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https://www.readbyqxmd.com/read/29232676/progressive-development-of-aberrant-smooth-muscle-cell-phenotype-in-abdominal-aortic-aneurysm-disease
#1
Kirsten Riches, Emily Clark, Rebecca J Helliwell, Timothy G Angelini, Karen E Hemmings, Marc A Bailey, Katherine I Bridge, D Julian A Scott, Karen E Porter
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of the differentiation marker miR-145 (2...
December 13, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29232299/the-axillary-intra-aortic-balloon-pump-as-a-bridge-to-recovery-allows-early-ambulation-in-long-term-use-case-series-and-literature-review
#2
Nnamdi Nwaejike, Andre Y Son, Chetan B Patel, Jacob N Schroder, Carmelo A Milano, Mani A Daneshmand
We evaluated the feasibility, tolerability, and efficacy of a strategy for transaxillary artery intra-aortic balloon pump placement for extended mechanical circulatory support of patients with postcardiotomy shock as a bridge to recovery. Patients requiring prolonged intra-aortic balloon pump support for postcardiotomy heart failure were identified. Intra-aortic balloon pump was tunneled through a 6-mm Dacron graft anastomosed to the right axillary artery. The intra-aortic balloon pump catheter is advanced under fluoroscopic guidance into the descending thoracic aorta...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29231794/intracranial-contrast-transit-times-on-digital-subtraction-angiography-decrease-more-in-patients-with-delayed-intraparenchymal-hemorrhage-after-pipeline
#3
Denise Brunozzi, Sophia F Shakur, Fady T Charbel, Ali Alaraj
Background Pipeline embolization devices (PEDs) are used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage (DIPH). Changes in intracranial hemodynamics after PED are poorly understood. Objective Here, we assess hemodynamic changes after PED in patients and compare these changes in patients with and without DIPH (DIPH+ and DIPH-). Methods Records of patients with distal internal carotid artery (ICA) aneurysms treated with PED at our institution between 2012 and 2017 were retrospectively reviewed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29231236/relevance-of-the-cerebral-collateral-circulation-in-ischaemic-stroke-time-is-brain-but-collaterals-set-the-pace
#4
Simon Jung, Roland Wiest, Jan Gralla, Richard McKinley, Heinrich Mattle, David Liebeskind
Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29230323/baseline-oxidative-stress-is-associated-with-memory-changes-in-omega-3-fatty-acid-treated-coronary-artery-disease-patients
#5
Graham Mazereeuw, Nathan Herrmann, Ana C Andreazza, Gustavo Scola, David W L Ma, Paul I Oh, Krista L Lanctôt
Objective: This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients. Methods: This was a secondary analysis of the CAROTID trial (NCT00981383). Composite immediate recall, measured using the California Verbal Learning Test, Second Edition, and the Brief Visuospatial Memory Test-Revised, was assessed...
2017: Cardiovascular Psychiatry and Neurology
https://www.readbyqxmd.com/read/29229867/intracranial-pulsatility-in-patients-with-cerebral-small-vessel-disease-a-systematic-review
#6
Yulu Shi, Michael J Thrippleton, Ian Marshall, Joanna M Wardlaw
Growing evidence suggests that increased intracranial pulsatility is associated with cerebral small vessel disease (SVD). We systematically reviewed papers that assessed intracranial pulsatility in subjects with SVD. We included 27 cross-sectional studies (n=3356): 20 used Doppler ultrasound and 7 used phase-contrast MRI. Most studies measured pulsatility in the internal carotid or middle cerebral arteries (ICA, MCA), whereas few assessed veins or cerebrospinal fluid (CSF). Methods to reduce bias and risk factor adjustment were poorly reported...
December 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29229785/the-chemokine-receptor-cx3cr1-coordinates-monocyte-recruitment-and-endothelial-regeneration-after-arterial-injury
#7
Tobias Getzin, Kashyap Krishnasamy, Jaba Gamrekelashvili, Tamar Kapanadze, Anne Limbourg, Christine Häger, L Christian Napp, Johann Bauersachs, Hermann Haller, Florian P Limbourg
Regeneration of arterial endothelium after injury is critical for the maintenance of normal blood flow, cell trafficking, and vascular function. Using mouse models of carotid injury, we show that the transition from a static to a dynamic phase of endothelial regeneration is marked by a strong increase in endothelial proliferation, which is accompanied by induction of the chemokine CX3CL1 in endothelial cells near the wound edge, leading to progressive recruitment of Ly6Clo monocytes expressing high levels of the cognate CX3CR1 chemokine receptor...
December 11, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29229316/risk-adjusted-hospital-outcomes-in-elective-carotid-artery-surgery-in-patients-with-medicare
#8
Donald E Fry, Susan M Nedza, Michael Pine, Agnes M Reband, Chun-Jung Huang, Gregory Pine
BACKGROUND: The risk-adjusted outcomes by hospital of elective carotid endarterectomy that is inclusive of inpatient and 90-day postdischarge adverse outcomes have not been studied. METHODS: We studied Medicare inpatients to identify hospitals with 25 or more qualifying carotid endarterectomy cases between 2012-2014. Risk-adjusted prediction models were designed for adverse outcomes of inpatient deaths, 3-sigma prolonged duration-of-stay outliers, 90-day postdischarge deaths without readmission, and 90-day postdischarge associated readmissions...
December 8, 2017: Surgery
https://www.readbyqxmd.com/read/29229106/cardiovascular-benefits-from-standard-pulmonary-rehabilitation-are-related-to-baseline-exercise-tolerance-levels-in-chronic-obstructive-pulmonary-disease
#9
Linn E Moore, Bradley W Byers, Desi P Fuhr, Eric Wong, Mohit Bhutani, Michael K Stickland
BACKGROUND: Heightened arterial stiffness is a marker of cardiovascular risk and is elevated in chronic obstructive pulmonary disease (COPD). Physical activity has been shown to reduce arterial stiffness, and our previous work has shown that arterial stiffness is related to physical activity and exercise tolerance in COPD. The purpose of this study was to evaluate whether baseline physical activity and exercise tolerance influence the cardiovascular benefits associated with standard COPD outpatient pulmonary rehabilitation (PR)...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228328/hypervascular-vestibular-schwannomas-clinical-characteristics-angiographical-classification-and-surgical-considerations
#10
Yu Teranishi, Michihiro Kohno, Shigeo Sora, Hiroaki Sato, Osamu Nagata
BACKGROUND: There is a rare type of vestibular schwannoma, scarcely discussed in the literature, known as a hypervascular vestibular schwannoma (HVS). OBJECTIVE: To evaluate its biological characteristics, angiographical classification, surgical outcomes, and the significance for surgical consideration, using a large series of this clinical entity. METHODS: The definition for HVS in this study was the tumor stain from the vertebrobasilar system (VBS) in angiography...
December 7, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29227793/bilateral-traumatic-caroticocavernous-fistulas-a-case-report-and-review-of-the-literature
#11
Lorna Leandro, Giovanni Dolci, Satheesh Prabhu, Rufus Corkill
A traumatic caroticocavernous fistula (CCF) is an acquired, abnormal communication between the internal carotid artery and the cavernous sinus, secondary to trauma. This rare condition can initially be misdiagnosed, because its presentation shares features common to those of facial trauma, which can result in serious complications. We describe a case of bilateral CCF in an adult patient after a road traffic accident.
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29227572/factors-associated-with-serum-magnesium-and-vascular-stiffness-in-maintenance-hemodialysis-patients
#12
Mai Yorifuji, Takahiro Kuragano, Sayuri Kawada, Wataru Fukao, Kazuhiro Toyoda, Takeshi Nakanishi
INTRODUCTION: We evaluated the associated factors of serum magnesium in patients on maintenance hemodialysis (MHD). Furthermore, we evaluated the relationship between low serum magnesium and arteriosclerosis in these patients. METHODS: In 129 patients on MHD, we evaluated the blood levels of magnesium, brachial-ankle pulse wave velocity (ba-PWV), ankle-brachial index (ABI), and intima-media thickness of the common carotid artery (IMT). FINDINGS: In MHD patients, the serum level of magnesium was significantly correlated with age, calcium, TNF-α, albumin, and ba-PWV but not with ABI or IMT...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29227295/an-unusual-presentation-of-pituitary-gland-apoplexy-with-noninfectious-meningitis
#13
Margaret LaPorte, Jenna Pollock, Michael Ward, James Fulcher
Pituitary adenomas make up 10% of intracranial tumors, but because of their location, they may go undetected for long periods. In this article, we report the case of a 68-year-old white man found deceased in his residence, who died of acute pituitary tumor apoplexy. He was known to have severe symptoms including acute headache, vision loss, and altered behavior. When found, his home was in extreme disarray, mimicking a possible assault. At autopsy, the decedent had multiple superficial abrasions about the upper and lower extremities, as well as a 2...
December 7, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#14
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29226137/identification-of-key-pathways-and-genes-in-advanced-coronary-atherosclerosis-using-bioinformatics-analysis
#15
Xiaowen Tan, Xiting Zhang, Lanlan Pan, Xiaoxuan Tian, Pengzhi Dong
Background: Coronary artery atherosclerosis is a chronic inflammatory disease. This study aimed to identify the key changes of gene expression between early and advanced carotid atherosclerotic plaque in human. Methods: Gene expression dataset GSE28829 was downloaded from Gene Expression Omnibus (GEO), including 16 advanced and 13 early stage atherosclerotic plaque samples from human carotid. Differentially expressed genes (DEGs) were analyzed. Results: 42,450 genes were obtained from the dataset...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29224943/outcomes-after-early-and-delayed-carotid-endarterectomy-in-patients-with-symptomatic-carotid-artery-stenosis
#16
Ying Huang, Peter Gloviczki, Audra A Duncan, Manju Kalra, Gustavo S Oderich, Randall R DeMartino, William S Harmsen, Thomas C Bower
OBJECTIVE: The objective of this study was to define outcomes after carotid endarterectomy (CEA) in patients with symptomatic carotid artery stenosis (CAS) when patients are operated on within 14 days after onset of symptoms. METHODS: Clinical data of consecutive patients who underwent CEA between 2003 and 2012 for symptomatic CAS were reviewed. Patients were classified into group 1, CEA ≤14 days of minor stroke or transient ischemic attack, and group 2, CEA >14 days...
December 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29224941/open-surgery-versus-endovascular-approach-in-treatment-of%C3%A2-extracranial-carotid-artery-aneurysms
#17
Leng Ni, Huiling Weng, Zuo Pu, Yuehong Zheng, Bao Liu, Wei Ye, Rong Zeng, Changwei Liu
OBJECTIVE: The objective of this study was to investigate and to compare the early and long-term results of open surgery with endovascular intervention in the treatment of extracranial carotid artery aneurysms (ECCAs). METHODS: A retrospective review of patients diagnosed with ECCAs who underwent open surgical or endovascular treatment from 1997 to 2017 was performed. Clinical characteristics, aneurysm profile, and treatment outcomes were recorded. Early results (<30 days) were evaluated in terms of mortality, perioperative stroke or transient ischemic attack, and cranial nerve injury...
December 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29224052/arterial-input-function-in-a-dedicated-slice-for-cerebral-perfusion-measurements-in-humans
#18
Elias Kellner, Irina Mader, Marco Reisert, Horst Urbach, Valerij Gennadevic Kiselev
OBJECT: We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting. MATERIALS AND METHODS: Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were optimized for the blood signal (short echo time, background suppression, magnitude and phase images)...
December 9, 2017: Magma
https://www.readbyqxmd.com/read/29223792/prediction-of-persistent-hemodynamic-depression-after-carotid-angioplasty-and-stenting-using-artificial-neural-network-model
#19
Jin Pyeong Jeon, Chulho Kim, Byoung-Doo Oh, Sun Jeong Kim, Yu-Seop Kim
OBJECTIVES: To assess and compare predictive factors for persistent hemodynamic depression (PHD) after carotid artery angioplasty and stenting (CAS) using artificial neural network (ANN) and multiple logistic regression (MLR) or support vector machines (SVM) models. PATIENTS AND METHODS: A retrospective data set of patients (n=76) who underwent CAS from 2007 to 2014 was used as input (training cohort) to a back-propagation ANN using TensorFlow platform. PHD was defined when systolic blood pressure was less than 90mmHg or heart rate was less 50 beats/min that lasted for more than one hour...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29223124/activation-of-mitochondrial-katp-channels-mediates-neuroprotection-induced-by-chronic-morphine-preconditioning-in-hippocampal-ca-1-neurons-following-cerebral-ischemia
#20
Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
PURPOSE: Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury...
December 6, 2017: Advances in Medical Sciences
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