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https://www.readbyqxmd.com/read/28220621/a-low-prevalence-of-non-alcoholic-fatty-liver-disease-in-patients-with-type-1-diabetes-is-associated-to-decreased-subclinical-cardiovascular-disease
#1
Enric Serra-Planas, Eva Aguilera, Laura Castro, Raúl Rodríguez, Isabel Salinas, Anna Lucas, Clara Joaquín, Rocio Puig, Dídac Mauricio, Manel Puig-Domingo
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD). METHODS: Cross-sectional study in which 100 T1D patients (39.4 ± 7.8 years, 54% male, all Caucasian, disease duration 21.7 ± 8.6 years, HbA1c 8.1 ± 1.0 % (64.2 ± 7...
February 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28219244/an-alternative-route-to-nanoscale-aggregates-with-a-ph-responsive-random-copolymer
#2
Jonathan C Pegg, Adam Czajka, Christopher Hill, Craig James, Jocelyn Alice Peach, Sarah E Rogers, Julian Eastoe
A random copolymer, poly(methyl methacrylate-co-2-dimethylaminoethyl methacrylate) (poly(MMA-co-DMAEMA)) is shown to form nano-scale aggregates (NAs) (~20 nm) at copolymer concentrations ≥ 10 % w/w, directly from the pre-formed surfactant-stabilised latex (~120 nm) in aqueous solution. The copolymer is prepared by a conventional emulsion polymerisation. Introducing a small mole fraction of DMAEMA (~10 %) allows the copolymer hydrophilicity to be adjusted by pH and external temperature, generating NAs with tuneable sizes and defined weight-average aggregation number, as observed by dynamic-light scattering (DLS) and small-angle neutron scattering (SANS)...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28216462/a-study-of-the-aggregation-of-cyclodextrins-determination-of-the-critical-aggregation-concentration-size-of-aggregates-and-thermodynamics-using-isodesmic-and-k2-k-models
#3
Thao Do Thi, Rob Van Hooghten, Guy Van den Mooter
The aggregation of three different cyclodextrins (CDs): 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD) was studied. The critical aggregation concentration (cac) of these three CDs is quite similar and is situated at ca. 2% (m/v). There was only a small difference in the cac values determined by DLS and (1)H NMR. DLS measurements revealed that CDs in solution have three size populations wherein one of them is that of a single CD molecule...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28216252/calcification-of-the-splenic-iliac-and-breast-arteries-and-risk-of-all-cause-and-cardiovascular-mortality
#4
Eva J E Hendriks, Joline W J Beulens, Pim A de Jong, Yvonne T van der Schouw, Wei-Ning Sun, C Michael Wright, Michael H Criqui, Matthew A Allison, Joachim H Ix
BACKGROUND AND AIMS: CVD risks associated with coronary artery calcification (CAC) and aortic calcification (AC) are well known, but less is known about other calcified arteries. We aimed to assess the associations of arterial calcification in the breast, splenic, and internal and external iliac arteries with CVD risk factors and mortality. METHODS: We conducted a case-cohort study nested in a cohort of 5196 individuals who self-referred or were referred by a health care provider for whole body computed tomography (CT), including a random subcohort (n = 395) and total and CVD mortality cases (n = 298 and n = 90), who died during a median follow-up of 9...
January 30, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28211790/flpstop-a-tool-for-conditional-gene-control-in-drosophila
#5
Yvette Erica Fisher, Helen H Yang, Jesse Isaacman-Beck, Marjorie Xie, Daryl M Gohl, Thomas R Clandinin
Manipulating gene function cell type-specifically is a common experimental goal in Drosophila research and has been central to studies of neural development, circuit computation, and behavior. However, current cell type-specific gene disruption techniques in flies often reduce gene activity incompletely or rely on cell division. Here we describe FlpStop, a generalizable tool for conditional gene disruption and rescue in post-mitotic cells. In proof-of-principle experiments, we manipulated apterous, a regulator of wing development...
February 17, 2017: ELife
https://www.readbyqxmd.com/read/28209366/quantifying-aortic-valve-calcification-using-coronary-computed-tomography-angiography
#6
Abdulrahman M Alqahtani, Kevin E Boczar, Vinay Kansal, Kwan Chan, Girish Dwivedi, Benjamin J W Chow
INTRODUCTION: Aortic valve calcification (AVC) has been associated with major adverse cardiovascular events and all-cause mortality. We sought to develop and validate a method to quantify AVC using coronary CT angiography (CTA). METHODS: Of 59 patients who underwent both non-contrast and contrast enhanced coronary CTA, 25 patients served as the derivation cohort and 34 patients served as the validation cohort. For non-contrast enhanced CT, quantification of AVC was performed using the Agatston method for coronary artery calcification (CAC)...
January 30, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28205492/significant-inverse-association-of-equol-producer-status-with-coronary-artery-calcification-but-not-dietary-isoflavones-in-healthy-japanese-men
#7
Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa
Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors...
January 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28202259/coronary-artery-calcium-score-as-a-predictor-for-incident-stroke-systematic-review-and-meta-analysis
#8
Kongkiat Chaikriangkrai, Hye Yeon Jhun, Ghanshyam Palamaner Subash Shantha, Aref Bin Abdulhak, Gardar Sigurdsson, Faisal Nabi, John J Mahmarian, Su Min Chang
BACKGROUND: Coronary artery calcium score (CACS) is a well-established test for risk stratifying asymptomatic patients for overall cardiovascular or coronary events. However; the prognostic value for incident stroke remains controversial. The objective of this study was to investigate the predictive value of CACS obtained by non-contrast electrocardiogram-gated computed tomography for incident stroke. METHODS: We searched PubMed, EMBASE, Cochrane databases for prospective longitudinal studies of CACS which reported the incidence of stroke...
February 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28196817/comparison-of-carotid-plaque-score-and-coronary-artery-calcium-score-for-predicting-cardiovascular-disease-events-the-multi-ethnic-study-of-atherosclerosis
#9
Adam D Gepner, Rebekah Young, Joseph A Delaney, Matthew J Budoff, Joseph F Polak, Michael J Blaha, Wendy S Post, Erin D Michos, Joel Kaufman, James H Stein
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown. METHODS AND RESULTS: CVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound-detected plaques in the common, bifurcation, and internal carotid artery segments...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28196265/association-of-coronary-artery-calcium-in-adults-aged-32-to-46-years-with-incident-coronary-heart-disease-and-death
#10
John Jeffrey Carr, David R Jacobs, James G Terry, Christina M Shay, Stephen Sidney, Kiang Liu, Pamela J Schreiner, Cora E Lewis, James M Shikany, Jared P Reis, David C Goff
Importance: Coronary artery calcium (CAC) is associated with coronary heart disease (CHD) and cardiovascular disease (CVD); however, prognostic data on CAC are limited in younger adults. Objective: To determine if CAC in adults aged 32 to 46 years is associated with incident clinical CHD, CVD, and all-cause mortality during 12.5 years of follow-up. Design, Setting, and Participants: The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a prospective community-based study that recruited 5115 black and white participants aged 18 to 30 years from March 25, 1985, to June 7, 1986...
February 8, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28193514/microrna-301a-promotes-intestinal-inflammation-and-colitis-associated-cancer-development-by-inhibiting-btg1
#11
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A), compared to tissues from patients without IBD. We studied the mechanisms of MIR301A in progression of IBD in human tissues and mice. METHODS: We isolated intestinal epithelial cells (IECs) from colon biopsy samples of 153 patients with different stages of IBD activity, 6 patients with colitis-associated cancer (CAC), and 35 healthy individuals (controls), enrolled in the study in Shanghai, China...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28193446/usefulness-of-calcium-scoring-as-a-screening-examination-in-patients-with-a-history-of-kawasaki-disease
#12
Andrew M Kahn, Matthew J Budoff, Lori B Daniels, Jun Oyamada, John B Gordon, Jane C Burns
Subsets of patients with a remote history of Kawasaki disease (KD) have coronary artery aneurysms with associated risks of late morbidity. In a pilot study, we previously showed that computed tomography (CT) coronary artery calcium (CAC) scoring detects late CAC in patients with aneurysms and a remote history of KD. We performed CT calcium volume scoring in 166 subjects (median age 19.5 years) with a remote history of KD (median interval from KD to CT 15.1 years). Coronary arteries were classified as normal (n = 100), transiently dilated (n = 23), persistently dilated (n = 10), remodeled aneurysm (n = 9), or aneurysm (n = 24) based on echocardiography...
January 6, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28192729/absence-of-association-between-gallstone-and-coronary-artery-calcification
#13
Chang Hee Kwon, Jung Gyu Kang, Hyun Jong Lee, Nan Hee Kim, Joo-Wook Sung, EunSun Cheong, Ki-Chul Sung
BACKGROUND AND AIMS: Gallstone has been suggested to be associated with cardiovascular disease (CVD). Coronary artery calcification (CAC) is an excellent value to predict future CVD. The aim of this study was to evaluate the association between gallstone and CAC. METHODS: Data were analyzed from an occupational cohort of 46,893 subjects (37,557 men and 9336 women) between 2011 and 2014. Participants with cancer or CVD histories or missing data at baseline were excluded from the study...
February 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28191873/orbital-atherectomy-treatment-of-severely-calcified-coronary-lesions-in-patients-with-impaired-left-ventricular-ejection-fraction-one-year-outcomes-from-the-orbit-ii-study
#14
Michael S Lee, Brad J Martinsen, Richard Shlofmitz, Evan Shlofmitz, Arthur C Lee, Jeffrey Chambers
AIMS: Percutaneous coronary intervention (PCI) of severe coronary artery calcification (CAC) is challenging. The ORBIT II study demonstrated the safety and efficacy of orbital atherectomy (OA) in patients with severe CAC. Microparticulate liberated during OA may disturb coronary microcirculation. We evaluated OA treatment in patients with left ventricular systolic dysfunction. METHODS AND RESULTS: Patients were grouped by left ventricular ejection fraction (LVEF): 26-40% (n=33), 41-50% (n=90), and >50% (n=314)...
February 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28190337/observed-dependence-of-colloid-detachment-on-the-concentration-of-initially-attached-colloids-and-collector-surface-heterogeneity-in-porous-media
#15
Tiantian Li, Yan Jin, Yuanfang Huang, Baoguo Li, Chongyang Shen
Sand column experiments were conducted to examine effects of concentration of attached colloids (CAC) on their subsequent detachment upon decreasing solution ionic strength (IS). Different pore volumes of latex microparticle suspension were injected into the columns to allow different amounts of colloids to attach at ISs of 0.001, 0.01, and 0.2 M, respectively. Then deionized water was introduced to release the attached colloids. Results show that the fraction of attachments that were reversible to reduction of IS (FRA) increased with increasing CAC at a given IS if the sand were extensively treated using acids to reduce surface charge heterogeneity...
February 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28177923/protein-calorie-malnutrition-nutritional-intervention-and-personalized-cancer-care
#16
Anju Gangadharan, Sung Eun Choi, Ahmed Hassan, Nehad M Ayoub, Gina Durante, Sakshi Balwani, Young Hee Kim, Andrew Pecora, Andre Goy, K Stephen Suh
Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexia-cachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174052/a-randomised-trial-of-expedited-transfer-to-a-cardiac-arrest-centre-for-non-st-elevation-ventricular-fibrillation-out-of-hospital-cardiac-arrest-the-arrest-pilot-randomised-trial
#17
Tiffany Patterson, Gavin D Perkins, Jubin Joseph, Karen Wilson, Laura Van Dyck, Steven Robertson, Hanna Nguyen, Hannah McConkey, Mark Whitbread, Rachael Fothergill, Joanne Nevett, Miles Dalby, Roby Rakhit, Philip MacCarthy, Divaka Perera, Jerry P Nolan, Simon R Redwood
BACKGROUND: Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC) may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation. The objective was to assess the feasibility of performing a large-scale randomised controlled trial. METHODS: Adult witnessed ventricular fibrillation OHCA of presumed cardiac cause were randomised 1:1 to either: (1) treatment: comprising expedited transfer to a CAC for goal-directed therapy including access to immediate reperfusion, or (2) control: comprising current standard of care involving delivery to the geographically closest hospital...
February 4, 2017: Resuscitation
https://www.readbyqxmd.com/read/28167282/comparison-of-low-dose-coronary-artery-calcium-scoring-using-low-tube-current-technique-and-hybrid-iterative-reconstruction-vs-filtered-back-projection
#18
Nada Sulaiman, Jeanette Soon, Jong Kwan Park, Christopher Naoum, Shaw-Hua Kueh, Philipp Blanke, Darra Murphy, Jennifer Ellis, Cameron J Hague, Jonathon Leipsic
INTRODUCTION: We sought to validate whether low dose CACS CT with hybrid IR (HIR) could replace standard dose filtered back projection (FBP). METHOD: We enrolled 100 patients to undergo low dose CACS CT with HIR, in addition to routine full dose FBP. RESULTS: No significant difference between full and low dose CT in Agatston score 138.2±360.6 vs. 137.3±356.4 (p=0.272) or calcium mass score 19±48.3 vs. 18.7±49 (p=0.8), respectively. Bland-Altman analysis showed no systematic bias...
February 2, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28166668/annals-express-association-between-plasma-proprotein-convertase-subtilisin-kexin-type-9-level-and-coronary-artery-calcification
#19
Xi Zhao, Hui-Wen Zhang, Sha Li, Yan Zhang, Rui-Xia Xu, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ping Qing, Xiao-Lin Li, Geng Liu, Qian Dong, Jing Sun, Jianjun Li
BACKGROUND: Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) has been reported to be related to several risk factors and diseases such as inflammatory markers and coronary artery disease (CAD). The aim of present study was to investigate whether plasma PCSK9 level was associated with coronary artery calcification (CAC). METHODS: A total of 403 consecutive untreated patients with angina-like chest pain who received electron beam computed tomography (EBCT) were enrolled and a CAC score (CACS) was also measured...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28166422/relation-of-heart-rate-recovery-after-exercise-testing-to-coronary-artery-calcification
#20
Sae Young Jae, Sudhir Kurl, Jari A Laukkanen, Eun Sun Yoon, Yoon-Ho Choi, Bo Fernhall, Barry A Franklin
BACKGROUND: We examined whether slow heart rate recovery (HRR) after exercise testing as an estimate of impaired autonomic function is related to coronary artery calcification (CAC), an emerging marker of coronary atherosclerosis. METHODS: We evaluated 2088 men who participated in a health screening program that included measures of CAC and peak or symptom-limited cardiopulmonary exercise testing. HRR was calculated as the difference between peak heart rate during exercise testing and the heart rate at 2 minutes of recovery after peak exercise...
February 6, 2017: Annals of Medicine
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