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Fluorouracil for keloids

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https://www.readbyqxmd.com/read/27784253/the-effectiveness-of-topical-anti-scarring-agents-and-a-novel-combined-process-on-cutaneous-scar-management
#1
Qing-Qing Fang, Chun- Ye Chen, Min-Xia Zhang, Chun-Lan Huang, Xiao-Wei Wang, Ji-Hua Xu, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan
Cutaneous scars (particularly hypertrophic and keloid scars), always follow after a dermal injury to the skin cutaneous scars leave a negative impact on people, both physically and mentally. Comparing to other surgical treatments, patients who do not opt for or can't opt for invasion therapy are more eligible for using the topical anti-scarring agents. In this mini-review, we have researched for and collected the data between October 2005 and October 2015, in PubMed and Web of Science, and identified those agents including silicone-based products, imiquimod, corticosteroids, 5- fluorouracil, bleomycin, mitomycin, and plant extracts such as onion extract, asiaticoside, aloe vera, vitamin E, and so on...
October 25, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27556757/evidence-based-scar-management-how-to-improve-results-with-technique-and-technology
#2
Ibrahim Khansa, Bridget Harrison, Jeffrey E Janis
BACKGROUND: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Numerous products are marketed for scar prevention or improvement, but their efficacy is unclear. METHODS: A literature review of high-level studies analyzing methods to prevent or improve hypertrophic scars, keloids, and striae distensae was performed...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27427423/efficacy-and-safety-of-triamcinolone-acetonide-alone-and-in-combination-with-5-fluorouracil-for-treating-hypertrophic-scars-and-keloids-a-systematic-review-and-meta-analysis
#3
YiMing Ren, XianHu Zhou, ZhiJian Wei, Wei Lin, BaoYou Fan, ShiQing Feng
Pathological scars, such as keloids and hypertrophic scars, readily cause physical and psychological problems. Combination 5-fluorouracil (5-FU) with triamcinolone acetonide (TAC) is presumed to enhance the treatment of pathological scars, although supportive evidence is lacking. We aimed to compare the efficacy and safety of TAC alone and in combination with 5-FU for the treatment of hypertrophic scars and keloids. Five databases (PubMed, Medline, Cochrane databases, Embase and CNKI) were searched with the limitations of human subjects and English-language text...
July 18, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27347634/keloids-and-hypertrophic-scars-pathophysiology-classification-and-treatment
#4
Brian Berman, Andrea Maderal, Brian Raphael
BACKGROUND: Keloid and hypertrophic scars represent an aberrant response to the wound healing process. These scars are characterized by dysregulated growth with excessive collagen formation, and can be cosmetically and functionally disruptive to patients. OBJECTIVE: Objectives are to describe the pathophysiology of keloid and hypertrophic scar, and to compare differences with the normal wound healing process. The classification of keloids and hypertrophic scars are then discussed...
June 24, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27163611/advances-in-scar-management-prevention-and-management-of-hypertrophic-scars-and-keloids
#5
Drew Del Toro, Raj Dedhia, Travis T Tollefson
PURPOSE OF REVIEW: Abnormal scarring remains a poorly understood but functional and aesthetic consequence of surgical and traumatic wounds. The purpose of this review is to describe the current state of the science behind the prevention and management of these scars. RECENT FINDINGS: A recent update in the International Clinical Recommendations on Scar Management provides a wealth of information on new and revised treatments for hypertrophic scars and keloids. Silicone-based products continue to be the premier option for prevention and initial treatment of hypertrophic and keloid scars...
August 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27119465/current-options-for-the-treatment-of-pathological-scarring
#6
Julian Poetschke, Gerd G Gauglitz
Scarring is the consequence of surgery, trauma or different skin diseases. Apart from fresh, immature scars,that transform into mature scars over the course of would healing and that do not require further treatment,linear hypertrophic scars, widespread hypertrophic scars, keloids and atrophic scars exist. Symptoms like pruritusand pain, stigmatization as well as functional and aesthetic impairments that are very disturbing for the affected patients can bethe basis for the desire for treatment. Today, a multitude of options for the treatment and prevention of scars exists...
May 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27105629/5-fluorouracil-in-the-treatment-of-keloids-and-hypertrophic-scars-a-comprehensive-review-of-the-literature
#7
REVIEW
Vidhi V Shah, Adam S Aldahan, Stephanie Mlacker, Mohammed Alsaidan, Sahal Samarkandy, Keyvan Nouri
Hypertrophic (HTSs) and keloid scars are common dermatological complaints produced by disruption of the normal wound-healing process. Despite a wide array of therapeutic options available to treat these lesions, HTSs and keloids continue to pose a significant challenge to clinicians in everyday practice. The chemotherapeutic drug 5-fluorouracil (5-FU) is a well-known treatment option reserved for recalcitrant HTSs and keloid lesions. We present clinicians with a comprehensive review of the published data concerning the use of 5-FU in the treatment of HTSs and keloids...
June 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/26529198/could-5-fluorouracil-or-triamcinolone-be-an-effective-treatment-option-for-keloid-after-surgical-excision-a-meta-analysis
#8
Jin Yong Shin, Jong Seung Kim
PURPOSE: There is no universally accepted treatment regimen to decrease the recurrence rate of keloid formation after its removal, although many treatment options have been suggested. The purpose of this study was to investigate treatment options to prevent keloid recurrence after surgical excision. MATERIALS AND METHODS: A systematic literature review and meta-analysis was performed using the Medline, Embase, and Cochrane databases. Predictor variables were 5-fluorouracil (5-FU) or triamcinolone adjuvant therapy, and the outcome variable was keloid recurrence rate...
May 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/26236447/the-use-of-chemotherapeutics-for-the-treatment-of-keloid-scars
#9
REVIEW
Christopher David Jones, Luke Guiot, Mike Samy, Mark Gorman, Hamid Tehrani
Keloid scars are pathological scars, which develop as a result of exaggerated dermal tissue proliferation following cutaneous injury and often cause physical, psychological and cosmetic problems. Various theories regarding keloidogenesis exist, however the precise pathophysiological events remain unclear. Many different treatment modalities have been implicated in their management, but currently there is no entirely satisfactory method for treating all keloid lesions. We review a number of different chemotherapeutic agents which have been proposed for the treatment of keloid and hypertrophic scars while giving insight into some of the novel chemotherapeutic drugs which are currently being investigated...
May 21, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25823177/intralesional-triamcinolone-alone-and-in-combination-with-5-fluorouracil-for-the-treatment-of-keloid-and-hypertrophic-scars
#10
RANDOMIZED CONTROLLED TRIAL
Muhammad Aslam Khan, Muhammad Mustehsan Bashir, Farid Ahmad Khan
OBJECTIVE: To compare the use of intralesional triamcinolone acetonide and its combination with 5 flourouracil in the treatment of keloid and hypertrophic scars in terms of reduction in initial height of the scar. METHODS: The randomised controlled trial was conducted at the Department of Plastic Surgery, King Edward Medical University, Lahore, from March 2011 to December 2012. It comprised patients of both genders having keloids or hypertrophic scars (1 cm to 5 cm in size) having no history of treatment for the scars in preceding 6 months...
September 2014: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25805099/intralesional-5-fluorouracil-in-keloid-treatment-a-systematic-review
#11
REVIEW
Eveline Bijlard, Sanne Steltenpool, Frank B Niessen
In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms "keloid" and "5-FU", together with all synonyms of these terms. Two reviewers selected original research reports using 5-FU alone or combined with a maximum of 2 other therapies...
September 2015: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/25569868/steroids-and-fluorouracil-for-keloids-and-hypertrophic-scars
#12
William Carroll, Krishna Patel
No abstract text is available yet for this article.
March 2015: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/25396172/recent-developments-in-the-use-of-intralesional-injections-keloid-treatment
#13
REVIEW
Aurelia Trisliana Perdanasari, Davide Lazzeri, Weijie Su, Wenjing Xi, Zhang Zheng, Li Ke, Peiru Min, Shaoqing Feng, Yi Xin Zhang, Paolo Persichetti
Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars...
November 2014: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/25141160/management-of-scars-updated-practical-guidelines-and-use-of-silicones
#14
REVIEW
Sylvie Meaume, Anne Le Pillouer-Prost, Bertrand Richert, Diane Roseeuw, Javid Vadoud
Hypertrophic scars and keloids resulting from surgery, burns, trauma and infection can be associated with substantial physical and psychological distress. Various non-invasive and invasive options are currently available for the prevention and treatment of these scars. Recently, an international multidisciplinary group of 24 experts on scar management (dermatologists; plastic and reconstructive surgeons; general surgeons; physical medicine, rehabilitation and burns specialists; psychosocial and behavioural researchers; epidemiologists; beauticians) convened to update a set of practical guidelines for the prevention and treatment of hypertrophic and keloid scars on the basis of the latest published clinical evidence on existing scar management options...
July 2014: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/25068544/updated-international-clinical-recommendations-on-scar-management-part-2-algorithms-for-scar-prevention-and-treatment
#15
Michael H Gold, Michael McGuire, Thomas A Mustoe, Andrea Pusic, Mukta Sachdev, Jill Waibel, Crystal Murcia
BACKGROUND: In 2002, an international advisory panel was convened to assess the scientific literature and develop evidence-based guidance for the prevention and treatment of pathologic scarring. Emerging clinical data, new treatment options, and technical advances warranted a renewed literature search and review of the initial advisory panel recommendations. OBJECTIVE: To update the management algorithm for pathologic scarring to reflect best practice standards at present...
August 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/24431948/eradication-of-keloids-surgical-excision-followed-by-a-single-injection-of-intralesional-5-fluorouracil-and-botulinum-toxin
#16
Adel Michel Wilson
BACKGROUND: Keloids may complicate wound healing secondary to trauma, inflammation or surgical incision. Although various treatment modalities have been used with variable degrees of success, overall recurrence rates have remained unacceptably high. METHODS: The present study involved 80 patients with keloids of at least one-years' duration. Following total surgical excision of the keloid, a single dose of 5-fluorouracil was injected into the edges of the healing wound on postoperative day 9 together with botulinum toxin...
2013: Canadian Journal of Plastic Surgery, Journal Canadien de Chirurgie Plastique
https://www.readbyqxmd.com/read/24299571/intralesional-treatment-for-keloids-and-hypertrophic-scars-a-review
#17
REVIEW
Jennifer A Ledon, Jessica Savas, Katlein Franca, Anna Chacon, Keyvan Nouri
BACKGROUND: Although differing in clinical presentation and prognosis, keloids and hypertrophic scars are generally characterized by abnormally proliferative scar tissue and are extremely debilitating. Several intralesional therapies have been studied in attempts to find a universally safe and effective modality, of which there are currently none. OBJECTIVE: To provide a comprehensive review of current intralesional treatment modalities for keloids and hypertrophic scars...
December 2013: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/24236820/medical-approaches-to-non-melanoma-skin-cancer
#18
REVIEW
Giuseppe Micali, Francesco Lacarrubba, Karishma Bhatt, Maria Rita Nasca
Medical therapy represents an alternative treatment approach that can be considered for some forms of non-melanoma skin cancer (NMSC). In selected cases, topical treatments are preferable to invasive procedures, especially in the case of multifocal lesions, unclear lesion edges, risk of keloids, surgical risk factors and localization in some areas such as the face and décolletage, as the cosmetic outcomes are generally excellent. In the case of advanced and metastatic NMSC, molecularly targeted therapy represents a reasonably promising alternative to classical cytotoxic chemotherapy...
December 2013: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/24098903/strategic-management-of-keloid-disease-in-ethnic-skin-a-structured-approach-supported-by-the-emerging-literature
#19
REVIEW
S Ud-Din, A Bayat
Keloid disease (KD) is a common, benign, dermal fibroproliferative growth of unknown aetiology. Lesions tend to grow over time; they often recur following therapy and do not regress spontaneously. KD causes considerable discomfort due to pain, pruritus and inflammation, and a significant psychosocial impact with reduced quality of life. It is unique to humans and occurrence is higher in individuals with dark, pigmented, ethnic skin. There is a strong familial heritability, with a high ethnic predisposition in individuals of African, Asian and Hispanic descent...
October 2013: British Journal of Dermatology
https://www.readbyqxmd.com/read/23810214/a-study-of-the-combination-of-triamcinolone-and-5-fluorouracil-in-modulating-keloid-fibroblasts-in%C3%A2-vitro
#20
COMPARATIVE STUDY
Lin Huang, Yi J Cai, Ivan Lung, Billy C S Leung, Andrew Burd
BACKGROUND: Preliminary clinical trials suggest a superior effect when steroids and 5-fluorouracil are injected together for the intralesional therapy of keloids. In addition, it has been proposed that low-dose 5-fluorouracil may have advantages over conventional high dosages. We explored the molecular basis for the potential synergy involved in the combined treatment with triamcinolone and 5-fluorouracil. METHODS: The effects of triamcinolone alone or in combination with low-dose 5-fluorouracil on cell proliferation, cell-cycle progression, apoptosis and regulation of p53, p21, type I collagen (Col-1), vascular endothelial growth factor (VEGF), transforming growth factor-beta1 (TGF-beta1) and matrix metalloproteinase-2 (MMP-2) production in primary cultured keloid fibroblasts were examined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), flow cytometric and Western blotting assays...
September 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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