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follicular adenoma

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https://www.readbyqxmd.com/read/27904595/cd56-hbme-1-and-cytokeratin-19-expressions-in-papillary-thyroid-carcinoma-and-nodular-thyroid-lesions
#1
Senay Erdogan-Durmus, Deniz Ozcan, Enver Yarikkaya, Ali Kurt, Aynur Arslan
BACKGROUND: Carcinomas of the thyroid follicular epithelium are the most common cancers of the endocrine system. In the diagnosis of thyroid nodules and tumors, the gold standard is histological evaluation. In cases which have morphological overlap, immunohistochemistry is needed for differential diagnosis. The purpose of this study is to investigate the expressions of CD56, HBME-1, cytokeratin 19 (CK19) antibodies in papillary thyroid carcinoma (PTC) and thyroid nodular lesions and their contributions to differential diagnosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903245/the-predictive-value-of-sonographic-images-of-follicular-lesions-a-comparison-with-nodules-unequivocal-in-fna-single-centre-prospective-study
#2
Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz, Mariusz Klencki
BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN). METHODS: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically...
December 1, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27872746/a-prospective-cohort-study-to-assess-the-role-of-fdg-pet-in-differentiating-benign-and-malignant-follicular-neoplasms
#3
K Alok Pathak, Andrew L Goertzen, Richard W Nason, Thomas Klonisch, William D Leslie
BACKGROUND: Follicular and Hürthle cell neoplasms are diagnostic challenges. This prospective study was designed to evaluate the efficacy of [18F]-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in predicting the risk of malignancy in follicular/Hürthle cell neoplasms. MATERIALS AND METHODS: Fifty thyroid nodules showing follicular/Hürthle cell neoplasm on prior ultrasonography guided fine needle aspiration cytology (FNAC) were recruited into this study...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27870787/can-nodular-hyperplasia-of-the-thyroid-gland-be-differentiated-from-follicular-adenoma-and-follicular-carcinoma-by-ultrasonography
#4
Sun Hye Jeong, Hyun Sook Hong, Eun Hye Lee
OBJECTIVES: The aim of this study was to evaluate the ultrasonographic features for differentiation of follicular thyroid lesions. METHODS: Ultrasonographic features of surgically confirmed 56 follicular adenoma (FA), 22 follicular carcinoma (FC), and 100 nodular hyperplasia (NH) were evaluated using univariable and multivariable multinomial logistic regression analyses, receiver operating characteristic analyses, and areas under the curve. RESULTS: Tumor diameter, margin, echotexture, cystic changes, calcification, hypoechoic rim, and vascularity were significant on univariable analysis...
December 2016: Ultrasound Quarterly
https://www.readbyqxmd.com/read/27852075/thyroid-atypia-follicular-lesion-of-undetermined-significance-attitudes-towards-the-diagnosis-of-bethesda-system-iii-nodules
#5
Lourdes Estrada Muñoz, Cristina Díaz Del Arco, Luis Ortega Medina, M Jesús Fernández Aceñero
OBJECTIVES: To review our institutional experience and to analyze the clinical decisions made after a cytological diagnosis of atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS). STUDY DESIGN: This is a retrospective review of all thyroid fine-needle aspiration (FNA) cytologies performed in the Hospital Clínico San Carlos (Madrid) between 2010 and 2014. RESULTS: One hundred thirty thyroid FNA were categorized as AUS/FLUS (5%)...
November 17, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27847655/surgical-management-of-life-threatening-thyroid-haematoma-following-occult-blunt-neck-trauma
#6
Ronak Ved, Neil Patel, Michael Stechman
A 42-year-old man arrived at the emergency department in severe respiratory distress, requiring immediate intubation and ventilation. An emergency computed tomography (CT) neck scan identified a substantial haematoma within a multinodular goitre, necessitating an emergency total thyroidectomy. It was later discovered that the patient had been the victim of an assault involving blunt trauma to the anterior neck. Five days postoperatively the patient was extubated and was well enough to self-discharge the following day...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27816963/defective-ciliogenesis-in-thyroid-h%C3%A3-rthle-cell-tumors-is-associated-with-increased-autophagy
#7
Junguee Lee, Shinae Yi, Yea Eun Kang, Joon Young Chang, Jung Tae Kim, Hae Joung Sul, Jong Ok Kim, Jin Man Kim, Joon Kim, Anna Maria Porcelli, Koon Soon Kim, Minho Shong
Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditis, follicular tumor, Hürthle cell tumor, and papillary carcinoma to observe the distribution of primary cilia. The distribution and length of primary cilia facing the follicular lumen were uniform across variable-sized follicles in the normal thyroid gland...
October 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27809694/low-elasticity-of-thyroid-nodules-at-ultrasound-elastography-is-correlated-with-malignancy-degree-of-fibrosis-and-high-expression-of-galectin-3-and-fibronectin-1
#8
Teresa Rago, Maria Scutari, Valeria Loiacono, Ferruccio Santini, Massimo Tonacchera, Liborio Torregrossa, Riccardo Giannini, Nicla Borrelli, Agnese Proietti, Fulvio Basolo, Paolo Miccoli, Paolo Piaggi, Francesco Latrofa, Paolo Vitti
BACKGROUND: Thyroid ultrasound elastography (US elastography) provides an estimation of tissue stiffness and is helpful to differentiate malignant from benign lesions. Tissue proprieties and molecules causing stiffness are not established. The aim of the study was to correlate US elastography findings with tissue properties in thyroid nodules. METHODS: 115 thyroid nodules from 112 patients who underwent surgery for the presence of of Thy 3 (indeterminate) cytology (n=67), Thy 4-5 (suspicious-indicative of carcinoma) cytology (n= 47) or large goiter in the presence of Thy 2 cytology (n= 1) and suspicious US features were examined by US elastography...
November 3, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27804857/histopathology-immunohistochemistry-and-molecular-biology-of-follicular-epithelium-derived-pediatric-thyroid-carcinomas
#9
Claudio Spinelli, Paola Collini, Marta Barisella, Angela Greco
Thyroid carcinomas derived from the follicular epithelium are rare in children up to 18 years of age. While the morphological features are superimposable in children and adults, the age at onset is relevant to both the frequency of histotypes and variants, and to their biologic behaviour. Papillary carcinomas (PCs) represent more than 90% of cases. Follicular carcinomas (FCs) rarely occur, and they are mostly represented by minimally invasive (encapsulated) FCs (MIFCs). Poorly differentiated carcinomas (PDCs) are very rare, while anaplastic (undifferentiated) carcinomas are practically nonexistent...
November 1, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27796194/aplp2-rrm2-and-prc1-new-putative-markers-for-the-differential-diagnosis-of-thyroid-follicular-lesions
#10
Esmeralda Castelblanco, Carles Zafon, Javier Maravall, Pilar Gallel, Montserrat Martinez, Ismael Capel, Maria Rosa Bella, Irene Halperin, Jordi Temprana, Carmela Iglesias, Manel Puig-Domingo, Mercedes Robledo, Xavier Matias-Guiu, Didac Mauricio
BACKGROUND: Current methods based on fine-needle aspiration biopsy (FNAB) are not sufficient to distinguish among follicular thyroid lesions, follicular adenoma (FA), follicular thyroid carcinoma (FTC), and the follicular variant of papillary thyroid cancer (FVPTC). Furthermore, none of the immunohistochemical markers currently available are sensitive or specific enough to be used in the clinical setting, necessitating a diagnostic hemithyroidectomy. The aim of this study was to identify proteins of value for differential diagnosis between benign and malignant thyroid follicular lesions...
November 30, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27776688/cytogenetic-status-and-oxidative-stress-parameters-in-patients-with-thyroid-diseases
#11
Marko Gerić, Ana Marija Domijan, Valentina Gluščić, Renato Janušić, Božena Šarčević, Vera Garaj-Vrhovac
Since the incidence of cancer has increased over the years, adequate prevention programmes are needed. Thyroid cancer is one of the fastest growing cancer types in the world. In this study we performed a case-control study of 100 untreated patients with thyroid diseases (papillary thyroid cancer, follicular thyroid adenoma, and other thyroid diseases) and 100 control volunteers. Oxidative status differed among the two investigated groups. The patients' group had 1.60-fold higher concentrations of malondialdehyde and 1...
November 1, 2016: Mutation Research
https://www.readbyqxmd.com/read/27773907/subacute-cerebellar-ataxia-with-amphiphysin-antibody-developing-in-a-patient-with-follicular-thyroid-adenoma-a-case-report
#12
Tomoki Hirunagi, Katsunori Sato, Masahiko Fujino, Keiko Tanaka, Yoji Goto, Kazuo Mano
The patient was a 61-year-old woman with thyroid enlargement since her 20s. She began to fall down repeatedly towards the end of June 2015. She was admitted to our hospital in the middle of August because of difficulty in walking. Upon admission, she presented with neck tremor and was unable to maintain a sitting position due to ataxia of the trunk and limbs. We studied serum anti-neuronal antibodies and obtained a positive result for anti-amphiphysin antibody (AMPH-Ab). Cerebrospinal fluid analysis revealed elevated protein levels and IgG index...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27760791/tert-promoter-mutations-a-genetic-signature-of-benign-and-malignant-thyroid-tumours-occurring-in-the-context-of-tinea-capitis-irradiation
#13
Paula Boaventura, Rui Batista, Ana Pestana, Marta Reis, Adélia Mendes, Catarina Eloy, Manuel Sobrinho-Simoes, Paula Soares
Objective - The aim of this study is to evaluate the frequency and molecular characteristics of TERTp mutations in thyroid adenomas and carcinomas occurring in the low dose radiation exposure tinea capitis setting. Design and methods - Twenty seven patients with 34 well differentiated thyroid carcinomas and 28 patients with 29 follicular adenomas diagnosed in a Portuguese tinea capitis cohort of 1375 patients, were studied. Blood samples were obtained from all the patients. Screening for TERTp mutations was performed by PCR amplification followed by Sanger sequencing...
October 19, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27717284/young-investigator-challenge-the-morphologic-analysis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-liquid-based-cytology-some-insights-into-their-identification
#14
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
https://www.readbyqxmd.com/read/27626165/mutational-burdens-and-evolutionary-ages-of-thyroid-follicular-adenoma-are-comparable-to-those-of-follicular-carcinoma
#15
Seung-Hyun Jung, Min Sung Kim, Chan Kwon Jung, Hyun-Chun Park, So Youn Kim, Jieying Liu, Ja-Seong Bae, Sung Hak Lee, Tae-Min Kim, Sug Hyung Lee, Yeun-Jun Chung
Follicular thyroid adenoma (FTA) precedes follicular thyroid carcinoma (FTC) by definition with a favorable prognosis compared to FTC. However, the genetic mechanism of FTA to FTC progression remains unknown. For this, it is required to disclose FTA and FTC genomes in mutational and evolutionary perspectives. We performed whole-exome sequencing and copy number profiling of 14 FTAs and 13 FTCs, which exhibited previously-known gene mutations (NRAS, HRAS, BRAF, TSHR and EIF1AX) and copy number alterations (CNAs) (22q loss and 1q gain) in follicular tumors...
September 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27586203/mirna-expression-profiling-of-noninvasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-compared-with-adenomas-and-infiltrative-follicular-variants-of-papillary-thyroid-carcinomas
#16
Nicla Borrelli, Maria Denaro, Clara Ugolini, Anello Marcello Poma, Mario Miccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Follicular variants of papillary thyroid carcinoma include encapsulated (with or without capsular/vascular invasion) and infiltrative forms, which have different clinical behaviors. The encapsulated forms that lack capsular invasion have an indolent clinical behavior that is similar to benign lesions; therefore, they were recently reclassified as 'noninvasive follicular thyroid neoplasms with papillary-like nuclear features' (NIFTPs). Because NIFTPs have nuclear features of papillary carcinomas, distinguishing between NIFTPs and infiltrative follicular variant of papillary thyroid carcinoma is almost impossible with cytological examination...
September 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27567273/immunohistochemical-detection-of-pax8-and-napsin-a-in-canine-thyroid-tumours-comparison-with-thyroglobulin-calcitonin-and-thyroid-transcription-factor-1
#17
J A Ramos-Vara, C B Frank, D DuSold, M A Miller
Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81 follicular tumours expressed thyroglobulin and were negative for calcitonin; 79/81 (98%) of these tumours expressed TTF-1 and Pax8 and 60/81 (74%) expressed napsin A...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27559247/historical-control-background-incidence-of-spontaneous-thyroid-and-parathyroid-glands-lesions-of-rats-and-cd-1-mice-used-in-104-week-carcinogenicity-studies
#18
Kaori Isobe, Sydney Mukaratirwa, Claudio Petterino, Alys Bradley
The incidence and range of spontaneous thyroid and parathyroid glands findings were determined in control Han-Wistar and Sprague-Dawley rats, and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the thyroid or parathyroid glands were generally uncommon apart from some findings in CD-1 mice such as ultimobranchial duct/cyst (5.72%), follicular distension/dilatation (3.84%), and cystic follicles (3...
July 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/27515261/histopathologic-findings-in-uterus-and-ovaries-collected-from-clinically-healthy-dogs-at-elective-ovariohysterectomy-a-cross-sectional-study
#19
Daniel Maya-Pulgarin, María S Gonzalez-Dominguez, Diego Aranzazu-Taborda, Natalia Mendoza, Juan G Maldonado-Estrada
Ovariohysterectomy (OHE) of bitches is a matter of conflict depending on the region and country in the world. In a descriptive, prospective cross-sectional study uterine tracts and ovaries exhibiting gross pathologic findings (n = 76) were collected post-surgery from a reference population of 3600 bitches (2,11% incidence) undergoing elective ovariohysterectomy during the warm-humid season (September-to-November 2013, average 26ºC) and were evaluated by histopathology examination. Data were evaluated by descriptive statistics and Chi-Squared test...
August 10, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27504318/parathyroid-adenoma-completely-impacted-within-the-thyroid-gland-a-case-report
#20
Sayed Mahmoud Mirhosaini, Soroush Amani, Rana Fereidani
Ectopic parathyroid adenoma can be seen in various locations. Sometimes ultrasound and even fine needle aspiration studies cannot distinguish this lesion from thyroid lesions. A 29-year-old woman with a prominent nodule of left thyroid lobe was referred to surgical department. Thyroid function test were normal. She had no family history of parathyroid disease, other endocrine disease, and any other malignancies and had received no radiation. Ultrasonography revealed a solid and hypoechoic mass, 25x20 mm in size, with a regular shape and contour without calcification in the inferior of left lobe of the thyroid gland...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
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