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https://www.readbyqxmd.com/read/28225286/-closure-of-the-left-atrial-appendage-by-means-of-the-atriclip-system
#1
Aleš Mokráček, Vojtěch Kurfirst, Alan Bulava, Jiří Haniš
INTRODUCTION: Atrial fibrillation (AFib) is related to a high risk of stroke. The main role in etiopathogenesis is played by the left atrial appendage (LAA). As many as 95 % of thrombi in nonvalvular atrial fibrillation are located in the appendage. Prevention of stroke then consists in permanent anticoagulation which, however, has its limits and risks. An alternative method is the left atrial appendage occlusion. In our report, we would like to present a new possibility of the closure using the epicardial system AtriClip (AtriCure)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28202350/chronic-social-instability-increases-anxiety-like-behavior-and-ethanol-preference-in-male-long-evans-rats
#2
Alyssa R Roeckner, Alexandra Bowling, Tracy R Butler
Chronic stress during adolescence is related to increased prevalence of anxiety disorders and alcohol use disorders in humans. This phenotype has been consistently recapitulated in animal models with male subjects, but models using female subjects are fewer. The aim of these studies was to test the hypothesis that chronic social instability (CSI) during adolescence engenders increased anxiety-like behavior, increased corticosterone, and greater ethanol intake and/or preference than control groups in male and female rats...
February 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28187972/late-results-of-the-cox-maze-iv-procedure-in-patients-undergoing-coronary-artery-bypass-grafting
#3
Matthew R Schill, Farah N Musharbash, Vivek Hansalia, Jason W Greenberg, Spencer J Melby, Hersh S Maniar, Laurie A Sinn, Richard B Schuessler, Marc R Moon, Ralph J Damiano
OBJECTIVE: Most patients with atrial fibrillation (AF) undergoing cardiac surgery do not receive concomitant ablation. This study reviewed outcomes of patients with AF undergoing Cox-maze IV (CMIV) procedure with radiofrequency and cryoablation and coronary artery bypass grafting (CABG) at our institution. METHODS: Between the introduction of radiofrequency ablation in 2002 and 2015, 135 patients underwent left- or biatrial CMIV with CABG. Patients undergoing other cardiac procedures, except mitral valve repair, or who had emergent, reoperative, or off-pump procedures were excluded...
January 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28167117/protection-against-alcohol-induced-neuronal-and-cognitive-damage-by-the-ppar%C3%AE-receptor-agonist-pioglitazone
#4
Andrea Cippitelli, Esi Domi, Massimo Ubaldi, James C Douglas, Hong Wu Li, Gregory Demopulos, George Gaitanaris, Marisa Roberto, Paul D Drew, Cynthia J M Kane, Roberto Ciccocioppo
Binge alcohol drinking has emerged as a typical phenomenon in young people. This pattern of drinking, repeatedly leading to extremely high blood and brain alcohol levels and intoxication is associated with severe risks of neurodegeneration and cognitive damage. Mechanisms involved in excitotoxicity and neuroinflammation are pivotal elements in alcohol-induced neurotoxicity. Evidence has demonstrated that PPARγ receptor activation shows anti-inflammatory and neuroprotective properties. Here we examine whether treatment with the PPARγ agonist pioglitazone is beneficial in counteracting neurodegeneration, neuroinflammation and cognitive damage produced by binge alcohol intoxication...
February 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28163037/laparoscopic-repair-of-an-intrapericardial-diaphragmatic-hernia-after-convergent-maze-procedure
#5
Andrew J Kaufman, Eugene T Kahn, Jonathan Villena-Vargas, Justin G Steele, Raja M Flores
The convergent maze procedure (CMP) is a new minimally invasive technique for the surgical treatment of atrial fibrillation (AF). Recently, multiple groups have published excellent results and few adverse events with CMP. However we now report the second case of an intrapericardial diaphragmatic hernia with small-bowel obstruction that resulted from CMP. This complication was managed successfully by laparoscopic repair of the hernia utilizing a PTFE mesh closure with hepatic buttress achieving an excellent result...
February 2, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28143767/striatal-dopamine-d1-receptor-suppression-impairs-reward-associative-learning
#6
Kerin K Higa, Jared W Young, Baohu Ji, David E Nichols, Mark A Geyer, Xianjin Zhou
Dopamine (DA) is required for reinforcement learning. Hence, disruptions in DA signaling may contribute to the learning deficits associated with psychiatric disorders. The DA D1 receptor (D1R) has been linked to learning and is a target for cognitive/motivational enhancement in patients with schizophrenia. Separating the striatal D1R contribution to learning vs. motivation, however, has been challenging. We suppressed striatal D1R expression in mice using a D1R-targeting short hairpin RNA (shRNA), delivered locally to the striatum via an adeno-associated virus (AAV)...
January 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28135884/intranasal-administration-of-dopamine-attenuates-unconditioned-fear-in-that-it-reduces-restraint-induced-ultrasound-vocalizations-and-escape-from-bright-light
#7
Teddy Talbot, Claudia Mattern, Maria Angelica de Souza Silva, Marcus Lira Brandão
BACKGROUND: Although substantial evidence suggests that dopamine (DA) enhances conditioned fear responses, few studies have examined the role of DA in unconditioned fear states. Whereas DA does not cross the blood-brain barrier, intranasally-applied dopamine reaches the brain directly via the nose-brain pathways in rodents, providing an alternative means of targeting DA receptors. Intranasal dopamine (IN-DA) has been demonstrated to bind to DA transporters and to increase extracellular DA in the striatum as well as having memory-promoting effects in rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28129318/initial-experience-with-minimally-invasive-surgical-exclusion-of-the-left-atrial-appendage-with-an-epicardial-clip
#8
Nathan E Smith, Jeevan Joseph, John Morgan, Saqib Masroor
OBJECTIVE: Atrial fibrillation (AF) is the primary cardiac abnormality associated with ischemic stroke. Atrial fibrillation affects 2.7 million people with a stroke rate of 3.5% per year. Most of the emboli in patients with nonvalvular AF originate in the left atrial appendage (LAA). Surgical exclusion of the LAA decreases the yearly risk of stroke to 0.7% when combined with a Maze procedure. Traditional oversewing the LAA from inside the left atrium is associated with a significant number of recanalizations of LAA...
January 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28117775/assessing-spatial-learning-and-memory-in-small-squamate-reptiles
#9
Lara D LaDage, Tracie E Cobb Irvin, Victoria A Gould
Clinical research has leveraged a variety of paradigms to assess cognitive decline, commonly targeting spatial learning and memory abilities. However, interest in the cognitive processes of nonmodel species, typically within an ecological context, has also become an emerging field of study. In particular, interest in the cognitive processes in reptiles is growing although experimental studies on reptilian cognition are sparse. The few reptilian studies that have experimentally tested for spatial learning and memory have used rodent paradigms modified for use in reptiles...
January 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28114845/effects-of-perinatal-diet-and-prenatal-stress-on-the-behavioural-profile-of-aged-male-and-female-rats
#10
Xabier Bengoetxea, Laura Paternain, Eva Martisova, Fermin I Milagro, J Alfredo Martínez, Javier Campión, María J Ramírez
The present work studies whether chronic prenatal stress (PS) influences the long-term sex-dependent neuropsychological status of offspring and the effects of an early dietary intervention in the dam. In addition, dams were fed with either a high-fat sugar diet (HFSD) or methyl donor supplemented diet (MDSD). PS procedure did not affect body weight of the offspring. MDSD induced decreases in body weight both in male and female offspring (1 month) that were still present in aged rats. HFSD induced an increase in body weight both in male and female offspring that did not persist in aged rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28087280/increased-homocysteine-levels-impair-reference-memory-and-reduce-cortical-levels-of-acetylcholine-in-a-mouse-model-of-vascular-cognitive-impairment
#11
Kevin Dam, Martina Füchtemeier, Tracy D Farr, Philipp Boehm-Sturm, Marco Foddis, Ulrich Dirnagl, Olga Malysheva, Marie A Caudill, Nafisa M Jadavji
Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic (methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levels of homocysteine. Clinical studies have shown that elevated levels of homocysteine (Hcy) may be associated with the development of dementia, however this link remains unclear. The purpose of this study was to evaluate the impact of increased Hcy levels on a mouse model of vascular cognitive impairment (VCI) produced by chronic hypoperfusion...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28070001/neuroimaging-biomarkers-predict-brain-structural-connectivity-change-in-a-mouse-model-of-vascular-cognitive-impairment
#12
Philipp Boehm-Sturm, Martina Füchtemeier, Marco Foddis, Susanne Mueller, Rebecca C Trueman, Marietta Zille, Jan Leo Rinnenthal, Theodore Kypraios, Laurence Shaw, Ulrich Dirnagl, Tracy D Farr
BACKGROUND AND PURPOSE: Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a reliable cognitive and pathological phenotype. This study aimed to identify neuroimaging biomarkers of brain pathology in aged, more severely hypoperfused mice. METHODS: We used magnetic resonance imaging to characterize brain degeneration in mice hypoperfused by refining the surgical procedure to use the smallest reported diameter microcoils (160 μm)...
February 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28066862/impact-of-race-on-outcome-of-patients-undergoing-rhythm-control-of-atrial-fibrillation
#13
Asad F Durrani, Siva Soma, Andrew D Althouse, George Leef, Dingxin Qin, Samir Saba
Racial disparities between African American (AA) and White patients have been documented in cardiovascular disease. We investigated whether these disparities exist in patients undergoing rhythm control for atrial fibrillation (AF). 5873 AF patients (241 AA) were followed to the endpoint of death, stroke, or AF recurrence. Invasive procedures for AF rhythm control were examined in both racial groups. Over a mean follow-up time of 40 months, AA patients had a higher adjusted risk of death [HR 1.39, 95% CI 1...
January 9, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28057698/left-atrial-thrombus-discovered-post-intra-operative-maze-procedure-the-dilemma-of-thrombus-screening-before-the-percutaneous-pulmonary-vein-isolation
#14
Krystyna Majkut, Krittapoom Akrawinthawong, Sasan Ryan Raeissi, Scott Wayne Ferreira, Ali Akbar Mehdirad
No abstract text is available yet for this article.
January 5, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28043900/assessment-of-mouse-cognitive-and-anxiety-like-behaviors-and-hippocampal-inflammation-following-a-repeated-and-intermittent-paradoxical-sleep-deprivation-procedure
#15
Mengmei Yin, Yali Chen, Hui Zheng, Tinglin Pu, Charles Marshall, Ting Wu, Ming Xiao
It has been reported that more than one fourth of the world's population suffers from sleep problems. However, there is not a stable and reliable animal model to mimic the persistent and periodic features of sleep disorders, and correspondingly, the feasibility and effectiveness of repeated behavioral tests remains to be determined. In the present study, we repetitively, and intermittently, treated mice with 3days and 7days of paradoxical sleep deprivation (SD), using the modified multiple small-platforms-over-water method for 3 months...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28027851/spatial-learning-deficits-in-parkinson-s-disease-with-and-without-mild-cognitive-impairment
#16
Christine B Schneider, Katharina Linse, Robby Schönfeld, Sebastian Brown, Rainer Koch, Heinz Reichmann, Bernd Leplow, Alexander Storch
BACKGROUND: Several MRI studies have demonstrated hippocampal atrophy in Parkinson's disease (PD), a structure considered a key element in spatial learning. Despite this, no study has been undertaken to investigate spatial navigation in PD using a virtual version of the Morris water maze, which is the gold standard for testing hippocampal function in rodents. METHODS: We studied 17 cognitively unimpaired PD patients, 12 PD patients with mild cognitive impairment (MCI) and 15 controls in a virtual water maze procedure...
December 22, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28009965/chordal-shortening-for-anterior-mitral-leaflet-prolapse-and-the-maze-procedure-for-persistent-atrial-fibrillation
#17
Jong Hun Kim, Kyung Hwa Kim, Jong Bum Choi, Ja Hong Kuh
Letter to the Editor We read with great interest the report by Inoue et al. (Cusp-level chordal shortening for non-rheumatic mitralanterior leaflet prolapse in a patient with persistent atrial fibrillation. J Heart Valve Dis 2015;24:586-589) that described their mitral valve repair technique for anterior leaflet prolapse (ALP) and perioperative adaptive servo-ventilation (ASV) therapy for preventing the recurrence of atrial fibrillation after the maze procedure. Latent recurrence of atrial fibrillation after the maze procedure is caused by many factors...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28007240/the-society-of-thoracic-surgeons-2017-clinical-practice-guidelines-for-the-surgical-treatment-of-atrial-fibrillation
#18
Vinay Badhwar, J Scott Rankin, Ralph J Damiano, A Marc Gillinov, Faisal G Bakaeen, James R Edgerton, Jonathan M Philpott, Patrick M McCarthy, Steven F Bolling, Harold G Roberts, Vinod H Thourani, Rakesh M Suri, Richard J Shemin, Scott Firestone, Niv Ad
Surgical ablation for atrial fibrillation (AF) can be performed without additional risk of operative mortality or major morbidity, and is recommended at the time of concomitant mitral operations to restore sinus rhythm. (Class I, Level A) Surgical ablation for AF can be performed without additional operative risk of mortality or major morbidity, and is recommended at the time of concomitant isolated aortic valve replacement, isolated coronary artery bypass graft surgery, and aortic valve replacement plus coronary artery bypass graft operations to restore sinus rhythm...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27993691/effects-of-znso4-induced-peripheral-anosmia-on-zebrafish-behavior-and-physiology
#19
Murilo S Abreu, Ana C V V Giacomini, Rubens Rodriguez, Allan V Kalueff, Leonardo J G Barcellos
Olfaction plays a key role in modulating behavioral and physiological responses of various animal species, including fishes. Olfactory deficits can be induced in fish experimentally, and utilized to examine the role of olfaction in their normal and pathological behaviors. Here, we examine whether experimental anosmia, evoked by ZnSO4 in adult zebrafish can be associated with behavioral and/or physiological responses. We show that experimental ZnSO4-induced anosmia caused acute, but not prolonged, anxiogenic-like effects on zebrafish behavior tested in the novel tank test...
December 16, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27981184/pioglitazone-a-ppar%C3%AE-agonist-rescues-depression-associated-with-obesity-using-chronic-unpredictable-mild-stress-model-in-experimental-mice
#20
Yeshwant Kurhe, Radhakrishnan Mahesh
Pioglitazone, a peroxisome proliferator activated receptor gamma (PPARγ) agonist belonging to thiazolidinedione class, is mainly used in diabetes mellitus. Obese subjects are twice likely to become depressed than non-obese individuals. The biological mechanisms linking depression with obesity still remain poorly understood and there is immense need for better therapeutic intervention against such co-morbid disorders. The present study investigates the effect of pioglitazone on the chronic unpredictable mild stress (CUMS) induced depression in obese mice by using behavioral tests and biochemical estimations...
June 2016: Neurobiology of Stress
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