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Microbiome AND cancer

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https://www.readbyqxmd.com/read/29774014/oral-microbiota-community-dynamics-associated-with-oral-squamous-cell-carcinoma-staging
#1
Chia-Yu Yang, Yuan-Ming Yeh, Hai-Ying Yu, Chia-Yin Chin, Chia-Wei Hsu, Hsuan Liu, Po-Jung Huang, Song-Nian Hu, Chun-Ta Liao, Kai-Ping Chang, Yu-Liang Chang
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer and the fourth leading malignancy among males in Taiwan. Some pathogenic bacteria are associated with periodontitis and oral cancer. However, the comprehensive profile of the oral microbiome during the cancer's progression from the early stage to the late stage is still unclear. We profiled the oral microbiota and identified bacteria biomarkers associated with OSCC. The microbiota of an oral rinse from 51 healthy individuals and 197 OSCC patients at different stages were investigated using 16S rRNA V3V4 amplicon sequencing, followed by bioinformatics and statistical analyses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29755427/16s-rrna-gene-sequencing-for-deciphering-the-colorectal-cancer-gut-microbiome-current-protocols-and-workflows
#2
REVIEW
Muhammad-Afiq Osman, Hui-Min Neoh, Nurul-Syakima Ab Mutalib, Siok-Fong Chin, Rahman Jamal
The human gut holds the densest microbiome ecosystem essential in maintaining a healthy host physiology, whereby disruption of this ecosystem has been linked to the development of colorectal cancer (CRC). The advent of next-generation sequencing technologies such as the 16S rRNA gene sequencing has enabled characterization of the CRC gut microbiome architecture in an affordable and culture-free approach. Nevertheless, the lack of standardization in handling and storage of biospecimens, nucleic acid extraction, 16S rRNA gene primer selection, length, and depth of sequencing and bioinformatics analyses have contributed to discrepancies found in various published studies of this field...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29751733/intestinal-absorption-of-fructose
#3
Ronaldo P Ferraris, Jun-Yong Choe, Chirag R Patel
Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. New insights in our knowledge of intestinal fructose absorption mediated by the facilitative glucose transporter GLUT5 in the apical membrane and by GLUT2 in the basolateral membrane are reviewed. We begin with studies related to structure as well as ligand binding, then revisit the controversial proposition that apical GLUT2 is the main mediator of intestinal fructose absorption...
May 11, 2018: Annual Review of Nutrition
https://www.readbyqxmd.com/read/29751360/intact-intraoperative-fluorescence-angiography-ifa-to-prevent-anastomotic-leak-in-rectal-cancer-surgery-a-randomised-controlled-trial
#4
G Armstrong, J Croft, N Corrigan, J M Brown, V Goh, P Quirke, C Hulme, D Tolan, A Kirby, R Cahill, R O'Connell, D Miskovic, M Coleman, D G Jayne
PURPOSE: Anastomotic leak (AL) is a major complication of rectal cancer surgery. Despite advances in surgical practice, rates of AL have remained static at around 10-15%. The aetiology of AL is multifactorial, but one of the most crucial risk factors, which is mostly under the control of the surgeon, is blood supply to the anastomosis. The MRC/NIHR IntAct study will determine whether assessment of anastomotic perfusion using a fluorescent dye (Indocyanine Green) and near-infrared laparoscopy can minimise the rate of anastomotic leak as compared to conventional white light laparoscopy...
May 11, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29740156/research-on-oral-microbiota-of-monozygotic-twins-with-discordant-caries-experience-in-vitro-and-in-vivo-study
#5
Hongle Wu, Benhua Zeng, Bolei Li, Biao Ren, Jianhua Zhao, Mingyun Li, Xian Peng, Mingye Feng, Jiyao Li, Hong Wei, Lei Cheng, Xuedong Zhou
Oral microbiome is potentially correlated with many diseases, such as dental caries, periodontitis, oral cancer and some systemic diseases. Twin model, as an effective method for studying human microbiota, is widely used in research of relationship between oral microbiota and dental caries. However, there were few researches focusing on caries discordant twins. In this study, in vitro assays were conducted combined with 16S rRNA sequencing analysis on oral microbiota sampled from twins who presented discordant caries experience and mice model was developed as well...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29731748/oral-bacterial-and-fungal-microbiome-impacts-colorectal-carcinogenesis
#6
REVIEW
Klara Klimesova, Zuzana Jiraskova Zakostelska, Helena Tlaskalova-Hogenova
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29725395/the-association-between-inflammation-the-microbiome-and-urethane-induced-pulmonary-adenocarcinoma
#7
Zenghua Deng, Zhihui Li, Changqing Sun, Hui Xie, Zhengang Chen, Jinbo Liu, Hui Wang, Chenggang Zhang, Guangshun Wang
Lung cancer is amongst the most common types of cancer throughout the world. The overall 5-year survival rate is ~17%. A number of studies have demonstrated that the microbiome existing within the host may affect the level of inflammation, and consequently contribute to the carcinogenesis of certain types of cancer. To investigate the role of inflammation and the microbiome in the carcinogenesis of lung cancer, an intervention study involving mice, including a control group (C; n=5), a urethane-induced pulmonary adenocarcinoma group (U; n=5) and a prebiotics intervention group (P; n=5) was carried out...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29720905/the-role-of-the-gut-microbiome-in-colorectal-cancer
#8
REVIEW
Grace Y Chen
There is increasing evidence that the gut microbiome, which consists of trillions of microbes representing over 1,000 species of bacteria with over 3 million genes, significantly impacts intestinal health and disease. The gut microbiota not only is capable of promoting intestinal homeostasis and antitumor responses but can also contribute to chronic dysregulated inflammation as well as have genotoxic effects that lead to carcinogenesis. Whether the gut microbiota maintains health or promotes colon cancer may ultimately depend on the composition of the gut microbiome and the balance within the microbial community of protective and detrimental bacterial populations...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#9
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29712667/restructuring-of-the-gut-microbiome-by-intermittent-fasting-prevents-retinopathy-and-prolongs-survival-in-db-db-mice
#10
Eleni Beli, Yuanqing Yan, Leni Moldovan, Cristiano P Vieira, Ruli Gao, Yaqian Duan, Ram Prasad, Ashay Bhatwadekar, Fletcher A White, Steven Townsend, Luisa Chan, Caitlin N Ryan, Daniel Morton, Emil G Moldovan, Fang-I Chu, Gavin Y Oudit, Hartmut Derendorf, Luciano Adorini, Xiaoxin X Wang, Carmella Evans-Molina, Raghavendra G Mirmira, Michael E Boulton, Mervin C Yoder, Qiuhong Li, Moshe Levi, Julia V Busik, Maria B Grant
Intermittent fasting (IF) protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is not known. In db/db mice, we examined the impact of long-term IF on diabetic retinopathy (DR). Despite no change in glycated hemoglobin, db/db mice on the IF regimen displayed significantly longer survival and a reduction in DR endpoints, including acellular capillaries and leukocyte infiltration. We hypothesized that IF mediated changes in the gut microbiota would produce beneficial metabolites and prevent the development of DR...
April 30, 2018: Diabetes
https://www.readbyqxmd.com/read/29705028/food-microbiome-and-colorectal-cancer
#11
REVIEW
Lukas Niederreiter, Timon E Adolph, Herbert Tilg
You are what you eat. This adage has been confirmed by many studies demonstrating the high impact of nutrition on risk of cardiovascular diseases, many malignancies and other diseases. Dietary factors are of major relevance in the evolution of colorectal carcinoma. Various aspects are involved in colorectal carcinoma pathogenesis including genetics, lifestyle, age, chronic inflammation and others. It has only recently been recognized that the gut microbiota might reflect an important missing link in the interaction between diet and subsequent colorectal carcinoma development...
April 3, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29703763/association-of-coffee-and-tea-intake-with-the-oral-microbiome-results-from-a-large-cross-sectional-study
#12
Brandilyn A Peters, Marjorie L McCullough, Mark P Purdue, Neal D Freedman, Caroline Y Um, Susan M Gapstur, Richard B Hayes, Jiyoung Ahn
BACKGROUND: The oral microbiota play a central role in oral health, and possibly in carcinogenesis. Research suggests coffee and tea consumption may have beneficial health effects. We examined the associations of these common beverages with the oral ecosystem in a large cross-sectional study. METHODS: We assessed oral microbiota in mouthwash samples from 938 participants in two U.S. cohorts using 16S rRNA gene sequencing. Coffee and tea intake were assessed from food frequency questionnaires...
April 27, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29702299/diets-that-promote-colon-inflammation-associate-with-risk-of-colorectal-carcinomas-that-contain-fusobacterium-nucleatum
#13
Li Liu, Fred K Tabung, Xuehong Zhang, Jonathan A Nowak, Zhi Rong Qian, Tsuyoshi Hamada, Daniel Nevo, Susan Bullman, Kosuke Mima, Keisuke Kosumi, Annacarolina da Silva, Mingyang Song, Yin Cao, Tyler S Twombly, Yan Shi, Hongli Liu, Mancang Gu, Hideo Koh, Wanwan Li, Chunxia Du, Yang Chen, Chenxi Li, Wenbin Li, Raaj S Mehta, Kana Wu, Molin Wang, Aleksander D Kostic, Marios Giannakis, Wendy S Garrett, Curtis Hutthenhower, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino, Edward L Giovannucci
BACKGROUND & AIMS: Specific nutritional components are likely to induce intestinal inflammation, which is characterized by increased levels of interleukin 6 (IL6), C-reactive protein (CRP), and TNF receptor superfamily member 1B (TNFRSF1B) in the circulation and promotes colorectal carcinogenesis. The inflammatory effects of a diet can be estimated based on empirical dietary inflammatory pattern (EDIP) score, calculated based on intake of 18 foods associated with plasma levels of IL6, CRP, and TNFRSF1B...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29694348/oral-microbiota-reveals-signs-of-acculturation-in-mexican-american-women
#14
Kristi L Hoffman, Diane S Hutchinson, Jerry Fowler, Daniel P Smith, Nadim J Ajami, Hua Zhao, Paul Scheet, Wong-Ho Chow, Joseph F Petrosino, Carrie R Daniel
The oral microbiome has been linked to a number of chronic inflammatory conditions, including obesity, diabetes, periodontitis, and cancers of the stomach and liver. These conditions disproportionately affect Mexican American women, yet few studies have examined the oral microbiota in this at-risk group. We characterized the 16S rDNA oral microbiome in 369 non-smoking women enrolled in the MD Anderson Mano a Mano Mexican American Cohort Study. Lower bacterial diversity, a potential indicator of oral health, was associated with increased age and length of US residency among recent immigrants...
2018: PloS One
https://www.readbyqxmd.com/read/29689266/alterations-in-enteric-virome-associate-with-colorectal-cancer-and-survival-outcomes
#15
Geicho Nakatsu, Haokui Zhou, William Ka Kei Wu, Sunny Hei Wong, Olabisi Oluwabukola Coker, Zhenwei Dai, Xiangchun Li, Chun-Ho Szeto, Naoki Sugimura, Thomas Yuen-Tung Lam, Allen Chi-Shing Yu, Xiansong Wang, Zigui Chen, Martin Chi-Sang Wong, Siew Chien Ng, Matthew T V Chan, Paul Kay Sheung Chan, Francis Ka Leung Chan, Joseph Jao-Yiu Sung, Jun Yu
BACKGROUND AND AIMS: Patients with colorectal cancer (CRC) have a different gut microbiome signature than individuals without CRC. Little is known about the viral component of CRC-associated microbiome. We aimed to identify and validate viral taxonomic markers of CRC that might be used in detection of disease or predicting outcome. METHODS: We performed shotgun metagenomic analyses of viromes of fecal samples from 74 patients with CRC (cases) and 92 individuals without CRC (controls) in Hong Kong (discovery cohort)...
April 21, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29687353/gut-microbiome-of-moroccan-colorectal-cancer-patients
#16
Imane Allali, Noureddine Boukhatem, Leila Bouguenouch, Hanaa Hardi, H Abir Boudouaya, M Belen Cadenas, Karim Ouldim, Saaïd Amzazi, M Andrea Azcarate-Peril, Hassan Ghazal
Although colorectal cancer is the third leading cause of death in Morocco, there are no studies of the microbiome changes associated with the disease in the Moroccan population. The aim of our study was to compare the stool microbiome of Moroccan cancer patients with healthy individuals. We analyzed the microbiome composition of samples from 11 CRC patients and 12 healthy individuals by 16S rRNA amplicon sequencing. Principal coordinate analysis of samples revealed defined cancer versus healthy clusters. Our findings showed that cancer samples had higher proportions of Firmicutes (T = 50...
April 23, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29686981/self-sampling-for-human-papillomavirus-testing-increased-cervical-cancer-screening-participation-and-incorporation-in-international-screening-programs
#17
REVIEW
Sarah Gupta, Christina Palmer, Elisabeth M Bik, Juan P Cardenas, Harold Nuñez, Laurens Kraal, Sara W Bird, Jennie Bowers, Alison Smith, Nathaniel A Walton, Audrey D Goddard, Daniel E Almonacid, Susan Zneimer, Jessica Richman, Zachary S Apte
In most industrialized countries, screening programs for cervical cancer have shifted from cytology (Pap smear or ThinPrep) alone on clinician-obtained samples to the addition of screening for human papillomavirus (HPV), its main causative agent. For HPV testing, self-sampling instead of clinician-sampling has proven to be equally accurate, in particular for assays that use nucleic acid amplification techniques. In addition, HPV testing of self-collected samples in combination with a follow-up Pap smear in case of a positive result is more effective in detecting precancerous lesions than a Pap smear alone...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29685174/drinking-alcohol-is-associated-with-variation-in-the-human-oral-microbiome-in-a-large-study-of-american-adults
#18
Xiaozhou Fan, Brandilyn A Peters, Eric J Jacobs, Susan M Gapstur, Mark P Purdue, Neal D Freedman, Alexander V Alekseyenko, Jing Wu, Liying Yang, Zhiheng Pei, Richard B Hayes, Jiyoung Ahn
BACKGROUND: Dysbiosis of the oral microbiome can lead to local oral disease and potentially to cancers of the head, neck, and digestive tract. However, little is known regarding exogenous factors contributing to such microbial imbalance. RESULTS: We examined the impact of alcohol consumption on the oral microbiome in a cross-sectional study of 1044 US adults. Bacterial 16S rRNA genes from oral wash samples were amplified, sequenced, and assigned to bacterial taxa...
April 24, 2018: Microbiome
https://www.readbyqxmd.com/read/29682676/how-human-microbiome-talks-to-health-and-disease
#19
REVIEW
Jing Cong, Xiaochun Zhang
Microbes are ubiquitous in the human body. They usually live in communities, and each of these communities has a distinct taxonomical structure. Due to its close relationship with human health and disease, the human microbiome has received great attention and is probably considered to be the most valuable biomarker in preventing and solving human diseases. In this paper, we first review the value of the human microbiome. Then, we focus on the role of the human microbiome in influencing human health and disease...
April 22, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#20
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
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