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https://www.readbyqxmd.com/read/29148015/clinical-performance-and-utility-of-a-nnmt-based-urine-test-for-bladder-cancer
#1
Valentina Pozzi, Giulia Di Ruscio, Davide Sartini, Roberto Campagna, Riccardo Seta, Paola Fulvi, Alexia Vici, Giulio Milanese, Gabriele Brandoni, Andrea B Galosi, Rodolfo Montironi, Monia Cecati, Monica Emanuelli
BACKGROUND: Bladder cancer (BC) represents the most common neoplasm of the urinary tract. Although cystoscopy and urine cytology represent the gold standard methods to monitor BC, both procedures have limitations. Therefore, the identification of reliable biomarkers for early and noninvasive detection of BC is urgently required. METHODS: In this study, we analyzed nicotinamide N-methyltransferase (NNMT) expression in urine samples from 55 BC patients and 107 controls, using real-time polymerase chain reaction (PCR)...
November 11, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29146217/bladder-herpes-infection-in-a-patient-with-low-grade-non-muscle-invasive-bladder-cancer
#2
Pablo Garrido-Abad, Ariel Díaz-Menéndez, Manuel Fernández-Arjona
Bladder herpes is a very uncommon event related to herpes simplex virus infection. We report a 69-year-old man with 4-year history of bladder cancer who presented with presented with dysuria and urinary frequency. Cystoscopy showed erythematous lesion of the bladder mucosa that was biopsied and revealed multi-lobed nuclei with eosinophilic intranuclear inclusions, and presence of intracytoplasmic vacuoles that were suggestive of bladder involvement by herpes simplex virus (HSV). Different bladder disorders have been associated to herpes virus, but spontaneous resolution generally occurs in 1 to 2 months...
November 13, 2017: Urology
https://www.readbyqxmd.com/read/29143974/%C3%AE-h2ax-formation-in-the-urinary-bladder-of-rats-treated-with-two-norharman-derivatives-obtained-from-o-toluidine-and-aniline
#3
T Toyoda, Y Totsuka, K Matsushita, T Morikawa, N Miyoshi, K Wakabayashi, K Ogawa
Aminomethylphenylnorharman (AMPNH) and aminophenylnorharman (APNH) are mutagenic norharman derivatives obtained from o-toluidine and aniline, respectively. APNH is carcinogenic to the urinary bladder of rats and present in urine samples of healthy volunteers, indicating that norharman derivatives may be associated with cancer development in the urinary bladder of humans. To evaluate the possible role of AMPNH and APNH in bladder carcinogenesis, we examined the formation of γ-H2AX, a DNA damage response marker, in the urinary bladder of rats...
November 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29141603/detect-i-detect-ii-a-study-protocol-for-a-prospective-multicentre-observational-study-to-validate-the-uromark-assay-for-the-detection-of-bladder-cancer-from-urinary-cells
#4
Wei Shen Tan, Andrew Feber, Liqin Dong, Rachael Sarpong, Sheida Rezaee, Simon Rodney, Pramit Khetrapal, Patricia de Winter, Frelyn Ocampo, Rumana Jalil, Norman R Williams, Chris Brew-Graves, John D Kelly
BACKGROUND: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. We have developed the UroMark assay, which can detect 150 methylation specific alteration specific to bladder cancer using DNA from urinary sediment cells...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29135152/-masks-of-urogenital-tuberculosis-as-the-cause-of-diagnostic-errors
#5
D P Kholtobin, E K Kulchavenya
Urogenital tuberculosis does not have pathognomonic symptoms, so diagnostic errors are quite common. This systematic review of literature was conducted to identify the causes and estimate the incidence of erroneous diagnoses. We critically evaluated some articles in which the authors describe observations of urogenital tuberculosis as rare and unusual because they never encountered this disease, but in fact that were typical manifestations of genitourinary tuberculosis. The authors analyzed and illustrated the features of urinary tuberculosis in patients with pulmonary tuberculosis, differential diagnosis of urogenital tuberculosis and kidney cancer and male genitourinary organs, described errors in the diagnosis of urethral, testicular, penile, prostatic and epididymal tuberculosis...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29130146/recent-developments-in-the-search-for-urinary-biomarkers-in-bladder-cancer
#6
REVIEW
Aaron Leiblich
PURPOSE OF REVIEW: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence. RECENT FINDINGS: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information. Furthermore, the isolation and characterisation of extracellular vesicles (EVs) from the urine patients with bladder cancer provide an exciting new development in biomarker research that is set to expand in the coming years...
November 13, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29126388/yrna-expression-predicts-survival-in-bladder-cancer-patients
#7
Yuri Tolkach, Anna Franziska Stahl, Eva-Maria Niehoff, Chenming Zhao, Glen Kristiansen, Stefan Cajetan Müller, Jörg Ellinger
BACKGROUND: Non-coding RNAs play an important role in human carcinogenesis. YRNAs (Ro-associated Y), a novel class of non-coding RNAs, have been identified as biomarker in various malignancies, but remain to be studied in urinary bladder cancer (BCA) patients. METHODS: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival BCA (urothelial carcinoma, n = 88) and normal urothelial bladder (n = 30) tissues using quantitative real-time PCR...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29116405/systematic-review-of-studies-reporting-positive-surgical-margins-after-bladder-neck-sparing-radical-prostatectomy
#8
REVIEW
Mariangela Bellangino, Clare Verrill, Tom Leslie, Richard W Bell, Freddie C Hamdy, Alastair D Lamb
PURPOSE OF REVIEW: Bladder neck preservation (BNP) during radical prostatectomy (RP) has been proposed as a method to improve early recovery of urinary continence after radical prostatectomy. However, there is concern over a possible increase in the risk of positive surgical margins and prostate cancer recurrence rate. A recent systematic review and meta-analysis reported improved early recovery and overall long-term urinary continence without compromising oncologic control. The aim of our study was to perform a critical review of the literature to assess the impact on bladder neck and base margins after bladder neck sparing radical prostatectomy...
November 7, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29116394/a-prospective-randomized-pilot-study-evaluating-an-eras-protocol-versus-a-standard-protocol-for-patients-treated-with-radical-cystectomy-and-urinary-diversion-for-bladder-cancer
#9
Sebastian Karl Frees, Jonathan Aning, Peter Black, Werner Struss, Robert Bell, Claudia Chavez-Munoz, Martin Gleave, Alan I So
PURPOSE: There is a lack of evidence demonstrating the benefits of using enhanced recovery after surgery protocols (ERAS). Here, we propose to use a randomized clinical pilot study to demonstrate the benefits and feasibility of implementing ERAS versus standard protocols (SP) in patients undergoing radical cystectomy (RC) and urinary diversion. METHODS: 27 consecutive patients undergoing RC were included in the study. 12 patients were prospectively randomized to follow an ERAS protocol and 15 patients followed an SP...
November 7, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29116175/sniffer-mice-discriminate-urine-odours-of-patients-with-bladder-cancer-a-proof-of-principle-study-for-non-invasive-diagnosis-of-cancer-induced-odours
#10
Takaaki Sato, Yoji Katsuoka, Kimihiko Yoneda, Mitsuo Nonomura, Shinya Uchimoto, Reiko Kobayakawa, Ko Kobayakawa, Yoichi Mizutani
Similar to fingerprints, humans have unique, genetically determined body odours. In case of urine, the odour can change due to variations in diet as well as upon infection or tumour formation. We investigated the use of mice in a manner similar to "sniffer dogs" to detect changes in urine odour in patients with bladder cancer. We measured the odour discrimination thresholds of mice in a Y-maze, using urine mixtures from patients with bladder cancer (Stage I) and healthy volunteers (dietary variations) as well as occult blood- or antibiotic drug metabolite-modulated samples...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115542/imp3-overexpression-occurs-in-various-important-cancer-types-and-is-linked-to-aggressive-tumor-features-a-tissue-microarray-study-on-8-877-human-cancers-and-normal-tissues
#11
Christoph Burdelski, Nilofar Jakani-Karimi, Frank Jacobsen, Christina Möller-Koop, Sarah Minner, Ronald Simon, Guido Sauter, Stefan Steurer, Till S Clauditz, Waldemar Wilczak
IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed for immunohistochemically detectable expression of IMP3 in 76 different normal tissue types and 3889 cancer samples from 95 different tumor categories...
November 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29115014/impact-of-variant-microscopic-interpretation-of-the-ucyt-immunocytological-urine-test-for-the-detection-of-bladder-cancer
#12
Susanne Deininger, Tilman Todenhöfer, Jörg Hennenlotter, Valentina Gerber, Jennifer Schwarz, Jens Bedke, Christian Schwentner, Arnulf Stenzl, Steffen Rausch
BACKGROUND: Urinary marker tests for bladder cancer (BC) detection and surveillance represent a desirable approach to diagnosis and follow-up. The SCIMEDX uCyt+ assay detects antigens expressed by BC cells (mucin glycoprotein and carcinoembryonic antigen) using green and red fluorescence and is interpreted according to specific manufacturer's recommendations. In the present study, we evaluated divergent approaches of numeric and morphological analysis of uCyt+ to generate a rationale for alternative test interpretation strategies...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29103775/cyclin-d1-promoter-56-and-54bp-cpg-un-methylation-predicts-invasive-progression-in-arsenic-induced-bowen-s-disease
#13
Wei-Ting Liao, Huey-Ling You, Chee-Yin Chai, Chih-Hung Lee, Cheng-Che E Lan, Shun-Jen Chang, Chu-Ling Yu, Hsin-Su Yu
BACKGROUND: Patients with arsenic-induced Bowen's disease (As-BD) are at risk of developing invasive cancers in the skin, lung, and urinary bladder. However, a longitudinal follow-up study on the association between As-BD and invasive cancers is still lacking. OBJECTIVES: This study aims to investigate the underlying molecular mechanisms of this malignant progression in the skin and internal organs. METHODS: This is a biopsy-based follow-up study...
October 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29102928/implementation-of-humane-endpoints-in-a-urinary-bladder-carcinogenesis-study-in-rats
#14
Mónica Oliveira, Elisabete Nascimento-Gonçalves, Jessica Silva, Paula A Oliveira, Rita Ferreira, Luís Antunes, Regina Arantes-Rodrigues, Ana I Faustino-Rocha
BACKGROUND/AIM: This study aimed to evaluate the utility of several biological parameters for the prediction of tumor development and animal welfare in a rat model of urinary bladder cancer. MATERIALS AND METHODS: The control group (n=9) received tap water while the test group (n=12) received the carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in drinking water. A score sheet with biological variables was used to monitor animals' welfare. Body weight, food and drink consumption and rectal temperature were measured weekly...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#15
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29102424/lower-tract-neoplasm-update-of-imaging-evaluation
#16
REVIEW
Robert Hartman, Akira Kawashima
Cancers of the lower urinary tract can arise from the bladder, urachus or urethra. Urothelial carcinoma of the bladder (UCB) is the most common of these. The presentation of bladder, urachal and urethral cancers can differ but many result in hematuria as an initial indication. The diagnosis and staging of these cancers often necessitate radiologic imaging often in the form of cross-section CT urography or MR urography. The following article reviews the specific nature of lower tract cancers and their imaging...
November 1, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29094888/bladder-cancer-diagnosis-and-treatment
#17
Katharine C DeGeorge, Harry R Holt, Stephanie C Hodges
Bladder cancer is the sixth most prevalent malignancy in the United States and causes more than 16,000 deaths annually. The most common clinical presentation is asymptomatic hematuria, which should prompt evaluation with cystoscopy, renal function testing, and upper urinary tract imaging in adults 35 years and older and in those with irritative voiding symptoms, risk factors for bladder cancer, or gross hematuria at any age. Transurethral resection of the bladder tumor allows for definitive diagnosis, staging, and primary treatment...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29080948/enhanced-recovery-after-surgery-for-radical-cystectomy-with-ileal-urinary-diversion-a-multi-institutional-randomized-controlled-trial-from-the-chinese-bladder-cancer-consortium
#18
Tianxin Lin, Kaiwen Li, Hao Liu, Xueyi Xue, Ning Xu, Yong Wei, Zhiwen Chen, Xiaozhou Zhou, Lin Qi, Wei He, Shiyu Tong, Fengshuo Jin, Xudong Liu, Qiang Wei, Ping Han, Xin Gou, Weiyang He, Xu Zhang, Guoqiang Yang, Zhoujun Shen, Tianyuan Xu, Xin Xie, Wei Xue, Ming Cao, Jin Yang, Jianyun Hu, Fubao Chen, Peijun Li, Guangyong Li, Tong Xu, Ye Tian, Wenying Wang, Dongkui Song, Lei Shi, Xiaoming Yang, Yang Yang, Benkang Shi, Yaofeng Zhu, Xigao Liu, Jinchun Xing, Zhun Wu, Kaiyan Zhang, Wei Li, Chaozhao Liang, Cheng Yang, Wei Li, Jinchun Qi, Chuanliang Xu, Weidong Xu, Liqun Zhou, Lin Cai, En'ci Xu, Weizhong Cai, Minggao Weng, Yiming Su, Fangjian Zhou, Lijuan Jiang, Zhuowei Liu, Qiuhong Chen, Tiejun Pan, Bo Liu, Yu Zhou, Xin Gao, Jianguang Qiu, Jie Situ, Cheng Hu, Shan Chen, Yupeng Zheng, Jian Huang
PURPOSE: Enhanced recovery after surgery (ERAS) has played an important role in recovery management for radical cystectomy with ileal urinary diversion (RC-IUD). This study is to evaluate ERAS compared with the conventional recovery after surgery (CRAS) for RC-IUD. METHODS: From October 2014 and July 2016, bladder cancer patients scheduled for curative treatment from 25 centers of Chinese Bladder Cancer Consortium were randomly assigned to either ERAS or CRAS group...
October 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29080694/castration-increases-pge2-release-from-the-bladder-epithelium-in-male-rats
#19
Hideaki Ito, Dong Wang, Xinmin Zha, So Inamura, Masaya Seki, Minekatsu Taga, Osamu Yokoyama
AIMS: Androgen deprivation therapy has been widely used for the treatment of prostate cancer. While sexual side effects including decreased sexual desire and function are well studied, there are only limited reports about its influences on lower urinary tract symptoms. The aim of this study is to clarify the influences of castration in male rats. METHODS: Ten-week-old male rats were divided into treatment group (bilateral orchiectomy) and control group (sham surgery)...
November 8, 2017: Life Sciences
https://www.readbyqxmd.com/read/29080017/safety-pharmacokinetics-metabolism-and-radiation-dosimetry-of-18-f-tetrafluoroborate-18-f-tfb-in-healthy-human-subjects
#20
Huailei Jiang, Nicholas R Schmit, Alex R Koenen, Aditya Bansal, Mukesh K Pandey, Robert B Glynn, Bradley J Kemp, Kera L Delaney, Angela Dispenzieri, Jamie N Bakkum-Gamez, Kah-Whye Peng, Stephen J Russell, Tina M Gunderson, Val J Lowe, Timothy R DeGrado
BACKGROUND: (18)F-Tetrafluoroborate ((18)F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The aim of this study was to evaluate the safety, pharmacokinetics, biodistribution, and radiation dosimetry of high-specific activity (18)F-TFB in healthy human subjects. METHODS: (18)F-TFB was synthesized with specific activity of 3.2 ± 1.3 GBq/μmol (at the end of synthesis)...
October 27, 2017: EJNMMI Research
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