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Urinary bladder cancer or bladder cancer

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https://www.readbyqxmd.com/read/28078533/risk-factors-for-intravesical-recurrence-after-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#1
Ryo Yamashita, Reiko Watanabe, Ichiro Ito, Hideo Shinsaka, Masafumi Nakamura, Masato Matsuzaki, Masashi Niwakawa
PURPOSE: To determine major risk factors for bladder cancer (BC) recurrence after nephroureterectomy (Nux) by focusing on the pathologic appearances of tumors in upper urinary tract urothelial carcinomas (UUTUCs). METHODS: We performed 147 Nux procedures between November 2002 and September 2015. Forty-eight patients were excluded because of a history of BC (28 patients), previous or concurrent radical cystectomy (9 patients), neoadjuvant chemotherapy (5 patients), and other reasons (6 patients)...
January 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28077116/quality-of-life-and-functional-outcome-after-infravesical-desobstruction-and-hifu-treatment-for-localized-prostate-cancer
#2
G Hatiboglu, I V Popeneciu, M Deppert, J Nyarangi-Dix, B Hadaschik, M Hohenfellner, D Teber, S Pahernik
BACKGROUND: To evaluate quality of life, functional and oncological outcome after infravesical desobstruction and HIFU treatment for localized prostate cancer. METHODS: One hundred thirty-one patients, treated with TURP and HIFU in a single institution were followed up for oncological and functional outcome. Oncological outcome was quantified by biochemical recurrence free survival using the Stuttgart and Phoenix criteria. Quality of life was assessed by usage of standardized QLQ-C30 and QLQ-PR25 questionnaires...
January 11, 2017: BMC Urology
https://www.readbyqxmd.com/read/28068467/exodisc-for-rapid-size-selective-and-efficient-isolation-and-analysis-of-nanoscale-extracellular-vesicles-from-biological-samples
#3
Hyun-Kyung Woo, Vijaya Sunkara, Juhee Park, Tae-Hyeong Kim, Ja-Ryoung Han, Chi-Ju Kim, Hyun-Il Choi, Yoon-Keun Kim, Yoon-Kyoung Cho
Extracellular vesicles (EVs) are cell-derived, nanoscale vesicles that carry nucleic acids and proteins from their cells of origin and show great potential as biomarkers for many diseases, including cancer. Efficient isolation and detection methods are prerequisites for exploiting their use in clinical settings and understanding their physiological functions. Here, we presented a rapid, label-free, and highly sensitive method for EV isolation and quantification using a lab-on-a-disc integrated with two nanofilters (Exodisc)...
January 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28065960/urinary-bladder-cancer-in-adults-a-histopathological-experience-from-madinah-saudi-arabia
#4
Abeer Abdalla El-Siddig, Abdulkader Mohammed Albasri, Akbar Shah Hussainy, Ahmed Safar Alhujaily
OBJECTIVE: To delineate the frequency and clinicopathological features of urinary bladder cancer. METHODS: This retrospective study was conducted at the King Fahd Hospital, Madinah, Saudi Arabia, and comprised medical records related to bladder tumours, from January 2006 to October 2015. Data was obtained from histopathologic reports and evaluated for age, gender, cystoscopic findings and histopathological characteristics at the time of presentation. RESULTS: Of the 116 cases, 96(82...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28064454/hgf-met-in-cancer-progression-and-biomarker-discovery
#5
REVIEW
Kunio Matsumoto, Masataka Umitsu, Dinuka M De Silva, Arpita Roy, Donald P Bottaro
Signaling driven by hepatocyte growth factor (HGF) and MET receptor facilitates conspicuous biological responses such as epithelial cell migration, 3-D morphogenesis, and survival. The dynamic migration and promotion of cell survival induced by MET activation are bases respectively for invasion-metastasis and resistance against targeted drugs in cancers. Recent studies indicated that MET in tumor-derived exosomes facilitates metastatic niche formation and metastasis in malignant melanoma. In lung cancer, gene amplification-induced MET activation and ligand-dependent MET activation in autocrine/paracrine manner are causes for resistance to EGF receptor tyrosine kinase inhibitors and ALK inhibitors...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28062595/the-clinical-impact-of-additional-late-pet-ct-imaging-with-68ga-psma-11-hbed-cc-in-the-diagnosis-of-prostate-cancer
#6
Ali Afshar-Oromieh, Lars Peter Sattler, Walter Mier, Boris Hadaschik, Jürgen Debus, Tim Holland-Letz, Klaus Kopka, Uwe Haberkorn
PURPOSE: While Positron Emission Tomography/Computed Tomography (PET/CT) with (68)Ga-PSMA-11 in the diagnosis of prostate cancer (PCa) is routinely performed at 1h post injection (p.i.), later scans may be beneficial since most lesions present with higher uptake and contrast. This evaluation aimed to investigate the clinical impact of additional late (68)Ga-PSMA-11-PET/CT. METHODS: Between 2011 and 2016, 112 patients with PCa who received early (at 1h p.i.) and late (at 3h p...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28058098/urinary-bladder-cancer-biomarkers-and-target-therapy-new-era-for-more-attention
#7
REVIEW
Amrallah A Mohammed, Hani El-Tanni, Hani M El-Khatib, Ahmad A Mirza, Abdulrahim A Mirza, Turki H Alturaifi
Currently, bladder cancer (BCa) evaluation depends mainly on traditional clinicopathological parameters encompassing tumor stage and grade, which will not reflect the behavior of the disease. Diverse molecular alterations are responsible for the heterogeneous course. The differences in molecular pathogenesis between non-invasive BCa and invasive BCa have been recognized. Molecular biomarkers are promising to predict progression and survival. The management of advanced BCa remains somewhat primitive in comparison with other more common malignancies...
October 10, 2016: Oncology Reviews
https://www.readbyqxmd.com/read/28049497/two-differentially-structured-collagen-scaffolds-for-potential-urinary-bladder-augmentation-proof-of-concept-study-in-a-g%C3%A3-ttingen-minipig-model
#8
Dorothea Leonhäuser, Katja Stollenwerk, Volker Seifarth, Isabella M Zraik, Michael Vogt, Pramod K Srinivasan, Rene H Tolba, Joachim O Grosse
BACKGROUND: The repair of urinary bladder tissue is a necessity for tissue loss due to cancer, trauma, or congenital abnormalities. Use of intestinal tissue is still the gold standard in the urological clinic, which leads to new problems and dysfunctions like mucus production, stone formation, and finally malignancies. Therefore, the use of artificial, biologically derived materials is a promising step towards the augmentation of this specialised tissue. The aim of this study was to investigate potential bladder wall repair by two collagen scaffold prototypes, OptiMaix 2D and 3D, naïve and seeded with autologous vesical cells, as potential bladder wall substitute material in a large animal model...
January 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28049011/fgfr3-tert-and-otx1-as-urinary-biomarker-combination-for-surveillance-of-bladder-cancer-patients-in-a-large-prospective-multicenter-study
#9
Willemien Beukers, Kirstin A van der Keur, Raju Kandimalla, Yvonne Vergouwe, Ewout W Steyerberg, Joost L Boormans, Jorgen B Jensen, José A Lorente, Francisco X Real, Ulrike Segersten, Torben F Orntoft, Nuria Malats, Per-Uno Malmström, Lars Dyrskjot, Ellen C Zwarthoff
PURPOSE: Non-muscle invasive bladder cancer (NMIBC) patients are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 are investigated as a diagnostic urinary marker combination during follow-up of patients with primary NMIBC. MATERIAL AND METHODS: In this international multi-center prospective study 977 NMIBC patients were included. Urines (n= 2496) were collected prior to cystoscopy during regular visits. Sensitivity was estimated for detection of concomitant recurrences...
December 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28048054/su-f-j-05-the-effect-of-air-pockets-in-the-urinary-bladder-during-bladder-hyperthermia-treatment
#10
G Schooneveldt, H P Kok, A Bakker, E D Geijsen, T M de Reijke, J Crezee
PURPOSE: Hyperthermia combined with Mitomycin C is used for the treatment of non-muscle invasive bladder cancer (NMIBC), using a phased array system of microwave antennas for bladder heating. Often some air is present in the bladder, which effectively blocks the microwave radiation, potentially preventing proper treatment of that part of the bladder. Air can be a relevant fraction of the bladder content and large air pockets are expected to have a noticeable influence on achieved temperatures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047756/we-ab-207b-09-margin-reduction-for-planning-target-volume-ptv-in-patients-with-localized-prostate-cancer-impact-on-delivered-dose-and-quality-of-life
#11
A Kumarasiri, C Liu, S Brown, C Glide-Hurst, M Elshaikh, I Chetty, B Movsas
PURPOSE: To estimate the delivered (cumulative) dose to targets and organs at risk for localized prostate cancer patients treated with reduced PTV margins and to evaluate preliminary patient reported quality-of-life (QOL). METHODS: Under an IRB-approved protocol, 20 prostate cancer patients (including 11 control patients) were treated with reduced planning margins (5 mm uniform with 4 mm at prostate/rectum interface). Control patients had standard margin (10/6 mm)-based treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038452/inhibition-of-long-non-coding-rna-uca1-by-crispr-cas9-attenuated-malignant-phenotypes-of-bladder-cancer
#12
Shuai Zhen, Ling Hua, Yun-Hui Liu, Xiao-Min Sun, Meng-Meng Jiang, Wei Chen, Le Zhao, Xu Li
CRISPR/Cas9 is a novel and effective genome editing technique, but its application is not widely expanded to manipulate long non-coding RNA (lncRNA) expression. The lncRNA urothelial carcinoma-associated 1 (UCA1) is upregulated in bladder cancer and promotes the progression of bladder cancer. Here, we design gRNAs specific to UCA1 and construct CRISPR/Cas9 systems targeting UCA1. Single CRISPR/Cas9-UCA1 can effectively inhibit UCA1 expression when transfected into 5637 and T24 bladder cancer cells, while the combined transfection of the two most effective CRISPR/Cas9-UCA1s can generate more satisfied inhibitory effect...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28027809/-laparoscopic-anterior-pelvic-exenteration-in-a-patient-with-locally-advanced-melanoma
#13
David Isla-Ortiz, Gonzalo Montalvo-Esquivel, Roberto Eduardo Herrera-Goepfert, Ángel Herrera-Gómez, Rosa Angélica Salcedo-Hernández
BACKGROUND: Pelvic exenteration is one of the most mutilating surgical procedures with high post-operative morbidity. The laparoscopic technique aims to reduce perioperative complications and reduce post-surgical recovery. OBJECTIVE: We present the first case of laparoscopic anterior exenteration for locally advanced melanoma, held at the National Cancer Institute and published in Mexico. CASE REPORT: Patient 60 years of age diagnosed with invasive vulvar melanoma with bladder extension upon whom laparoscopic anterior pelvic exenteration with external urinary reconstruction was performed...
December 24, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28025135/doxorubicin-enhances-the-capacity-of-b-cells-to-activate-t-cells-in-urothelial-urinary-bladder-cancer
#14
A Ali Zirakzadeh, Johan Kinn, David Krantz, Robert Rosenblatt, Malin E Winerdal, Jin Hu, Ciputra Adijaya Hartana, Christian Lundgren, Emma Ahlén Bergman, Markus Johansson, Benny Holmström, Johan Hansson, Alexander Sidikii, Janos Vasko, Per Marits, Amir Sherif, Ola Winqvist
Cancer is currently treated by a combination of therapies, including chemotherapy which is believed to suppress the immune system. Combination of immunotherapy and chemotherapy correlates with improved survival but needs careful planning in order to achieve a synergistic effect. In this study we have demonstrated that Doxorubicin treatment of B cells resulted in increased expression of CD86 and concordantly increased CD4(+) T cell activation in presence of superantigen, an effect that was inhibited by addition of a CD86 blocking antibody...
December 23, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28025079/%C3%AE-iii-tubulin-overexpression-is-linked-to-agressive-tumor-features-and-genetic-instability-in-urinary-bladder-cancer
#15
Andrea Hinsch, Aref Chaker, Christian Burdelski, Christina Koop, Maria Christina Tsourlakis, Stefan Steurer, Michael Rink, Till Simon Eichenauer, Waldemar Wilczak, Corinna Wittmer, Margit Fisch, Ronald Simon, Guido Sauter, Franziska Büschek, Till Clauditz, Sarah Minner, Frank Jacobsen
Development of genetic instability is a hallmark of tumor progression. Type III ß-tubulin (TUBB3) is a component of microtubules involved in chromosome segregation. Its overexpression has been linked to adverse features of urinary bladder cancer. To investigate the role of TUBB3 for development of genetic instability, we compared TUBB3 expression with histopathological features and surrogate markers of genetic instability and tumor aggressiveness, copy number changes of HER2, TOP2A, CCND1, RAF1, and FGFR1, nuclear accumulation of p53, and cell proliferation, in a tissue microarray with >700 bladder cancers...
December 23, 2016: Human Pathology
https://www.readbyqxmd.com/read/28018158/estrogen-catechols-detection-as-biomarkers-in-schistosomiasis-induced-cancer-and-infertility
#16
M C Botelho, H Alves, J Richter
Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations...
2017: Letters in Drug Design & Discovery
https://www.readbyqxmd.com/read/28013490/is-there-a-link-between-urinary-microbiota-and-bladder-cancer
#17
Didier Raoult
No abstract text is available yet for this article.
December 24, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28009144/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal
#18
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28007167/examination-of-in-vivo-mutagenicity-of-sodium-arsenite-and-dimethylarsinic-acid-in-gpt-delta-rats
#19
Masaki Fujioka, Min Gi, Satoko Kawachi, Kumiko Tatsumi, Naomi Ishii, Kenichiro Doi, Anna Kakehashi, Hideki Wanibuchi
Arsenic is a well-known human bladder and liver carcinogen, but its exact mechanism of carcinogenicity is not fully understood. Dimethylarsinic acid (DMA(V)) is a major urinary metabolite of sodium arsenite (iAs(III)) and induces urinary bladder cancers in rats. DMA(V) and iAs(III) are negative in in vitro mutagenicity tests. However, their in vivo mutagenicities have not been determined. The purpose of present study is to evaluate the in vivo mutagenicities of DMA(V) and iAs(III) in rat urinary bladder epithelium and liver using gpt delta F344 rats...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28005163/intratumoral-th2-predisposition-combines-with-an-increased-th1-functional-phenotype-in-clinical-response-to-intravesical-bcg-in-bladder-cancer
#20
Renate Pichler, Georg Gruenbacher, Zoran Culig, Andrea Brunner, Dietmar Fuchs, Josef Fritz, Hubert Gander, Andrea Rahm, Martin Thurnher
Th1-type immunity is considered to be required for efficient response to BCG in bladder cancer, although Th2 predisposition of BCG responders has recently been reported. The aim was to evaluate the relationship of Th1 and Th2 components in 23 patients undergoing BCG treatment. Peripheral blood, serum and urine samples were prospectively collected at baseline, during and after BCG. Th1 (neopterin, tryptophan, kynurenine, kynurenine-to-tryptophan ratio (KTR), IL-12, IFN-γ, soluble TNF-R75 and IL-2Rα) and Th2 (IL-4, IL-10) biomarkers as well as CD4 expression in T helper (Th), effector and regulatory T cells were determined...
December 22, 2016: Cancer Immunology, Immunotherapy: CII
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