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https://www.readbyqxmd.com/read/27899854/association-of-neutrophil-to-lymphocyte-ratio-with-the-severity-and-morphology-of-coronary-atherosclerotic-plaques-detected-by-multidetector-computerized-tomography
#1
Ahmet Hakan Ateş, Kudret Aytemir, Duygu Koçyiğit, Muhammed Ulvi Yalcin, Kadri Murat Gürses, Hikmet Yorgun, Uğur Canpolat, Tuncay Hazırolan, Necla Özer
BACKGROUND: Studies have demonstrated a consistent relationship between white blood cell (WBC) counts and coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR) has been considered as a potential marker for identifying individuals under risk of CAD and associated events. In this study, we aimed to evaluate whether NLR was associated with the severity and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT). METHODS: Our study population consisted of 684 patients who underwent dual-source 64 slice MDCT for the assessment of CAD...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27835741/plaque-progression-assessed-by-a-novel-semi-automated-quantitative-plaque-software-on-coronary-computed-tomography-angiography-between-diabetes-and-non-diabetes-patients-a-propensity-score-matching-study
#2
Rine Nakanishi, Indre Ceponiene, Kazuhiro Osawa, Yanting Luo, Mitsuru Kanisawa, Nichelle Megowan, Negin Nezarat, Sina Rahmani, Alexander Broersen, Pieter H Kitslaar, Christopher Dailing, Matthew J Budoff
BACKGROUND AND AIMS: We aimed at investigating whether diabetes is associated with progression in coronary plaque components. METHODS: We identified 142 study subjects undergoing serial coronary computed tomography angiography. The resulting propensity score was applied 1:1 to match diabetic patients to non-diabetic patients for clinical risk factors, prior coronary stenting, coronary artery calcium (CAC) score and the serial scan interval, resulting in the 71 diabetes and 71 non-diabetes patients...
November 3, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27824692/long-term-marathon-running-is-associated-with-low-coronary-plaque-formation-in-women
#3
William O Roberts, Robert S Schwartz, Stacia Merkel Kraus, Jonathan G Schwartz, Gretchen Peichel, Ross F Garberich, John R Lesser, Stephen N Oesterle, Kelly K Wickstrom, Thomas Knickelbine, Kevin M Harris
INTRODUCTION: Marathon running is presumed to improve cardiovascular risk, but health benefits of high volume running are unknown. High resolution coronary computed tomography angiography (CCTA) and a cardiac risk factor assessment were completed in women with long term marathon running histories to compare to sedentary women with similar risk factors. METHODS: Women who had run at least one marathon per year for 10-25 years underwent CCTA, 12-lead ECG, blood pressure and heart rate measurement, lipid panel, and a demographic/health risk factor survey...
November 7, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27738787/integrated-non-invasive-approach-to-atherosclerosis-with-cardiac-ct-and-carotid-ultrasound-in-patients-with-suspected-coronary-artery-disease
#4
Ludovico La Grutta, Marta Marasà, Patrizia Toia, Daniele Ajello, Domenico Albano, Erica Maffei, Emanuele Grassedonio, Giuseppina Novo, Massimo Galia, Giuseppe Caruso, Salvatore Novo, Filippo Cademartiri, Massimo Midiri
OBJECTIVE: The aim of the study was to compare the atherosclerotic disease in the coronary and carotid arteries in patients who underwent non-invasive imaging for suspected stable coronary artery disease (CAD). MATERIALS AND METHODS: 107 patients (64 men, age 59 ± 12) with atypical chest pain underwent cardiac CT (CCT) and carotid ultrasound (US) on the same day. Severity (obstructive or not-obstructive disease), location, shape, and composition of atherosclerotic plaques in the two districts were evaluated...
October 13, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27733980/comparison-of-coronary-plaque-coronary-artery-calcification-and-major-adverse-cardiac-events-in-chinese-outpatients-with-and-without-type-2-diabetes
#5
Lijie Zhu, Jingjing Liu, Chuanyu Gao, Wenli Zhao, Jing Que, Xianpei Wang, Datun Qi, Jun Liu, Wentao Xiao, Juanjuan Yan, Wentao Li, You Zhang, Honghui Yang
OBJECTIVE: Diabetes substantially increases the risk of cardiovascular disease (CAD) and is associated with an increased risk of CAD mortality. The purpose of this study was to investigate the differences in coronary artery plaque, coronary artery calcification (CAC) measured in outpatients with and without type 2 diabetes, and the occurrence rate of a major adverse cardiac event (MACE) throughout follow-up with the same patients. METHODS: Five hundred eighty-eight outpatients with suspected CAD comprising 208 diabetic and 380 non-diabetic patients were enrolled in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27733727/epicardial-adipose-tissue-as-a-predictor-for-the-development-of-non-calcified-coronary-plaque
#6
Koichi Kaikita
No abstract text is available yet for this article.
October 12, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27721862/association-of-neutrophil-lymphocyte-ratio-with-plaque-morphology-in-patients-with-asymptomatic-intermediate-carotid-artery-stenosis
#7
İsa Öner Yüksel, Erkan Köklü, Şakir Arslan, Göksel Çağırcı, Eylem Özaydın Göksu, Pınar Koç, Serkan Çay, Filiz Kızılırmak
BACKGROUND AND OBJECTIVES: Non-calcified carotid plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism, and consequently, stroke. The purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis with respect to neutrophil/lymphocyte ratio (NLR). SUBJECTS AND METHODS: A total number of 139 asymptomatic patients with 50-70% stenosis of the carotid artery were included in this study...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27714714/evaluation-of-mean-platelet-volume-and-platelet-distribution-width-in-patients-with-asymptomatic-intermediate-carotid-artery-plaque
#8
Fatih Yılmaz, Erkan Köklü, Filiz Kizilirmak Yilmaz, Elif Sarıönder Gencer, Ahmet Şükrü Alparslan, Özlem Yıldırımtürk
BACKGROUND: Platelets play a significant role in the pathogenesis of atherosclerosis. In atherosclerotic plaques, the risk of plaque rupture is more crucial than the severity of stenosis they cause. Non-calcified carotid artery plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism and consequently, stroke. AIM: Purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis with respect to mean platelet volume (MPV) and platelet distribution width (PDW)...
October 7, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27677761/national-trends-among-radiologists-in-reporting-coronary-artery-calcium-in-non-gated-chest-computed-tomography
#9
Jacobo Kirsch, Felipe Martinez, David Lopez, Gian M Novaro, Craig R Asher
Coronary artery calcification (CAC) is a known risk factor for adverse outcomes in the general population and in patients with coronary artery disease. We performed a survey of United States radiologists to evaluate the trends in reporting the presence or absence of CAC on NCCT examinations. An 11 multiple-choice questionnaire was distributed to members of the American College of Radiology, and 530 members participated in the study. Eighty-seven percent of the analyzed group report the presence of CAC on standard CT scans of the chest, and approximately half them (52 %) use a qualitative modifier...
September 27, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27633455/application-of-dual-source-ct-coronary-angiography-in-type-2-diabetic-patients-with-symptomatic-coronary-heart-disease
#10
Ci He, Peng Wang, Fei-Zhou Du, Jian-Wen Gu, Zhi-Gang Yang
OBJECTIVE: To evaluate the epidemiological and morphological characteristics of coronary plaque in diabetic patients with symptomatic coronary heart disease (CHD) by dual-source computed tomography (DSCT). MATERIALS AND METHODS: From June 2013 to December 2014, 267 consecutive patients with type 2 diabetes mellitus were examined by DSCT. Plaque type, distribution, as well as extent and obstructive characteristics were determined for each segment. RESULTS: A total of 225 patients were included in the final study...
September 14, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27619745/promising-but-still-a-matter-of-debate
#11
EDITORIAL
Yohei Sotomi, Patrick W Serruys
Several trials failed to demonstrate the efficacy of plaque modification device in patients with severely calcified coronary lesions. Safety and efficacy of the Diamondback 360® Coronary OAS have been demonstrated by the ORBIT II trial. The 2-year follow-up of the ORBIT II trial extends the favorable results previously shown at 30-day and 1-year follow-up. The single arm, non-randomized character of the trial with indirect historical comparison may restrict the results to hypothesis generating and entail further prospective randomized trials...
September 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27579325/coronary-plaque-characteristics-assessed-by-256-slice-coronary-ct-angiography-and-association-with-high-sensitivity-c-reactive-protein-in-symptomatic-patients-with-type-2-diabetes
#12
Jinling Zhang, Zhehao Lv, Deli Zhao, Lili Liu, Yong Wan, Tingting Fan, Huimin Li, Ying Guan, Bailu Liu, Qi Yang
Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (p < 0...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27544607/optical-coherence-tomography-assessment-of-incidence-morphological-characteristics-and-spontaneous-healing-course-of-edge-dissections-following-percutaneous-coronary-intervention-with-stent-implantation-in-patients-with-non-st-segment-elevation-myocardial-infarction
#13
Lisbeth Antonsen, Per Thayssen, Henrik Steen Hansen, Anders Junker, Karsten Tange Veien, Knud Nørregaard Hansen, Mikkel Hougaard, Lisette Okkels Jensen
BACKGROUND: Stenting-induced edge dissections (ED) can be assessed in detail by optical coherence tomography (OCT). This study sought to investigate the incidence, morphological characteristics, and spontaneous healing course of OCT-identified EDs following drug-eluting stent (DES) implantation in a non-ST segment elevation myocardial infarction (NSTEMI) patient-population. METHODS: Acute vessel wall injury at the 5-mm stent adjacent distal and proximal reference segments was assessed by post-procedure OCT and intravascular ultrasound (IVUS) in n=97 NSTEMI-patients (n=97 lesions)...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27522574/prognostic-implications-of-coronary-ct-angiography-derived-quantitative-markers-for-the-prediction-of-major-adverse-cardiac-events
#14
Christian Tesche, Fabian Plank, Carlo N De Cecco, Taylor M Duguay, Moritz H Albrecht, Akos Varga-Szemes, Richard R Bayer, Junjie Yang, Isaac L Jacks, Bettina M Gramer, Ullrich Ebersberger, Ellen Hoffmann, Salvatore A Chiaramida, Gudrun Feuchtner, U Joseph Schoepf
OBJECTIVE: To evaluate quantitative markers derived from coronary CT angiography (coronary CTA) for the prediction of major adverse cardiac events (MACE). MATERIALS AND METHODS: Pooled data from two centers in the US and Europe were retrospectively analyzed. Forty-six patients (65.5 ± 8.1 years, 62% male) with suspected coronary artery disease (CAD) who had undergone dual-source CCTA and had experienced MACE within 12 months were included and compared to a Framingham risk score matched cohort (n = 46) without MACE...
August 5, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27519655/high-risk-coronary-plaque-invasive-coronary-procedures-and-cardiac-events-among-hiv-positive-individuals-and-matched-controls
#15
James Nadel, Eoin O'Dwyer, Sam Emmanuel, Justyn Huang, Sarat Cheruvu, Neville Sammel, Bruce Brew, James Otton, Cameron J Holloway
BACKGROUND: Human immunodeficiency virus (HIV) infection is considered a chronic, treatable disease, although treatment is associated with increased rates of coronary artery disease (CAD). We analyzed the utility of coronary CTA in the assessment of CAD among HIV patients and explored whether HIV patients are at greater risk of associated morbidity and mortality compared to HIV-negative controls. METHODS: In a retrospective, single center cohort study 97 males without history of previous coronary artery disease who had undergone coronary CTA between 2011 and 2014 was analyzed, including 32 HIV positive patients and 65 matched HIV negative controls...
September 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27506880/epicardial-adipose-tissue-contributes-to-the-development-of-non-calcified-coronary-plaque-a-5-year-computed-tomography-follow-up-study
#16
In-Chang Hwang, Hyo Eun Park, Su-Yeon Choi
AIM: Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated. METHODS: A total of 122 asymptomatic individuals (age, 56.0±7.6 years; male, 80.3%) without prior history of coronary artery disease (CAD) or metabolic syndrome and without NCP or obstructive CAD at baseline cardiac computed tomography (CT) were enrolled...
August 9, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27502292/the-high-risk-criteria-low-attenuation-plaque-60-hu-and-the-napkin-ring-sign-are-the-most-powerful-predictors-of-mace-a-long-term-follow-up-study
#17
Gudrun Feuchtner, Johannes Kerber, Philipp Burghard, Wolfgang Dichtl, Guy Friedrich, Nikolaos Bonaros, Fabian Plank
AIMS: To assess the prognostic value of coronary CT angiography (CTA) for prediction of major adverse cardiac events (MACE) over a long-term follow-up period. METHODS AND RESULTS: A total of 1469 low-to-intermediate-risk patients (65.9 years; 44.2% females) were included in our prospective cohort study. CTA was evaluated for (i) stenosis severity (minimal <10%; mild <50%; moderate 50-70%; severe >70%), (ii) plaque types (calcified, mixed dominantly calcified, mixed dominantly non-calcified, non-calcified), and (iii) high-risk plaque criteria [low-attenuation plaque (LAP) quantified by HU, napkin-ring (NR) sign, spotty calcification <3 mm, and remodelling index (RI)]...
August 7, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27489020/outcomes-in-diabetic-patients-undergoing-orbital-atherectomy-system
#18
Michael S Lee, Evan Shlofmitz, Heajung Nguyen, Richard A Shlofmitz
OBJECTIVES: We evaluated the angiographic and clinical outcomes of orbital atherectomy to treat severely calcified coronary lesions in diabetic and non-diabetic patients. BACKGROUND: Diabetics have increased risk for death, myocardial infarction, and target vessel revascularization after percutaneous coronary intervention. Severely calcified coronary lesions are associated with increased cardiac events. Orbital atherectomy facilitates stent delivery and optimizes stent expansion by modifying severely calcified plaque...
October 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27486804/the-incremental-prognostic-value-of-cardiac-computed-tomography-in-comparison-with-single-photon-emission-computed-tomography-in-patients-with-suspected-coronary-artery-disease
#19
Heesun Lee, Yeonyee E Yoon, Jun-Bean Park, Hack-Lyoung Kim, Hyo Eun Park, Seung-Pyo Lee, Hyung-Kwan Kim, Su-Yeon Choi, Yong-Jin Kim, Goo-Yeong Cho, Joo-Hee Zo, Dae-Won Sohn
BACKGROUND: Coronary computed tomographic angiography (CCTA) facilitates comprehensive evaluation of coronary artery disease (CAD), including plaque characterization, and can provide additive diagnostic value to single-photon emission computed tomography (SPECT). However, data regarding the incremental prognostic value of CCTA to SPECT remain sparse. We evaluated the independent and incremental prognostic value of CCTA, as compared with clinical risk factors and SPECT. MATERIALS AND METHODS: A total of 1,077 patients with suspected CAD who underwent both SPECT and cardiac CT between 2004 and 2012 were enrolled retrospectively...
2016: PloS One
https://www.readbyqxmd.com/read/27446259/association-between-serum-n-terminal-pro-b-type-natriuretic-peptide-levels-and-characteristics-of-coronary-atherosclerotic-plaque-detected-by-coronary-computed-tomography-angiography
#20
Lu Gan, Cong Feng, Chunlei Liu, Shuping Tian, Xiang Song, Li Yang
The aim of the present study was to explore the association between the levels of serum N-terminal pro-B-type natriuretic peptide (NT-pro BNP) and the characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography (CCTA), in patients with unstable angina (UA). A total of 202 patients (age range, 47-82 years) were divided into the following three groups: Non-cardiac disease group (57 patients); stable angina pectoris (SAP) group (62 patients); and UA group (83 patients)...
August 2016: Experimental and Therapeutic Medicine
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