Read by QxMD icon Read

cardiac sarcoidosis

Xiaowen Hu, Eva M Carmona, Eunhee S Yi, Patricia A Pellikka, Jay Ryu
INTRODUCTION: Sarcoidosis is a multi-system, granulomatous disorder of unknown etiology that is associated with a variable prognosis and sometimes results in death. There are conflicting reports regarding the causes of death in patients with sarcoidosis. METHODS: Forty-four consecutive patients with sarcoidosis who underwent an autopsy (35 patients) or died at Mayo Clinic (Rochester, MN, USA) over a 20-yr period, from January 1, 1994 to December 31, 2013 were analyzed...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Z Aktop, H Tanrıverdi, F Uygur, A İşleyen, B Kalaycı, Y C Gursoy, T Karabağ, M Aydın, I Akpınar
BACKGROUND: The aim of this study was to evaluate autonomic nervous system function by measuring heart rate variability (HRV) in patients with sarcoidosis without known cardiac manifestations. PATIENTS AND METHODS: The study comprised 61 participants, including 31 patients with sarcoidosis without known cardiac manifestations and 30 healthy volunteers. All participants underwent echocardiographic examination, 12-channel electrocardiography (ECG), and 24-h Holter monitoring...
October 13, 2016: Herz
Makoto Sano, Hiroshi Satoh, Kenichiro Suwa, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hideharu Hayashi, Takeji Saitoh
Cardiac involvement of sarcoid lesions is diagnosed by myocardial biopsy which is frequently false-negative, and patients with cardiac sarcoidosis (CS) who have impaired left ventricular (LV) systolic function are sometimes diagnosed with dilated cardiomyopathy (DCM). Late gadolinium enhancement (LE) in magnetic resonance imaging is now a critical finding in diagnosing CS, and the novel Japanese guideline considers myocardial LE to be a major criterion of CS. This article describes the value of LE in patients with CS who have impaired LV systolic function, particularly the diagnostic and clinical significance of LE distribution in comparison with DCM...
September 26, 2016: World Journal of Cardiology
Said Ashraf, Alexandros Briasoulis, Luis Afonso
Cardiac sarcoidosis (CS) is found in 2-7% of patients with systemic sarcoidosis (SS). Its diagnosis and treatment is challenging, notwithstanding the poor prognosis and treatment. Hereby, we present a case of systemic sarcoidosis with rare cardiac manifestations of severe mitral incompetence and large coronary aneurysm in a previously healthy woman. She underwent successful mitral valve replacement and coronary artery bypass surgery and was maintained on low dose glucocorticoid therapy.
September 28, 2016: Heart & Lung: the Journal of Critical Care
David R Okada, Paco E Bravo, Tomas Vita, Vikram Agarwal, Michael T Osborne, Viviany R Taqueti, Hicham Skali, Panithaya Chareonthaitawee, Sharmila Dorbala, Garrick Stewart, Marcelo Di Carli, Ron Blankstein
No abstract text is available yet for this article.
September 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Gillian Murtagh, Luke J Laffin, Kershaw V Patel, Amit V Patel, Catherine A Bonham, Zoe Yu, Karima Addetia, Nadia El-Hangouche, Francesco Maffesanti, Victor Mor-Avi, D Kyle Hogarth, Nadera J Sweiss, John F Beshai, Roberto M Lang, Amit R Patel
BACKGROUND: Cardiac infiltration is an important cause of death in sarcoidosis. Transthoracic echocardiography (TTE) has limited sensitivity for the detection of cardiac sarcoidosis (CS). Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is used to diagnose CS but has limitations of cost and availability. We sought to determine whether TTE-derived global longitudinal strain (GLS) may be used to identify individuals with CS, despite preserved left ventricular ejection fraction (LVEF), and whether abnormal GLS is associated with major cardiovascular events (MCE)...
September 2016: Echocardiography
Thomas Hellmut Schindler
With the recent advent of PET/MRI scanners, the combination of molecular imaging with a variety of known and novel PET radiotracers, the high spatial resolution of MRI, and its potential for multi-parametric imaging are anticipated to increase the diagnostic accuracy in cardiovascular disease detection, while providing novel mechanistic insights into the initiation and progression of the disease state. For the time being, cardiac PET/MRI emerges as potential clinical tool in the identification and characterization of infiltrative cardiac diseases, such as sarcoidosis, acute or chronic myocarditis, and cardiac tumors, respectively...
September 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
S Piel, M Kreuter, F Herth, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role...
October 2016: Der Radiologe
Felix Nensa, Julia Kloth, Ercan Tezgah, Thorsten D Poeppel, Philipp Heusch, Juliane Goebel, Kai Nassenstein, Thomas Schlosser
OBJECTIVE: Besides cardiac sarcoidosis, FDG-PET is rarely used in the diagnosis of myocardial inflammation, while cardiac MRI (CMR) is the actual imaging reference for the workup of myocarditis. Using integrated PET/MRI in patients with suspected myocarditis, we prospectively compared FDG-PET to CMR and the feasibility of integrated FDG-PET/MRI in myocarditis. METHODS: A total of 65 consecutive patients with suspected myocarditis were prospectively assessed using integrated cardiac FDG-PET/MRI...
September 8, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Han W Kim, Raymond J Kim
No abstract text is available yet for this article.
September 2016: Circulation. Cardiovascular Imaging
Edward Hulten, Vikram Agarwal, Michael Cahill, Geoff Cole, Tomas Vita, Scott Parrish, Marcio Sommer Bittencourt, Venkatesh L Murthy, Raymond Kwong, Marcelo F Di Carli, Ron Blankstein
BACKGROUND: Individuals with cardiac sarcoidosis have an increased risk of ventricular arrhythmia and death. Several small cohort studies have evaluated the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to predict adverse cardiovascular events. However, studies have yielded inconsistent results, and some analyses were underpowered. Therefore, we sought to systematically review and perform meta-analysis of the prognostic value of cardiac MRI for patients with known or suspected cardiac sarcoidosis...
September 2016: Circulation. Cardiovascular Imaging
Deniz Akdis, Corinna Brunckhorst, Firat Duru, Ardan M Saguner
This overview gives an update on the molecular mechanisms, clinical manifestations, diagnosis and therapy of arrhythmogenic cardiomyopathy (ACM). ACM is mostly hereditary and associated with mutations in genes encoding proteins of the intercalated disc. Three subtypes have been proposed: the classical right-dominant subtype generally referred to as ARVC/D, biventricular forms with early biventricular involvement and left-dominant subtypes with predominant LV involvement. Typical symptoms include palpitations, arrhythmic (pre)syncope and sudden cardiac arrest due to ventricular arrhythmias, which typically occur in athletes...
August 2016: Arrhythmia & Electrophysiology Review
Ying Zhou, Elyse E Lower, Hui-Ping Li, Alexandru Costea, Mehran Attari, Robert P Baughman
OBJECTIVE: To assess the clinical characteristics, diagnosis, and outcome of cardiac sarcoidosis in a single institution sarcoidosis clinic. METHODS: Patients with cardiac sarcoidosis were identified using refined WASOG criteria of highly probable and probable. Patient demographics, local and systemic treatments and clinical outcome were collected. RESULTS: Of the 1815 patients evaluated over a six year period, 73 patients met the WASOG criteria for cardiac sarcoidosis...
September 8, 2016: Chest
David R Okada, Paco E Bravo, Tomas Vita, Vikram Agarwal, Michael T Osborne, Viviany Taqueti, Hicham Skali, Panithaya Chareonthaitawee, Sharmila Dorbala, Garrick Stewart, Marcelo Di Carli, Ron Blankstein
There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS...
September 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Simon Greulich, Daniel Kitterer, Reto Kurmann, Joerg Henes, Joerg Latus, Steffen Gloekler, Andreas Wahl, Sebastian J Buss, Hugo A Katus, Marco Bobbo, Massimo Lombardi, Maik Backes, Hannah Steubing, Pascal Schepat, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: The diagnosis of cardiac involvement in rheumatic disorders is challenging due to its varying clinical presentation. Since clinical consequences range from immediate treatment changes to adverse long-term outcome, individual risk stratification is of great clinical interest. Primary aim was to evaluate the prevalence of cardiac involvement in patients with different rheumatic disorders using late gadolinium enhancement-cardiac magnetic resonance imaging (LGE-CMR). In addition, we sought to investigate if different rheumatic disorders would demonstrate different LGE patterns...
August 24, 2016: International Journal of Cardiology
Luca Presotto, Elena Busnardo, Luigi Gianolli, Valentino Bettinardi
Positron emission tomography (PET) is indicated for a large number of cardiac diseases: perfusion and viability studies are commonly used to evaluate coronary artery disease; PET can also be used to assess sarcoidosis and endocarditis, as well as to investigate amyloidosis. Furthermore, a hot topic for research is plaque characterization. Most of these studies are technically very challenging. High count rates and short acquisition times characterize perfusion scans while very small targets have to be imaged in inflammation/infection and plaques examinations...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Daniel Juneau, Fernanda Erthal, Atif Alzahrani, Ali Alenazy, Pablo B Nery, Rob S Beanlands, Benjamin J Chow
Cardiac inflammatory disorders, either primarily cardiac or secondary to a systemic process, are associated with significant morbidity and/or mortality. Their diagnosis can be challenging, especially due to significant overlap in their clinical presentation with other cardiac diseases. Recent publications have investigated the potential diagnostic role of positron emission tomography (PET) imaging in these patients. Most of the available literature is focused on Fluorine-18 fluorodeoxyglucose (FDG), a tracer which has already demonstrated its use in other inflammatory and infectious processes...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Shahin Zandieh, Reinhard Bernt, Siroos Mirzaei, Joerg Haller, Klaus Hergan
BACKGROUND: Sarcoidosis is a systemic disorder of unknown etiology. It is distinguished by the presence of noncaseating epithelioid granulomas. This study demonstrates the use of image fusion between (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) and magnetic resonance imaging (MRI) to diagnose patients with cardiac sarcoidosis (CS). METHODS: Seven patients diagnosed with sarcoidosis were retrospectively included. All patients underwent 18F-FDG PET/CT and cardiac MRI...
September 7, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Antje Prasse
BACKGROUND: Sarcoidosis is a granulomatous inflammatory disease of unknown cause. Its prevalence in Germany is approximately 46 per 100 000 persons. METHODS: This article is based on pertinent publications retrieved by a selective search in PubMed. RESULTS: A presumptive diagnosis of sarcoidosis is made in any patient with a granulomatous inflammation that is not explained by any other identifiable cause, such as an infection or foreign body...
August 22, 2016: Deutsches Ärzteblatt International
Christoph Rischpler, Stephan G Nekolla
Hybrid PET/MR imaging is a complex imaging modality that has raised high expectations not only for oncological and neurologic imaging applications, but also for cardiac imaging applications. Initially, physicians and physicists had to become accustomed to technical challenges including attenuation correction, gating, and more complex workflow and more elaborate image analysis as compared with PET/CT or standalone MR imaging. PET/MR imaging seems to be particularly valuable to assess inflammatory myocardial diseases (such as sarcoidosis), to cross-validate PET versus MR imaging data (eg, myocardial perfusion imaging), and to help validate novel biomarkers of various disease states (eg, postinfarction inflammation)...
October 2016: PET Clinics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"