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https://www.readbyqxmd.com/read/29753765/maximization-of-the-usage-of-coronary-cta-derived-plaque-information-using-a-machine-learning-based-algorithm-to-improve-risk-stratification-insights-from-the-confirm-registry
#1
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29751284/association-of-skin-autofluorescence-with-plaque-vulnerability-evaluated-by-optical-coherence-tomography-in-patients-with-cardiovascular-disease
#2
Yusuke Fujino, Guilherme F Attizzani, Satoko Tahara, Wei Wang, Kensuke Takagi, Toru Naganuma, Hiroto Yabushita, Kentaro Tanaka, Tomohiko Sato, Yusuke Watanabe, Satoru Mitomo, Naoyuki Kurita, Hisaaki Ishiguro, Shotaro Nakamura, Koji Hozawa, Hiram G Bezerra, Sho-Ichi Yamagishi, Sunao Nakamura
BACKGROUND AND AIMS: Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. METHODS: We prospectively enrolled 108 patients with CVD, who underwent OCT images during percutaneous coronary intervention (PCI)...
March 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29707480/all-optical-extravascular-laser-ultrasound-and-photoacoustic-imaging-of-calcified-atherosclerotic-plaque-in-excised-carotid-artery
#3
Jami L Johnson, Mervyn Merrilees, Jeffrey Shragge, Kasper van Wijk
Photoacoustic (PA) imaging may be advantageous as a safe, non-invasive imaging modality to image the carotid artery. However, calcification that accompanies atherosclerotic plaque is difficult to detect with PA due to the non-distinct optical absorption spectrum of hydroxyapatite. We propose reflection-mode all-optical laser-ultrasound (LUS) imaging to obtain high-resolution, non-contact, non-ionizing images of the carotid artery wall and calcification. All-optical LUS allows for flexible acquisition geometry and user-dependent data acquisition for high repeatability...
March 2018: Photoacoustics
https://www.readbyqxmd.com/read/29617981/impact-of-statin-therapy-on-coronary-plaque-burden-and-composition-assessed-by-coronary-computed-tomographic-angiography-a-systematic-review-and-meta-analysis
#4
Linn Andelius, Martin Bødtker Mortensen, Bjarne Linde Nørgaard, Jawdat Abdulla
Aim: To clarify the potential role of coronary computed tomographic angiography (CCTA) in assessing the remodelling impact of statin therapy on plaque burden and compositions. Methods and results: A systematic literature review and meta-analysis were conducted to examine the effect of statin therapy on different plaque volumes assessed by serial CCTA. Twelve studies were included with a mean (±standard deviation) follow-up period of 14.5 ± 9.5 months. Data on plaque volume were pooled using weighted mean difference method...
March 30, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29616745/in-situ-analysis-of-mast-cells-and-dendritic-cells-in-coronary-atherosclerosis-in-chronic-kidney-disease-ckd
#5
D L Wachter, D Neureiter, V Câmpean, K F Hilgers, M Büttner-Herold, C Daniel, K Benz, K Amann
AIMS: Mast cells (MC) and dendritic cells (DC) have immune modulatory function and can influence T-cell activity. Both cell types have been found in atherosclerotic plaques and are thought to play an important role for plaque stability. Compared to matched segments of the non-renal population, patients with chronic kidney disease (CKD) show a more pronounced and more aggressive course of atherosclerosis with higher plaque calcification and significantly higher complications rates. It was the aim of this study to analyze the number and localization of MCs and DCs, macrophages, T- and B-cells as well as the expression of markers of inflammation such as CRP and NFκB in calcified and non-calcified atherosclerotic plaques of patients with CKD and control patients...
April 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29590332/subclinical-coronary-artery-disease-in-swiss-hiv-positive-and-hiv-negative-persons
#6
Philip E Tarr, Bruno Ledergerber, Alexandra Calmy, Thanh Doco-Lecompte, Alex Marzel, Rainer Weber, Philipp A Kaufmann, René Nkoulou, Ronny R Buechel, Helen Kovari
Aims: HIV-positive persons have increased cardiovascular event rates but data on the prevalence of subclinical atherosclerosis compared with HIV-negative persons are not uniform. We assessed subclinical atherosclerosis utilizing coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) in 428 HIV-positive participants of the Swiss HIV Cohort Study and 276 HIV-negative controls concurrently referred for clinically indicated CCTA. Methods and results: We assessed the association of HIV infection, cardiovascular risk profile, and HIV-related factors with subclinical atherosclerosis in univariable and multivariable analyses...
March 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29554376/high-sensitivity-cardiac-troponin-i-is-a-biomarker-for-occult-coronary-plaque-burden-and-cardiovascular-events-in-patients-with-rheumatoid-arthritis
#7
George A Karpouzas, Joel Estis, Panteha Rezaeian, John Todd, Matthew J Budoff
Objectives: Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events (CVEs) in RA. Methods: We evaluated 150 patients with 64-slice coronary CT angiography. Coronary artery calcium, number of segments with plaque (segment involvement score), stenotic severity and plaque burden were assessed...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29530620/influence-of-vitamin-k-antagonists-and-direct-oral-anticoagulation-on-coronary-artery-disease-a-cta-analysis
#8
Fabian Plank, Christoph Beyer, Guy Friedrich, Markus Stühlinger, Florian Hintringer, Wolfgang Dichtl, Matthias Wildauer, Gudrun Feuchtner
OBJECTIVE: Vitamin K antagonists (VKA) are associated with increased vascular calcification which may lead to an elevated cardiovascular risk. If the direct anticoagulants (DOACs) have similar negative vascular effects is unknown. We evaluated the influence of different anticoagulation strategies on coronary artery disease (CAD) using coronary computed tomography angiography (CTA). METHODS: Overall 702 consecutive patients with non-valvular atrial fibrillation (AF) who underwent CTA for AF ablation planning were enrolled and stratified according to their anticoagulation into VKA, DOAC (all agents) and a control group without oral anticoagulation...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29520183/natural-history-of-untreated-coronary-total-occlusions-revealed-with-follow-up-semi-automated-quantitative-coronary-ct-angiography-the-morphological-characteristics-of-initial-ct-predict-occlusion-shortening
#9
Qian Wu, Mengmeng Yu, Yuehua Li, Wenbin Li, Zhigang Lu, Meng Wei, Jing Yan, Jiayin Zhang
Objective: To investigate the morphological changes of coronary chronic total occlusion (CTO) as determined by coronary computed tomography angiography (CCTA) follow-up using semi-automated quantitative analysis. Materials and Methods: Thirty patients with 31 CTO lesions confirmed by invasive coronary angiography and baseline/follow-up CCTA were retrospectively included. CTOs were quantitatively analyzed by a semi-automated coronary plaque analysis software (Coronary Plaque Analysis, version 2...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29472090/non-invasive-characterization-of-coronary-artery-atherosclerotic-plaque-using-dual-energy-ct-explanation-in-ex-vivo-samples
#10
Susama Rani Mandal, Avinav Bharati, Rezvan Ravanfar Haghighi, Sudhir Arava, Ruma Ray, Priya Jagia, Sanjiv Sharma, Sabyasachi Chatterjee, Millo Tabin, Munish Sharma, Sanjay Sharma, Pratik Kumar
PURPOSE: In this study non-calcified plaque composition is evaluated by Dual Energy CT (DECT). Energy Dispersive X-ray Spectroscopy (EDS) has been used to study the Plaque composition. An attempt has been made to explain the DECT results with EDS analysis. METHODS: Thirty-two ex-vivo human cadaver coronary artery samples were scanned by DECT and data was evaluated to calculate their effective atomic number and electron density (Zeff & ρe ) by inversion method...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29407881/combination-of-biomarkers-of-vascular-calcification-and-stweak-to-predict-cardiovascular-events-in-chronic-kidney-disease
#11
Milica Bozic, Nerea Méndez-Barbero, Carmen Gutiérrez-Muñoz, Angels Betriu, Jesús Egido, Elvira Fernández, Jose L Martín-Ventura, Jose M Valdivielso, Luis M Blanco-Colio
BACKGROUND AND AIMS: Vascular calcification (VC) and atherosclerosis are associated with an increased cardiovascular morbimortality in chronic kidney disease (CKD). Osteoprotegerin (OPG) and osteopontin (OPN) are involved in both VC and CKD. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) has been related to cardiovascular disease. We hypothesized that OPG, OPN and sTWEAK levels may be associated with a higher prevalence of cardiovascular outcomes in patients with CKD...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29397334/optimized-energy-of-spectral-coronary-ct-angiography-for-coronary-plaque-detection-and-quantification
#12
Rolf Symons, Younhee Choi, Tyler E Cork, Mark A Ahlman, Marissa Mallek, David A Bluemke, Veit Sandfort
BACKGROUND: To optimize spectral coronary computed tomography angiography (CTA) for quantification of coronary artery plaque components. MATERIALS AND METHODS: Fifty-one subjects were prospectively enrolled (88.2% male) (NCT02740699). Dual energy coronary CTA was performed at 90/Sn150 kVp using a 3rd generation dual-source CT scanner (SOMATOM Force, Siemens Healthcare). Dual energy images were reconstructed with a) linear mixed blending of 90 and Sn150 kVp data, b) virtual monoenergetic algorithm from 40 to 150 keV (at 10- keV intervals), and c) noise-optimized virtual monoenergetic algorithm from 40 to 150 keV...
March 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29396194/low-thigh-muscle-mass-is-associated-with-coronary-artery-stenosis-among-hiv-infected-and-hiv-uninfected-men-the-multicenter-aids-cohort-study-macs
#13
Martin Tibuakuu, Di Zhao, Ankita Saxena, Todd T Brown, Lisa P Jacobson, Frank J Palella, Mallory D Witt, Susan L Koletar, Joseph B Margolick, Eliseo Guallar, Sai Krishna C Korada, Matthew J Budoff, Wendy S Post, Erin D Michos
BACKGROUND: HIV-infected individuals are at increased risk for both sarcopenia and cardiovascular disease. Whether an association between low muscle mass and subclinical coronary artery disease (CAD) exists, and if it is modified by HIV serostatus, are unknown. METHODS: We performed cross-sectional analysis of 513 male MACS participants (72% HIV-infected) who underwent mid-thigh computed tomography (CT) and non-contrast cardiac CT for coronary artery calcium (CAC) during 2010-2013...
March 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29387923/association-between-histological-features-of-epicardial-adipose-tissue-and-coronary-plaque-characteristics-on-computed-tomography-angiography
#14
Atsuhiro Senoo, Toshiro Kitagawa, Shinya Torimaki, Hideya Yamamoto, Kazuhiro Sentani, Shinya Takahashi, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
The means by which epicardial adipose tissue (EAT) could influence coronary plaque progression biologically remain unclear. We investigated the association between the histological findings of EAT and coronary plaque characteristics assessed by coronary computed tomography angiography (CCTA). We enrolled 34 patients in whom one or more coronary plaques containing non-calcified components were detected on CCTA before cardiac surgery [coronary artery bypass graft (CABG) or non-CABG]. We evaluated visceral adipose tissue (VAT) area, EAT volume, and coronary plaque characteristics including minimum computed tomography density (CTD) and vascular Remodeling Index (RI)...
January 31, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29386888/predictors-of-pneumonia-on-routine-chest-radiographs-in-patients-with-copd-a-post-hoc-analysis-of-two-1-year-randomized-controlled-trials
#15
David B Rubin, Harris A Ahmad, Michael O'Neal, Sophie Bennett, Sally Lettis, Dmitry V Galkin, Courtney Crim
Background: Patients with COPD are at risk for life-threatening pneumonia. Although anatomical abnormalities in the thorax may predispose to pneumonia, those abnormalities identified on routine chest X-rays (CXRs) in patients with COPD have not been studied to better understand pneumonia risk. Methods: We conducted a post hoc exploratory analysis of data from two replicate year-long clinical trials assessing the impact of fluticasone furoate-vilanterol versus vilanterol alone on COPD exacerbations (GSK studies: HZC102871/NCT01009463 and HZC102970/NCT01017952)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29352380/integrated-prediction-of-lesion-specific-ischaemia-from-quantitative-coronary-ct-angiography-using-machine-learning-a-multicentre-study
#16
Damini Dey, Sara Gaur, Kristian A Ovrehus, Piotr J Slomka, Julian Betancur, Markus Goeller, Michaela M Hell, Heidi Gransar, Daniel S Berman, Stephan Achenbach, Hans Erik Botker, Jesper Moller Jensen, Jens Flensted Lassen, Bjarne Linde Norgaard
OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS: In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29274406/association-between-non-alcoholic-fatty-liver-disease-and-subclinical-coronary-atherosclerosis-an-observational-cohort-study
#17
Seung Bum Lee, Gyung-Min Park, Jong-Young Lee, Byung Uk Lee, Jae Ho Park, Byung Gyu Kim, Seok Won Jung, In Du Jeong, Sung-Jo Bang, Jung Woo Shin, Neung Hwa Park, Dong Hyun Yang, Joon-Won Kang, Tae-Hwan Lim, Hong-Kyu Kim, Jaewon Choe, Han Chu Lee
BACKGROUND & AIMS: There are limited data on the association between non-alcoholic fatty liver disease (NAFLD) and subclinical coronary atherosclerosis. This study investigated the influence of NAFLD on subclinical coronary atherosclerosis as detected by coronary computed tomography angiography (CCTA) in an asymptomatic population. METHODS: A total of 5,121 consecutive asymptomatic individuals with no prior history of coronary artery disease or significant alcohol intake voluntarily underwent abdominal ultrasonography and CCTA as part of a general health examination...
December 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29237273/a-novel-mechanism-for-atherosclerotic-calcification-potential-resolution-of-the-oxidation-paradox
#18
Aladdin Riad, Chandrakala Aluganti Narasimhulu, Pragney Deme, Sampath Parthasarathy
AIM: In this study, we tested the hypothesis that lipid peroxide-derived dicarboxylic acids (DCAs), by virtue of their ability to bind to calcium (Ca), might be involved in atherosclerotic calcification. We determined the ability of azelaic acid (AzA) to promote calcification in human aortic smooth muscle cells (HASMCs), identified AzA in human calcified atherosclerotic lesions, and compared its levels with control and noncalcified atherosclerotic lesions. RESULTS: HASMCs efficiently converted 9-oxononanoic acid (ONA), a lipid peroxide-derived monocarboxylic aldehyde, to AzA...
January 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29211402/sonographic-patterns-of-peyronie-s-disease-in-patients-with-absence-of-palpable-plaques
#19
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Non-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature. MATERIALS AND METHODS: We reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29205743/rotational-atherectomy-and-new-generation-drug-eluting-stent-implantation
#20
Daisuke Hachinohe, Yoshifumi Kashima, Daitaro Kanno, Ken Kobayashi, Takuro Sugie, Umihiko Kaneko, Yutaka Tadano, Tomohiko Watanabe, Hidemasa Shitan, Tsutomu Fujita
OBJECTIVES: The aim of this study was to evaluate the clinical outcomes of rotational atherectomy (RA) followed by new-generation drug-eluting stent (DES) implantation in patients with an extensive amount of calcified and fibrotic plaque. BACKGROUND: RA followed by new-generation DES implantation for complex lesions has not been thoroughly evaluated. METHODS: A total of 744 consecutive patients (770 lesions) treated with new-generation DES implantation following RA for de novo lesions between January 2013 and November 2015 were retrospectively identified using our institutional database...
December 5, 2017: Catheterization and Cardiovascular Interventions
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