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https://www.readbyqxmd.com/read/28646397/concentrations-of-environmental-chemicals-in-urine-and-blood-samples-of-children-from-san-luis-potos%C3%A3-mexico
#1
Ivan N Perez-Maldonado, Angeles C Ochoa-Martinez, Sandra T Orta-Garcia, Tania Ruiz-Vera, Jose A Varela-Silva
Human biomonitoring (HBM) is an appreciated tool used to evaluate human exposure to environmental, occupational or lifestyle chemicals. Therefore, the aim of this study was to evaluate the exposure levels for environmental chemicals in urine and blood samples of children from San Luis Potosí, Mexico (SLP). This study identifies environmental chemicals of concern such as: arsenic (45.0 ± 15.0 µg/g creatinine), lead (5.40 ± 2.80 µg/dL), t,t-muconic acid (266 ± 220 µg/g creatinine), 1-hydroxypyrene (0...
June 23, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28646256/a-dose-response-relation-exists-between-different-classes-of-pre-gravid-obesity-and-selected-perinatal-outcomes
#2
Andreja Trojner Bregar, Nataša Tul, Vesna Fabjan Vodušek, Ivan Verdenik, Miha Lucovnik, Vid Janša, Isaac Blickstein
OBJECTIVE: To examine if a "dose-response" relation exists between different classes of pre-gravid obesity and selected perinatal outcomes. METHODS: We evaluated 16,566 obese mothers, including 12,064 (72.8%), 3410 (20.6%), and 1092 (6.6%) with obesity class I, II, and III, respectively. We compared maternal age, primiparity, gestational age at birth, birth weight, GDM, hypertensive disorders, and the incidence of cesarean sections. RESULTS: There was a significantly increased incidence (from class I to class III) for GDM (8...
June 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28646249/public-acceptability-of-financial-incentives-to-reward-pregnant-smokers-who-quit-smoking-a-united-kingdom-france-comparison
#3
Noémi Berlin, Léontine Goldzahl, Linda Bauld, Pat Hoddinott, Ivan Berlin
A substantial amount of research has been conducted on financial incentives to increase abstinence from smoking among pregnant smokers. If demonstrated to be effective, financial incentives could be proposed as part of health care interventions to help pregnant smokers quit. Public acceptability is important; as such interventions could be publicly funded. Concerns remain about the acceptability of these interventions in the general population. We aimed to assess the acceptability of financial incentives to reward pregnant smokers who stop smoking using a survey conducted in the UK and then subsequently in France, two developed countries with different cultural and social backgrounds...
June 23, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28646223/regular-exercise-participation-improves-genomic-stability-in-diabetic-patients-an-exploratory-study-to-analyse-telomere-length-and-dna-damage
#4
Ivan Dimauro, Antonella Sgura, Monica Pittaluga, Fiorenza Magi, Cristina Fantini, Rosa Mancinelli, Antonio Sgadari, Stefania Fulle, Daniela Caporossi
Physical activity has been demonstrated to be effective in the prevention and treatment of different chronic conditions, including type 2 diabetes (T2D). In particular, several studies highlighted how the beneficial effects of physical activity may be related to the stability of the DNA molecule, such as longer telomeric ends. Here we analyze the effect of exercise training on telomere length, spontaneous and H2O2-induced DNA damage, as well as the apoptosis level in leukocytes from untrained or trained T2D patients vs...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646021/eif1ax-and-nras-mutations-co-occur-and-cooperate-in-low-grade-serous-ovarian-carcinomas
#5
Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Australian Ovarian Cancer Study Group, Raghwa Sharma, Paul Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, John V Pearson, Nicola Waddell, Sean Grimmond, Martin Köbel, Helen Rizos, Ivan Lomakin, David D L Bowtell, Anna DeFazio
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized by RAS pathway activation. Using exome and whole genome sequencing we identified recurrent mutations in the protein translational regulator EIF1AX and in NF1, USP9X, KRAS, BRAF and NRAS. RAS pathway mutations were mutually exclusive, however we found significant co-occurrence of mutations in NRAS and EIF1AX Missense EIF1AX mutations were clustered at the N-terminus of the protein in a region associated with its role in ensuring translational initiation fidelity...
June 23, 2017: Cancer Research
https://www.readbyqxmd.com/read/28646010/patient-ventilator-asynchrony-and-standard-waveforms-looks-can-be-deceiving-reply
#6
Ivan I Ramirez, Daniel H Arellano, Rodrigo S Adasme
No abstract text is available yet for this article.
July 2017: Respiratory Care
https://www.readbyqxmd.com/read/28645266/poorer-outcomes-among-cancer-patients-diagnosed-with-clostridium-difficile-infections-in-united-states-community-hospitals
#7
Andrew Delgado, Ivan A Reveles, Felicia T Cabello, Kelly R Reveles
BACKGROUND: Cancer predisposes patients to Clostridium difficile infection (CDI) due to health care exposures and medications that disrupt the gut microbiota or reduce immune response. Despite this association, the national rate of CDI among cancer patients is unknown. Furthermore, it is unclear how CDI affects clinical outcomes in cancer. The objective of this study was to describe CDI incidence and health outcomes nationally among cancer patients in the United States (U.S.). METHODS: Data for this study were obtained from the U...
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28644860/time-dependent-genetic-analysis-links-field-and-controlled-environment-phenotypes-in-the-model-c4-grass-setaria
#8
Max J Feldman, Rachel E Paul, Darshi Banan, Jennifer F Barrett, Jose Sebastian, Muh-Ching Yee, Hui Jiang, Alexander E Lipka, Thomas P Brutnell, José R Dinneny, Andrew D B Leakey, Ivan Baxter
Vertical growth of plants is a dynamic process that is influenced by genetic and environmental factors and has a pronounced effect on overall plant architecture and biomass composition. We have performed six controlled growth trials of an interspecific Setaria italica x Setaria viridis recombinant inbred line population to assess how the genetic architecture of plant height is influenced by developmental queues, water availability and planting density. The non-destructive nature of plant height measurements has enabled us to monitor height throughout the plant life cycle in both field and controlled environments...
June 23, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28644701/comparison-between-briganti-partin-and-mskcc-tools-in-predicting-positive-lymph-nodes-in-prostate-cancer-a-systematic-review-and-meta-analysis
#9
Sebastiano Cimino, Giulio Reale, Tommaso Castelli, Vincenzo Favilla, Raimondo Giardina, Giorgio Ivan Russo, Salvatore Privitera, Giuseppe Morgia
OBJECTIVE: The aim of this study was to analyze the discriminative capabilities of Briganti, Partin and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms in predicting lymph-node invasion (LNI) and to perform a meta-analysis to yield pooled area under the receiver operating characteristics curves (AUCs) for model comparison. MATERIALS AND METHODS: An electronic search of the MEDLINE and Embase databases up to October 2016 was undertaken. The AUC value, total number of patients and rate of LNI were extracted from the included references...
June 23, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28644091/prevention-of-cardiovascular-disease-in-patients-with-familial-hypercholesterolaemia-the-role-of-pcsk9-inhibitors
#10
Ivan Pećin, Merel L Hartgers, G Kees Hovingh, Ricardo Dent, Željko Reiner
Familial hypercholesterolaemia is an autosomal dominant inherited disorder characterised by elevated low-density lipoprotein cholesterol levels and consequently an increased risk of atherosclerotic cardiovascular disease (ASCVD). Familial hypercholesterolaemia is relatively common, but is often underdiagnosed and undertreated. Cardiologists are likely to encounter many individuals with familial hypercholesterolaemia; however, patients presenting with premature ASCVD are rarely screened for familial hypercholesterolaemia and fasting lipid levels are infrequently documented...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28644062/4-nerolidylcatechol-apoptosis-by-mitochondrial-mechanisms-with-reduction-in-cyclin-d1-at-g0-g1-stage-of-the-chronic-myelogenous-k562-cell-line
#11
Polyana Lopes Benfica, Renato Ivan de Ávila, Bruna Dos Santos Rodrigues, Alane Pereira Cortez, Aline Carvalho Batista, Marilisa Pedroso Nogueira Gaeti, Eliana Martins Lima, Kênnia Rocha Rezende, Marize Campos Valadares
CONTEXT: 4-Nerolidylcatechol (4-NRC) has showed antitumor potential through apoptosis. However, its apoptotic mechanisms are still unclear, especially in leukemic cells. OBJECTIVES: To evaluate the cytotoxic potential of 4-NRC and its cell death pathways in p53-null K562 leukemic cells. MATERIALS AND METHODS: Cytotoxicity of 4-NRC (4.17-534.5 μM) over 24 h of exposure was evaluated by MTT assay. 4-NRC-induced apoptosis in K562 cells was investigated by phosphatidylserine (PS) externalization, cell cycle, sub-G1, mitochondrial evaluation, cytochrome c, cyclin D1 and intracellular reactive oxygen species (ROS) levels, and caspase activity analysis...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28644015/photochromic-hydrazone-switches-with-extremely-long-thermal-half-lives
#12
Hai Qian, Susnata Pramanik, Ivan Aprahamian
A family of easily accessible light-activated hydrazone switches has been developed having thermal half-lives of up to 2700 years! Structure-property analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with a phenyl one leads to the long-live negative photochromic compounds. The switching properties of the hydrazones in both toluene and DMSO were assessed offering insights into the kinetics and thermodynamics of the switching process.
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28643476/low-leptin-concentration-may-identify-heart-failure-patients-with-central-sleep-apnea
#13
Ivan Cundrle, Virend K Somers, Prachi Singh, Bruce D Johnson, Christopher G Scott, Lyle J Olson
Low leptin concentration has been shown to be associated with central sleep apnea in heart failure patients. We hypothesized that low leptin concentration predicts central sleep apnea. Consecutive ambulatory New York Heart Association (NYHA) classes I-IV heart failure patients were studied prospectively, including measurement of serum leptin, echocardiography and polysomnography. Sleep apnea was defined by type (central/mixed/obstructive) and by apnea-hypopnea index ≥5 by polysomnography. Subjects were divided into four groups by polysomnography: (1) central sleep apnea, (2) mixed apnea, (3) no apnea and (4) obstructive sleep apnea...
June 23, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28642092/chemokine-ccl17-is-expressed-by-dendritic-cells-in-the-cns-during-experimental-autoimmune-encephalomyelitis-and-promotes-pathogenesis-of-disease
#14
Christina Ruland, Hannes Renken, Ivan Kuzmanov, Arezoo Fattahi Mehr, Kathrin Schwarte, Manuela Cerina, Alexander Herrmann, David-Marian Otte, Andreas Zimmer, Nicholas Schwab, Sven G Meuth, Volker Arolt, Luisa Klotz, Irmgard Förster, Stefanie Scheu, Judith Alferink
The CC chemokine ligand 17 (CCL17) and its cognate CC chemokine receptor 4 (CCR4) are known to control leukocyte migration, maintenance of TH17 cells, and regulatory T cell (Treg) expansion in vivo. In this study we characterized the expression and functional role of CCL17 in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). Using a CCL17/EGFP reporter mouse model, we could show that CCL17 expression in the CNS can be found in a subset of classical dendritic cells (DCs) that immigrate into the CNS during the effector phase of MOG-induced EAE...
June 19, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28641825/-yours-sincerely-barney-ralph-waters-barindra-sircar-and-the-training-of-an-international-anesthesiologist
#15
Aaron S Hess, Mark E Schroeder
In 1936, Ralph Milton Waters accepted a proposal to train an Indian physician who could return home and become the first native anesthesiologist in the subcontinent. Waters founded the United States' first anesthesiology residency in 1927 and in 1937 welcomed Barindra Sircar, MBBS, to the University of Wisconsin in Madison. Sircar trained with Waters for two years and did further training with Robert Macintosh and Ivan Magill. He became one of the first specialty-trained anesthesiologists in India and founded the Indian Society of Anaesthesiologists...
April 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28641787/social-jet-lag-potentiates-obesity-and-metabolic-syndrome-when-combined-with-cafeteria-diet-in-rats
#16
Estefania Espitia-Bautista, Mario Velasco-Ramos, Iván Osnaya-Ramírez, Manuel Ángeles-Castellanos, Ruud M Buijs, Carolina Escobar
BACKGROUND/OBJECTIVES: Modern lifestyle promotes shifted sleep onset and shifted wake up time between weekdays and weekends, producing a condition termed "social-jet lag." Disrupted sleep promotes increased appetite for carbohydrate and fat-rich food, which in long term leads to overweight, obesity and metabolic syndrome. In order to mimic the human situation we produced an experimental model of social-jet lag (Sj-l). With this model, we explored the link between shifted sleep time with consumption of a cafeteria diet (CafD) and the development of obesity and metabolic syndrome...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641116/mechanisms-for-selective-single-cell-reactivation-during-offline-sharp-wave-ripples-and-their-distortion-by-fast-ripples
#17
Manuel Valero, Robert G Averkin, Ivan Fernandez-Lamo, Juan Aguilar, Diego Lopez-Pigozzi, Jorge R Brotons-Mas, Elena Cid, Gabor Tamas, Liset Menendez de la Prida
Memory traces are reactivated selectively during sharp-wave ripples. The mechanisms of selective reactivation, and how degraded reactivation affects memory, are poorly understood. We evaluated hippocampal single-cell activity during physiological and pathological sharp-wave ripples using juxtacellular and intracellular recordings in normal and epileptic rats with different memory abilities. CA1 pyramidal cells participate selectively during physiological events but fired together during epileptic fast ripples...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28639832/comparing-diagnostic-performance-of-digital-breast-tomosynthesis-and-full-field-digital-mammography-in-a-hybrid-screening-environment
#18
Catherine S Giess, Sarvenaz Pourjabbar, Ivan K Ip, Ronilda Lacson, Emily Alper, Ramin Khorasani
OBJECTIVE: The purpose of this study is to compare the diagnostic performance of screening digital breast tomosynthesis (DBT) to that of full-field digital mammography (FFDM) in a mixed DBT and FFDM imaging environment. MATERIALS AND METHODS: This retrospective observational study consisted of all female patients undergoing screening DBT or FFDM at an academic medical center and outpatient imaging facility between October 2012 and May 2015. Patient demographics and personal history of breast cancer were collected from the electronic medical record...
June 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28639258/tandem-in-situ-monitoring-for-quantitative-assessment-of-mechanochemical-reactions-involving-structurally-unknown-phases
#19
Stipe Lukin, Tomislav Stolar, Martina Tireli, Maria Blanco, Darko Babić, Tomislav Friščić, Krunoslav Užarević, Ivan Halasz
Despite recent advances in real-time and in situ monitoring techniques, a thorough mechanistic understanding of mechanochemical milling reactions is often hindered by the inability of their quantitative evaluation. Here, a tandem approach combining in situ powder X-ray diffraction and Raman spectroscopy enabled quantitative assessment and kinetic analysis of mechanochemical reaction, even when involving new phases of unknown crystal structures, and short-lived intermediates. We also introduce in situ Raman monitoring as a standalone laboratory technique for quantitative assessment of mechanochemical reactions...
June 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28639216/biocomparison-study-of-adult-and-paediatric-dose-strengths-of-the-prostacyclin-receptor-agonist-selexipag
#20
Margaux Boehler, Shirin Bruderer, Ivan Ulč, Jasper Dingemanse
BACKGROUND AND OBJECTIVES: Selexipag is an oral, non-prostanoid, selective prostacyclin receptor agonist recently marketed for the treatment of pulmonary arterial hypertension (PAH) in adults. Selexipag may also be an effective treatment in children with PAH. The aim of this study was to compare the pharmacokinetics of selexipag and its active metabolite ACT-333679 following single oral administration of one tablet of 200 µg selexipag (Treatment A) vs. 4 paediatric tablets of 50 µg (Treatment B) in healthy adult male subjects...
June 21, 2017: European Journal of Drug Metabolism and Pharmacokinetics
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