keyword
MENU ▼
Read by QxMD icon Read
search

follicular adenoma

keyword
https://www.readbyqxmd.com/read/28214214/diagnostic-utility-of-ck19-and-cd56-in-the-differentiation-of-thyroid-papillary-carcinoma-from-its-mimics
#1
Nehal S Abouhashem, Suzan M Talaat
BACKGROUND: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. AIM: To evaluate Cytokeratin 19 (CK19) and CD56 immunostains as useful diagnostic markers in distinguishing papillary thyroid carcinoma from other mimicking thyroid lesions. METHODS: Eighty cases of different thyroid lesions were submitted for immunohistochemical staining of CK19 and CD56...
January 22, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28188700/how-suspicious-is-that-nodule-review-of-suspicious-afirma-gene-expression-classifier-in-high-risk-thyroid-nodules
#2
Sudarshana Roychoudhury, Melissa Klein, Fabiola Souza, Cecilia Gimenez, Alice Laser, Rubina Shaheen Cocker, Karen Chau, Kasturi Das
BACKGROUND: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. METHODS: The pathology database was searched for all thyroid nodules with Afirma test results over a three year period, 2013-2015...
February 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28182068/evaluation-of-thyroid-nodules-classified-as-bethesda-category-iii-on-fnac
#3
Shiwani Garg, Leena P Naik, Kanchan S Kothari, Gwendolyn C Fernandes, Mona A Agnihotri, Jagruti C Gokhale
BACKGROUND: The Bethesda (BSRTC) category III has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable. AIM: To evaluate category III with respect to its rate and risk of malignancy and substratify it. SETTINGS AND DESIGN: Atypia of undetermined significance/Follicular lesion of undetermined significance (AUS/FLUS) percentage, cytohistological correlation, and risk of malignancy were analyzed and substratification was done...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#4
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28130940/false-positive-cytopathology-results-for-papillary-thyroid-carcinoma-a-trap-for-thyroid-surgeons
#5
Keun Ik Yi, Sangjeong Ahn, Do Youn Park, Jin-Choon Lee, Byung-Joo Lee, Soo-Geun Wang, Wonjae Cha
OBJECTIVES: Current preoperative diagnosis of thyroid nodules remains imperfect despite recent advances in cytopathology and molecular diagnostics. False-positivity in preoperative fine needle aspiration cytology (FNAC) may lead to overtreatment of patients, including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analyzed clinical characteristics and pathologic findings in patients with false-positivity for papillary thyroid carcinoma (PTC) in FNAC...
January 28, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28112041/braf-k601e-mutation-in-a-follicular-thyroid-adenoma
#6
Elisabetta Macerola, Liborio Torregrossa, Clara Ugolini, Sohail Bakkar, Paolo Vitti, Guido Fadda, Fulvio Basolo
BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. On the other hand, the p.K601E mutation is peculiar to the follicular variant of PTC, and seems to be a favorable prognostic indicator. A 12-year-old boy presented with a 10-mm left-sided thyroid nodule. Fine-needle aspiration cytology reported the lesion as suspicious for a follicular neoplasm (Bethesda category IV)...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28064410/detecting-n-ras-q61r-mutated-thyroid-neoplasias-by-immunohistochemistry
#7
A Crescenzi, F Fulciniti, M Bongiovanni, L Giovanella, Pierpaolo Trimboli
Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled. Paraffin sections were stained for IHC using the rabbit monoclonal anti-human N-RAS Q61R, clone SP174. N-RAS mutations in codon 61 were also investigated by automated sequencing. At histology, 12 cases of follicular carcinoma, cytologically defined as follicular lesions, 1 papillary cancer, 7 follicular adenomas, and 4 hyperplastic nodules were found...
January 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28008451/values-of-molecular-markers-in-the-differential-diagnosis-of-thyroid-abnormalities
#8
REVIEW
T M P B Tennakoon, M Rushdhi, A D C U Ranasinghe, R S Dassanayake
INTRODUCTION: Thyroid cancer (TC), follicular adenoma (FA) and Hashimoto's thyroiditis (HT) are three of the most frequently reported abnormalities that affect the thyroid gland. A frequent co-occurrence along with similar histopathological features is observed between TC and FA as well as between TC and HT. The conventional diagnostic methods such as histochemical analysis present complications in differential diagnosis when these abnormalities occur simultaneously. Hence, the authors recognize novel methods based on screening genetic defects of thyroid abnormalities as viable diagnostic and prognostic methods that could complement the conventional methods...
December 22, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28003924/intrathyroidal-clear-cell-tumor-of-parathyroid-origin-with-review-of-literature
#9
Daniela Pirela, Daniela Treitl, Siba El Hussein, Robert Poppiti, Thomas Mesko, Alex Manzano
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27997422/psma-expression-in-tumor-neovasculature-endothelial-cells-of-follicular-thyroid-adenoma-as-identified-by-molecular-imaging-using-68ga-psma-ligand-pet-ct
#10
Thorsten Derlin, Hans-Heinrich Kreipe, Udo Schumacher, Bisharah Soudah
The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#11
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27979483/minimally-invasive-follicular-thyroid-cancer-treat-as-a-benign-or-malignant-lesion
#12
Aaron Robinson, David Schneider, Rebecca Sippel, Herbert Chen
BACKGROUND: Follicular thyroid cancer is the second most common thyroid cancer, accounting for 10%-15% of all cases. Follicular thyroid carcinomas (FTCs) can be classified into two subtypes: classic (C), which exhibit both vascular and capsular invasion and minimally invasive (MI), which only has limited capsular invasion. Both types, like most well-differentiated thyroid cancers, are traditionally treated the same: a completion thyroidectomy usually followed by radioiodine ablation. We hypothesize that MI-FTC may behave more like a benign follicular adenoma rather than C-FTC and may not require total thyroidectomy and radioiodine...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27978891/-advances-in-studies-of-the-genes-related-to-thyroid-carcinoma
#13
J T Zhi, X Q Zheng, M Gao
Thyroid carcinoma (TC) is the most common endocrine cancer and its incidence has been increasing globally over the past decades. With the development of the genetic technology, more and more evidences showed that many genes affect the biological behaviors of TC, making sense to early diagnosis, predicting the prognosis and targeted therapy for TC. BRAF mutation is specific to papillary thyroid carcinoma (PTC). It can not only predict the prognosis, but also have diagnosis value. RET rearrangements are identified as a specific genetic event in PTC...
December 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27976552/parotidectomy-outcomes-diagnosis-and-complications-on-pediatric-patients-twelve-years-of-experiences-in-a-tertiary-care-center
#14
Oğuz Kuşcu, Bahar Kayahan, Övsen Önay, Rıza Önder Günaydın, Mehmet Umut Akyol
The aim of this study is to evaluate parotid masses management in pediatric population. From June 2002 to December 2014, 13 patients under the age of 18 with parotid tumors were treated via surgery at Hacettepe University Department of Otorhinolaryngology. Information on patients' demographics, clinical and histopathologic tumor characteristics and treatment modalities with results was obtained from medical records, retrospectively. The age was ranging between 8-17 years. Ten (76.9%) patients had benign tumors and 8 (61...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27943373/most-thyroid-cancers-detected-by-sonography-lack-intranodular-vascularity-on-color-doppler-imaging-review-of-the-literature-and-sonographic-pathologic-correlations-for-698-thyroid-neoplasms
#15
Grace C H Yang, Karen O Fried
OBJECTIVES: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation. METHODS: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. RESULTS: The data were collected from 698 patients (557 women and 141 men) with a mean age of 48 years (range, 16-87 years)...
December 1, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27936964/preoperative-serum-thyroglobulin-and-changes-in-serum-thyroglobulin-during-tsh-suppression-independently-predict-follicular-thyroid-carcinoma-in-thyroid-nodules-with-a-cytological-diagnosis-of-follicular-lesion
#16
Hye Jeong Kim, Ji-Oh Mok, Chul Hee Kim, Yeo Joo Kim, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
BACKGROUND: Fine-needle aspiration biopsy (FNAB) cannot distinguish a follicular thyroid carcinoma (FTC) from a follicular adenoma in follicular lesions. We designed this study to determine whether the preoperative thyroglobulin (Tg) and change in serum Tg during thyroid-stimulating hormone (TSH) suppression can predict FTC in thyroid nodules with a cytological diagnosis of follicular lesion. METHODS: Among 854 patients who underwent thyroid surgery, the 198 patients who presented with thyroid nodules with a cytological diagnosis of follicular lesion were analyzed...
December 12, 2016: Endocrine Research
https://www.readbyqxmd.com/read/27929599/surgical-management-of-parapharyngeal-space-tumors-the-role-of-cervical-and-lateral-skull-base-approaches
#17
Arturo Mario Poletti, Siba P Dubey, Giovanni Colombo, Giovanni Cugini
We conducted a retrospective study to analyze the role of the cervical and lateral skull base approaches in the surgical excision of parapharyngeal space (PPS) tumors. Our study population was made up of 34 patients-15 males and 19 females, aged 13 to 73 years (mean: 50.6)-who had presented to us with a PPS tumor during a 9-year period. The 34 cases included 23 benign tumors and 11 malignancies. The 23 benign tumors consisted of 11 pleomorphic adenomas, 5 schwannomas, 2 paragangliomas, 2 Warthin tumors, 1 oncocytoma, 1 hamartoma, and 1 osteochondroma...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27914217/hla-g-3-untranslated-region-polymorphic-sites-associated-with-increased-hla-g-production-are-more-frequent-in-patients-exhibiting-differentiated-thyroid-tumors
#18
Nathalie Lobo de Figueiredo-Feitosa, Gustavo Martelli Palomino, Daiani Cristina Cilião Alves, Celso Teixeira Mendes Junior, Eduardo Antonio Donadi, Léa Maria Zanini Maciel
BACKGROUND: HLA-G is a non-classical class I histocompatibility molecule implicated on the immune escape mechanism of tumor cells. We evaluated the genetic diversity of HLA-G 3' untranslated region (3'UTR) and associated polymorphic sites with clinical presentation and with the magnitude of HLA-G thyroid expression. PATIENTS AND METHODS: Polymorphic sites at 3'UTR (14bpINS/DEL, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G, +3196C/G) were characterized by sequencing analyses in blood samples of 72 patients exhibiting papillary thyroid carcinoma (PTC), 22 follicular thyroid carcinomas (FTC), 19 follicular adenomas (FA), 21 colloid goiters and 156 healthy controls...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27904595/cd56-hbme-1-and-cytokeratin-19-expressions-in-papillary-thyroid-carcinoma-and-nodular-thyroid-lesions
#19
Senay Erdogan-Durmus, Deniz Ozcan, Enver Yarikkaya, Ali Kurt, Aynur Arslan
BACKGROUND: Carcinomas of the thyroid follicular epithelium are the most common cancers of the endocrine system. In the diagnosis of thyroid nodules and tumors, the gold standard is histological evaluation. In cases which have morphological overlap, immunohistochemistry is needed for differential diagnosis. The purpose of this study is to investigate the expressions of CD56, HBME-1, cytokeratin 19 (CK19) antibodies in papillary thyroid carcinoma (PTC) and thyroid nodular lesions and their contributions to differential diagnosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903245/the-predictive-value-of-sonographic-images-of-follicular-lesions-a-comparison-with-nodules-unequivocal-in-fna-single-centre-prospective-study
#20
Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz, Mariusz Klencki
BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN). METHODS: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically...
December 1, 2016: BMC Endocrine Disorders
keyword
keyword
58744
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"