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https://www.readbyqxmd.com/read/29782805/maintaining-supersaturation-of-nimodipine-by-pvp-with-or-without-the-presence-of-sodium-lauryl-sulfate-and-sodium-taurocholate
#1
Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery system to improve the dissolution rate and oral bioavailability of poorly water soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 years, yet the mechanism by which PVP maintains the supersaturation and subsequently improves the bioavailability of NMD was rarely investigated. In this research, we first studied the molecular interactions between NMD and PVP by solution NMR using CDCl3 as the solvent, and drug-polymer Flory-Huggins interaction parameter...
May 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29782700/nonionic-dendritic-and-carbohydrate-based-amphiphiles-self-assembly-and-transport-behavior
#2
Suchita Prasad, Katharina Achazi, Boris Schade, Rainer Haag, Sunil K Sharma
Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10-5 m and hydrodynamic diameters in the 8-10 nm range and supplemented by cryogenic transmission electron microscopy...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29780849/incidental-findings-on-coronary-computed-tomography-angiography-in-human-immunodeficiency-virus-hiv-positive-and-hiv-negative-persons
#3
Sara Reinschmidt, Teja Turk, Philip E Tarr, Roger Kouyos, Christoph Hauser, Patrick Schmid, Rainer Weber, Philipp Kaufmann, Ronny R Buechel, Helen Kovari
Background: Incidental findings on coronary computed tomography angiography (CCTA) have a great impact on the benefits and costs of testing for cardiovascular disease. The number of incidental findings might be increased in human immunodeficiency virus (HIV)-positive individuals compared with the general population. Data are limited regarding the association between incidental findings and HIV infection. Methods: We assessed the prevalence and factors associated with incidental findings among HIV-positive and HIV-negative participants ≥45 years undergoing CCTA...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29770264/calcified-triticeous-cartilage-detected-on-digital-panoramic-radiographs-in-a-sample-of-lebanese-population
#4
Georges Aoun, Ibrahim Nasseh
Objective: Triticeous cartilage is a small ovoid structure belonging to the laryngeal skeleton. When calcified, it becomes visible on panoramic radiographs and be mistaken for a carotid artery calcification (CAC) associated with cerebrovascular accidents. This study aimed to estimate the prevalence of calcified triticeous cartilage (CTC) detected by means of digital panoramic radiographs in a sample of Lebanese population. Materials and Methods: Digital panoramic radiographs of 500 Lebanese adult patients (281 females and 219 males) with a mean age of 47...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29768322/lung-cancer-screening-ct-based-coronary-artery-calcification-in-predicting-cardiovascular-events-a-systematic-review-and-meta-analysis
#5
Lili Fan, Kaikai Fan
BACKGROUND: Coronary artery calcificition (CAC) is a well-established predictor of cardiovascular events (CVEs). We aimed to evaluate whether lung cancer screening computed tomography (CT)-based CAC score has a good cost-effectiveness for predicting CVEs in heavy smokers. METHODS: A literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pubmed, EMBASE, and Cochrane library databases were systematically searched for relevant studies that investigated the association between lung cancer screening CT-based CAC and CVEs up to December 31, 2017...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29765227/age-gender-distribution-of-coronary-artery-calcium-score-in-a-black-african-population-in-ghana
#6
George Asafu Adjaye Frimpong, Isaac Kofi Owusu, Ijeoma Chinedum Anyitey-Kokor, Caitlin Selassie Naa Sarku Wiafe-Kwakye, Evans Aboagye, Nana Esi Coleman, Pierre Amankwah, Nakao Kuukua Abaidoo
Background: Distribution of coronary artery calcium (CAC) has been determined in different heterogeneous populations in the Multi-Ethnic Study of Atherosclerosis (MESA). Based on findings showing that geography and culture can influence CAC scoring beyond traditional race groups, we determined the distribution of CAC in a homogenous black African population to provide an initial basis for a larger CAC score study in Africa. Methods and results: This is a preliminary study using computed tomography to determine the CAC scores within a black African population who were referred to our center...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29760599/vascular-erectile-dysfunction-and-subclinical-cardiovascular-disease
#7
Zain Gowani, S M Iftekhar Uddin, Mohammadhassan Mirbolouk, Dawar Ayyaz, Kevin L Billups, Martin Miner, David I Feldman, Michael J Blaha
Purpose of review: We review the recent literature on the hypothesized temporal relationship between subclinical cardiovascular disease (CVD), vascular erectile dysfunction (ED), and clinical CVD. In addition, we combine emerging research with expert consensus guidelines such as The Princeton Consensus III to provide a preventive cardiologist's perspective toward an ideal approach to evaluating and managing CVD and ED risk in patients. Recent findings: Development of ED was found to occur during the progression from subclinical CVD to clinical CVD...
December 2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29760543/microbiota-modification-by-probiotic-supplementation-reduces-colitis-associated-colon-cancer-in-mice
#8
Maria Carolina S Mendes, Daiane Sm Paulino, Sandra R Brambilla, Juliana A Camargo, Gabriela F Persinoti, José Barreto C Carvalheira
AIM: To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer (CAC). METHODS: C57BL/6 mice received an intraperitoneal injection of azoxymethane (10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water (5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus , Lactobacillus rhamnosus and Bifidobacterium bifidum . Microbiota composition was assessed by 16S rRNA Illumina HiSeq sequencing...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29757351/m10-a-novel-derivative-of-myricetin-prevents-ulcerative-colitis-and-colorectal-tumor-through-attenuating-robust-endoplasmic-reticulum-stress
#9
Feng Wang, Zhi-Yu Song, Xian-Jun Qu, Feng Li, Liang Zhang, Wen-Bao Li, Shu-Xiang Cui
Chronic gut inflammation disposes to an increased risk of colitis-associated cancer (CAC). Chemoprevention is an attractive complementary strategy. We aimed to evaluate the chemopreventive effects of M10, a novel derivative of Myricetin, in the murine azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Oral administration of M10 at 50-100 mg/kg once a day for consecutive 12 weeks significantly prevented ulcerative colitis and colorectal tumor. Pathological analysis of intestines showed that M10 reduced the degree of chronic inflammation and prevented the progression of colorectal tumorigenesis...
May 11, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29754303/preparation-and-cr-vi-removal-performance-of-corncob-activated-carbon
#10
Hongyan Li, Pei Gao, Jianguo Cui, Feng Zhang, Fang Wang, Jici Cheng
Corncob activated carbon (CCAC) was prepared by a H3 PO4 activation method. The optimum conditions for the preparation of CCAC were determined by orthogonal experiments. The effects of pH, reaction time, CCAC dosage, and hexavalent chromium (Cr(VI)) concentrations on Cr(VI) removal by CCAC were studied. Corn straw activated carbon (CSAC) was also prepared using the optimum preparation conditions determined for CCAC. The properties of samples were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS)...
May 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29753636/coronary-arterial-calcification-a-review-of-mechanisms-promoters-and-imaging
#11
REVIEW
Jordan Andrews, Peter J Psaltis, Belinda A Di Bartolo, Stephen J Nicholls, Rishi Puri
Coronary artery calcification (CAC) was once thought to be a passive, degenerative, and quiescent development of disease. However, it has now been shown to be an active process associated with atherosclerosis that is stimulated by inflammatory pathways. Calcification forms within the intimal and medial layers of the vessel wall by way of mechanisms similar to bone development. A variety of imaging modalities have been used to identify and characterize CAC, from early microcalcifications to well-developed fibroatheromas that have calcified...
May 2, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29753291/an-experimental-and-theoretical-study-of-the-adsorption-removal-of-toluene-and-chlorobenzene-on-coconut-shell-derived-carbon
#12
Xiaoyan Zhao, Xiaolan Zeng, Yu Qin, Xiang Li, Tianle Zhu, Xiaolong Tang
The adsorption performance of toluene and chlorobenzene on prepared coconut shell derived carbon (CDC) is investigated and compared with commercial activated carbon (CAC) by experiment and theory calculation. Textural properties of prepared adsorbents are characterized by N2 adsorption, infrared spectra (FT-IR), Raman spectra and X-ray photoelectron spectra (XPS). Adsorption isotherms of toluene and chlorobenzene are obtained and fitted using structure optimizations, Grand Canonical Monte Carlo (GCMC) simulation and thermodynamic models...
April 26, 2018: Chemosphere
https://www.readbyqxmd.com/read/29751802/associations-of-coronary-artery-calcified-plaque-density-with-mortality-in-type-2-diabetes-the-diabetes-heart-study
#13
Laura M Raffield, Amanda J Cox, Michael H Criqui, Fang-Chi Hsu, James G Terry, Jianzhao Xu, Barry I Freedman, J Jeffrey Carr, Donald W Bowden
BACKGROUND: Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. METHODS: We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study...
May 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29751286/the-prevalence-and-correlates-of-subclinical-atherosclerosis-among-adults-with-low-density-lipoprotein-cholesterol-70-mg-dl-the-multi-ethnic-study-of-atherosclerosis-mesa-and-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#14
Mahmoud Al Rifai, Seth S Martin, John W McEvoy, Khurram Nasir, Ron Blankstein, Joseph Yeboah, Michael Miedema, Steven J Shea, Joseph F Polak, Pamela Ouyang, Roger S Blumenthal, Marcio Bittencourt, Isabela Bensenor, Raul D Santos, Bruce B Duncan, Itamar S Santos, Paulo A Lotufo, Michael J Blaha
BACKGROUND AND AIMS: The prevalence and correlates of subclinical atherosclerosis when low-density lipoprotein cholesterol (LDL-C) levels are low remain unclear. Therefore, we examined the association of cardiovascular risk factors and subclinical atherosclerosis among individuals with untreated LDL-C <70 mg/dL. METHODS: We included participants from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohorts...
April 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29751282/sleep-duration-and-subclinical-atherosclerosis-the-aragon-workers-health-study
#15
Elena Blasco-Colmenares, Belén Moreno-Franco, Montserrat León Latre, Eusebio Mur-Vispe, Miguel Pocovi, Estíbaliz Jarauta, Fernando Civeira, Martín Laclaustra, José A Casasnovas, Eliseo Guallar
BACKGROUND AND AIMS: Few studies have evaluated the association of sleep duration with subclinical atherosclerosis, and with heterogeneous findings. We evaluated the association of sleep duration with the presence of coronary, carotid, and femoral subclinical atherosclerosis in healthy middle-age men with low prevalence of clinical comorbidities. METHODS: We performed a cross-sectional analysis of 1968 men, 40-60 years of age, participating in the Aragon Workers' Health Study (AWHS)...
May 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29750180/reporting-of-coronary-artery-calcification-on-chest-ct-studies-in-breast-cancer-patients-at-high-risk-of-cancer-therapy-related-cardiac-events
#16
William J Phillips, Christopher Johnson, Angeline Law, Michele Turek, Alex R Small, Joao R Inacio, Susan Dent, Terrence Ruddy, Rob S Beanlands, Benjamin J W Chow, Gary R Small
Background: The identification of coronary artery calcification (CAC) detected coincidentally on chest CT exams could assist in cardiovascular risk assessment but may not be reported consistently on clinical studies. Cardiovascular risk factor stratification is important to predict short term cardiac events during cancer therapy and long term cardiac event free survival in cancer patients. We sought to determine the prevalence of CAC and clinical reporting rates in a cohort of cancer patients at high risk of cancer therapy related cardiac events...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29748857/dynamic-of-changes-in-coronary-artery-calcification-in-early-rheumatoid-arthritis-patients-over-18-months
#17
Helen V Udachkina, Diana S Novikova, Tatiana V Popkova, Irina G Kirillova, Evgenia I Markelova
The coronary artery calcification (CAC) progression may be useful noninvasive predictor of future cardiovascular events (CVE). The progression rate of CAC in patients with early rheumatoid arthritis (RA) is poorly understood. To assess the dynamic of CAC scores in early RA patients for 18 months, 74 RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, with moderate/high RA activity, without prior administration of disease-modifying anti-rheumatic drugs or glucocorticoids) were enrolled within the framework of the observational study: women 73%, median age 56 years, median RA duration 6 months, median DAS28[ESR] 5...
May 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29748526/association-of-single-nucleotide-polymorphisms-of-cd44-gene-with-susceptibility-to-breast-cancer-in-chinese-women
#18
Xiao Lin, Xiaojing You, Xuezhen Cao, Shenghua Pan
BACKGROUND This study aimed to evaluate the association of CD44 gene single-nucleotide polymorphisms with susceptibility to breast cancer. MATERIAL AND METHODS This case-control study included 242 breast cancer patients and 252 normal people without disease. The single-nucleotide polymorphisms of the CD44 gene in the 2 groups were genotyped by PCR-LDR method. The OR and its 95% CI was calculated by chi-square test and logistic regression analysis. The construction of haplotypes and their interaction analysis with relevant factors were carried out by SHEsis and SNPStats online...
May 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29745664/towards-high-level-theoretical-studies-of-large-biodiesel-molecules-an-oniom-qcisd-t-cbs-dft-study-of-the-reactions-between-unsaturated-methyl-esters-c-n-h-2n-1-cooch-3-and-hydrogen-radical
#19
Lidong Zhang, Qinghui Meng, Yicheng Chi, Peng Zhang
A two-layer ONIOM[QCISD(T)/CBS:DFT] method was proposed for the high-level single-point energy calculations of large biodiesel molecules and was validated for the hydrogen abstraction reactions of unsaturated methyl esters that are important components of real biodiesel. The reactions under investigation include all the reactions on the potential energy surface of CnH2n-1COOCH3 (n=2-5, 17) + H, including the hydrogen abstraction, the hydrogen addition, the isomerization (intramolecular hydrogen shift), and the -scission reactions...
May 10, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29744610/walnut-phenolic-extract-inhibits-nuclear-factor-kappab-signaling-in-intestinal-epithelial-cells-and-ameliorates-experimental-colitis-and-colitis-associated-colon-cancer-in-mice
#20
Seong-Joon Koh, Youn-I Choi, Yuri Kim, Yoo-Sun Kim, Sang Woon Choi, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee
PURPOSE: Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS: COLO205 cells were pretreated with WPE and then stimulated with tumor necrosis factor (TNF)-α. In the acute colitis model, wild type mice (C57BL/6) were administered 4% dextran sulfate sodium (DSS) for 5 days. In the chronic colitis model, interleukin (IL)-10-/- mice were administered with either the vehicle or WPE (20 mg/kg) by oral gavage daily for 2 weeks...
May 9, 2018: European Journal of Nutrition
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