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https://www.readbyqxmd.com/read/29914397/association-of-chlamydia-trachomatis-infections-with-preterm-delivery-a-systematic-review-and-meta-analysis
#1
Amjad Ahmadi, Rashid Ramazanzadeh, Koroush Sayehmiri, Fatemeh Sayehmiri, Nour Amirmozafari
BACKGROUND: Premature birth is a primary cause of infant mortality and its etiology varies in different countries. Chlamydia trachomatis (CT) is a common infectious agent transmitted through sexual contact. The purpose of this study is to investigate the connection between CT infections and preterm birth by meta-analysis. METHODS: All articles published in literature databases including Google Scholar, PubMed, ISI (Web of Science), Biological Abs, IranMedex, SID, and Scopus were investigated...
June 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29912592/breast-cancer-during-pregnancy-results-of-maternal-and-perinatal-outcomes-in-a-single-institution-and-systematic-review-of-the-literature
#2
Natalia R Gomez-Hidalgo, Elsa Mendizabal, Laura Joigneau, Pilar Pintado, Juan De Leon-Luis
To compare the maternal and the perinatal variables of the patients with pregnancy associated breast cancer (PABC) and the pregnant patients without breast cancer (PNABC), we retrospectively included 13 PABC cases and 66.265 PNABC patients. The PABC patients presented a lower mean gestational age at their delivery and had higher induction of labour and prematurity rates. A diagnosis was performed before stage III in 77% of the cases. The overall survival was 90%; moreover, we collected 16 manuscripts when gathering data from 1581 patients with PABC...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#3
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29907917/neurologic-consequences-of-preterm-birth
#4
REVIEW
Margie A Ream, Lenora Lehwald
PURPOSE OF REVIEW: Preterm birth is the leading cause of death worldwide in children < 5 years of age; however, technology and advances in medical knowledge are increasing the survival of children born even at the fringes of viability. With increased survival comes increased risk of long-term neurologic impairments. This paper aims to review recent findings related to changes in brain development associated with prematurity and its impact on neurodevelopmental disabilities. RECENT FINDINGS: Advanced imaging techniques, longitudinal follow-up of individuals born extremely preterm into adulthood and improved understanding of risk factors associated with neurologic impairment contribute to recent discoveries...
June 16, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#5
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#6
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905542/the-features-of-the-women-s-simpathoadrenal-system-functional-state-with-risk-of-early-pregnancy-termination
#7
S Korovay
Preterm labor is an urgent medical-social and demographic issue at the present stage. A considerable number of factors affects the course of pregnancy and its outcome, their effect is realized at the level of the central nervous system through numerical metabolic interactions, where monoaminergic systems play an important role. Objective - to study the features of the sympathoadrenal system state by determining the excretion level of DOPHA, dopamine, norepinephrine and epinephrine in women's daily urine with different periods of abortion...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29901986/ultrasound-triggered-conversion-of-porphyrin-camptothecin-fluoroxyuridine-triad-microbubbles-into-nanoparticles-overcomes-multidrug-resistance-in-colorectal-cancer
#8
Min Chen, Xiaolong Liang, Chuang Gao, Ranran Zhao, Nisi Zhang, Shumin Wang, Wen Chen, Bo Zhao, Jinrui Wang, Zhifei Dai
Multidrug resistance remains a major obstacle to efficient chemotherapy of colorectal cancer. Herein, an efficient drug delivery and combination therapeutic strategy is proposed based on porphyrin/camptothecin-fluxoridine triad microbubbles (PCF-MBs), which show remarkably high drug loading content, highly stable co-delivery drug combinations and no premature release. The triad PCF-MBs can act not only as a contrast agent for ultrasound/fluorescence bi-modal imaging but also a multi-modal therapeutic agent for synergetic combined chemo-photodynamic therapy...
June 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29898693/peripartum-fetal-distress-in-diabetic-women-a-retrospective-case-cohort-study
#9
B Castelijn, Kwp Hollander, J F Hensbergen, R G IJzerman, A W Valkenburg-van den Berg, Jwr Twisk, Cjm De Groot, Mgaj Wouters
BACKGROUND: Major concerns of pregnancies complicated by diabetes mellitus are an increased risk of adverse perinatal outcome. The objective of this study was to analyse the rate of fetal distress during labor in women with type 1, type 2 and gestational diabetes compared to control women. METHODS: A retrospective case-cohort study was conducted at the VU University Medical Center, Amsterdam; a tertiary care hospital. 117 women with type 1 diabetes, 59 women with type 2 diabetes, 303 women with gestational diabetes and 15,260 control women were included, who delivered between March 2004 and February 2014...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29896230/s-adenosyl-methionine-regulates-calcium-channels-and-inhibits-uterine-smooth-muscle-contraction-in-rats-with-infectious-premature-delivery-through-the-transient-receptor-protein-3-protein-kinase-c%C3%AE-c-kinase-activated-protein-phosphatase-1-inhibitor-of-17-kda
#10
Jing Ge, Tao Han, Xiaoqiu Li, Lili Shan, Jinhuan Zhang, Yan Hong, Yanqiu Xia, Jun Wang, Mingxiao Hou
The aim of the present study was to investigate the effects of S-adenosyl methionine (SAMe) on infectious premature inflammatory factors and uterine contraction, and to further explore its mechanism of action via the transient receptor protein 3 (TRPC3)/protein kinase Cβ (PKCβ)/C-kinase-activated protein phosphatase-1 inhibitor of 17 kDa (CPI-17) signaling pathway, following intervention by a TRPC3 inhibitor. A rat model of premature delivery induced by lipopolysaccharide (LPS) was established. Following treatment with SAMe and inhibiting TRPC3 expression, rat serum and uterus were isolated...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29892210/recurrent-risk-of-preterm-birth-in-the-third-pregnancy-in-korea
#11
Yung-Taek Ouh, Jong Heon Park, Ki Hoon Ahn, Soon-Cheol Hong, Min-Jeong Oh, Hai-Joong Kim, Sung Won Han, Geum Joon Cho
Background: Although preterm delivery is the most common cause of infant morbidity and mortality, an obvious cause cannot be found in most cases. Preterm delivery is known to be the most important risk factor for preterm birth in a subsequent pregnancy. We aimed to evaluate the recurrence rate of premature births for subsequent pregnancies in women with a history of a preterm birth. Methods: Study data were collected from the Korea National Health Insurance (KNHI) claims database and data from a national health-screening program for infants and children...
June 11, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29888663/-effect-of-the-treatment-of-periodontal-disease-on-the-outcome-of-pregnancy
#12
Tibor Novák, Márta Radnai, Zoltán Kozinszky, Nándor Práger, László Hodoniczki, István Gorzó, Gábor Németh
INTRODUCTION: Correlations between periodontitis and its effects on the outcome of pregnancies are actually more focused topics. Maternal motivation for a good oral hygiene and preventive dental treatment must be highlighted tasks during pregnancy care. AIM: The authors analysed the effect of the preventive dental treatment during pregnancy and its obstetrical effects. METHOD: In a prospective randomised study, including pregnant women observed for threatening preterm deliveries, patients with dental examination (n = 71) were compared with patients undergoing dental treatment at the same time (n = 79)...
June 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29886805/psychosocial-and-biological-paternal-role-in-pregnancy-outcomes
#13
Maryam Kashanian, Masoomeh Faghankhani, Hasti Hadizadeh, MMasoud Salehi, Masoomeh YousefzadehRoshan, Mohammad EhsaniPour, Ladan Sayyah, Narges Sheikhansari
BACKGROUND: Pregnancy outcomes are affected by many different factors. One of the influential factors on pregnancy outcomes is the male partner as an important person to mother's wellbeing. OBJECTIVE: The aim of the present study was to investigate the effects of male partner's role including socioeconomic support, emotional support, accompanying pregnant women during prenatal care visits (PNC) and labor, and the level of pregnant women's satisfaction from their partners' support and involvement during pregnancy on pregnancy outcomes...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886774/labor-induction-in-indicated-moderate-to-late-preterm-birth
#14
Charline Bertholdt, Olivier Morel, Matthieu Dap, Marion Choserot, Hélène Minebois
INTRODUCTION: The primary objective of the study was to evaluate the success of labor induction for indicated moderate and late preterm birth. As secondary objectives, the mode of delivery was assessed. MATERIAL AND METHODS: This is an observational study conducted in a tertiary care unit between 2013 and 2015. All patients who underwent labor induction for indicated preterm birth between 32 + 0 and 36 + 6 weeks of gestation (as premature rupture of membranes, preeclampsia, intrauterine growth restriction, fetomaternal alloimmunization, or intrahepatic cholestasis) were included...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29885528/glutathione-detonated-and-ph-responsive-nano-clusters-of-au-nanorods-with-a-high-dose-of-dox-for-treatment-of-multidrug-resistant-cancer
#15
Yun Wang, Feihu Wang, Ying Liu, Shaohui Xu, Yuanyuan Shen, Nianping Feng, Shengrong Guo
Effects of nanosized drug delivery systems on cancer are often compromised due to their low drug loadings, premature drug release and multi-drug resistance (MDR). Herein, we reported a glutathione detonated and pH responsive nano-cluster of Au nanorods (AuNRs) with chemotherapeutic doxorubicin (DOX) and pre-chemosensitizer polycurcumin to treat MCF-7/ADR cells. The nano-cluster was prepared by self-assembling of AuNRs conjugated with DOX and amphiphilic poly(curcumin-co-dithiodipropionic acid)-b-biotinylated poly(ethylene glycol) via an emulsion/solvent evaporation technique, termed AuNR Cluster...
June 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29885371/consequences-of-brucellosis-infection-during-pregnancy-a-systematic-review-of-the-literature
#16
REVIEW
Manal Alsaif, Kamal Dabelah, Robin Featherstone, Joan L Robinson
BACKGROUND: The aim was to establish the incidence of adverse outcomes with brucellosis infection during pregnancy. METHODS: Ovid Medline (1946-), Ovid Embase (1974-), and Web of Science (Clarivate Analytics) (1900-), the World Health Organization website and Google were searched September 27, 2017 for i) outcomes with brucellosis diagnosed during pregnancy and ii) studies with retrospective diagnosis of maternal brucellosis following adverse pregnancy outcomes...
June 6, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29884919/preeclampsia-risks-in-kidney-donors-and-recipients
#17
REVIEW
Pratik B Shah, Manpreet Samra, Michelle A Josephson
PURPOSE OF REVIEW: To review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients. RECENT FINDINGS: There is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29884712/salvage-therapy-for-acute-severe-ulcerative-colitis-during-pregnancy
#18
Manjri Raval, Matthew C Choy, Peter De Cruz
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an age of onset that affects young people during the peak of their reproductive years. Management of flares of disease during pregnancy can be complex and there are few case reports of pregnant women with acute severe ulcerative colitis (ASUC). We present the case of a 31-year-old pregnant woman who at 16 weeks gestation developed ASUC in the context of primary non-response to infliximab therapy. She subsequently underwent an emergency laparoscopic colectomy after failing to respond to hydrocortisone and cyclosporine salvage therapy...
June 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29883983/the-relationship-of-assisted-reproductive-technology-on-perinatal-outcomes-in-triplet-gestations
#19
Jaimin S Shah, Tania Roman, Oscar A Viteri, Ziad A Haidar, Alejandra Ontiveros, Baha M Sibai
OBJECTIVE:  To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception. STUDY DESIGN:  Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death...
June 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29883808/polymeric-microsphere-facilitated-site-specific-delivery-of-quercetin-prevents-senescence-of-pancreatic-islets-in-vivo-and-improves-transplantation-outcomes-in-mouse-model-of-diabetes
#20
Shiva Pathak, Shobha Regmi, Tiep Tien Nguyen, Biki Gupta, Milan Gautam, Chul Soon Yong, Jong Oh Kim, Youlim Son, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, So Young Park, Daewon Jeong, Simmyung Yook, Jee-Heon Jeong
Attenuation of senescence progression may be attractive way to preserve the functionality of pancreatic islets (PI) after transplantation. In this study, we developed a model for in vitro induction of premature senescence in rat PI and showed the effectiveness of quercetin (QU) to prevent the senescence. To provide targeted-delivery of QU to the PI after transplantation, we prepared the hybrid clusters (HC) of islet single cells (ISC) and QU-loaded polymeric microspheres (QU; ∼7.55 ng HC-1 ). Long-term culture of the HC revealed reduced levels of reactive oxygen species and decreased expression of senescence-associated beta galactosidase, Rb, p53, p16, and p21 compared to that of the control islets...
June 5, 2018: Acta Biomaterialia
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