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https://www.readbyqxmd.com/read/29929196/cpg-odn-a-tlr9-agonist-aggravates-myocardial-ischemia-reperfusion-injury-by-activation-of-tlr9-p38-mapk-signaling
#1
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong
BACKGROUND/AIMS: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury. METHODS: Male Sprague-Dawley rats were treated with either CpG-ODN or control ODN 1 h prior to myocardial ischemia (30 min) followed by reperfusion. Rats treated with phosphate-buffered saline (PBS) served as I/R controls (n = 8/group). Infarct size was determined by 2,3,5-triphenyltetrazolium chloride and Evans blue straining...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929193/induction-of-pro-inflammatory-response-via-activated-macrophage-mediated-nf-%C3%AE%C2%BAb-and-stat3-pathways-in-gastric-cancer-cells
#2
Yujuan Zhou, Longzheng Xia, Qiang Liu, Heran Wang, Jingguan Lin, Linda Oyang, Xiaoyan Chen, Xia Luo, Shiming Tan, Yutong Tian, Min Su, Ying Wang, Pan Chen, Yang Wu, Hui Wang, Qianjin Liao
BACKGROUND/AIMS: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of activated macrophages with gastric mucous epithelium cells in initiating and maintaining the inflammatory process during gastric carcinogenesis remains unclear. METHODS: The tumour associated macrophages (TAMs) density of gastric cancer was characterized by immunohistochemistry, and the relationship between macrophages and gastric epithelium cells was analysed using an in vitro culture system that imitates the inflammatory microenvironment...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929190/salt-inducible-kinase-1-sik1-is-induced-by-alcohol-and-suppresses-microglia-inflammation-via-nf-%C3%AE%C2%BAb-signaling
#3
Yu Zhang, Weida Gao, Kongbin Yang, Haiquan Tao, Haicheng Yang
BACKGROUND/AIMS: Alcohol consumption has been shown to cause neuroinflammation and increase a variety of immune-related signaling processes. Microglia are a crucial part of alcohol-induced neuroinflammation and undergo apoptosis. Even though the importance of these inflammatory processes in the effects of alcohol-related neurodegeneration have been established, the mechanism of alcohol-induced microglia apoptosis is unknown. In prior research, we discovered that alcohol increases expression of salt-inducible kinase 1 (SIK1) in rodent brain tissue...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929189/dexmedetomidine-protects-neural-stem-cells-from-ketamine-induced-injury
#4
Pan Lu, Shan Lei, Weisong Li, Yang Lu, Juan Zheng, Ning Wang, Yongjun Xia, Haixia Lu, Xinlin Chen, Yong Liu, Peng-Bo Zhang
BACKGROUND/AIMS: Ketamine inhibits the proliferation of neural stem cells (NSCs) and disturbs normal neurogenesis. Dexmedetomidine provides neuroprotection against volatile anesthetic-induced neuroapoptosis and cognitive impairment in the developing brain. Whether it may protect NSCs from ketamine-induced injury remains unknown. In this study, we investigated the protective effects of dexmedetomidine on ketamine-exposed NSCs and explored the mechanisms potentially involved. METHODS: Primary NSC cultures were characterized using immunofluorescence...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929186/increased-fatty-acid-oxidation-in-differentiated-proximal-tubular-cells-surviving-a-reversible-episode-of-acute-kidney-injury
#5
Aurélien Bataille, Pierre Galichon, Nadjim Chelghoum, Badreddine Mohand Oumoussa, Marie-Julia Ziliotis, Iman Sadia, Sophie Vandermeersch, Noémie Simon-Tillaux, David Legouis, Raphaël Cohen, Yi-Chun Xu-Dubois, Morgane Commereuc, Eric Rondeau, Stéphane Le Crom, Alexandre Hertig
BACKGROUND/AIMS: Fatty acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong determinant of renal fibrogenesis, hence a focus for therapeutic interventions. Nevertheless, whether persistently differentiated renal tubules, surviving in a pro-fibrotic environment, also suffer from a decrease in FAO, is currently unknown...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929111/calcification-in-cerebral-parenchyma-affects-pharmacoresistant-epilepsy-in-tuberous-sclerosis
#6
Meng-Na Zhang, Li-Ping Zou, Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Lu-Lu Huang, Yang Gao, Qian Lu, David Neal Franz
PURPOSE: Tuberous sclerosis (TSC) is an autosomal dominant inherited disease caused by mutations in the TSC1 or TSC2 gene and results in the over-activation of the mammalian target of the rapamycin (mTOR) signaling pathway. Rapamycin, an mTOR inhibitor, is clinically used to treat hamartomatous lesionsas in TSC and its effect on controlling epilepsy is also reported in many studies. This study aims to evaluate the risk factors of pharmacoresistant epilepsy in patients with TSC receiving long-term rapamycin treatment...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929084/rna-seq-analysis-of-transcriptome-responses-in-atlantic-cod-gadus-morhua-precision-cut-liver-slices-exposed-to-benzo-a-pyrene-and-17%C3%AE-ethynylestradiol
#7
Fekadu Yadetie, Xiaokang Zhang, Eileen Marie Hanna, Libe Aranguren-Abadía, Marta Eide, Nello Blaser, Morten Brun, Inge Jonassen, Anders Goksøyr, Odd André Karlsen
Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) that activate the aryl hydrocarbon receptor (Ahr) pathway, and endocrine disruptors acting through the estrogen receptor pathway are among environmental pollutants of major concern. In this work, we exposed Atlantic cod (Gadus morhua) precision-cut liver slices (PCLS) to BaP (10 nM and 1000 nM), ethynylestradiol (EE2) (10 nM and 1000 nM), and equimolar mixtures of BaP and EE2 (10 nM and 1000 nM) for 48 h, and performed RNA-Seq based transcriptome mapping followed by systematic bioinformatics analyses...
June 7, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29929056/n-acetyl-cysteine-inhibits-lipopolysaccharide-mediated-induction-of-interleukin-6-synthesis-in-mc3t3-e1-cells-through-the-nf-kb-signaling-pathway
#8
Ling Guo, Hui Zhang, Wangyang Li, Danting Zhan, Min Wang
BACKGROUND: Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-α and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited. N-acetyl cysteine (NAC) is an antioxidant small molecule that possibly modulates osteoblastic differentiation. However, whether NAC can affect the LPS-mediated reduction of IL-6 synthesis in MC3T3-E1 cells is still unknown...
June 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29928987/angiotensin-1-7-does-not-interact-directly-with-mas1-but-can-potently-antagonize-signaling-from-the-at1-receptor
#9
Ibragim Gaidarov, John Adams, John Frazer, Todd Anthony, Xiaohua Chen, Joel Gatlin, Graeme Semple, David J Unett
Angiotensin (1-7) has been reported to be a ligand for the GPCR MAS1. Small molecule MAS1 modulators have also been recently characterized. Aside from convincing evidence for MAS1 activation of Gq signaling, little is known about MAS1 mediated signaling pathways initiated by these ligands, especially Ang (1-7). We performed a comprehensive characterization of recombinant MAS1 signaling induced by Ang (1-7) and small molecule ligands through numerous G protein-dependent and independent pathways, and in a signaling pathway agnostic approach...
June 18, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29928944/protective-effects-of-apigenin-on-lps-induced-endometritis-via-activating-nrf2-signaling-pathway
#10
Pei-Yue Jiang, Xiao-Jun Zhu, Yi-Na Zhang, Fei-Fei Zhou, Xiao-Fu Yang
Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. The levels of inflammatory cytokines were measured by ELISA. The expression of NF-κB and Nrf2 were detected by Western blot analysis. The results showed that LPS treatment induced severe histological alteration of uterus and this change was attenuated by the treatment of apigenin...
June 18, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29928912/d-cycloserine-facilitates-fear-extinction-in-adolescent-rats-and-differentially-affects-medial-and-lateral-prefrontal-cortex-activation
#11
Kathryn D Baker, Gavan P McNally, Rick Richardson
Adolescent humans and rodents are impaired in extinguishing learned fear relative to younger and older groups. This impairment could be due to differences in recruitment of medial prefrontal cortex (PFC), orbitofrontal cortex (OFC), or amygdala during extinction. For example, unlike juveniles and adults, adolescent rats do not express extinction-induced increases in phosphorylated mitogen activated protein kinase (pMAPK), a marker of synaptic plasticity, in the medial PFC. The NMDA receptor partial agonist d-cycloserine (DCS) improves extinction retention in adolescent rats...
June 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29928901/rapamycin-mediates-mtor-signaling-in-reactive-astrocytes-and-reduces-retinal-ganglion-cell-loss
#12
Ningfeng Li, Feifei Wang, Qinglin Zhang, Ming Jin, Ye Lu, Shanshan Chen, Cuiju Guo, Xu Zhang
Damage and loss of retinal ganglion cells (RGCs) can cause visual impairment. The underlying molecular mechanisms that mediate RGC death in ischemic retinal diseases are still unclear. In this study, we sought to understand the neuroprotective effect of rapamycin, the selective inhibitor of mTORC1, on RGC survival and the cellular mechanics that mediate this effect. Recent studies have reported that the epidermal growth factor (EGF) receptor shows an increase in expression in astrocytes after injury, and this receptor can promote their transformation into reactive astrocytes...
June 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29928896/an-fxr-agonist-reduces-bile-acid-synthesis-independently-of-increases-in-fgf19-in-healthy-volunteers
#13
Amani Al-Khaifi, Mats Rudling, Bo Angelin
Bile acid (BA) synthesis is regulated through suppression of hepatic cholesterol 7α-hydroxylase via FXR activation in hepatocytes and/or enterocytes; in enterocytes, this process requires FGF19 signaling. To study these pathways, we quantified markers of BA synthesis (7α-hydroxy-4-cholesten-3-one;C4) and cholesterol production (lathosterol), FGF19, and BAs in serum from healthy male volunteers given 1 oral dose of the nonsteroidal FXR agonist Px-102 (0.15mg/kg, 0.3mg/kg, 0.6mg/kg, 1.12mg/kg, 2.25mg/kg, 3...
June 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29928895/hdl-apoa-i-induces-the-expression-of-angiopoietin-like-4-angptl4-in-endothelial-cells-via-a-pi3k-akt-foxo1-signaling-pathway
#14
Dimitris Theofilatos, Panagiotis Fotakis, Efi Valanti, Despina Sanoudou, Vassilis Zannis, Dimitris Kardassis
BACKGROUND: High Density Lipoprotein (HDL) and its main protein component, apolipoprotein A-I (apoA-I) have numerous atheroprotective functions on various tissues including the endothelium. Therapies based on reconstituted HDL containing apoA-I (rHDL-apoA-I) have been used successfully in patients with acute coronary syndrome, peripheral vascular disease or diabetes but very little is known about the genomic effects of rHDL-apoA-I and how they could contribute to atheroprotection. OBJECTIVE: The present study aimed to understand the endothelial signaling pathways and the genes that may contribute to rHDL-apoA-I-mediated atheroprotection...
June 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29928880/ube2s-enhances-the-ubiquitination-of-p53-and-exerts-oncogenic-activities-in-hepatocellular-carcinoma
#15
Ying-Hua Pan, Mei Yang, Li-Ping Liu, Dan-Chun Wu, Ming-Yue Li, Shu-Guang Su
Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Increased expression of UBE2S was significantly correlated with higher serum AFP level, higher pathological grade, advanced TNM stage, larger tumor size, vascular invasion and unfavorable patient survivals in two independent cohorts containing a total of 845 patients with HCC...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928877/ptp1b-promotes-the-malignancy-of-ovarian-cancer-cells-in-a-jnk-dependent-mechanism
#16
Wenyan Wang, Yunxia Cao, Xiao Zhou, Bing Wei, Yu Zhang, Xiaochun Liu
Ovarian cancer is the leading cause of death from gynecological malignancies in women. Diagnosis at the early stage remains challenging and efficient treatment is still highly needed. The development and progression of this cancer is associated with many genetic and epigenetic changes, representing the dysregulation of a highly complex signaling network. Previous studies found that protein-tyrosine phosphatase 1 B (PTP1B) was aberrantly expressed in many types of ovarian cancer cells. The exact role of this protein, however, remains controversial...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928866/hepatitis-b-virus-promotes-proliferation-and-metastasis-in-male-chinese-hepatocellular-carcinoma-patients-through-the-lef-1-mir-371a-5p-srcin1-pleiotrophin-slug-pathway
#17
Pei-Song Bai, Peng Hou, Ying Kong
Hepatocellular carcinoma (HCC) is a male-dominant cancer. Several factors may contribute to the gender difference. Recent investigations have reported that miRNAs are involved in sex-linked signaling pathways and play a critical role in the molecular pathogenesis of hepatitis B virus (HBV)-related HCC. Therefore, we speculated that some of these miRNAs might contribute to the gender differences observed in HBV-related HCC. Our results showed that miR-371a-5p was significantly upregulated in tumor tissue and serum from HCC patients and that the expression level of miR-371a-5p was related to HBV infection, sexuality, TNM stage, adjacent organ invasion and microvascular invasion...
June 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29928859/inhibition-of-the-signaling-pathway-of-syndecan-1-by-synstatin-a-promising-anti-integrin-inhibitor-of-angiogenesis-and-proliferation-in-hcc-in-rats
#18
Heba A Metwaly, Amal M El-Gayar, Mamdouh M El-Shishtawy
AIM OF WORK: The study was conducted for evaluation of the antitumor activity of SSTN92-119 against HCC induced by thioacetamide in rats. METHODS: Sixty male Sprague-Dawley rats were randomized into four equal groups: Control, SSTN92-119 , HCC, and HCC + SSTN92-119 . Liver function tests were measured in serum. Liver homogenate was used for determination of: i) integrinαѴβ3 (ITGαѴβ3), insulin like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2) and alpha-fetoprotein (AFP) levels by ELISA, ii) syndecan-1 (CD-138), IGF-1R and VEGF genes expressions by qRT-PCR, iii) MDA, NO, GSH concentrations and SOD activity...
June 18, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29928795/egf-regulates-the-interaction-of-tks4-with-src-through-its-sh2-and-sh3-domains
#19
Metta Dulk, Balint Szeder, Gabor Glatz, Balazs Mero, Kitti Koprivanacz, Gyongyi Kudlik, Virag Vas, Szabolcs Sipeki, Anna Cserkaszky, László Radnai, Laszlo Buday
The non-receptor tyrosine kinase Src is a central component of the EGF signaling pathway. Our group recently showed that the Frank-ter Haar syndrome protein Tks4 (tyrosine kinase substrate with four Src homology 3 domains) is also involved in EGF signaling. Here we demonstrate that Tks4 and Src bind directly to each other and elucidate the details of the molecular mechanism of this complex formation. Results of GST pull-down and fluorescence polarization assays show that both a proline-rich SH3 binding motif (PSRPLPDAP, residues: 466-474) and an adjacent phosphotyrosine-containing SH2 binding motif (pYEEI, residues: 508-511) in Tks4 are responsible for Src binding...
June 21, 2018: Biochemistry
https://www.readbyqxmd.com/read/29928760/mild-electrical-stimulation-with-heat-shock-reduces-the-inflammatory-symptoms-in-imiquimod-induced-psoriasis-mouse-model
#20
Yu Tsurekawa, Misaki Morita, Mary Ann Suico, Masataka Moriuchi, Yoshio Nakano, Mariam Piruzyan, Masafumi Takada, Sanako Fukami, Tsuyoshi Shuto, Hirofumi Kai
Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. Our previous studies showed that the optimized combination treatment of mild electrical stimulation (MES, 0.1-millisecond; ms, 55-pulses per second; pps) and heat shock (HS, 42°C) modulates inflammatory symptoms of metabolic disorders and chronic kidney disease in mice models and clinical trials...
June 21, 2018: Experimental Dermatology
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