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pickpocket drosophila

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https://www.readbyqxmd.com/read/27378227/a-pair-of-oviduct-born-pickpocket-neurons-important-for-egg-laying-in-drosophila-melanogaster
#1
Hyunjin Lee, Hyun Woo Choi, Chen Zhang, Zee-Yong Park, Young-Joon Kim
During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating...
July 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27309770/individual-differences-in-sensory-responses-influence-decision-making-by-drosophila-melanogaster-larvae-on-exposure-to-contradictory-cues
#2
Nozomi Koseki, Satoshi Mori, Shoki Suzuki, Yuta Tonooka, Sakiko Kosugi, Hiroyoshi Miyakawa, Takako Morimoto
Animals make decisions on behavioral choice by evaluating internal and external signals. Individuals often make decisions in different ways, but the underlying neural mechanisms are not well understood. Here we describe a system for observing the behavior of individual Drosophila melanogaster larvae simultaneously presented with contradictory signals, in this case attractive (yeast paste) and aversive (NaCl) signals. Olfaction was used to detect the yeast paste, whereas the ENaC/Pickpocket channel was important for NaCl detection...
June 16, 2016: Journal of Neurogenetics
https://www.readbyqxmd.com/read/26477743/drosophila-chemoreceptors-a-molecular-interface-between-the-chemical-world-and-the-brain
#3
REVIEW
Ryan M Joseph, John R Carlson
Chemoreception is essential for survival. Feeding, mating, and avoidance of predators depend on detection of sensory cues. Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones, and noxious stimuli, including receptors of the odor receptor (Or), gustatory receptor (Gr), ionotropic receptor (IR), Pickpocket (Ppk), and Trp families. We consider recent progress in understanding chemoreception in the fly, including the identification of new receptors, the discovery of novel biological functions for receptors, and the localization of receptors in unexpected places...
December 2015: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/26102453/molecular-neurobiology-of-drosophila-taste
#4
REVIEW
Erica Gene Freeman, Anupama Dahanukar
Drosophila is a powerful model in which to study the molecular and cellular basis of taste coding. Flies sense tastants via populations of taste neurons that are activated by compounds of distinct categories. The past few years have borne witness to studies that define the properties of taste neurons, identifying functionally distinct classes of sweet and bitter taste neurons that express unique subsets of gustatory receptor (Gr) genes, as well as water, salt, and pheromone sensing neurons that express members of the pickpocket (ppk) or ionotropic receptor (Ir) families...
October 2015: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/25497433/evolved-differences-in-larval-social-behavior-mediated-by-novel-pheromones
#5
Joshua D Mast, Consuelo M De Moraes, Hans T Alborn, Luke D Lavis, David L Stern
Pheromones, chemical signals that convey social information, mediate many insect social behaviors, including navigation and aggregation. Several studies have suggested that behavior during the immature larval stages of Drosophila development is influenced by pheromones, but none of these compounds or the pheromone-receptor neurons that sense them have been identified. Here we report a larval pheromone-signaling pathway. We found that larvae produce two novel long-chain fatty acids that are attractive to other larvae...
2014: ELife
https://www.readbyqxmd.com/read/25454784/balboa-binds-to-pickpocket-in-vivo-and-is-required-for-mechanical-nociception-in-drosophila-larvae
#6
Stephanie E Mauthner, Richard Y Hwang, Amanda H Lewis, Qi Xiao, Asako Tsubouchi, Yu Wang, Ken Honjo, J H Pate Skene, Jörg Grandl, W Daniel Tracey
The Drosophila gene pickpocket (ppk) encodes an ion channel subunit of the degenerin/epithelial sodium channel (DEG/ENaC) family. PPK is specifically expressed in nociceptive, class IV multidendritic (md) neurons and is functionally required for mechanical nociception responses. In this study, in a genome-wide genetic screen for other ion channel subunits required for mechanical nociception, we identify a gene that we name balboa (also known as CG8546, ppk26). Interestingly, the balboa locus encodes a DEG/ENaC ion channel subunit highly similar in amino acid sequence to PPK...
December 15, 2014: Current Biology: CB
https://www.readbyqxmd.com/read/24821805/water-sensor-ppk28-modulates-drosophila-lifespan-and-physiology-through-akh-signaling
#7
Michael J Waterson, Brian Y Chung, Zachary M Harvanek, Ivan Ostojic, Joy Alcedo, Scott D Pletcher
Sensory perception modulates lifespan across taxa, presumably due to alterations in physiological homeostasis after central nervous system integration. The coordinating circuitry of this control, however, remains unknown. Here, we used the Drosophila melanogaster gustatory system to dissect one component of sensory regulation of aging. We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan...
June 3, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24642409/natural-antisense-transcripts-regulate-the-neuronal-stress-response-and-excitability
#8
Xingguo Zheng, Vera Valakh, Aaron Diantonio, Yehuda Ben-Shahar
Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood. Here we show that pickpocket 29 (ppk29), a gene that encodes a Drosophila degenerin/epithelial sodium channel (DEG/ENaC), regulates neuronal excitability via a protein-independent mechanism. We demonstrate that the mRNA 3'UTR of ppk29 affects neuronal firing rates and associated heat-induced seizures by acting as a natural antisense transcript (NAT) that regulates the neuronal mRNA levels of seizure (sei), the Drosophila homolog of the human Ether-à-go-go Related Gene (hERG) potassium channel...
2014: ELife
https://www.readbyqxmd.com/read/24631243/sexually-dimorphic-octopaminergic-neurons-modulate-female-postmating-behaviors-in-drosophila
#9
Carolina Rezával, Tetsuya Nojima, Megan C Neville, Andrew C Lin, Stephen F Goodwin
Mating elicits profound behavioral and physiological changes in many species that are crucial for reproductive success. After copulation, Drosophila melanogaster females reduce their sexual receptivity and increase egg laying [1, 2]. Transfer of male sex peptide (SP) during copulation mediates these postmating responses [1, 3-6] via SP sensory neurons in the uterus defined by coexpression of the proprioceptive neuronal marker pickpocket (ppk) and the sex-determination genes doublesex (dsx) and fruitless (fru) [7-9]...
March 31, 2014: Current Biology: CB
https://www.readbyqxmd.com/read/24089336/multiple-pathways-mediate-the-sex-peptide-regulated-switch-in-female-drosophila-reproductive-behaviours
#10
Irmgard U Haussmann, Yash Hemani, Thilini Wijesekera, Brigitte Dauwalder, Matthias Soller
Male-derived sex-peptide (SP) induces profound changes in the behaviour of Drosophila females, resulting in decreased receptivity to further mating and increased egg laying. SP can mediate the switch in female reproductive behaviours via a G protein-coupled receptor, SPR, in neurons expressing fruitless, doublesex and pickpocket. Whether SPR is the sole receptor and whether SP induces the postmating switch in a single pathway has not, to our knowledge been tested. Here we report that the SP response can be induced in the absence of SPR when SP is ectopically expressed in neurons or when SP, transferred by mating, can access neurons through a leaky blood brain barrier...
November 22, 2013: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/23973209/a-presynaptic-enac-channel-drives-homeostatic-plasticity
#11
Meg A Younger, Martin Müller, Amy Tong, Edward C Pym, Graeme W Davis
An electrophysiology-based forward genetic screen has identified two genes, pickpocket11 (ppk11) and pickpocket16 (ppk16), as being necessary for the homeostatic modulation of presynaptic neurotransmitter release at the Drosophila neuromuscular junction (NMJ). Pickpocket genes encode Degenerin/Epithelial Sodium channel subunits (DEG/ENaC). We demonstrate that ppk11 and ppk16 are necessary in presynaptic motoneurons for both the acute induction and long-term maintenance of synaptic homeostasis. We show that ppk11 and ppk16 are cotranscribed as a single mRNA that is upregulated during homeostatic plasticity...
September 18, 2013: Neuron
https://www.readbyqxmd.com/read/23449991/the-genetic-architecture-of-degenerin-epithelial-sodium-channels-in-drosophila
#12
Kathleen M Zelle, Beika Lu, Sarah C Pyfrom, Yehuda Ben-Shahar
Degenerin/epithelial sodium channels (DEG/ENaC) represent a large family of animal-specific membrane proteins. Although the physiological functions of most family members are not known, some have been shown to act as nonvoltage gated, amiloride-sensitive sodium channels. The DEG/ENaC family is exceptionally large in genomes of Drosophila species relative to vertebrates and other insects. To elucidate the evolutionary history of the DEG/ENaC family in Drosophila, we took advantage of the genomic and genetic information available for 12 Drosophila species that represent all the major species groups in the Drosophila clade...
March 2013: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/22658598/neural-circuitry-underlying-drosophila-female-postmating-behavioral-responses
#13
Carolina Rezával, Hania J Pavlou, Anthony J Dornan, Yick-Bun Chan, Edward A Kravitz, Stephen F Goodwin
BACKGROUND: After mating, Drosophila females undergo a remarkable phenotypic switch resulting in decreased sexual receptivity and increased egg laying. Transfer of male sex peptide (SP) during copulation mediates these postmating responses via sensory neurons that coexpress the sex-determination gene fruitless (fru) and the proprioceptive neuronal marker pickpocket (ppk) in the female reproductive system. Little is known about the neuronal pathways involved in relaying SP-sensory information to central circuits and how these inputs are processed to direct female-specific changes that occur in response to mating...
July 10, 2012: Current Biology: CB
https://www.readbyqxmd.com/read/22632976/contact-chemoreceptors-mediate-male-male-repulsion-and-male-female-attraction-during-drosophila-courtship
#14
Robert Thistle, Peter Cameron, Azeen Ghorayshi, Lisa Dennison, Kristin Scott
The elaborate courtship ritual of Drosophila males is dictated by neural circuitry established by the transcription factor Fruitless and triggered by sex-specific sensory cues. Deciphering the role of different stimuli in driving courtship behavior has been limited by the inability to selectively target appropriate sensory classes. Here, we identify two ion channel genes belonging to the degenerin/epithelial sodium channel/pickpocket (ppk) family, ppk23 and ppk29, which are expressed in fruitless-positive neurons on the legs and are essential for courtship...
May 25, 2012: Cell
https://www.readbyqxmd.com/read/22343891/the-role-of-drosophila-piezo-in-mechanical-nociception
#15
Sung Eun Kim, Bertrand Coste, Abhishek Chadha, Boaz Cook, Ardem Patapoutian
Transduction of mechanical stimuli by receptor cells is essential for senses such as hearing, touch and pain. Ion channels have a role in neuronal mechanotransduction in invertebrates; however, functional conservation of these ion channels in mammalian mechanotransduction is not observed. For example, no mechanoreceptor potential C (NOMPC), a member of transient receptor potential (TRP) ion channel family, acts as a mechanotransducer in Drosophila melanogaster and Caenorhabditis elegans; however, it has no orthologues in mammals...
March 8, 2012: Nature
https://www.readbyqxmd.com/read/20171104/pickpocket-is-a-deg-enac-protein-required-for-mechanical-nociception-in-drosophila-larvae
#16
Lixian Zhong, Richard Y Hwang, W Daniel Tracey
Highly branched class IV multidendritic sensory neurons of the Drosophila larva function as polymodal nociceptors that are necessary for behavioral responses to noxious heat (>39 degrees C) or noxious mechanical (>30 mN) stimuli. However, the molecular mechanisms that allow these cells to detect both heat and force are unknown. Here, we report that the pickpocket (ppk) gene, which encodes a Degenerin/Epithelial Sodium Channel (DEG/ENaC) subunit, is required for mechanical nociception but not thermal nociception in these sensory cells...
March 9, 2010: Current Biology: CB
https://www.readbyqxmd.com/read/19953079/isolation-and-purification-of-drosophil-peripheral-neurons-by-magnetic-bead-sorting
#17
Eswar Prasad R Iyer, Srividya Chandramouli Iyer, Mikolaj J Sulkowski, Daniel N Cox
The Drosophila peripheral nervous system (PNS) is a powerful model for investigating the complex processes of neuronal development and dendrite morphogenesis at the functional and molecular levels. To aid in these analyses, we have developed a strategy for the isolation of a subclass of PNS neurons called dendritic arborization (da) neurons that have been widely used for studying dendrite morphogenesis. These neurons are very difficult to isolate as a pure population, due in part to their extremely low occurrence and their difficult-to-reach location below the tough chitinous larval cuticle...
2009: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/19249272/sensory-neurons-in-the-drosophila-genital-tract-regulate-female-reproductive-behavior
#18
Martin Häsemeyer, Nilay Yapici, Ulrike Heberlein, Barry J Dickson
Females of many animal species behave very differently before and after mating. In Drosophila melanogaster, changes in female behavior upon mating are triggered by the sex peptide (SP), a small peptide present in the male's seminal fluid. SP activates a specific receptor, the sex peptide receptor (SPR), which is broadly expressed in the female reproductive tract and nervous system. Here, we pinpoint the action of SPR to a small subset of internal sensory neurons that innervate the female uterus and oviduct...
February 26, 2009: Neuron
https://www.readbyqxmd.com/read/18758451/dynein-is-required-for-polarized-dendritic-transport-and-uniform-microtubule-orientation-in-axons
#19
Yi Zheng, Jill Wildonger, Bing Ye, Ye Zhang, Angela Kita, Susan H Younger, Sabina Zimmerman, Lily Yeh Jan, Yuh Nung Jan
Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. Changes in organelle distribution within the dendritic arbors of dynein mutant neurons correlate with a proximal shift in dendritic branch position. Dynein is also necessary for the dendrite-specific localization of Golgi outposts and the ion channel Pickpocket...
October 2008: Nature Cell Biology
https://www.readbyqxmd.com/read/18234173/control-of-multidendritic-neuron-differentiation-in-drosophila-the-role-of-collier
#20
Michèle Crozatier, Alain Vincent
Proper sampling of sensory inputs critically depends upon neuron morphogenesis and expression of sensory channels. The highly stereotyped organisation of the Drosophila peripheral nervous system (PNS) provides a model to study neuronal determination and morphogenesis. Here, we report that Collier/Knot (Col/Kn), the Drosophila member of the COE family of transcription factors, is transiently expressed in the subset of multidendritic arborisation (da) sensory neurons that display an highly branched dendritic arborisation, class IV neurons...
March 1, 2008: Developmental Biology
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