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https://www.readbyqxmd.com/read/29138850/role-of-mitochondrial-function-in-the-invasiveness-of-human-colon-cancer-cells
#1
Chen-Sung Lin, Li-Tzu Liu, Liang-Hung Ou, Siao-Cian Pan, Chia-I Lin, Yau-Huei Wei
We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mitochondrial function was achieved by the exposure of cells to oligomycin A (OA) or by knockdown of mitochondrial transcriptional factor A (TFAM) to evaluate their effects on energy metabolism, reactive oxygen species, protein expression levels of epithelial-mesenchymal transition (EMT) markers and invasive activity of CRC cells...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29138774/exploring-the-effect-of-substituent-in-the-hydrazone-ligand-of-a-family-of-%C3%AE-oxidodivanadium-v-hydrazone-complexes-on-structure-dna-binding-and-anticancer-activity
#2
Debashis Patra, Subhabrata Paul, Indira Majumder, Nayim Sepay, Sachinath Bera, Rita Kundu, Michael G B Drew, Tapas Ghosh
The reaction of 2-hydroxybenzoylhydrazine (H2bh) separately with equimolar amounts of [V(IV)O(aa)2] and [V(IV)O(ba)2] in CHCl3 afforded the complexes [VO3(HL(1))2] (1) and [VO3(HL(2))2] (2) respectively in good to excellent yield ((HL(1))(2-) and (HL(2))(2-) represent respectively the dianionic form of 2-hydroxybenzoylhydrazones of acetylacetone (H3L(1)) and benzoylacetone (H3L(2)) (general abbreviation H3L)). From X-ray structure analysis, the V(V)-O-V(V) angle was found to be ∼115° and 180° in 1 and 2 respectively...
November 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29138503/dihydrotestosterone-levels-at-birth-associate-positively-with-higher-proportions-of-circulating-immature-na%C3%A3-ve-cd5-b-cells-in-boys
#3
Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Anna Strömbeck, Claes Ohlsson, Åsa Tivesten, Anna Rudin
Boys present with higher proportions of immature/naïve CD5(+) B cells than girls up to 3 years of age. Boys also have higher fractions of regulatory T cells (Tregs) in early infancy, but the mechanisms for these sex-related differences are unknown. In the prospective FARMFLORA follow-up study of 23 boys and 25 girls, we investigated if these immunological differences remained at 8 years of age. We also examined if testosterone or dihydrotestosterone (DHT) levels at birth and at 8 years of age were associated with immune maturation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133393/sequential-induction-of-fur-regulated-genes-in-response-to-iron-limitation-in-bacillus-subtilis
#4
Hualiang Pi, John D Helmann
Bacterial cells modulate transcription in response to changes in iron availability. The ferric uptake regulator (Fur) senses intracellular iron availability and plays a central role in maintaining iron homeostasis in Bacillus subtilis Here we utilized FrvA, a high-affinity Fe(2+) efflux transporter from Listeria monocytogenes, as an inducible genetic tool to deplete intracellular iron. We then characterized the responses of the Fur, FsrA, and PerR regulons as cells transition from iron sufficiency to deficiency...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29133301/taming-the-beast-control-of-apc-c-cdc20-dependent-destruction
#5
Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
The anaphase-promoting complex/cyclosome (APC/C) is a large multisubunit ubiquitin ligase that triggers the metaphase-to-anaphase transition in the cell cycle by targeting the substrates cyclin B and securin for destruction. APC/C activity toward these two key substrates requires the coactivator Cdc20. To ensure that cells enter mitosis and partition their duplicated genome with high accuracy, APC/C(Cdc20) activity must be tightly controlled. Here, we discuss the mechanisms that regulate APC/C(Cdc20) activity both before and during mitosis...
November 13, 2017: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29130234/-expression-of-acetyl-coenzyme-a-synthetase-2-in-colorectal-cancer-and-its-biological-role
#6
Tong Yu, Long Cui, Chenying Liu, Guanghui Wang, Tingyu Wu, Yuji Huang
OBJECTIVE: To investigate the expression of acetyl coenzyme A synthetase short-chain family member 2 (ACSS2) in patients with colorectal cancer (CRC) and its biological role. METHODS: A total of 74 CRC tissue samples and 40 normal colorectal tissues were tested by immunohistochemical staining to detect the expression of ACSS2 (cell staining intensity score: 0 points: without staining, 1 points: weak staining, 2 points: intensity staining, 3 point: strong staining; the percentage of positive cells in tumor or negative score: 0 points: negative, 1 point: <25% positive cells, 2 points: 25%-50% positive cells, 3 points: 50%-75% positive cells, 4 points: >75% positive cells...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29129683/non-monotonic-changes-in-progenitor-cell-behavior-and-gene-expression-during-aging-of-the-adult-v-svz-neural-stem-cell-niche
#7
Maria Apostolopoulou, Thomas R Kiehl, Mark Winter, Edgar Cardenas De La Hoz, Nathan C Boles, Christopher S Bjornsson, Kristen L Zuloaga, Susan K Goderie, Yue Wang, Andrew R Cohen, Sally Temple
Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome of male mice at 2, 6, 18, and 22 months, we found that most of the genes that change significantly over time show a reversal of trend, with a maximum or minimum expression at 18 months. In vivo, MASH1(+) progenitor cells decreased in number and proliferation between 2 and 18 months but increased between 18 and 22 months...
November 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29128610/changes-in-redox-regulation-during-transition-from-c3-to-single-cell-c4-photosynthesis-in-bienertia-sinuspersici
#8
Baris Uzilday, Rengin Ozgur, Tolga Yalcinkaya, Ismail Turkan, A Hediye Sekmen
Bienertia sinuspersici performs single cell C4 photosynthesis without Kranz anatomy. Peripheral and central cytoplasmic compartments in a single chlorenchyma cell act as mesophyll cells and bundle sheath cells. Development of this specialized mechanism is gradual during plant development. Young leaves perform C3 photosynthesis, while mature leaves have complete C4 cycle. The aim of this work was to investigate changes in redox regulation and antioxidant defence during transition from C3 to single cell C4 photosynthesis in B...
October 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29128540/electrospun-thermosensitive-hydrogel-scaffold-for-enhanced-chondrogenesis-of-human-mesenchymal-stem-cells
#9
Alexander R Brunelle, Christopher B Horner, Karen Low, Gerardo Ico, Jin Nam
Hydrogels have shown great potential for cartilage tissue engineering applications due to their capability to encapsulate cells within biomimetic, 3-dimensional (3D) microenvironments. However, the multi-step fabrication process that is necessary to produce cell/scaffold constructs with defined dimensions, limits their off-the-shelf translational usage. In this study, we have developed a hybrid scaffolding system which combines a thermosensitive hydrogel, poly(ethylene glycol)-poly(N-isopropylacrylamide) (PEG-PNIPAAm), with a biodegradable polymer, poly(ε-caprolactone) (PCL), into a composite, electrospun microfibrous structure...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29128370/the-inhibition-of-sphingomyelin-synthase-1-activity-induces-collecting-duct-cells-to-lose-their-epithelial-phenotype
#10
Yamila Romina Brandán, Edith Del Valle Guaytima, Nicolás Octavio Favale, Lucila Gisele Pescio, Norma B Sterin-Speziale, María Gabriela Márquez
Epithelial tissue requires that cells attach to each other and to the extracellular matrix by the assembly of adherens junctions (AJ) and focal adhesions (FA) respectively. We have previously shown that, in renal papillary collecting duct (CD) cells, both AJ and FA are located in sphingomyelin (SM)-enriched plasma membrane microdomains. In the present work, we investigated the involvement of SM metabolism in the preservation of the epithelial cell phenotype and tissue organization. To this end, primary cultures of renal papillary CD cells were performed...
November 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29123683/thermomechanical-effect-in-molecular-crystals-the-role-of-halogen-bonding-interactions
#11
Sudhir Mittapalli, D Sravanakumar Perumalla, Jagadeesh Babu Nanubolu, Ashwini Nangia
The design and synthesis of mechanically responsive materials is interesting because they are potential candidates to convert thermal energy into mechanical work. Reported in this paper are thermosalient effects in a series of halogen derivatives of salinazids. The chloro derivative, with higher electronegativity and a weaker inter-halogen bond strength (Cl⋯Cl) exhibits an excellent thermal response, whereas the response is weaker in the iodo derivative with stronger I⋯I halogen bonding. 3,5-Di-chloro-salinazid (Compound-A) exists in three polymorphic forms, two room-temperature polymorphs (Forms I and II) and one high-temperature modification (Form III)...
November 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/29123267/bpifb1-lplunc1-inhibits-migration-and-invasion-of-nasopharyngeal-carcinoma-by-interacting-with-vtn-and-vim
#12
Fang Wei, Yingfen Wu, Le Tang, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Qianjin Liao, Wenling Zhang, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
BACKGROUND: Bactericidal/Permeability-increasing-fold-containing family B member 1 (BPIFB1, previously termed LPLUNC1) is highly expressed in the nasopharynx, significantly downregulated in nasopharyngeal carcinoma (NPC), and associated with prognosis in NPC patients. Because metastasis represents the primary cause of NPC-related death, we explored the role of BPIFB1 in NPC migration and invasion. METHODS: The role of BPIFB1 in NPC metastasis was investigated in vitro and in vivo...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29123210/plasticity-of-the-inner-cell-mass-in-mouse-blastocyst-is-restricted-by-the-activity-of-fgf-mapk-pathway
#13
M Wigger, K Kisielewska, K Filimonow, B Plusa, M Maleszewski, A Suwińska
In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequential cell fate decisions. We revealed that TE-deprived ICMs derived from 32-cell blastocysts are still able to reconstruct TE during in vitro culture, confirming totipotency of ICM cells at this stage...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121598/novel-c-terminal-heat-shock-protein-90-inhibitors-ku711-and-ku757-are-effective-in-targeting-head-and-neck-squamous-cell-carcinoma-cancer-stem-cells
#14
C Subramanian, K J Kovatch, M W Sim, G Wang, M E Prince, T E Carey, R Davis, B S J Blagg, M S Cohen
Advanced head and neck squamous cell carcinoma (HNSCC) remains a therapeutic challenge due to the development of therapy resistance. Several studies have implicated the development of cancer stem cells as a possible mechanism for therapy resistance in HNSCC. Heat shock protein 90's (Hsp90's) molecular chaperone function is implicated in pathways of resistance in HNSCC. Therefore, in the present study, we investigated the efficacy of novel C-terminal Hsp90 inhibitors (KU711 and KU757) in targeting HNSCC cancer stem cells (CSCs)...
November 6, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29120853/ultrastructural-characteristics-of-the-respective-forms-of-hepatic-stellate-cells-in-chronic-hepatitis-b-as-an-example-of-high-fibroblastic-cell-plasticity-the-first-assessment-in-children
#15
Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn
PURPOSE: Activation of hepatic stellate cells (HSCs), mainly responsible for extracellular matrix synthesis, is assumed to be central event in the process of liver fibrogenesis. The major objective of the research was to analyze the ultrastructural profile of activated HSCs in children with chronic hepatitis B (chB), with respect to fibrosis intensity. MATERIALS/METHODS: Ultrastructural investigations of HSCs were conducted on liver bioptates from 70 children with clinicopathologically diagnosed chB before antiviral treatment...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29118542/the-role-of-the-endothelin-axis-in-promoting-epithelial-to-mesenchymal-transition-and-lymph-node-metastasis-in-prostate-adenocarcinoma
#16
Sophia Papanikolaou, Vasiliki Bravou, Helen Papadaki, Kostis Gyftopoulos
Introduction: Aberrant activation of endothelin (ET) axis has been identified as a key player in tumor growth and metastasis in several tumor types. However, little is known about the possible interaction of the ET with epithelial to mesenchymal transition (EMT), a process that transforms tumor cells in a motile, resistant to apoptosis phenotype prone to invasion and metastasis. The aim of this study was to investigate the activation of the ET axis in prostate adenocarcinoma and examine possible associations with EMT markers, lymph node (LN) metastasis, and other clinicopathological parameters...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29116427/cart-neurons-in-the-lateral-hypothalamus-communicate-with-the-nucleus-accumbens-shell-via-glutamatergic-neurons-in-paraventricular-thalamic-nucleus-to-modulate-reward-behavior
#17
Amit G Choudhary, Amita R Somalwar, Sneha Sagarkar, Abhishek Rale, Amul Sakharkar, Nishikant K Subhedar, Dadasaheb M Kokare
Paraventricular thalamic nucleus (PVT) serves as a transit node processing food and drug-associated reward information, but its afferents and efferents have not been fully defined. We test the hypothesis that the CART neurons in the lateral hypothalamus (LH) project to the PVT neurons, which in turn communicate via the glutamatergic fibers with the nucleus accumbens shell (AcbSh), the canonical site for reward. Rats conditioned to self-stimulate via an electrode in the right LH-medial forebrain bundle were used...
November 7, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29115483/hepatocellular-toxicity-of-oxalicumone-a-via-oxidative-stress-injury-and-mitochondrial-dysfunction-in-healthy-human-liver-cells
#18
Si Shi, Limei Yao, Kunbin Guo, Xiangyu Wang, Qi Wang, Weirong Li
The marine‑derived oxalicumone A (POA) has been demonstrated as a potent anti‑tumor bioactive agent for a variety of human carcinoma, but to the best of our knowledge, remains to be evaluated in healthy liver cells. As many drugs distribute preferentially in the liver, the present study aimed to investigate the effects of POA on apoptosis, oxidative stress and mitochondrial function in L‑02 healthy liver cells. A Cell‑Counting kit‑8 assay demonstrated that POA inhibits the proliferation of L‑02 cells in a dose‑ and time‑dependent manner...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115480/protective-effects-of-probucol-on-ox-ldl-induced-epithelial-mesenchymal-transition-in-human-renal-proximal-tubular-epithelial-cells-via-lox%C3%A2-1-ros-mapk-signaling
#19
Bing Bing Zhu, Hao Wang, Yang Feng Chi, Yun Man Wang, Xing Mei Yao, Shuang Liu, Huiling Qiu, Ji Fang, Pei Hao Yin, Xue Mei Zhang, Wen Peng
Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human renal proximal tubular epithelial cells (HK‑2) and to further explore the role and interrelation of lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1), reactive oxygen species (ROS) and mitogen‑activated protein kinase (MAPK) pathway...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113242/eupatolide-inhibits-the-tgf-%C3%AE-1-induced-migration-of-breast-cancer-cells-via-downregulation-of-smad3-phosphorylation-and-transcriptional-repression-of-alk5
#20
Ariundavaa Boldbaatar, Sunyi Lee, Sora Han, Ae Lee Jeong, Hye In Ka, Sumiyasuren Buyanravjikh, Jeong Hyung Lee, Jong-Seok Lim, Myung Sok Lee, Young Yang
The epithelial-mesenchymal transition (EMT) is a hallmark of cancer metastasis, and the associated molecular signaling pathways are regarded as therapeutic targets for cancer treatment. Thus, suppressing EMT with a natural chemical compound may be of therapeutic benefit. Eupatolide is a natural chemical compound extracted from the medicinal plant Inula britannica, which is used in Eastern Asia to treat bronchitis, disorders of the digestive system and inflammation. Besides the anti-inflammatory function of eupatolide, the present study found that eupatolide suppressed the migration and invasion of breast cancer cells, which was associated with the downregulation of vimentin in MDA-MB-231 cells and the upregulation of E-cadherin in MCF-7 cells...
November 2017: Oncology Letters
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