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Hepatobiliary AND gall bladder

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https://www.readbyqxmd.com/read/29058732/selenium-mediated-arsenic-excretion-in-mammals-a-synchrotron-based-study-of-whole-body-distribution-and-tissue-specific-chemistry
#1
Olena Ponomarenko, Paul F La Porte, Satya P Singh, George Langan, David E B Fleming, Julian E Spallholz, Mohammad Alauddin, Habibul Ahsan, Selim Ahmed, Jürgen Gailer, Graham N George, Ingrid J Pickering
Arsenicosis, a syndrome caused by ingestion of arsenic contaminated drinking water, currently affects millions of people in South-East Asia and elsewhere. Previous animal studies revealed that the toxicity of arsenite essentially can be abolished if selenium is co-administered as selenite. Although subsequent studies have provided some insight into the biomolecular basis of this striking antagonism, many details of the biochemical pathways that ultimately result in the detoxification and excretion of arsenic using selenium supplements have yet to be thoroughly studied...
November 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29043249/interactions-between-bacteria-and-bile-salts-in-the-gastrointestinal-and-hepatobiliary-tracts
#2
REVIEW
Verónica Urdaneta, Josep Casadesús
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the intestinal microbiota. As a consequence, alteration of the microbiome-bile salt homeostasis can play a role in hepatic and gastrointestinal pathological conditions. Intestinal bacteria use bile salts as environmental signals and in certain cases as nutrients and electron acceptors...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28764144/variant-anatomy-of-the-hepatic-vasculature-importance-in-hepatobiliary-resections
#3
Sarika Rachel Tigga, Sandeep Saluja, Virendra Budhiraja, Rakhi Rastogi
A variant anatomy of the hepatic vasculature has a clinically significant role in hepatobiliary transplantation, resection, tumour embolisation as well as in extrahepatic abdominal surgeries involving the stomach, pancreas or gall bladder. During routine cadaveric dissection, we observed a case of unusually small calibre hepatic artery proper. An accessory hepatic artery was seen emerging from the superior mesenteric artery to the right hepatic lobe along with an accessory hepatic vein from the right hepatic lobe that drained directly into the inferior vena cava...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28687948/role-of-hepatobiliary-scintigraphy-and-preoperative-liver-biopsy-for-exclusion-of-biliary-atresia-in-neonatal-cholestasis-syndrome
#4
Ankur Mandelia, Richa Lal, Nijagal Mutt
All diagnostic algorithms for Neonatal Cholestasis Syndrome (NCS) focus on differentiating numerous medical causes from Biliary Atresia (BA). No preoperative diagnostic algorithm has 100% diagnostic accuracy for BA and yet, timely diagnosis is crucial to optimize surgical outcome. Markers for high index of clinical suspicion for BA are: a "usually" well thriving infant with conjugated hyperbilirubinemia, raised gamma glutamyl transpeptidase, persistently "acholic" stools, firm hepatomegaly with dysmorphic, hypoplastic gall bladder...
September 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28365715/gall-bladder-agenesis-a-rare-embryonic-cause-of-recurrent-biliary-colic
#5
Aarthi Rajkumar, Albina Piya
BACKGROUND Gallbladder agenesis (GA) is an extremely rare anatomic anomaly with a reported incidence of less than 0.5%. It is usually asymptomatic, but can present with features of biliary colic and cholecystitis. We present here a case of GA in a patient with recurrent biliary colic.  CASE REPORT A 24-year-old African American woman presented with recurrent episodes of right upper-quadrant abdominal pain. During her first episode, she was found to have elevated transaminases and clinical features of cholecystitis, but ultrasound did not visualize a gallbladder and she was discharged with a diagnosis of biliary colic...
April 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28337321/prototypic-18-f-labeled-argininamide-type-neuropeptide-y-y1r-antagonists-as-tracers-for-pet-imaging-of-mammary-carcinoma
#6
Max Keller, Simone Maschauer, Albert Brennauer, Philipp Tripal, Norman Koglin, Ralf Dittrich, Günther Bernhardt, Torsten Kuwert, Hans-Jürgen Wester, Armin Buschauer, Olaf Prante
The neuropeptide Y (NPY) Y1 receptor (Y1R) selective radioligand (R)-N(α)-(2,2-diphenylacetyl)-N(ω)-[4-(2-[(18)F]fluoropropanoylamino)butyl]aminocarbonyl-N-(4-hydroxybenzyl)argininamide ([(18)F]23), derived from the high-affinity Y1R antagonist BIBP3226, was developed for imaging studies of Y1R-positive tumors. Starting from the argininamide core bearing amine-functionalized spacer moieties, a series of fluoropropanoylated and fluorobenzoylated derivatives was synthesized and studied for Y1R affinity. The fluoropropanoylated derivative 23 displayed high affinity (Ki = 1...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28152549/circulating-copper-and-zinc-levels-and-risk-of-hepatobiliary-cancers-in-europeans
#7
Magdalena Stepien, David J Hughes, Sandra Hybsier, Christina Bamia, Anne Tjønneland, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Verena Katzke, Tilman Kühn, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Phlippos Orfanos, Domenico Palli, Sabina Sieri, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, H B As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Cristina Lasheras, Catalina Bonet Bonet, Elena Molina-Portillo, Miren Dorronsoro, José María Huerta, Aurelio Barricarte, Bodil Ohlsson, Klas Sjöberg, Mårten Werner, Dmitry Shungin, Nick Wareham, Kay-Tee Khaw, Ruth C Travis, Heinz Freisling, Amanda J Cross, Lutz Schomburg, Mazda Jenab
BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort...
February 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28128682/percutaneous-cholecystocentesis-in-cats-with-suspected-hepatobiliary-disease
#8
Victoria L Byfield, Julie E Callahan Clark, Bradley J Turek, Charles W Bradley, Mark P Rondeau
Objectives The objective was to evaluate the safety and diagnostic utility of percutaneous ultrasound-guided cholecystocentesis (PUC) in cats with suspected hepatobiliary disease. Methods Medical records of 83 cats with suspected hepatobiliary disease that underwent PUC were retrospectively reviewed. Results At the time of PUC, at least one additional procedure was performed in 79/83 cats, including hepatic aspiration and/or biopsy (n = 75) and splenic aspiration (n = 18). Complications were noted in 14/83 cases, including increased abdominal fluid (n = 11), needle-tip occlusion (n = 1), failed first attempt to penetrate the gall bladder wall (n = 1) and pneumoperitoneum (n = 1)...
January 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28051047/evaluation-of-the-use-of-laparoscopic-guided-cholecystocholangiography-and-liver-biopsy-in-definitive-diagnosis-of-neonatal-cholestatic-jaundice
#9
Khalid Shreef, Abdullah Alhelal
BACKGROUND: Once it is established that a jaundiced infant has direct hyperbilirubinemia, the principal diagnostic concern is to differentiate hepatocellular from obstructive cholestasis. Traditional tests such as ultrasonography, percutaneous liver biopsy and technetium 99 m hepatobiliary iminodiacetic acid (HIDA) scan are often not sufficiently discriminating. Definitive exclusion of biliary atresia (BA) in the infant with cholestatic jaundice usually requires mini-laparotomy and intra-operative cholangiography...
October 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/27920840/unusual-use-of-gd-eob-dtpa-in-mrcp-in-order-to-reveal-the-source-of-bile-leakage-in-a-patient-with-neuroendocrine-tumor-case-report
#10
Rafał Mazur, Aleksander Pawluś, Kinga Szymańska, Mateusz Patyk, Anna Otlewska, Krzysztof Międzybrodzki, Dąbrówka Sokołowska-Dąbek, Eliza Kubicka, Urszula Zaleska-Dorobisz
BACKGROUND: MRCP is the method of choice in diagnosing pathologies of the biliary system. One of them is bile fistulae. They are uncommon but tend to cause many diagnostic problems. The possible way to improve MRCP is using it with intravenous injection of hepatobiliary-specific contrast agents. As it is eliminated via the hepatobiliary system, it can be visualized in the bile ducts and may help to reveal disorders undetected by a standard MRCP. CASE REPORT: We report a case of a 36-year-old woman with leakage in the biliary system which led to creation of a subcutaneous bile reservoir...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27796890/primary-extragastrointestinal-stromal-tumours-in-the-hepatobiliary-tree-and-telocytes
#11
Somanath Padhi, Hemanta Kumar Nayak
The first decade of the twenty-first century witnessed the presence and light microscopic, immunophenotypic, and ultrastructural characterization of interstitial Cajal-like cells (coined as 'telocytes') in virtually every extragastrointestinal site of the human body by Laurentiu M. Popescu and his co-workers. Not surprisingly, stromal tumours, immunophenotypically similar to that of telocytes [CD117 (c-KIT) +/CD34 +], have also been sporadically reported outside the tubular gut (so-called extragastrointestinal stromal tumours, EGISTs), including the gall bladder, liver, and pancreas...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27437266/a-study-on-spectrum-of-hepatobiliary-dysfunctions-and-pattern-of-liver-involvement-in-dengue-infection
#12
Dhrubajyoti Bandyopadhyay, Sayan Chattaraj, Adrija Hajra, Sabyasachi Mukhopadhyay, Vijayan Ganesan
INTRODUCTION: The most common arthropod-borne viral (arboviral) disease in humans is dengue. It is transmitted by female Aedes mosquitoes. These mosquitoes are widely distributed in subtropical and tropical areas of the world. Study of dengue infection and its complications are rare from countries like India. AIM: In this prospective observational cross-sectional study, we intended to assess the frequency and degree of hepatobiliary dysfunction in adult patients with dengue infection presenting to a tertiary-care medical facility...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27437238/an-unusual-combination-of-biliary-cystadenoma-and-renal-angiomyolipoma-a-case-report
#13
Sheeja S, Renu Thambi, Sylvia Syriac, Anil Kumar
Hepatobiliary cystadenomas are mucinous cystic neoplasms arising in the liver, extrahepatic bile ducts or gall bladder. Extrahepatic cystadenomas are rare neoplasms requiring complete excision as there is a chance for recurrence and malignant transformation. Angiomyolipoma (AML) belongs to the perivascular epithelioid cell group of neoplasms, and kidney is the commonest site involved. We report a case of an unusual combination of extrahepatic biliary cystadenoma with angiomyolipoma in an adult female without evidence of tuberous sclerosis...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27275091/multiorgan-chronic-inflammatory-hepatobiliary-pancreatic-murine-model-deficient-in-tumor-necrosis-factor-receptors-1-and-2
#14
Helieh S Oz
AIM: To provoke persistent/chronic multiorgan inflammatory response and to contribute to stones formation followed by fibrosis in hepatobiliary and pancreatic tissues. METHODS: Tumor necrosis factor receptors 1 and 2 (TNFR1/R2) deficient mice reared in-house were given dibutyltin dichloride (DBTC) twice within 10 d by oral gavage delivery. Sham control animals received vehicle treatment and naïve animals remained untreated throughout the study. Animals were monitored daily for symptoms of pain and discomfort...
June 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26926244/tissue-distribution-and-acute-toxicity-of-silver-after-single-intravenous-administration-in-mice-nano-specific-and-size-dependent-effects
#15
COMPARATIVE STUDY
Camilla Recordati, Marcella De Maglie, Silvia Bianchessi, Simona Argentiere, Claudia Cella, Silvana Mattiello, Francesco Cubadda, Federica Aureli, Marilena D'Amato, Andrea Raggi, Cristina Lenardi, Paolo Milani, Eugenio Scanziani
BACKGROUND: Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications. However toxicity of AgNPs and impact of their physicochemical characteristics in in vivo models still need to be comprehensively characterized. The aim of this study was to investigate the effect of size and coating on tissue distribution and toxicity of AgNPs after intravenous administration in mice, and compare the results with those obtained after silver acetate administration...
February 29, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/26883676/observation-of-the-seleno-bis-s-glutathionyl-arsinium-anion-in-rat-bile
#16
Graham N George, Jürgen Gailer, Olena Ponomarenko, Paul F La Porte, Karen Strait, Mohammad Alauddin, Habibul Ahsan, Selim Ahmed, Julian Spallholz, Ingrid J Pickering
Certain arsenic and selenium compounds show a remarkable mutual cancelation of toxicities, where a lethal dose of one can be voided by an equimolar and otherwise lethal dose of the other. It is now well established that the molecular basis of this antagonism is the formation and biliary excretion of seleno bis-(S-glutathionyl) arsinium anion [(GS)2AsSe](-). Previous work has definitively demonstrated the presence of [(GS)2AsSe](-) in rabbit bile, but only in the presence of other arsenic and selenium species...
May 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/26768945/education-and-imaging-hepatobiliary-and-pancreatic-gall-bladder-duplication-presenting-with-gall-stone-pancreatitis-use-of-hepatobiliary-specific-mrcp-in-preoperative-evaluation-of-ductal-anatomy
#17
P Nepal, D Kumar, S Ramanathan, A Faki
No abstract text is available yet for this article.
December 2015: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26627605/hsp90-and-hepatobiliary-transformation-during-sea-lamprey-metamorphosis
#18
Yu-Wen Chung-Davidson, Chu-Yin Yeh, Ugo Bussy, Ke Li, Peter J Davidson, Kaben G Nanlohy, C Titus Brown, Steven Whyard, Weiming Li
BACKGROUND: Biliary atresia (BA) is a human infant disease with inflammatory fibrous obstructions in the bile ducts and is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult. Therefore, sea lamprey liver metamorphosis may serve as an etiological model for human BA and provide pivotal information for hepatobiliary transformation and possible therapeutics...
December 1, 2015: BMC Developmental Biology
https://www.readbyqxmd.com/read/26393113/dual-cystic-arteries-in-association-with-caterpillar-hump-of-right-hepatic-artery-a-case-report-and-its-surgical-relevance
#19
Kavitha Kamath B
A rare variation was seen in the arterial supply of liver and gall bladder during dissection of an adult female cadaver. The right hepatic artery was having a tortuous course with double loops and cystic artery was arising from the distal loop within the hepatobiliary triangle. There was an accessory cystic artery arising from the superior pancreaticoduodenal artery outside the hepatobiliary triangle which ascended anterior to the common bile duct and cystic duct towards the gall bladder. The knowledge of these vascular variations is very much essential owing to increase in surgical interventions involving the biliary tract...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25608662/imaging-of-malignancies-of-the-biliary-tract-an-update
#20
REVIEW
Tiffany Priyanthi Hennedige, Wee Thong Neo, Sudhakar Kundapur Venkatesh
Malignancies of the biliary tract include cholangiocarcinoma, gallbladder cancers and carcinoma of the ampulla of Vater. Biliary tract adenocarcinomas are the second most common primary hepatobiliary cancer. Due to their slow growing nature, non-specific and late symptomatology, these malignancies are often diagnosed in advanced stages with poor prognosis. Apart from incidental discovery of gall bladder carcinoma upon cholecystectomy, early stage biliary tract cancers are now detected with computed tomography (CT) and magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP)...
April 22, 2014: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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