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https://www.readbyqxmd.com/read/28806788/chronic-unpredictable-stress-exacerbates-surgery-induced-sickness-behavior-and-neuroinflammatory-responses-via-glucocorticoids-secretion-in-adult-rats
#1
Na Wang, Hong Ma, Zhe Li, Yalei Gao, Xuezhao Cao, Yanhua Jiang, Yongjian Zhou, Sidan Liu
METHODS: Sprague-Dawley adult male rats (12-14 weeks old) were exposed to 14-day CUS and then subjected to partial hepatectomy 24 h after the last stress session. The rats were pretreated with an antagonist of the glucocorticoids (GCs) receptor RU486 (30 mg/kg, i.p.) 1 h prior to stress exposure. The behavioral changes were evaluated with open field test and elevated plus-maze test. The hippocampal cytokines interleukin (IL)-1β and IL-6 were measured on postoperative days 1, 3 and 7...
2017: PloS One
https://www.readbyqxmd.com/read/28797677/emergence-of-atrioventricular-nodal-reentry-tachycardia-after-surgical-or-catheter-ablation-for-atrial-fibrillation-are-we-creating-the-arrhythmia-substrate
#2
Jorge Romero, Saurabh Kumar, Fujii Akira, David F Briceño, Usha B Tedrow, Laurence Epstein, Roy John, William G Stevenson, Gregory F Michaud
BACKGROUND: Atrioventricular nodal reentry tachycardia (AVNRT) is common in adults and often involves reentry through two or more AV nodal-atrial connections. Although AVNRT can be a trigger for atrial fibrillation (AF), we have observed new onset AVNRT after AF ablation procedures. OBJECTIVE: To determine whether ablation involving the septum or proximal coronary sinus during AF ablation may create a substrate favorable for AVNRT METHODS: Cases of ablation for persistent AF who required a repeat ablation procedure between 2009 to 2016 were reviewed for diagnosis of AVNRT...
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28769783/age-and-chronicity-of-administration-dramatically-influenced-the-impact-of-low-dose-paraquat-exposure-on-behavior-and-hypothalamic-pituitary-adrenal-activity
#3
Chris A Rudyk, Jessica McNeill, Natalie Prowse, Zach Dwyer, Kyle Farmer, Darcy Litteljohn, Warren Caldwell, Shawn Hayley
Little is known of the age-dependent and long-term consequences of low exposure levels of the herbicide and dopaminergic toxicant, paraquat. Thus, we assessed the dose-dependent effects of paraquat using a typical short-term (3 week) exposure procedure, followed by an assessment of the effects of chronic (16 weeks) exposure to a very low dose (1/10th of what previously induced dopaminergic neuronal damage). Short term paraquat treatment dose-dependently induced deficits in locomotion, sucrose preference and Y-maze performance...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28756933/pericardial-herniation-of-small-bowel-post-minimally-invasive-hybrid-maze-of-atrial-fibrillation
#4
David A Farcy, Angelo Lapietra, Benjamin N Abo, Michael Dalley
BACKGROUND: Herniation of intraabdominal contents into the pericardial cavity is exceptionally rare, and when seen, it is most often the result of trauma, postsurgical complication, or genetic defect. There have been only a few case reports describing spontaneous bowel herniation into the pericardium in minimally invasive cardiac procedures like cardiac ablation, pacemaker placement, and minimally invasive coronary artery bypass graft. CASE REPORT: We report the case of a 65-year-old man who presented to an urgent care center complaining of abdominal and chest pain...
July 27, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28756201/multiple-mild-traumatic-brain-injury-in-the-rat-produces-persistent-pathological-alterations-in-the-brain
#5
Diane M Brooks, Sarjubhai A Patel, Eric D Wohlgehagen, Erin O Semmens, Alan Pearce, Edmond A Sorich, Thomas F Rau
Multiple mild traumatic brain injury (mmTBI), in certain cases, produces persistent symptoms. However, the molecular mechanisms underlying these symptoms remain unclear. Here, we demonstrate extended pathological changes in the rat brain following mmTBI. Using the lateral fluid percussion (LFP) technique we exposed adult male Wistar rats to a mild TBI (mTBI) once a week for four weeks and compared them to surgical shams. At 90days following the last TBI or sham procedure the animals were cognitively tested in the Morris Water Maze (MWM), euthanized, and the brains removed for immunohistochemistry...
July 27, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28750215/binge-pattern-cocaine-administration-causes-long-lasting-behavioral-hyperarousal-but-does-not-enhance-vulnerability-to-single-prolonged-stress-in-rats
#6
Michael J Lisieski, Shane A Perrine
Cocaine use disorder and post-traumatic stress disorder (PTSD) commonly co-occur. This could be due to vulnerability to post-traumatic symptoms conferred by previous exposure to cocaine. Therefore, we combined chronic binge-pattern cocaine with a model of psychological trauma (single prolonged stress) to determine whether the behavioral effects of psychological trauma are enhanced in cocaine-sensitized individuals. Adult male Sprague Dawley rats received 14 days of cocaine (15mg/kg/injection) or saline in a binge pattern (3 injections per day, 1h apart)...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28740625/pulmonary-valve-replacement-in-patients-with-corrected-tetralogy-of-fallot
#7
Fotios M Mitropoulos, Meletios A Kanakis, Christos Ntellos, Constantinos Loukas, Periklis Davlouros, Theophili Kousi, Andrew C Chatzis
Introduction: Development of pulmonary insufficiency in patients with surgically corrected tetralogy of Fallot (TOF) may lead to severe right heart failure with serious consequences. We herein present our experience with pulmonary valve replacement (PVR) in these patients. Methods: From 2005-2013, 99 consecutive patients (71 males/28 females, mean age 38±8 years), underwent PVR after 7 to 40 (mean 29 ± 8) years from the initial correction. Seventy nine of the symptomatic patients presented in NYHA II, 14 in III and 2 in IV...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28738900/impact-of-ablation-duration-on-rhythm-outcome-after-concomitant-maze-procedure-using-cryoablation-in-patients-with-persistent-atrial-fibrillation
#8
Dong Seop Jeong, Ji Hoon You, Chang-Seok Jeon, Pyo Won Park, Kiick Sung, Wook Sung Kim, Young Tak Lee
BACKGROUND: The aim of this study was to evaluate the impact of ablation duration during a maze procedure using a nitrous oxide-based cryosurgical system. METHODS: From May 2001 to December 2006, 256 consecutive patients who underwent a concomitant maze procedure using nitrous oxide-based cryoablation for chronic atrial fibrillation (AF) during cardiac surgery were enrolled. The ablation duration for each lesion was between 120 s at -60 °C in 140 patients (control group) and 160 s in 116 patients (long duration group)...
July 24, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28725993/are-young-children-able-to-learn-exploratory-strategies-by-observation
#9
Francesca Foti, Domenico Martone, Stefania Orrù, Simone Montuori, Esther Imperlini, Pasqualina Buono, Laura Petrosini, Laura Mandolesi
New competencies may be learned through active experience (experiential learning or learning by doing) or observation of others' experiences (learning by observation). Observing another person performing a complex action facilitates the observer's acquisition of the same action. The present research is aimed at analyzing if the observation of specific explorative strategies adopted in a constrained environment, such as the Radial Arm Maze (RAM), could help young children to explore the maze and to build a cognitive spatial map of the explored environment...
July 20, 2017: Psychological Research
https://www.readbyqxmd.com/read/28706476/long-term-sex-dependent-vulnerability-to-metabolic-challenges-in-prenatally-stressed-rats
#10
Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A Riva, Francesca Cirulli
Prenatal stress (PNS) might affect the developmental programming of adult chronic diseases such as metabolic and mood disorders. The molecular mechanisms underlying such regulations may rely upon long-term changes in stress-responsive effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect neuronal plasticity underlying mood disorders and may also play a role in metabolic regulation. Based upon previous data, we hypothesized that PNS might lead to greater vulnerability to an obesogenic challenge experienced at adulthood...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28678926/late-results-of-cox-maze-iii-procedure-in-patients-with-atrial-fibrillation-associated-with-structural-heart-disease
#11
Gustavo Gir Gomes, Wagner Luis Gali, Alvaro Valentim Lima Sarabanda, Claudio Ribeiro da Cunha, Iruena Moraes Kessler, Fernando Antibas Atik
Background: Cox-Maze III procedure is one of the surgical techniques used in the surgical treatment of atrial fibrillation (AF). Objectives: To determine late results of Cox-Maze III in terms of maintenance of sinus rhythm, and mortality and stroke rates. Methods: Between January 2006 and January 2013, 93 patients were submitted to the cut-and-sew Cox-Maze III procedure in combination with structural heart disease repair. Heart rhythm was determined by 24-hour Holter monitoring...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28669901/maternal-alcohol-binge-drinking-induces-persistent-neuroinflammation-associated-with-myelin-damage-and-behavioural-dysfunctions-in-offspring-mice
#12
Lídia Cantacorps, Silvia Alfonso-Loeches, Maria Moscoso-Castro, Javier Cuitavi, Irene Gracia-Rubio, Raúl López-Arnau, Elena Escubedo, Consuelo Guerri, Olga Valverde
Alcohol binge drinking is on the increase in the young adult population, and consumption during pregnancy can be deleterious for foetal development. Maternal alcohol consumption leads to a wide range of long-lasting morphological and behavioural deficiencies known as foetal alcohol spectrum disorders (FASD), associated with neurodevelopmental disabilities. We sought to test the effects of alcohol on neuroimmune system activation and its potential relation to alcohol-induced neurodevelopmental and persistent neurobehavioural effects in offspring after maternal alcohol binge drinking during the prenatal period or in combination with lactation...
June 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28663110/sucrose-and-naltrexone-prevent-increased-pain-sensitivity-and-impaired-long-term-memory-induced-by-repetitive-neonatal-noxious-stimulation-role-of-bdnf-and-%C3%AE-endorphin
#13
Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabour
Pain in neonates is associated with short and long-term adverse outcomes. Data demonstrated that long-term consequences of untreated pain are linked to the plasticity of the neonate's brain. Sucrose is effective and safe for reducing painful procedures from single events. However, the mechanism of sucrose-induced analgesia is not fully understood. The role of the opioid system in this analgesia using the opioid receptor antagonist Naltrexone was investigated, plus the long-term effects on learning and memory formation during adulthood...
June 27, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28662512/ru486-reverses-emotional-disorders-by-influencing-astrocytes-and-endoplasmic-reticulum-stress-in-chronic-restraint-stress-challenged-rats
#14
Liru Dong, Songjun Wang, Yingmin Li, Ziqin Zhao, Yiwen Shen, Li Liu, Guangming Xu, Chunling Ma, Shujin Li, Xiaojing Zhang, Bin Cong
AIMS: To investigate the effect of RU486 (mifepristone) on emotional disorders in chronic restraint stress-induced rats and to explore the mechanisms of that phenomenon. METHODS: For this purpose, 80 healthy male Sprague Dawley rats were randomly divided into four groups: the normal group (Con group, The Con group members received no treatment, eating and drinking freely), the chronic restraint stress group (CRS group, normal Sprague Dawley rats treated with chronic restraint stress, 6 h/day for 21days), the propylene glycol group (CRS+propylene glycol) and the RU486 group (CRS+RU486)...
June 29, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28638710/nicotine-prevented-learning-and-memory-impairment-in-rem-sleep-deprived-rat-is-modulated-by-dream-protein-in-the-hippocampus
#15
Norlinda Abd Rashid, Hermizi Hapidin, Hasmah Abdullah, Zalina Ismail, Idris Long
INTRODUCTION: REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment. METHODS: Male Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28634446/are-distal-and-proximal-visual-cues-equally-important-during-spatial-learning-in-mice-a-pilot-study-of-overshadowing-in-the-spatial-domain
#16
Marie Hébert, Jan Bulla, Denis Vivien, Véronique Agin
Animals use distal and proximal visual cues to accurately navigate in their environment, with the possibility of the occurrence of associative mechanisms such as cue competition as previously reported in honey-bees, rats, birds and humans. In this pilot study, we investigated one of the most common forms of cue competition, namely the overshadowing effect, between visual landmarks during spatial learning in mice. To this end, C57BL/6J × Sv129 mice were given a two-trial place recognition task in a T-maze, based on a novelty free-choice exploration paradigm previously developed to study spatial memory in rodents...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28626989/electrical-isolation-of-the-left-atrial-appendage-by-maze-like-catheter-substrate-modification-a-reproducible-strategy-for-pulmonary-vein-isolation-non-responders
#17
Stefano Bordignon, Laura Perrotta, Daniela Dugo, Fabrizio Bologna, Takahiko Nagase, Alexander Fuernkranz, Kr Julian Chun, Boris Schmidt
INTRODUCTION: The ablation strategy for atrial fibrillation (AF) despite pulmonary vein isolation (PVI) is controversial. Left atrial appendage isolation (LAAI) may contribute to improve outcome. We describe an ablation approach ("Maze-like"-LAAI) that (1) modifies the underlying LA substrate by linear ablation (2) eliminates the LAA as a putative AF trigger site and (3) incorporates an unambiguous procedural endpoint. The role of LAA closure (LAAC) after LAAI was investigated. METHODS: Patients with atrial tachyarrhythmias non-responsive to PVI underwent a LAAI ablation procedure...
June 19, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28602672/surgical-and-hybrid-ablation-of-atrial-fibrillation
#18
REVIEW
Reece A Davies, Saurabh Kumar, Richard B Chard, Stuart P Thomas
Atrial fibrillation (AF) is the most common arrhythmia in humans and is known to be associated with an increased risk of stroke, dementia, heart failure and mortality. Non-pharmacological therapy with ablation using either surgical or percutaneous techniques is recommended in drug refractory AF. Early attempts to devise procedures to ablate AF and restore sinus rhythm culminated with the Cox-Maze procedure, the first truly successful procedure. Since then, ablation surgery has been conducted predominately as a concomitant procedure...
September 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28593161/surgical-management-of-a-coronary-bronchial-artery-fistula-combined-with-myocardial-ischemia-revealed-by-13-n-ammonia-positron-emission-tomography
#19
Hang Jun Choi, Hwan Wook Kim, Do Yeon Kim, Kuk Bin Choi, Keon Hyon Jo
A 71-year-old male with known bronchiectasis and atrial fibrillation was admitted to Seoul St. Mary's Hospital with recurrent transient ischemic attack. Radiofrequency ablation was performed to resolve the patient's atrial fibrillation, but failed. However, a fistula between the left circumflex artery and the bilateral bronchial arteries was found on computed tomography. Fistula ligation and a left-side maze operation were planned due to his recurrent symptom of dizziness, and these procedures were successfully performed...
June 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28593152/treatment-of-atrial-fibrillation-in-elderly-patients-with-the-cox-maze-procedure-concurrently-with-other-cardiac-operations
#20
Ja Hong Kuh, Joon Young Song, Tae Youn Kim, Jong Hun Kim, Jong Bum Choi
BACKGROUND: In elderly patients who have atrial fibrillation (AF), surgical ablation of the arrhythmia during cardiac surgery may be challenging. Despite the reported advantages of ablating AF with the Cox maze procedure (CMP), the addition of the CMP may complicate other cardiac operations. We evaluated the effect of the CMP in elderly patients concurrent with other cardiac operations. METHODS: From October 2007 to December 2015, we enrolled 27 patients aged >70 years who had AF and who underwent the CMP concurrently with other cardiac operations...
June 2017: Korean Journal of Thoracic and Cardiovascular Surgery
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