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https://www.readbyqxmd.com/read/29777366/is-ganglionated-plexus-ablation-effective-for-treating-atrial-fibrillation
#1
Michiko Watanabe, Hiroki Kohno, Yusuke Kondo, Hideki Ueda, Keiichi Ishida, Yusaku Tamura, Shinichiro Abe, Yasunori Sato, Yoshio Kobayashi, Goro Matsumiya
PURPOSE: Very few studies have investigated the efficacy of ganglionated plexus ablation during the conventional maze procedure. In this study, we sought to evaluate its additive effect in reducing recurrent atrial fibrillation after concomitant maze surgery. METHODS: A retrospective study was conducted of 79 patients who underwent Cox maze IV concomitantly with open-heart surgery with (GP group) or without (Maze group) ganglionated plexus mapping. All active ganglionated plexuses were ablated...
May 18, 2018: Surgery Today
https://www.readbyqxmd.com/read/29755075/-huge-left-thrombosis-after-mitral-valvuloplasty-and-maze-procedure-report-of-a-case
#2
Hitomi Naruse, Noriyasu Kawada, Koichi Muramatsu, Hirokuni Naganuma, Kazuhiro Hashimoto
Generally, anticoagulation therapy is not essential for patients who maintain sinus rhythm after mitral valvuloplasty. A 66-year-old woman who had undergone mitral valvuloplasty and maze procedure for treatment of mitral valve regurgitation and atrial fibrillation 4 years ago was diagnosed as having left atrial thrombosis despite maintenance of sinus rhythm on electrocardiography. Echocardiography showed narrow mitral valvular area(1.5 cm2), loss of A wave and a huge left atrium. Repeat surgery was performed to replace the mitral valve and to remove the thrombus...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29736913/effects-of-caffeine-on-behavioural-and-cognitive-deficits-in-rats
#3
Melissa S Assis, Aluízio C Soares, Dircilei N de Sousa, João Eudes-Filho, Lilian Rosana F Faro, Fabiana P Carneiro, Mônica V da Silva, Andrea B Motoyama, Greice Maria R de Souza, Stéphanie Marchiori, Nadyelle T de Lima, Raphael Boëchat-Barros, Vania M Ferreira
There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the cecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity...
May 7, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29730345/hemiarch-reconstruction-vs-clamped-aortic-anastomosis-for-concomitant-ascending-aortic-aneurysm
#4
Ibrahim Sultan, Valentino Bianco, Ibrahim Yajzi, Arman Kilic, Keith Dufendach, Arturo Cardounel, Andrew D Althouse, Ahmad Masri, Forozan Navid, Thomas G Gleason
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) is often avoided in patients with concomitant ascending aortic pathology when treating other cardiac disease to avoid increased risk of morbidity and mortality. We hypothesized that the use of DHCA with retrograde cerebral perfusion (RCP) does not add incremental risk to ascending aortic replacement alone in the setting of concomitant cardiac surgery. METHODS: 408 ascending aortic ± hemiarch replacements and aortic (root)/mitral/tricuspid valve(s), CABG, or MAZE procedures were performed for concomitant cardiac disease...
May 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29715537/resveratrol-prevents-cognitive-deficits-induced-by-chronic-unpredictable-mild-stress-sirt1-mir-134-signalling-pathway-regulates-creb-bdnf-expression-in-hippocampus-in-vivo-and-in-vitro
#5
Jun Shen, Linling Xu, Chujie Qu, Huimin Sun, Junjian Zhang
Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, such as depression, anxiety and cognitive impairment. Resveratrol is a natural polyphenol existed in polygonum cuspidatum and has been demonstrated to be a potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol treatment ameliorated CUMS-induced depressive-like behavior and cognitive deficits through upregulating cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression...
April 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29701167/amaze-a-double-blind-multicentre-randomised-controlled-trial-to-investigate-the-clinical-effectiveness-and-cost-effectiveness-of-adding-an-ablation-device-based-maze-procedure-as-an-adjunct-to-routine-cardiac-surgery-for-patients-with-pre-existing-atrial-fibrillation
#6
Linda Sharples, Colin Everett, Jeshika Singh, Christine Mills, Tom Spyt, Yasir Abu-Omar, Simon Fynn, Benjamin Thorpe, Victoria Stoneman, Hester Goddard, Julia Fox-Rushby, Samer Nashef
BACKGROUND: Atrial fibrillation (AF) can be treated using a maze procedure during planned cardiac surgery, but the effect on clinical patient outcomes, and the cost-effectiveness compared with surgery alone, are uncertain. OBJECTIVES: To determine whether or not the maze procedure is safe, improves clinical and patient outcomes and is cost-effective for the NHS in patients with AF. DESIGN: Multicentre, Phase III, pragmatic, double-blind, parallel-arm randomised controlled trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29684531/rapamycin-relieves-anxious-emotion-and-synaptic-plasticity-deficits-induced-by-hindlimb-unloading-in-mice
#7
Baohui Zhai, Xueliang Shang, Jingxuan Fu, Fangjuan Li, Tao Zhang
This study examined whether increasing autophagy could improve cognitive deficits in hindlimb unloaded (HU) mice, which was used as an animal model of synaptic plasticity impairment. Male C57BL/6 mice were randomly divided into three groups: control, HU and HU + rapamycin groups. Hindlimb unloading treatment was used to establish the animal model for 2 weeks. Rapamycin was intraperitoneally injected at a dose of 0.5 mg/kg/day along with hindlimb unloading procedure. The open field test and the elevated plus maze test showed that rapamycin considerably prevented the level of anxiety and increased exploratory behaviour in HU mice...
April 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#8
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29672731/amaze-a-randomized-controlled-trial-of-adjunct-surgery-for-atrial-fibrillation
#9
Samer A M Nashef, Simon Fynn, Yasir Abu-Omar, Tomasz J Spyt, Christine Mills, Colin C Everett, Julia Fox-Rushby, Jeshika Singh, Malcolm Dalrymple-Hay, Catherine Sudarshan, Massimiliano Codispoti, Peter Braidley, Francis C Wells, Linda D Sharples
OBJECTIVES: Atrial fibrillation (AF) reduces survival and quality of life (QoL). It can be treated at the time of major cardiac surgery using ablation procedures ranging from simple pulmonary vein isolation to a full maze procedure. The aim of this study is to evaluate the impact of adjunct AF surgery as currently performed on sinus rhythm (SR) restoration, survival, QoL and cost-effectiveness. METHODS: In a multicentre, Phase III, pragmatic, double-blinded, parallel-armed randomized controlled trial, 352 cardiac surgery patients with >3 months of documented AF were randomized to surgery with or without adjunct maze or similar AF ablation between 2009 and 2014...
April 17, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29672694/successful-surgical-ablation-of-atrial-fibrillation-does-not-disturb-long-term-sinus-rhythm-variability
#10
Grzegorz Suwalski, Piotr Suwalski
OBJECTIVES: Surgical ablation of atrial fibrillation (AF) aims to restore normal sinus rhythm while protecting the sinus node from surgical damage. Surgical lesions may affect autonomic neural structures and influence physiological heart rate variability (HRV). The primary aim of this study was to describe long-term dynamics of HRV after successful surgical ablation of AF. The secondary aim was to compare sinus node function after successful ablation of AF with either left atrial modified Maze procedure or epicardial pulmonary vein isolation after long-term follow-up...
April 16, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29652289/iatrogenic-atrio-esophageal-fistula-following-a-video-assisted-thoracoscopic-maze-procedure-is-esophageal-instrumentation-justified-even-when-the-diagnosis-is-equivocal
#11
Shvetank Agarwal, Muhammad Salman Tahir Janjua, Paramvir Singh, Nadine Odo, Manuel R Castresana
A 74-year-old female underwent an uneventful bilateral thoracoscopic maze procedure for persistent atrial fibrillation with continuous transesophageal echocardiographic (TEE) guidance. She presented six weeks later with persistent fever and focal neurological signs. Computed tomography of the thorax revealed air in the posterior LA, raising suspicion for an abscess versus an atrioesophageal fistula (AEF). Before undergoing an exploratory median sternotomy, an esophagogastroduodenoscopy (EGD) was performed by the surgeon to check for any esophageal pathology...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29651452/barnes-maze-procedure-for-spatial-learning-and-memory-in-mice
#12
Matthew W Pitts
The Barnes maze is a dry-land based rodent behavioral paradigm for assessing spatial learning and memory that was originally developed by its namesake, Carol Barnes. It represents a well-established alternative to the more popular Morris Water maze and offers the advantage of being free from the potentially confounding influence of swimming behavior. Herein, the Barnes maze experimental setup and corresponding procedures for testing and analysis in mice are described in detail.
March 5, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29629552/combined-cryo-maze-procedure-and-mitral-valve-repair-through-a-ministernotomy
#13
Vishal Shah, Oleg Orlov, Cinthia Orlov, Manabu Takebe, Matthew Thomas, Konstadinos Plestis
Atrial fibrillation is associated with increased morbidity and mortality in patients undergoing mitral valve surgery. There is a growing consensus that patients with preexisting atrial fibrillation should undergo surgical ablation at the time of mitral valve surgery. Novel surgical ablation techniques, including cryoablation, have been developed to facilitate concurrent minimally invasive procedures. This video tutorial describes a combined cryo-maze procedure and mitral valve repair through an upper ministernotomy in a patient with long-standing persistent atrial fibrillation and severe mitral regurgitation...
March 5, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/29617931/robotic-mitral-valve-replacements-with-bioprosthetic-valves-in-52-patients-experience-from-a-tertiary-referral-hospital
#14
Chia-Cheng Kuo, Hsiao-Huang Chang, Chung-Hsi Hsing, Hiong-Ping Hii, Nan-Chun Wu, Chin-Ming Hsu, Chun-I Chen, Bor-Chih Cheng
OBJECTIVES: Robotic mitral valve replacement (MVR) emerged in the late 1990s as an alternative approach to conventional sternotomy. With the increased use of bioprosthetic valves worldwide and strong patient desire for minimally invasive procedures, the safety and feasibility of robotic MVRs with bioprosthetic valves require investigation. METHODS: Between January 2013 and May 2017, 52 consecutive patients underwent robotic MVRs using the da Vinci Si surgical system (Intuitive Surgical Inc...
March 30, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29596995/applying-ketamine-to-alleviate-the-ptsd-like-effects-by-regulating-the-hcn1-related-bdnf
#15
Lanwei Hou, Yirui Qi, Hongwei Sun, Gang Wang, Qi Li, Yanyu Wang, Zuoji Zhang, Zhongde Du, Lin Sun
BACKGROUND: Post-traumatic stress disorder (PTSD) is commonly associated with concurrent anxiety and depression symptoms, and reduce the expression of the Brain-Derived Neurotrophic Factor (BDNF) which promotes the proliferation and survival of neurons. The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived...
March 26, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29590383/the-cox-maze-iv-procedure-in-its-second-decade-still-the-gold-standard
#16
Chawannuch Ruaengsri, Matthew R Schill, Ali J Khiabani, Richard B Schuessler, Spencer J Melby, Ralph J Damiano
Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29551538/sutureless-aortic-valve-replacement-with-concomitant-valvular-surgery
#17
Cagdas Baran, Mustafa Serkan Durdu, Fatih Gumus, Mehmet Cakici, Mustafa Bahadir Inan, Mustafa Sirlak, Ahmet Ruchan Akar
OBJECTIVES: Sutureless aortic valve replacement (SU-AVR) is an alternative technique to standard aortic valve replacement. We evaluated our experience with the Perceval SU-AVR with concomitant mitral valve surgery, with or without tricuspid valve surgery, and aimed to discuss the technical considerations. METHODS: From January 2013 through June 2016, 30 patients with concomitant severe mitral valve disease, with or without tricuspid valve disease, underwent SU-AVR with the Perceval prosthesis in a single center...
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29510186/the-anxiolytic-effects-of-cannabidiol-in-chronically-stressed-mice-are-mediated-by-the-endocannabinoid-system-role-of-neurogenesis-and-dendritic-remodeling
#18
Manoela V Fogaça, Alline C Campos, Ludmila D Coelho, Ronald S Duman, Francisco S Guimarães
Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic Unpredictable Stress (CUS). The specific mechanisms remain to be fully understood but seem to involve adult hippocampal neurogenesis and recruitment of endocannabinoids. Here we investigated for the first time if the behavioral and pro-neurogenic effects of CBD administered concomitant the CUS procedure (14 days) are mediated by CB1 , CB2 or 5HT1A receptors, as well as CBD effects on dendritic remodeling and on intracellular/synaptic signaling (fatty acid amide hydrolase - FAAH, Akt, GSK3β and the synaptic proteins Synapsin Ia/b, mGluR1 and PSD95)...
March 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29487681/surgical-epicardial-left-atrial-appendage-closure-a-true-alternative
#19
Sacha Salzberg, Maximillian Emmert
Left atrial appendage closure was originally described by Madden in 1949 who was the first to perform appendix amputation. This was a very invasive procedure with poor outcome, but preformed for stroke prevention. Much later, it was James Cox whom described the Cox-Maze procedure, which included multiple incisions to create a maze like pathway for the electrical impulse to go undisturbed from the sinus node down to the atrio-ventricular node. Since then cardiac surgeons stopped focusing on the left atrial appendage and went on about seemingly more important things...
December 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29486171/sex-differences-and-the-role-of-acute-stress-in-the-open-field-tower-maze
#20
Olga Lipatova, Matthew M Campolattaro, Dawndra C Dixon, Ayse Durak
Many studies provide evidence that differences in spatial learning exist between males and females. However, it is necessary to consider non-mnemonic factors that may influence these findings. The present experiment investigated acquisition, retention, and the effects of stress on response- and place-learning in male and female rats. Rats were trained in an open-field tower maze. Procedures were used to minimize stress in the rats, and their ability to solve place- or response-learning in the maze was determined by analyzing a response variable (i...
May 15, 2018: Physiology & Behavior
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