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https://www.readbyqxmd.com/read/29223789/medical-and-developmental-outcomes-of-bevacizumab-versus-laser-for-retinopathy-of-prematurity
#1
Kathleen A Kennedy, Helen A Mintz-Hittner
BACKGROUND: Infants with stage 3+ retinopathy of prematurity (ROP) in zone I or zone II posterior were randomized to initial treatment with bevacizumab or laser in a multicenter trial (BEAT-ROP). The purpose of this study was to assess the effects of bevacizumab on nonophthalmologic outcomes. METHODS: At one study site, inborn infants of <27 weeks' gestational age underwent medical and standardized neurologic and developmental assessments at 18-22 months' corrected age (age after expected date of full-term delivery)...
December 6, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29222972/factors-associated-with-adverse-pregnancy-outcomes-in-women-with-systematic-lupus-erythematosus
#2
Masashi Deguchi, Yoko Maesawa, Shino Kubota, Mayumi Morizane, Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
The aim of this prospective study was to determine clinical factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus (SLE). Fifty-six pregnancies from 46 women with SLE were enrolled. Risk factors for pregnancy loss, premature delivery, hypertensive disorders of pregnancy (HDP), and light-for-date neonate (LFD), were evaluated. Univariate and multivariate logistic regression analyses revealed a history of two or more pregnancy losses before 10 gestational weeks (GW) (OR 11...
November 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29222900/comparisons-of-proteomic-profiles-of-whey-protein-between-donor-human-milk-collected-earlier-than-3-months-and-6-months-after-delivery
#3
Won-Ho Hahn, Joon-Hwan Song, Jong-Bok Seo, Jung Eun Lee, Jeong-Sang Lee, Seunghyun Song, Joohyun Lee, Nam Mi Kang
BACKGROUND AND OBJECTIVES: Human milk has nutritional, protective, and developmental advantages for premature infants. However, proteomic information of low abundant protein of donor milk is insufficient. The purpose of this study is to analyze and compare the proteome of low abundant protein of donor milk obtained at different postpartum ages other than the colostrum. METHODS AND STUDY DESIGN: Donor breast milk from 12 healthy mothers was collected 15 days, 2 months and 6 months after delivery and stored by medically approved methods...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29217686/synaptic-regulator-%C3%AE-synuclein-in-dopaminergic-fibers-is-essentially-required-for-the-maintenance-of-subependymal-neural-stem-cells
#4
Ana Perez-Villalba, Mª Salomé Sirerol-Piquer, Germán Belenguer, Raúl Soriano-Cantón, Ana Belén Muñoz-Manchado, Javier Villadiego, Diana Alarcón-Arís, Federico N Soria, Benjamin Dehay, Erwan Bezard, Miquel Vila, Analía Bortolozzi, Juan José Toledo-Aral, Francisco Pérez-Sánchez, Isabel Fariñas
Synaptic protein α-synuclein (α-SYN) modulates neurotransmission in a complex and poorly understood manner and aggregates in the cytoplasm of degenerating neurons in Parkinson's disease. Here, we report that α-SYN present in dopaminergic nigral afferents is essential for the normal cycling and maintenance of neural stem cells (NSCs) in the brain subependymal zone of adult male and female mice. We also show that premature senescence of adult NSCs into non-neurogenic astrocytes in mice lacking α-SYN resembles the effects of dopaminergic fiber degeneration resulting from chronic exposure to MPTP or intranigral inoculation of aggregated toxic α-SYN...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217291/pregnancy-outcomes-in-adult-patients-with-dermatomyositis-and-polymyositis
#5
Kathleen D Kolstad, David Fiorentino, Shufeng Li, Eliza F Chakravarty, Lorinda Chung
OBJECTIVE: The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are autoimmune diseases that can affect females of childbearing potential. We assessed pregnancy outcomes in DM and PM patients compared with the general obstetric population. METHODS: The Nationwide Inpatient Sample (NIS) (1993-2007) was used to identify delivery-associated hospitalizations in women with DM or PM (DM/PM, n = 853). Controls were from the general obstetric population delivery-associated hospitalizations matched to each case by year of delivery...
November 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29214476/acute-effects-of-air-pollution-on-spontaneous-abortion-premature-delivery-and-stillbirth-in-ahvaz-iran-a-time-series-study
#6
Maryam Dastoorpoor, Esmaeil Idani, Gholamreza Goudarzi, Narges Khanjani
Living in areas with high air pollution may have adverse effects on human health. There are few studies about the association between breathing polluted air and adverse pregnancy outcomes in the Middle East. The aim of this study was to determine the relationship between air pollution and spontaneous abortion, premature birth, and stillbirth in Ahvaz. A time-series study was conducted. Data about spontaneous abortion, premature deliveries, and stillbirth was collected from Ahvaz Imam Khomeini Hospital. Air pollution data including NO, CO, NO2, PM10, SO2, O3, and climate data were, respectively, collected from the Environmental Protection Agency and the Khuzestan Province Meteorology Office from March 2008 until March 2015...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29207822/estimation-of-correlation-between-chronological-age-skeletal-age-and-dental-age-in-children-a-cross-sectional-study
#7
Madhulika Macha, Bharti Lamba, Jogendra Sai Sankar Avula, Sridhar Muthineni, Pratap Gowd Jai Shankar Margana, Prasad Chitoori
Introduction: In the modern era, identification and determination of age is imperative for diversity of reasons that include disputed birth records, premature delivery, legal issues and for validation of birth certificate for school admissions, adoption, marriage, job and immigration. Several growth assessment parameters like bone age, dental age and the combination of both have been applied for different population with variable outcomes. It has been well documented that the chronological age does not necessarily correlate with the maturational status of a child...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205651/gut-microbiota-in-early-life-and-its-influence-on-health-and-disease-a-position-paper-by-the-malaysian-working-group-on-gastrointestinal-health
#8
Yeong Yeh Lee, Siti Asma Hassan, Intan Hakimah Ismail, Sze Yee Chong, Raja Affendi Raja Ali, Syafinaz Amin Nordin, Way Seah Lee, Noorizan Abdul Majid
The role of gut microbiota in early life and its impact on gut health and subsequent diseases remain unclear. There is a lack of research and awareness in this area, especially in the Asia-Pacific region, including Malaysia. This paper reports the position of a Malaysian Working Group on some key issues surrounding gut microbiota in early life and its role in gut health and diseases, as well as experts' stand on probiotics and prebiotics. The group reached a consensus that certain factors, including elective caesarean; premature deliveries; complementary feeding; use of antibiotics, prebiotics and/or probiotics; and exposure to the external environmental, have an impact on gut microbiota in early life...
December 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29200852/natural-material-decorated-mesoporous-silica-nanoparticle-container-for-multifunctional-membrane-controlled-targeted-drug-delivery
#9
Yan Hu, Lei Ke, Hao Chen, Ma Zhuo, Xinzhou Yang, Dan Zhao, Suying Zeng, Xincai Xiao
To avoid the side effects caused by nonspecific targeting, premature release, weak selectivity, and poor therapeutic efficacy of current nanoparticle-based systems used for drug delivery, we fabricated natural material-decorated nanoparticles as a multifunctional, membrane-controlled targeted drug delivery system. The nanocomposite material coated with a membrane was biocompatible and integrated both specific tumor targeting and responsiveness to stimulation, which improved transmission efficacy and controlled drug release...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29200473/effect-of-premature-rupture-of-membranes-on-induction-of-labor-a-historical-cohort-study
#10
Sven Kehl, Christel Weiss, Ulf Dammer, Friederike Baier, Florian Faschingbauer, Matthias W Beckmann, Marc Sütterlin, Jutta Pretscher
Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM group); the primary outcome measure was the cesarean section rate...
November 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29196812/early-elective-delivery-for-fetal-ventriculomegaly-are-neurosurgical-and-medical-complications-mitigated-by-this-practice
#11
Clinton D Morgan, Travis R Ladner, George L Yang, Marjorie N Moore, Russell D Parks, William F Walsh, John C Wellons, Chevis N Shannon
PURPOSE: Antenatally diagnosed ventriculomegaly (VM) requires the balance of risks of neurological injury with premature delivery. The purpose of this study was to evaluate outcomes related to early elective delivery due to fetal VM at our institution. METHODS: We retrospectively assessed 120 babies (2008-2012) with antenatally diagnosed fetal VM. Inclusion criteria for ("early") cohort were (1) elective delivery occurred for expedited neurosurgical intervention between 32 and 36 weeks EGA and (2) fetal VM noted on official antenatal ultrasound...
December 1, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29188070/the-first-case-report-of-septic-abortion-resulting-from-%C3%AE-lactamase-negative-ampicillin-resistant-non-typeable-haemophilus-influenzae-infection
#12
Hiroaki Baba, Risako Kakuta, Hasumi Tomita, Minako Miyazoe, Masatoshi Saito, Chihiro Oe, Noriomi Ishibashi, Misa Sogi, Kengo Oshima, Tetsuji Aoyagi, Yoshiaki Gu, Makiko Yoshida, Koichi Tokuda, Shiro Endo, Hisakazu Yano, Mitsuo Kaku
Introduction. This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable Haemophilus influenzae infection. In Japan, BLNAR H. influenzae is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but H. influenzae has not been previously recognized as a causative agent of obstetric or gynaecological infection. Case presentation. A 31-year-old pregnant woman presented at 17 weeks and 6 days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery...
October 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29187645/single-cut-genome-editing-restores-dystrophin-expression-in-a-new-mouse-model-of-muscular-dystrophy
#13
Leonela Amoasii, Chengzu Long, Hui Li, Alex A Mireault, John M Shelton, Efrain Sanchez-Ortiz, John R McAnally, Samadrita Bhattacharyya, Florian Schmidt, Dirk Grimm, Stephen D Hauschka, Rhonda Bassel-Duby, Eric N Olson
Duchenne muscular dystrophy (DMD) is a severe, progressive muscle disease caused by mutations in the dystrophin gene. The majority of DMD mutations are deletions that prematurely terminate the dystrophin protein. Deletions of exon 50 of the dystrophin gene are among the most common single exon deletions causing DMD. Such mutations can be corrected by skipping exon 51, thereby restoring the dystrophin reading frame. Using clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9), we generated a DMD mouse model by deleting exon 50...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29187120/growth-and-neurodevelopmental-outcomes-of-early-high-dose-parenteral-amino-acid-intake-in-very-low-birth-weight-infants-a-randomized-controlled-trial
#14
Maya Balakrishnan, Alishia Jennings, Lynn Przystac, Chanika Phornphutkul, Richard Tucker, Betty Vohr, Bonnie E Stephens, Joseph M Bliss
BACKGROUND: Administration of high-dose parenteral amino acids (AAs) to premature infants within hours of delivery is currently recommended. This study compared the effect of lower and higher AA administration starting close to birth on short-term growth and neurodevelopmental outcomes at 18-24 months corrected gestational age (CGA). METHODS: Infants <1250 g birth weight (n = 168) were randomly assigned in a blinded fashion to receive parenteral nutrition providing 1-2 g/kg/d AA and advancing daily by 0...
March 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29186867/outlook-on-the-application-of-metal-liganded-bioactives-for-stimuli-responsive-release
#15
REVIEW
Gretta C M'bitsi-Ibouily, Thashree Marimuthu, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Pierre P D Kondiah, Viness Pillay
Direct metal-liganded bioactive coordination complexes are known to be sensitive to stimuli such as pH, light, ion activation, or redox cues. This results in the controlled release of the bioactive(s). Compared to other drug delivery strategies based on metal complexation, this type of coordination negates a multi-step drug loading methodology and offers customized physiochemical properties through judicious choice of modulating ancillary ligands. Bioactive release depends on simple dissociative kinetics. Nonetheless, there are challenges encountered when translating the pure coordination chemistry into the biological and physiological landscape...
November 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29179773/sustained-inflations-versus-uk-standard-inflations-during-initial-resuscitation-of-prematurely-born-infants-in-the-delivery-room-a-study-protocol-for-a-randomised-controlled-trial
#16
Katie A Hunt, Kamal Ali, Theodore Dassios, Anthony D Milner, Anne Greenough
BACKGROUND: Many infants born at less than 34 weeks of gestational age will require resuscitation in the delivery suite. Yet, different resuscitation techniques are specified in different national guidelines, likely reflecting a limited evidence base. One difference is the length of mechanical inflation initially delivered to infants either via a facemask or endotracheal tube. Some guidelines specify short inflations delivered at rates of 40-60/min, others recommend initial inflations lasting 2-3 s or sustained inflations lasting for ≥ 5 s for initial resuscitation...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29179664/incorporating-peer-support-during-in-vivo-exposure-to-reverse-dropout-from-prolonged-exposure-therapy-for-posttraumatic-stress-disorder-clinical-outcomes
#17
Melba A Hernandez-Tejada, Stephanie Hamski, David Sánchez-Carracedo
Objective Prolonged exposure is characterized by reported dropout rates ranging from 25% to 40%. This premature attrition is also observed in other evidence-based treatments for posttraumatic stress disorder. While home-based telehealth delivery of prolonged exposure resolves logistical barriers to care such as travel time and cost, dropout appears unaffected. A previous study on dropouts from prolonged exposure delivered via telehealth found that Veterans, particularly those receiving care via telehealth, reported problems with in vivo exposure and that having a peer to offer support during in vivo exposure assignments might have prevented their attrition from treatment...
July 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29179243/pyelonephritis-in-pregnancy-clinical-and-laboratorial-aspects-and-perinatal-results
#18
Djulie Anne de Lemos Zanatta, Mariane de Mello Rossini, Alberto Trapani Júnior
Objective To identify the prevalence of pyelonephritis during pregnancy and to analyze the clinical and laboratorial aspects, perinatal results and complications. Methods A transversal study of 203 pregnant women who had pyelonephritis during pregnancy and whose labor took place between 2010 and 2016 at a hospital in the state of Santa Catarina, Brazil. The analysis was based on medical records as well as on the hospital's database. Clinical and laboratory conditions, antibiotics, bacterial resistance, perinatal outcomes and complications were all taken into account...
November 27, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29178652/mutations-in-fetal-genes-involved-in-innate-immunity-and-host-defense-against-microbes-increase-risk-of-preterm-premature-rupture-of-membranes-pprom
#19
Bhavi P Modi, Maria E Teves, Laurel N Pearson, Hardik I Parikh, Hannah Haymond-Thornburg, John L Tucker, Piya Chaemsaithong, Nardhy Gomez-Lopez, Timothy P York, Roberto Romero, Jerome F Strauss
BACKGROUND: Twin studies have revealed a significant contribution of the fetal genome to risk of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm delivery. Infection and inflammation of the fetal membranes is commonly found associated with PPROM. METHODS: We carried out whole exome sequencing (WES) of genomic DNA from neonates born of African-American mothers whose pregnancies were complicated by PPROM (76) or were normal term pregnancies (N = 43) to identify mutations in 35 candidate genes involved in innate immunity and host defenses against microbes...
November 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29175819/decreased-oxygen-exposure-during-transportation-of-newborns
#20
Chayatat Ruangkit, Sasivimon Soonsawad, Thavatchai Tutchamnong, Buranee Swatesutipun
Oxygen is the most common treatment for newborns in need of respiratory support. However, oxygen can cause tissue injury through reactive oxygen species formation, especially in premature infants with reduced antioxidant defences, and may result in short-term and long-term toxic effects in multiple organ systems. Although most hospitals have the capability to tightly control oxygen delivery to hospitalised neonates, in many circumstances, the need is overlooked during infant transport. Lack of awareness of harm or appropriate medical equipment invariably results in excessive oxygen exposure...
November 25, 2017: Archives of Disease in Childhood
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