The PKA signaling pathway is differentially activated by the expression of regulatory subunits 1 (R1) and 2 (R2), whose levels change during development, differentiation, and neoplastic transformation. Following the identification of gene mutations within the PKA regulatory subunit R1A (PRKAR1A) that cause Carney complex-associated neoplasms, several investigators have studied PRKAR1A expression in sporadic thyroid tumors...
August 1, 2016: Experimental Cell Research
Andrey Bychkov, Pichet Sampatanukul, Shanop Shuangshoti, Somboon Keelawat
We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and medullary carcinomas were negative for TROP-2 immunostaining. The majority of papillary thyroid carcinoma (PTC) specimens (94/114, 82.5%) were positive for TROP-2; however, the pattern of staining differed significantly between the histopathological variants...
August 2016: Pathology
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