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J A Crosse
Topological insulators subject to a time-reversal-symmetry-breaking perturbation are predicted to display a magneto-electric effect that causes the electric and magnetic induction fields to mix at the material's surface. This effect induces polarization rotations of between ≈1-10 mrad per interface in an incident plane-polarized electromagnetic wave normal to a multilayered structure. Here we show, theoretically and numerically, that by using a waveguide geometry with a topological insulator guide layer and magneto-dielectric cladding it is possible to achieve rotations of ≈100 mrad and generate an elliptical polarization with only a three-layered structure...
February 21, 2017: Scientific Reports
David Ruttens, An Martens, Sofie Ordies, Stijn E Verleden, Arne P Neyrinck, Robin Vos, Marc Boada Collado, Bart M Vanaudenaerde, Geert M Verleden, Dirk Van Raemdonck
BACKGROUND: Donation after cardiac death (DCD) to overcome the donor organ shortage is well accepted in the clinical setting, although long-term outcome after DCD lung transplantation (LTx) remains largely unknown. METHODS: In this retrospective study, DCD LTx recipients (n=59) were compared with a cohort of donation after brain-death (DBD) LTx recipients (n=331) transplanted between February 2007 and September 2013; follow-up was until January 1st 2016. Short-term (duration of mechanical ventilation, ICU stay, hospital stay and highest PGD score within 72 hours) and long-term (CLAD-free and overall survival) follow-up were compared over a median follow-up of 50...
February 15, 2017: Transplantation
Xin Lu, Hang Qu, Maksim Skorobogatiy
We report an all-polymer flexible piezoelectric fiber that uses both judiciously chosen geometry and advanced materials in order to enhance fiber piezoelectric response. The microstructured/nanostructured fiber features a soft hollow polycarbonate core surrounded by a spiral multilayer cladding consisting of alternating layers of piezoelectric nanocomposites (polyvinylidene enhanced with BaTiO3, PZT, or CNT) and conductive polymer (carbon-filled polyethylene). The conductive polymer layers serve as two electrodes, and they also form two spatially offset electric connectors on the fiber surface designed for the ease of connectorization...
February 14, 2017: ACS Nano
Thomas A Wall, Roger P Chu, Joshua W Parks, Damla Ozcelik, Holger Schmidt, Aaron R Hawkins
Ridge and buried channel waveguides (BCWs) made using plasma-enhanced chemical vapor deposition SiO2 were fabricated and tested after being subjected to long 85°C water baths. The water bath was used to investigate the effects of any water absorption in the ridge and BCWs. Optical mode spreading and power throughput were measured over a period of three weeks. The ridge waveguides quickly absorbed water within the critical guiding portion of the waveguide. This caused a nonuniformity in the refractive index profile, leading to poor modal confinement after only seven days...
April 2016: Optical Engineering: the Journal of the Society of Photo-optical Instrumentation Engineers
Daniel C Chambers, Debra Enever, Sharon Lawrence, Marian J Sturm, Richard Herrmann, Stephanie Yerkovich, Michael Musk, Peter M A Hopkins
Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell therapy in inflammatory diseases, including organ rejection, given their relative immune privilege and immunosuppressive and tolerogenic properties. Preclinical studies in models of obliterative bronchiolitis and human trials in graft versus host disease and renal transplantation suggest potential efficacy in CLAD...
February 1, 2017: Stem Cells Translational Medicine
Liron Stern, Boris Desiatov, Noa Mazurski, Uriel Levy
In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plethora of light-vapour interactions can be studied. Moreover, such platform may exhibit new functionalities such as low-power nonlinear light-matter interactions. One immense challenge is to study the effects of quantum coherence and shifts in nanoscale waveguides, characterized by ultra-small mode areas and fast dynamics...
February 9, 2017: Nature Communications
Christopher R Ensor, Samuel A Yousem, Marilyn Marrari, Matthew R Morrell, Massimo Mangiola, Joseph M Pilewski, Jonathan D'Cunha, Stephen R Wisniewski, Raman Venkataramanan, Adriana Zeevi, John F McDyer
We present this observational study of lung transplant recipients (LTR) treated with Carfilzomib (CFZ)-based therapy for antibody-mediated rejection (AMR) of the lung. Patients were considered responders to CFZ if C1q-fixing ability of their immunodominant (ID) DSA was suppressed after treatment. Treatment consisted of CFZ plus plasma exchange and immunoglobulins. Fourteen LTRs underwent CFZ for 20 ID DSA AMR. Ten (71.4%) of LTRs responded to CFZ. DSA IgG MFI fell from 7664 (IQR 3230-11874) to 1878 (653-7791) after therapy (p=0...
February 7, 2017: American Journal of Transplantation
Abdulyezir A Badmos, Qizhen Sun, Zhongyuan Sun, Junxi Zhang, Zhijun Yan, Petro Lutsyk, Alex Rozhin, Lin Zhang
No abstract text is available yet for this article.
February 1, 2017: Journal of Biomedical Optics
Changgeng Ye, Joona Koponen, Ville Aallos, Teemu Kokki, Ossi Kimmelma
The measurement of fundamental mode bend loss is thoroughly studied in large-mode-area few-mode optical fibers. The influencing factors, including spectral properties of the light source, modal power content and cladding light, are experimentally investigated. Monte Carlo simulations are performed to help in understanding and illustrating the distribution of the variations. Practical guidelines and an example setup are provided for precise and accurate measurements.
February 1, 2017: Applied Optics
Yuta Ooka, Tomohiro Tetsumoto, Nurul Ashikin Binti Daud, Takasumi Tanabe
We demonstrate ultrasmall demultiplexers based on photolithographic photonic crystals. The footprint of the demultiplexers is 110 μm<sup>2</sup> per channel. Our in-plane demultiplexers are clad with silica, which makes them stable and easy to integrate with other silicon photonic devices. We describe two types of demultiplexers with spacings of 136 and 267 GHz between channels for application to dense wavelength division multiplexing. Integrated titanium nitride heaters allow us to precisely control the channel wavelength...
January 23, 2017: Optics Express
Chaolong Fang, Bo Dai, Qiao Xu, Ran Zhuo, Qi Wang, Xu Wang, Dawei Zhang
This paper presents an in-plane hydrodynamically reconfigurable optofluidic microlens, which is formed by the laminar flow of two streams of a low-refractive-index fluid and two streams of a high-refractive-index fluid in the two microchannels connecting to an expansion chamber where the microlens finally forms. In the expansion chamber, the stream of high-refractive-index fluid, acting as core, is sandwiched by the two streams of low-refractive-index fluid, acting as cladding. The interfaces between the streams can be flexibly manipulated by controlling the flow rate ratio between the two fluids in real time...
January 23, 2017: Optics Express
Hiromu Sato, Hiroki Miura, Feng Qiu, Andrew M Spring, Tsubasa Kashino, Takamasa Kikuchi, Masaaki Ozawa, Hideyuki Nawata, Keisuke Odoi, Shiyoshi Yokoyama
An electro-optic (EO) polymer waveguide using an ultra-thin silicon hybrid has been designed and fabricated. The silicon core has the thickness of 50 nm and a width of 5 μm. The waveguide was completed after covering the cladding with the high temperature stable EO polymer. We have demonstrated a low half-wavelength voltage of 0.9 V at the wavelength of 1.55 μm by using a Mach-Zehnder interference modulator with TM mode operation. The measured modulation corresponded to an effective in-device EO coefficient of 165 pm/V...
January 23, 2017: Optics Express
Yue-Yu Xiao, Shao-Fan Lu
A terahertz (THz) fiber circular polarizer based on suspended core fibers is proposed and analyzed. The THz mode guides within a subwavelength-scale core, which is suspended in a polymer tube. The dry air inner cladding not only suppresses the absorption loss of the device but also supports the leaky cladding modes. The circularly polarized core mode with the same handedness of the grating couples to the leaky cladding modes suffers from loss near resonant frequencies due to the spiral structure of the fiber...
January 20, 2017: Applied Optics
Ozan Aktaş, Mehmet Bayındır
We report production of air-clad tapered chalcogenide fibers by directly drawing bulk glasses between cleaved tips of tapered silica fibers. Exploiting these tapered fibers with nanoscale waists as evanescent optical couplers, we demonstrate phase-matched coupling of light into on-chip whispering gallery mode chalcogenide microresonators with coupling efficiencies as high as 95%. To the best of our knowledge, this is the first-time demonstration of critical coupling into high-index microresonators by using high-index tapered fibers...
January 20, 2017: Applied Optics
Yaakov Glick, Viktor Fromzel, Jun Zhang, Nikolay Ter-Gabrielyan, Mark Dubinskii
We demonstrate a high-power, high-efficiency Raman fiber laser pumped directly by laser diode modules at 978 nm. 154 W of CW power were obtained at a wavelength of 1023 nm with an optical to optical efficiency of 65%. A commercial graded-index (GRIN) core fiber acts as the Raman fiber in a power oscillator configuration, which includes spectral selection to prevent generation of the second Stokes. In addition, brightness enhancement of the pump beam by a factor of 8.4 is attained due to the Raman gain distribution profile in the GRIN fiber...
January 20, 2017: Applied Optics
Tuanjie Du, Zhengqian Luo, Runhua Yang, Yizhong Huang, Qiujun Ruan, Zhiping Cai, Huiying Xu
Mode-locked pulses in the dissipative soliton resonance (DSR) regime enable extremely high pulse energy, but typically have the limited peak power of <100  W and a nanosecond-long pulse duration. In this Letter, we demonstrate high-peak-power, ultrashort DSR pulses in a compact Er:Yb co-doped double-clad fiber laser. The linear cavity is simply formed by two fiber loop mirrors (FLMs) using a 50/50 optical coupler (OC) and a 5/95 OC. The 5/95 FLM with a short loop length of 3 m is not only used as the output mirror, but also acts as a nonlinear optical loop mirror for initiating high-peak-power DSR...
February 1, 2017: Optics Letters
Danny Jonigk, Berenice Rath, Paul Borchert, Peter Braubach, Lavinia Maegel, Nicole Izykowski, Gregor Warnecke, Wiebke Sommer, Hans Kreipe, Robert Blach, Adrian Anklamm, Axel Haverich, Matthias Eder, Michael Stadler, Tobias Welte, Jens Gottlieb, Mark Kuehnel, Florian Laenger
Chronic lung allograft dysfunction (CLAD) remains the major obstacle to long-term survival following lung transplantation (LuTx). Morphologically CLAD is defined by obliterative remodelling of the small airways (bronchiolitis obliterans, BO) as well as a more recently described collagenous obliteration of alveoli with elastosis summarised as alveolar fibroelastosis (AFE). Both patterns are not restricted to pulmonary allografts, but have also been reported following haematopoietic stem cell transplantation (HSCT) and radio chemotherapy (RC)...
January 2017: Journal of Pathology. Clinical Research
M A Zainal, A Ahmad, M S Mohamed Ali
This paper reports the wireless Shape-Memory-Polymer actuator operated by external radio frequency magnetic fields and its application in a drug delivery device. The actuator is driven by a frequency-sensitive wireless resonant heater which is bonded directly to the Shape-Memory-Polymer and is activated only when the field frequency is tuned to the resonant frequency of heater. The heater is fabricated using a double-sided Cu-clad Polyimide with much simpler fabrication steps compared to previously reported methods...
March 2017: Biomedical Microdevices
N J Goffin, R L Higginson, J R Tyrer
In laser cladding, the potential benefits of wire feeding are considerable. Typical problems with the use of powder, such as gas entrapment, sub-100% material density and low deposition rate are all avoided with the use of wire. However, the use of a powder-based source material is the industry standard, with wire-based deposition generally regarded as an academic curiosity. This is because, although wire-based methods have been shown to be capable of superior quality results, the wire-based process is more difficult to control...
December 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
Abraham Kirwa Tuwei, Nicholas H Williams, Mohammad Yusuf Mulla, Corrado Di Natale, Roberto Paolesse, Martin Grell
When films of zinc 5-(4-carboxyphenyl),10,15,20-triphenyl porphyrin (ZnTPP) are exposed to waterborne amine in pH- neutral or alkaline media, both Q- band and Soret band respond with a change of absorbance due to the donation of amine 'lone pair' electrons to the metalloprophyrin π orbital. However, this is difficult to reveal with a conventional spectrometer even under high amine concentration. We therefore introduce optical fibres coated with ZnTPP into a bespoke 'light balance' evanescent wave absorbance meter [doi:10...
March 1, 2017: Talanta
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