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https://www.readbyqxmd.com/read/27868092/endourologic-diagnosis-and-robotic-treatment-of-a-giant-fibroepithelial-polyp-of-the-ureter
#1
Francesco Cattaneo, Fabio Zattoni, Luca Meggiato, Claudio Valotto, Fabrizio Dal Moro, Marina Paola Gardiman, Paolo Beltrami, Filiberto Zattoni
Background: Fibroepithelial polyps (FEPs) are a rare cause of ureteropelvic junction (UPJ) obstruction. Radiologists and urologists are not always confident with this disease because of its rarity, complex diagnosis, and heterogeneity of the available treatment options. Case Presentation: We present the endourologic diagnosis and the robotic management of a ureteral polyp close to the left UPJ. A 16-year-old woman with a 12 years history of left lumbar pain was referred to our Center. A computed tomography scan detected a left hydronephrosis with no signs of obstructions at MAG-3 scintigraphy...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27867849/laparoscopic-transposition-of-lower-pole-crossing-vessels-vascular-hitch-in-children-with-pelviureteric-junction-obstruction
#2
Ciro Esposito, Cosimo Bleve, Maria Escolino, Paolo Caione, Simona Gerocarni Nappo, Alessandra Farina, Maria Grazia Caprio, Mariapina Cerulo, Angela La Manna, Salvatore Fabio Chiarenza
BACKGROUND: Congenital hydronephrosis due to intrinsic or extrinsic uretero-pelvic-junction (UPJ) obstruction (UPJO) is a common problem in childhood UPJO may be caused by intrinsic disorganization or by extrinsic compression from crossing vessels (CV); extrinsic causes usually present symptomatically in older children. This report the large Italian experience in the treatment of children with extrinsic-UPJO by CV. METHODS: We analyzed the data of 51 children (17 girls and 34 boys, median age 10, 7 years) affected by extrinsic-UPJO were treated in three Italian institutions with laparoscopic transposition of CV (Hellström Vascular Hitch modified by Chapman)...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27867848/pyeloplasty-techniques-using-minimally-invasive-surgery-mis-in-pediatric-patients
#3
REVIEW
Francesco Turrà, Maria Escolino, Alessandra Farina, Alessandro Settimi, Ciro Esposito, François Varlet
Hydronephrosis is the most common presentation of ureteropelvic junction (UPJ) obstruction. We reviewed literature, collecting data from Medline, to evaluate the current status of minimally invasive surgery (MIS) approach to pyeloplasty. Since the first pyeloplasty was described in 1939, several techniques has been applied to correct UPJ obstruction, but Anderson-Hynes dismembered pyeloplasty is established as the gold standard, to date also in MIS technique. According to literature several studies underline the safety and effectiveness of this approach for both trans- and retro-peritoneal routes, with a success rate between 81-100% and an operative time between 90-228 min...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27790508/role-of-urinary-and-serum-carbohydrate-antigen-19-9-as-a-biomarker-in-diagnosis-of-adult-giant-hydronephrosis
#4
Indraneel Banerjee, Vinay Tomar, Sher Singh Yadav, Nachiket Vyas, Suresh Yadav, Brijesh Sathian
INTRODUCTION: The most common cause of adult Giant Hydronephrosis (GH) is congenital Uretero-Pelvic Junction (UPJ) obstruction. Conventional imaging modalities, like Intravenous Urography (IVU) and Computed Tomography Urography (CTU) and radionuclide renal scan can be fallacious. Serum carbohydrate antigen 19-9 (CA19-9) is a useful tumour marker for gastrointestinal and pancreatic cancer. Only a few studies and case reports have shown raised serum levels due to benign hydronephrosis and GH...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27765696/laparoscopic-versus-open-pyeloplasty-in-children-results-of-a-randomized-prospective-controlled-trial
#5
John M Gatti, Sable Amstutz, Paul R Bowlin, Heidi A Stephany, J Patrick Murphy
PURPOSE: Open dismembered pyeloplasty is the preferred repair for ureteropelvic junction (UPJ) obstruction. Minimally invasive techniques have been applied to the original open approach, but no clear advantage has been shown to these technological advances. We evaluate outcomes between transperitoneal laparoscopic (LP) and open pyeloplasty (OP) in children. METHODS: All children aged 1 to 18 years with UPJ obstruction requiring operative repair were offered enrollment in the study...
October 17, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27717566/retroperitoneoscopic-assisted-single-site-pyeloplasty-using-ez-access-in-children-comparison-with-open-dismembered-pyeloplasty
#6
Yuichiro Yamazaki, Woo Jin Kim, Sayaka Akiyama, Takashi Ikeda
PURPOSE: The aim of this study was to compare the results of the retroperitoneoscopic assisted pyeloplasty (RASP) using EZ access (silicone rubber cap) with open dismembered pyeloplasty (ODP) in children. METHODS: A retrospective review was performed of patients treated for ureteropelvic junction (UPJ) obstruction with either RASP or ODP from 2010 to 2015. For patients with RASP, two 5-mm trocars were placed in the EZ access. The UPJ was dissected retroperitoneoscopically and dismembered pyeloplasty was performed extracorporeally...
September 23, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27694997/a-capillary-electrophoresis-coupled-to-mass-spectrometry-pipeline-for-long-term-comparable-assessment-of-the-urinary-metabolome
#7
Franck Boizard, Valérie Brunchault, Panagiotis Moulos, Benjamin Breuil, Julie Klein, Nadia Lounis, Cécile Caubet, Stéphanie Tellier, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra, Bénédicte Buffin-Meyer
Although capillary electrophoresis coupled to mass spectrometry (CE-MS) has potential application in the field of metabolite profiling, very few studies actually used CE-MS to identify clinically useful body fluid metabolites. Here we present an optimized CE-MS setup and analysis pipeline to reproducibly explore the metabolite content of urine. We show that the use of a beveled tip capillary improves the sensitivity of detection over a flat tip. We also present a novel normalization procedure based on the use of endogenous stable urinary metabolites identified in the combined metabolome of 75 different urine samples from healthy and diseased individuals...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693478/dismembered-pyeloplasy-in-infants-six-months-old-or-younger-with-and-without-external-trans-anastomotic-nephrostent-a-prospective-randomized-study
#8
Farouk M Nasser, Ahmed M Shouman, Mohammed S ElSheemy, Mohammed A Lotfi, Waseem Aboulela, Mohamed El Ghoneimy, Mohammed Abdelwahab, Ahmed I Shoukry, Waleed Ghoneima, Hany Morsi, Hesham Badawy
OBJECTIVES: To compare outcome of dismembered-pyeloplasty in infants with and without external nephro-ureteric stent (ENUS) for treatment of congenital ureteropelvic junction obstruction (UPJ-O). METHODS: This is a parallel, randomized comparative study between October 2013 and September 2014. 30 infants ≤6 months old with UPJ-O indicated for dismembered-pyeloplasty were randomly assigned (block randomization, closed envelope method) into two groups; group-A (stentless) and group-B (ENUS)...
September 28, 2016: Urology
https://www.readbyqxmd.com/read/27635277/minimally-invasive-approach-of-a-retrocaval-ureter
#9
Nuno Fidalgo, Hugo Pinheiro, Frederico Ferronha, Jorge Morales, Luís Campos Pinheiro
The retrocaval ureter is a rare congenital entity, classically managed with open pyeloplasty techniques. The experience obtained with the laparoscopic approach of other more frequent causes of ureteropelvic junction (UPJ) obstruction has opened the method for the minimally invasive approach of the retrocaval ureter. In our paper, we describe a clinical case of a right retrocaval ureter managed successfully with laparoscopic dismembered pyeloplasty. The main standpoints of the procedure are described. Our results were similar to others published by other urologic centers, which demonstrates the safety and feasibility of the procedure for this condition...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27511831/fibroproliferative-response-to-urothelial-failure-obliterates-the-ureter-lumen-in-a-mouse-model-of-prenatal-congenital-obstructive-nephropathy
#10
Amanda J Lee, Noemi Polgar, Josephine A Napoli, Vanessa H Lui, Kadee-Kalia Tamashiro, Brent A Fujimoto, Karen S Thompson, Ben Fogelgren
Congenital obstructive nephropathy (CON) is the most prevalent cause of pediatric chronic kidney disease and end-stage renal disease. The ureteropelvic junction (UPJ) region, where the renal pelvis transitions to the ureter, is the most commonly obstructed site in CON. The underlying causes of congenital UPJ obstructions remain poorly understood, especially when they occur in utero, in part due to the lack of genetic animal models. We previously showed that conditional inactivation of Sec10, a central subunit of the exocyst complex, in the epithelial cells of the ureter and renal collecting system resulted in late gestational bilateral UPJ obstructions with neonatal anuria and death...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27460642/new-congenital-anomalies-of-the-kidney-and-urinary-tract-and-outcomes-in-robo2-mutant-mice-with-the-inserted-piggybac-transposon
#11
Jialu Liu, Li Sun, Qian Shen, Xiaohui Wu, Hong Xu
BACKGROUND: Disruption of ROBO2 in humans causes vesicoureteral reflux (VUR)/congenital anomalies of the kidney and urinary tract (CAKUT). PiggyBac (PB) is a DNA transposon, and its insertion often reduces-but does not eliminate-gene expression. The Robo2 insertion mutant exhibited non-dilating VUR, ureteropelvic junction obstruction (UPJO) not found in reported models. We studied the incidence and outcomes of VUR/CAKUT in this mutant and explored the relationship between Robo2 gene expression and the occurrence and severity of VUR/CAKUT...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27448803/mmp9-overexpression-is-associated-with-good-surgical-outcome-in-children-with-upjo-preliminary-results
#12
Sabrina Thalita Reis, Kátia R M Leite, Nayara Izabel Viana, Roberto Iglesias Lopes, Caio Martins Moura, Renato F Ivanovic, Marcos Machado, Francisco Tibor Denes, Amilcar Giron, William Carlos Nahas, Miguel Srougi, Carlo C Passerotti
BACKGROUND: Ureteropelvic junction obstruction (UPJO) diagnosed prenatally occurs in 1:150 - 1:1200 pregnancies. Although many studies investigating the molecular changes of this obstructed segment have been performed, the underlying mechanisms are still unclear. The role of extracellular matrix (ECM) components remains controversial, and the investigations in the field of ECM changes, might help the better understanding of the pathogenesis of this common condition. The aim of the present study was to investigate for the first time in the literature whether MMP9 and its specific inhibitors, TIMP1 and RECK, are expressed in a reproducible, specific pattern in UPJ...
2016: BMC Urology
https://www.readbyqxmd.com/read/27381532/sonic-hedgehog-tbx18-and-tshz3-proteins-involved-in-pyeloureteral-motility-development-are-overexpressed-in-ureteropelvic-junction-obstruction-an-immunohistochemical-histopathological-and-clinical-comparative-study
#13
Omer Yilmaz, Nalan Nese, Mustafa Dalgic, Gonca P Kesici, Abdulkadir Genc, Can Taneli, Cuneyt Gunsar, Aydın Sencan, Hasan Cayirli, Aydın Isisag
OBJECTIVES: To compare pathological samples obtained from cases that underwent surgery for ureteropelvic junction (UPJ) obstruction with samples obtained during autopsies of subjects.  METHODS: Retrospectively, 42 patients who had undergone surgery due to UPJ obstruction (group 1) were included in the study. Histopathological and immunohistochemical features for sonic hedgehog (SHH), TBX18, and TSHZ3 of UPJ were evaluated and findings were compared with 20 autopsy cases (group 2)...
July 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27346071/global-minimally-invasive-pyeloplasty-study-in-children-results-from-the-pediatric-urology-expert-group-of-the-european-association-of-urology-young-academic-urologists-working-party
#14
M S Silay, A F Spinoit, S Undre, V Fiala, Z Tandogdu, T Garmanova, A Guttilla, A A Sancaktutar, B Haid, M Waldert, A Goyal, E C Serefoglu, E Baldassarre, G Manzoni, A Radford, R Subramaniam, A Cherian, P Hoebeke, M Jacobs, B Rocco, R Yuriy, Fabio Zattoni, R Kocvara, C J Koh
INTRODUCTION: Minimally invasive pyeloplasty (MIP) for ureteropelvic junction (UPJ) obstruction in children has gained popularity over the past decade as an alternative to open surgery. The present study aimed to identify the factors affecting complication rates of MIP in children, and to compare the outcomes of laparoscopic (LP) and robotic-assisted laparoscopic pyeloplasty (RALP). MATERIALS AND METHODS: The perioperative data of 783 pediatric patients (<18 years old) from 15 academic centers who underwent either LP or RALP with an Anderson Hynes dismembered pyeloplasty technique were retrospectively evaluated...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27279495/robot-assisted-laparoscopic-excision-of-ureteral-and-ureteropelvic-junction-fibroepithelial-polyps-in-children
#15
Nathan Osbun, Jonathan S Ellison, Thomas S Lendvay
INTRODUCTION: Fibroepithelial polyps of the ureter are a rare cause of asymptomatic and symptomatic upper urinary tract obstruction in children. While these lesions can often be managed endoscopically, large or multifocal polyps may preclude such an approach. OBJECTIVE: We aim to describe our institutional experience with robot-assisted laparoscopic treatment of ureteral polyps and show that a robotic approach is an effective alternative for large or multifocal polyps...
August 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27251522/umbilical-only-access-laparoscopic-pyeloplasty-in-children-preliminary-report
#16
Rajendra B Nerli, Prasad V Magdum, Shridhar C Ghagane, Murigendra B Hiremath, Mallikarjuna Reddy
BACKGROUND: Over the past three decades, laparoscopic surgery has become a well-established alternative to open surgery in the management of ureteropelvic junction (UPJ) obstruction. Currently, several efforts are being made, aimed at further reducing the morbidity associated with conventional laparoscopy. We report our experience with modified umbilical port laparoscopic pyeloplasty in children. MATERIALS AND METHODS: Children presenting with hydronephrosis secondary to UPJ obstruction formed the study group...
January 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/27229497/magnetic-resonance-urography-in-the-pediatric-population-a-clinical-perspective
#17
REVIEW
Michael E Chua, Jessica M Ming, Walid A Farhat
Diagnostic imaging in pediatric urology has traditionally relied upon multiple modalities based on availability, use of ionizing radiation, and invasiveness to evaluate urological anomalies. These modalities include ultrasonography, voiding cystourethrography, fluoroscopy and radionuclide scintigraphy. Magnetic resonance urography (MRU) has become increasingly useful in depicting more detailed abdominal and pelvic anatomy, specifically in duplex collecting systems, ectopic ureter, ureteropelvic junction (UPJ) obstruction, megaureter and congenital pelvic anomalies...
May 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27141202/spontaneous-large-renal-pelvis-hematoma-in-ureteropelvic-junction-obstruction-presenting-as-an-acute-abdomen-rare-case-report
#18
Ajit Sawant, Gaurav Kasat, Prakash Pawar, Ashwin Tamhankar
Patients with ureteropelvic junction (UPJ) obstruction can present with flank pain or hematuria. We present 20-year-old male presenting with acute pain in lumbar and right fossa with tenderness and guarding, this case was clinically mimicking general surgical emergency. On computed tomography with urography and angiography, there was 15 cm × 11 cm × 10 cm size non-enhancing hyperdense lesion (average Hounsfield units - +64) in right renal pelvis suggestive of hematoma. Patient's diethylenetriaminepentaacetic acid diuretic renography was suggestive of right kidney glomerular function rate of 48...
April 2016: Urology Annals
https://www.readbyqxmd.com/read/27120949/-computed-tomography-imaging-in-ureteropelvic-junction-obstruction-case-report
#19
Katarzyna Pilch, Przemysław Jaźwiec, Krystian Truszkiewicz, Paweł Gać
Ureteropelvic junction obstruction (UPJO) is defined as an impedance in the normal flow of urine from the renal pelvis into the proximal ureter. This leads to an increase urine pressure in the pelvicalyceal system and as a consequence cause hydronephrosis and damage of renal parenchyma. Presence of anomalous vessels crossing the ureter (crossing vessels) is one of the many reasons of UPJ obstruction. We report a case of 32-year-old female patient with chronic abdominal pain and recurrent episodes of pyelonephritis in the past...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27105017/early-mercaptoacetyltriglycine-mag-3-diuretic-renography-results-after-pyeloplasty
#20
Alice Faure, Kevin London, Grahame H H Smith
OBJECTIVE: To describe the drainage and functional outcome of paediatric pyeloplasty, 1 week after stent removal 7-9 weeks after pyeloplasty using diuretic renography. PATIENTS AND METHODS: Between 2009 and 2014, we assessed the functional and drainage outcomes according to mercaptoacetyltriglycine MAG-3 diuretic renograms from 66 children (69 kidneys) who underwent modified dismembered Anderson-Hynes pyeloplasty for pelvi-ureteric junction (PUJ) obstruction. Stents were left in place for 6-8 weeks and postoperative renal units were evaluated with MAG-3 renogram 1 week after stent removal...
November 2016: BJU International
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