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Hepatic stroma

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https://www.readbyqxmd.com/read/29121977/intrahepatic-biliary-cystadenoma-mimicking-hydatid-cyst-of-liver-a-clinicopathologic-study-of-six-cases
#1
Zubair Ahmad, Nasir Uddin, Wasim Memon, Jamshid Abdul-Ghafar, Arsalan Ahmed
BACKGROUND: Intrahepatic biliary cystadenomas are rare hepatic neoplasms, which are usually cystic. These tumors are often misdiagnosed as simple liver cysts and hydatid cysts clinically and radiologically owing to nonspecific clinical and radiologic features. These tumors require complete resection, as recurrence and malignant transformation can occur following incomplete excision. It is essential that these tumors be diagnosed accurately so that they can be adequately excised. METHODS: Clinical and radiological features of six cases of biliary cystadenoma are described...
November 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29036356/lipopolysaccharide-promotes-angiogenesis-in-mice-model-of-hcc-by-stimulating-hepatic-stellate-cell-activation-via-tlr4-pathway
#2
Yi Lu, Jianliang Xu, Shuxian Chen, Zheng Zhou, Nan Lin
Angiogenesis plays a key role in the progression of hepatocellular carcinoma (HCC). This study aimed to investigate whether lipopolysaccharide (LPS) could promote HCC angiogenesis and the role of hepatic stellate cell (HSC) in this process. In vivo orthotopic HCC model and the effect of LPS on HSC in vitro were studied. Our results demonstrated that LPS-induced HSC activation during the promotion of HCC growth and angiogenesis in mice. The LPS-TLR4 (Toll-like receptor 4) pathway in HSC is responsible for HCC angiogenesis...
November 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29035907/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#3
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
October 13, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29028787/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#4
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29016404/hepatobiliary-mucinous-cystic-neoplasms-with-ovarian-type-stroma-so-called-hepatobiliary-cystadenoma-cystadenocarcinoma-clinicopathologic-analysis-of-36-cases-illustrates-rarity-of-carcinomatous-change
#5
Brian Quigley, Michelle D Reid, Burcin Pehlivanoglu, Malcolm H Squires, Shishir Maithel, Yue Xue, Choi Hyejeong, Gizem Akkas, Takashi Muraki, David A Kooby, Juan M Sarmiento, Ken Cardona, Aarti Sekhar, Alyssa Krasinskas, Volkan Adsay
The literature is highly conflicting on hepatobiliary mucinous cystic neoplasms (MCNs), aka "hepatobiliary cystadenoma/cystadenocarcinoma," largely because ovarian stroma (OS) was not a requirement until WHO-2010 and is not widely applied even today. In this study, MCNs (with OS) accounted for 24 of 229 (11%) resected hepatic cysts in one institution. Eight of the 32 (25%) cysts that had been originally designated as hepatobiliary cystadenoma/cystadenocarcinoma at the time of diagnosis proved not to have an OS during this review and were thus re-classified as non-MCN...
October 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28941454/components-of-the-hepatocellular-carcinoma-microenvironment-and-their-role-in-tumor-progression
#6
REVIEW
M V Novikova, N V Khromova, P B Kopnin
This review summarizes recently published data on the mechanisms of tumor cell interaction with the tumor microenvironment. Tumor stroma influences the processes of hepatocarcinogenesis, epithelial-to-mesenchymal transition, invasion, and metastasis. The tumor microenvironment includes both cellular and noncellular components. Main cellular components of hepatocellular carcinoma (HCC) stroma are tumor-associated fibroblasts, hepatic stellate cells, immune cells, and endothelial cells that produce extracellular components of tumor microenvironment such as extracellular matrix, various proteins, proteolytic enzymes, growth factors, and cytokines...
August 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28901507/%C3%AE-7-nicotinic-acetylcholine-receptor-in-tumor-associated-macrophages-inhibits-colorectal-cancer-metastasis-through-the-jak2-stat3-signaling-pathway
#7
Rushan Fei, Yuanwei Zhang, Saisai Wang, Tao Xiang, Wenbin Chen
Considerable evidence has implied that α7 nicotinic receptor subtypes play an important role in chronic inflammatory and neuropathic pain signaling. The aim of the present study was to determine the role of endogenous α7nAChR signaling in tumor-associated macrophages (TAMs) in human colorectal cancer (CRC) metastasis and prognosis. α7nAChR expression in primary tumor cells and adjacent stroma cells especially in TAMs in 51 CRC patients was observed. Using a human monocyte THP-derived macrophages (TMs) with α7nAChR-siRNA knockdown (TMα7-/-) and a CRC cell Transwell co-culture model, the migration and invasion of two CRC cells, LoVo and SW620, were determined...
November 2017: Oncology Reports
https://www.readbyqxmd.com/read/28822084/giant-biatrial-myxoma-with-two-different-gross-findings
#8
Taiyo Kuroda, Yukifusa Yokoyama, Satoshi Yuhara, Hideyuki Okawa, Hiroki Hasegawa, Jun Yokote, Shuji Tamaki, Shinji Mii
We experienced a giant biatrial myxoma concomitant with hepatocellular carcinoma. Most of myxomas originate from the left atrium, and biatrial myxomas are extremely rare. Excision of the giant cardiac tumor was performed to avoid risks of life-threatening complications. The resected mass was grossly composed of two parts with the border of interatrial septum and with the shape of peanut shell. Although microscopic examinations revealed enlarged vessels, hemorrhages and hemosiderosis in the left part and high cellularity with chronic inflammation in the right part, spindle-shaped cells in a loose myxoid stroma were observed in both parts of the tumor, consistent with the diagnosis of myxoma...
August 18, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28668580/elevated-levels-of-circulating-osteopontin-are-associated-with-a-poor-survival-after-resection-of-cholangiocarcinoma
#9
Sven H Loosen, Christoph Roderburg, Katja L Kauertz, Inês Pombeiro, Catherine Leyh, Fabian Benz, Mihael Vucur, Thomas Longerich, Alexander Koch, Till Braunschweig, Tom F Ulmer, Christoph Heidenhain, Frank Tacke, Marcel Binnebösel, Maximilian Schmeding, Christian Trautwein, Ulf P Neumann, Tom Luedde
BACKGROUND & AIMS: Cholangiocarcinoma (CCA) represents a primary hepatic malignancy with incidence and mortality rising globally. Surgical treatment has remained the only potentially curative treatment option, but it is still unclear which patients benefit most from extended liver surgery, highlighting the need for new pre-operative stratification strategies. Osteopontin is a secreted extracellular glyco-phosphoprotein that has been associated with inflammation, metabolic disorders and cancer...
October 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28664988/hepatitis-c-virus-induced-tumor-initiating-cancer-stem-like-cells-activate-stromal-fibroblasts-in-a-xenograft-tumor-model
#10
Reina Sasaki, Pradip Devhare, Ratna B Ray, Ranjit Ray
Hepatitis C virus (HCV) often causes persistent infection and is an increasingly important factor in the etiology of fibrosis/cirrhosis and hepatocellular carcinoma, although the mechanisms for the disease processes remain unclear. We have shown previously that HCV infection generates an epithelial-mesenchymal transition state and tumor-initiating cancer stem-like cells in human hepatocytes. In this study, we investigated whether HCV-induced tumor-initiating cancer stem-like cells when implanted into mice activate stromal fibroblasts...
December 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28626929/successful-liver-transplantation-for-non-resectable-desmoplastic-nested-spindle-cell-tumor-complicated-by-cushing-s-syndrome
#11
Sarah Tehseen, Louis Rapkin, Erwin Schemankewitz, Joseph F Magliocca, Rene Romero
Desmoplastic spindle cell tumors of liver are rare tumors of low malignant potential characterized by well-demarcated nests of spindle and epithelioid cells in a dense desmoplastic stroma. While surgery remains the definitive treatment, there have been reports of tumor recurrence locally and metastasis which respond poorly to chemotherapy. Hepatic transplant has been attempted in cases of recurrence or large size of primary tumor. Long-term follow-up and imaging surveillance are required as these tumors have shown a tendency for recurrence many years after initial therapy...
September 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28620145/hepatic-stroma-educated-regulatory-dcs-suppress-cd8-t-cell-proliferation-in-mice
#12
Qian Wang, Hao He, Dongwei Chen, Chao Wang, Yingping Xu, Wengang Song
Liver dendritic cells (DCs) display immunosuppressive activities and inhibit the CD4+ T cell response. The present study assessed whether and how liver DCs suppress CD8+ T cells. We found that bone marrow-derived mature DCs incubated with liver stromal cells were characterized by a longer life span, reduced CD11c, IA/IE, CD80, CD86, and CD40 expression, and increased CD11b expression. These unique liver stromal cell-educated mature DCs (LSed-DCs) stimulated CD8+ T cells to express CD25 and CD69, but inhibited their proliferation...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28585251/tfe3-rearranged-hepatic-epithelioid-hemangioendothelioma-a-case-report-with-immunohistochemical-and-molecular-study
#13
Fang-Ying Kuo, Hsuan-Ying Huang, Chao-Long Chen, Hock-Liew Eng, Chao-Cheng Huang
A recurrent YAP1-TFE3 gene fusion has been identified in WWTR1-CAMTA1-negative epithelioid hemangioendotheliomas arising in soft tissue, bone, and lung, but not in liver. We present the first case of TFE3-rearranged hepatic epithelioid hemangioendothelioma in a 39-year-old Taiwanese woman. Computed tomography scan revealed multifocal, ill-defined nodules involving both hepatic lobes. She then underwent deceased donor liver transplantation. Histologically, the tumors in the liver explant showed a biphasic growth pattern...
September 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28538690/dysregulation-of-mirna-expression-in-cancer-associated-fibroblasts-cafs-and-its-consequences-on-the-tumor-microenvironment
#14
REVIEW
Maren Schoepp, Anda Jana Ströse, Jörg Haier
The tumor microenvironment, including cancer-associated fibroblasts (CAF), has developed as an important target for understanding tumor progression, clinical prognosis and treatment responses of cancer. Cancer cells appear to transform normal fibroblasts (NF) into CAFs involving direct cell-cell communication and epigenetic regulations. This review summarizes the current understanding on miR involvement in cancer cell-tumor environment/stroma communication, transformation of NFs into CAFs, their involved targets and signaling pathways in these interactions; and clinical relevance of CAF-related miR expression profiles...
May 24, 2017: Cancers
https://www.readbyqxmd.com/read/28373218/hepatic-stellate-cells-limit-hepatocellular-carcinoma-progression-through-the-orphan-receptor-endosialin
#15
Carolin Mogler, Courtney König, Matthias Wieland, Anja Runge, Eva Besemfelder, Dorde Komljenovic, Thomas Longerich, Peter Schirmacher, Hellmut G Augustin
Hepatocellular carcinoma (HCC) is among the most common and deadliest cancers worldwide. A major contributor to HCC progression is the cross talk between tumor cells and the surrounding stroma including activated hepatic stellate cells (HSC). Activation of HSC during liver damage leads to upregulation of the orphan receptor endosialin (CD248), which contributes to regulating the balance of liver regeneration and fibrosis. Based on the established role of endosialin in regulating HSC/hepatocyte cross talk, we hypothesized that HSC-expressed endosialin might similarly affect cell proliferation during hepatocarcinogenesis...
June 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28365784/magnetic-resonance-findings-of-hepatic-epithelioid-hemangioendothelioma-emphasis-on-hepatobiliary-phase-using-gd-eob-dtpa
#16
Jeong Hyun Lee, Woo Kyoung Jeong, Young Kon Kim, Won Jae Lee, Sang Yun Ha, Kyoung Won Kim, Jihun Kim
PURPOSE: To examine the characteristic features of hepatic epithelioid hemangioendothelioma (HEH) on magnetic resonance imaging (MRI) using Gd-EOB-DTPA. MATERIAL AND METHODS: Twelve patients (mean age, 50 years; male:female = 6:6) who were pathologically confirmed to have HEH in two tertiary institutions were retrospectively investigated. For qualitative analysis, the MRI features of HEH including core pattern were characterized, and lesions were divided into core and non-core groups...
April 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28348474/malignant-hepatic-epithelioid-hemangioendothelioma-with-villaret-syndrome
#17
Hanchanale Pavan, Joy Varghese, Kavya Harika, Mukul Vij, Venkataraman Jayanthi, Mohamed Rela
Malignant hepatic epithelioid hemangioendothelioma is a rare, vascular tumor of the liver with peak incidence in the middle age with a female preponderance and of unknown etiology. Majority of the tumors are asymptomatic. The gold standard for diagnosis of the tumor is liver histology showing presence of epithelioid tumor cells on a background of a hyaline stroma. Immunohistochemical positivity for CD31, CD34, Factor VIII, and Podoplanin (D2-40) is confirmatory. The treatment of choice is liver transplantation...
March 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28279493/effect-of-melanoma-cells-on-proliferation-and-migration-of-activated-hepatic-stellate-cells-in-vitro
#18
Theresa Meyer, Andreas Koch, Eva-Vanessa Ebert, Barbara Czech, Martina Mueller, Anja Bosserhoff, Sven Arke Lang, Claus Hellerbrand
Melanoma is a highly aggressive tumor of the skin. The clinical outcome is determined by the presence or absence of metastases, and the liver is a common site of distant metastases. Hepatic metastasis is causing activation of hepatic stellate cells (HSC), which form the stroma of hepatic metastases and are increasingly recognized as a crucial component of the pro- metastatic liver microenvironment. Most studies have focused on the effects of HSC on (metastasizing) tumor cells. Here, we aimed to analyze functional in vitro effects of conditioned medium (CM) of twelve different human melanoma cell lines on LX2 cells and HSC(htert) cells, two well established human activated HSC cell lines...
April 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28266931/biliary-adenofibroma-of-liver-morphology-tumor-genetics-and-outcomes-in-6-cases
#19
Thomas Arnason, Darrell R Borger, Christopher Corless, Catherine Hagen, A John Iafrate, Hala Makhlouf, Joseph Misdraji, Heidi Sapp, Wilson M Tsui, Ian R Wanless, Tania Zuluaga Toro, Gregory Y Lauwers
Biliary adenofibroma is a rare primary hepatic neoplasm, recognized in the World Health Organization classification, although only 14 cases have been reported to date. This series includes extended follow-up from 2 of the early case reports and 4 novel cases. Clinical history and histology were reviewed in all 6 cases. Tumor DNA was analyzed for point mutations by multiplex polymerase chain reaction and copy number alterations by array comparative genomic hybridization. The patients included 4 females and 2 males presenting between 46 and 83 years of age, with tumors ranging from 7 to 16 cm in diameter...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28261592/pathology-of-intrahepatic-cholangiocarcinoma
#20
REVIEW
Sandrine Vijgen, Benoit Terris, Laura Rubbia-Brandt
Intrahepatic cholangiocarcinoma (iCC) is a primary carcinoma of the liver with increasing significance and major pathogenic, clinical and therapeutic challenges. Classically, it arises from malignant transformation of cholangiocytes bordering small portal bile duct (BD) to second-order segmental large BDs. It has three major macroscopic growth pattern [mass-forming (MF), periductal infiltrative (PI), and intraductal growth (IG)] and histologically is a desmoplastic stroma-rich adenocarcinoma with cholangiocyte differentiation...
February 2017: Hepatobiliary Surgery and Nutrition
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