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Idiopathic sudden sensorineural hearing loss

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https://www.readbyqxmd.com/read/28290919/intratympanic-methylprednisolone-perfusion-as-a-salvage-treatment-for-profound-idiopathic-sudden-sensorineural-hearing-loss
#1
Y Dai, L Lu, J Hou, X Yang, H Li, Y Yang, W She
OBJECTIVE: This study aimed to examine the effectiveness of intratympanic methylprednisolone perfusion as salvage treatment for profound idiopathic sudden sensorineural hearing loss. METHODS: A retrospective clinical study of 97 patients with unilateral profound idiopathic sudden sensorineural hearing loss was performed. In all, 83 patients who received salvage intratympanic methylprednisolone perfusion plus conventional treatment (except for steroids) as the second-line therapy were assigned to the study group, while 14 patients who received conventional treatment alone were assigned to the comparison group...
March 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28286637/a-retrospective-study-of-the-clinical-characteristics-and-post-treatment-hearing-outcome-in-idiopathic-sudden-sensorineural-hearing-loss
#2
Purushothaman Ganesan, Purushothaman Pavanjur Kothandaraman, Simham Swapna, Vinaya Manchaiah
The purpose of this retrospective study was to analyze the clinical characteristics and document hearing recovery in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). 122 patients diagnosed with unilateral ISSNHL, from March 2009 to December 2014, were treated with oral steroids and pentoxifylline. Hearing change was evaluated by comparing pre-treatment and post-treatment pure-tone average (PTA) (500, 1K, and 2K Hz), and categorized into complete, partial, and no recovery of hearing. T-test, Wilcoxon Signed Rank test and Regression analysis were employed to analyze the statistical significance...
February 1, 2017: Audiology Research
https://www.readbyqxmd.com/read/28261890/ozone-prevents-cochlear-damage-from-ischemia-reperfusion-injury-in-guinea-pigs
#3
Merih Onal, Cagdas Elsurer, Nebil Selimoglu, Mustafa Yilmaz, Ender Erdogan, Jale Bengi Celik, Oznur Kal, Ozkan Onal
The cochlea is an end organ, which is metabolically dependent on a nutrient and oxygen supply to maintain its normal physiological function. Cochlear ischemia and reperfusion (IR) injury is considered one of the most important causes of human idiopathic sudden sensorineural hearing loss. The aim of the present study was to study the efficacy of ozone therapy against cochlear damage caused by IR injury and to investigate the potential clinical use of this treatment for sudden deafness. Twenty-eight guinea pigs were randomized into four groups...
March 5, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28224621/laboratory-assessment-of-sudden-sensorineural-hearing-loss-a-case-control-study
#4
Tommaso Fasano, Thelma A Pertinhez, Lorenzo Tribi, Daniela Lasagni, Annalisa Pilia, Luigi Vecchia, Roberto Baricchi, Giovanni Bianchin
OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. STUDY DESIGN: Prospective case-control study. METHODS: One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28177591/insulin-effect-on-hearing-recovery-in-idiopathic-sudden-sensorineural-hearing-loss-retrospective-study-of-145-patients
#5
O H Ryu, J R Chao, M G Choi, C Kim, J-G Suh, Y Y Kim, C H Park, H-J Kim, J H Lee
No abstract text is available yet for this article.
February 8, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28159388/correlation-between-auditory-brainstem-response-and-hearing-prognosis-in-idiopathic-sudden-sensorineural-hearing-loss-patients
#6
Hung-Che Lin, Yu-Ching Chou, Chih-Hung Wang, Li-Wen Hung, Cheng-Ping Shih, Bor-Hwang Kang, Wen-Ying Yeh, Hsin-Chien Chen
OBJECTIVE: To investigate the latency and amplitude of auditory brainstem response (ABR) and hearing prognosis in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: Patients with ISSNHL were classified into four different recovery groups. All patients' clinical and demographic features were analyzed. Two-channel ABRs were collected in response to click stimuli at 90dB nHL. ABR amplitudes for wave I and ABR latency for waves I, III, and V were analyzed...
January 31, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28018692/sudden-sensorineural-hearing-loss-in-the-only-hearing-ear-large-vestibular-aqueduct-syndrome
#7
Kemal Koray Bal, Onur Ismi, Helen Bucioglu, Yusuf Vayısoğlu, Kemal Gorur
Sudden hearing loss in the only hearing ear cases are rarely published in the English literature; most of the cases are idiopathic. It is an otologic emergency needing urgent treatment. Delayed diagnosis can interfere with patient's social life with interrupting the verbal communication. In this case report we presented a 33-year-old female patient having sudden sensorineural hearing loss in the only hearing ear diagnosed as bilateral large vestibular aqueduct syndrome.
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27921520/a-comparison-between-systemic-and-intratympanic-steroid-therapies-as-initial-therapy-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#8
Qingfen Qiang, Xuewen Wu, Tao Yang, Chunguang Yang, Hong Sun
CONCLUSIONS: Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE: This article was aimed at evaluating whether intratympanic steroid (ITS) treatment would provide benefits over systemic steroid therapy (SST) as initial therapy in patients with idiopathic sudden sensorineural hearing loss (ISSHL)...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27917721/prognostic-factors-for-idiopathic-sudden-sensorineural-hearing-loss-treated-with-hyperbaric-oxygen-therapy-and-intravenous-steroids
#9
S Hosokawa, K Sugiyama, G Takahashi, S Takebayashi, H Mineta
OBJECTIVE: This study evaluated the prognosis of idiopathic sudden sensorineural hearing loss when treated with hyperbaric oxygen therapy and intravenous steroids. METHODS: The clinical data for 334 patients with idiopathic sudden sensorineural hearing loss treated by hyperbaric oxygen therapy and intravenous steroids at our hospital were retrospectively reviewed. These data included the initial averaged five-frequency hearing level, patient age, interval between onset of symptoms and treatment, vertigo as a complication, and co-existence of diabetes mellitus...
January 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27846752/chronic-cerebrospinal-venous-insufficiency-as-a-cause-of-inner-ear-diseases
#10
Giuseppe Attanasio, Laura Cagnoni, Eleonora Masci, Francesco Ciciarello, Francesco Diaferia, Aldo Bruno, Antonio Greco, Marco De Vincentiis
CONCLUSION: The present study confirms a correlation between chronic cerebrospinal venous insufficiency (CCSVI) diagnosis and Ménière's disease (MD). CCSVI could be considered a new ultrasound vascular pattern of the cerebrospinal venous system in patients affected by definite MD. Conversely, the present results showed that CCSVI cannot be considered a pathogenic mechanism for idiopathic sudden sensorineural hearing loss (ISSNHL). OBJECTIVES: The aim of this study is to investigate the correlation between CCSVI and MD and to evaluate if CCSVI can be considered a risk factor also for ISSNHL...
November 16, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27846039/activation-of-igf1-signaling-in-the-cochlea-induces-the-transcription-of-its-mediators-during-the-protection-of-cochlear-hair-cells-against-aminoglycoside
#11
Yushi Hayashi, Norio Yamamoto, Takayuki Nakagawa, Koichi Omori, Juichi Ito
HYPOTHESIS: Transcription of the Erk and Akt genes and phosphorylation of their products are promoted by insulin-like growth factor 1 (IGF1) during hair cell protection. BACKGROUND: IGF1 protects mammalian hair cells in animal models from various types of damage, including aminoglycoside. Moreover, clinical trials have revealed that IGF1 was effective for idiopathic sudden sensorineural hearing loss. In this process, activation of the downstream of IGF1 signaling, including the phosphorylation of extracellular signal-regulated kinase (ERK) and AKT proteins, is involved...
November 14, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27842665/revisiting-the-relationship-of-three-dimensional-fluid-attenuation-inversion-recovery-imaging-and-hearing-outcomes-in-adults-with-idiopathic-unilateral-sudden-sensorineural-hearing-loss
#12
COMPARATIVE STUDY
Wen-Huei Liao, Hsiu-Mei Wu, Hung-Yi Wu, Tzong-Yang Tu, An-Suey Shiao, Mauricio Castillo, Sheng-Che Hung
BACKGROUND AND PURPOSE: Three-dimensional fluid attenuation inversion recovery (3D FLAIR) may demonstrate high signal in the inner ears of patients with idiopathic sudden sensorineural hearing loss (ISSNHL), but the correlations of this finding with outcomes are still controversial. Here we compared 4 3D MRI sequences with the outcomes of patients with ISSNHL. MATERIALS AND METHODS: 77 adult patients with ISSNHL underwent MRI with pre contrast FLAIR, fast imaging employing steady-state acquisition images (FIESTA-C), post contrast T1WI and post contrast FLAIR...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27817938/metabolomic-analysis-of-urine-with-nuclear-magnetic-resonance-spectroscopy-in-patients-with-idiopathic-sudden-sensorineural-hearing-loss-a-preliminary-study
#13
Filippo Carta, Milena Lussu, Fabrizio Bandino, Noto Antonio, Marcello Peppi, Natalia Chuchueva, Atzori Luigi, Vassilios Fanos, Roberto Puxeddu
OBJECTIVE: Idiopathic sudden sensorineural hearing loss is a frequent emergency, with unknown aetiology and usually treated with empiric therapy. Steroids represent the only validated treatment but prognosis is unpredictable and the possibility to select the patients who will not respond to steroids could avoid unnecessary treatments. Metabolomic profiling of the biofluids target the analysis of the final product of genic expression and enzymatic activity, defining the biochemical phenotype of a whole biologic system...
November 3, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27800104/epidemiological-and-clinical-aspects-of-ear-nose-and-throat-sensorineural-emergencies-in-the-yaound%C3%A3-reference-hospital
#14
François Djomou, Yves Christian Andjock Nkouo, Eko David Mindja, Choffor Nchinda, Luc Meka, Emilia Mbamyah-Lyonga, Alexis Ndjolo
INTRODUCTION: Sensorineural emergencies (SNE) are rare clinical situations. Few patients consult early explaining subsequent difficulty in having accurate data and management. Three clinical conditions are considered SNE in otolaryngology; they include sudden sensorineural hearing loss (SSHL), Bell's palsy and acute vertigo. There is very little data available on sensorineural emergencies in our setting. The aim of this study was to provide preliminary data on the management of Ear Nose and Throat (ENT) sensorineural emergency cases in Yaoundé Reference Hospital...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27723017/hyperbaric-oxygen-therapy-in-the-treatment-of-sudden-sensorineural-hearing-loss-a-retrospective-analysis-of-outcomes
#15
Susannah Sherlock, Kenneth Thistlethwaite, Alessandro Rubini, Mohsina Khatun, Christopher Perry, Alexis Tabah
OBJECTIVE: To analyse predictive factors affecting outcome after treatment with hyperbaric oxygen (HBOT) in patients with idiopathic sudden sensorineural hearing loss (ISSHL). METHODS: This is a retrospective audit of outcome in 77 consecutive patients referred for consideration of HBOT for ISSHL for either adjunctive treatment or after failure of steroid therapy. The hearing measured from the pre- and post-HBOT pure-tone audiogram (PTA4) at four frequencies; 500 Hz, 1 kHz, 2 kHz and 4 kHz, was averaged and compared...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27614879/a-comprehensive-study-of-oxidative-stress-in-sudden-hearing-loss
#16
REVIEW
Fatih Gul, Togay Muderris, Gokhan Yalciner, Ergun Sevil, Sami Bercin, Merve Ergin, Mehmet Ali Babademez, Muzaffer Kiris
Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated...
March 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27609270/sudden-hearing-loss-as-the-initial-symptom-in-japanese-patients-with-multiple-sclerosis-and-seropositive-neuromyelitis-optica-spectrum-disorders
#17
Masami Tanaka, Keiko Tanaka
Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective analysis of the medical records of 173 consecutive patients with multiple sclerosis (MS) and 101 consecutive patients with NMOSD who tested positive for anti-aquaporin-4 antibodies in addition to 37 consecutive patients with clinically isolated syndromes (CIS) to investigate the frequency and onset timing of SNHL...
September 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27588164/endothelial-dysfunction-in-idiopathic-sudden-sensorineural-hearing-loss-a-review
#18
REVIEW
Nicola Quaranta, Vincenzo De Ceglie, Alessandra D'Elia
An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade...
April 20, 2016: Audiology Research
https://www.readbyqxmd.com/read/27572676/is-hyperbaric-oxygen-therapy-a-salvage-treatment-option-for-sudden-sensorineural-hearing-loss
#19
Y Alimoglu, E Inci
OBJECTIVE: To investigate of the efficacy of hyperbaric oxygen therapy as a salvage treatment after unsuccessful oral corticosteroid therapy. METHODS: Case notes of patients who were followed up because of idiopathic sudden sensorineural hearing loss between 2005 and 2011 in a tertiary care centre were examined retrospectively. Audiograms from before and after hyperbaric oxygen therapy were examined in terms of mean gains in pure tone average and at 0.25, 0.5, 1, 2, 4 and 8 kHz...
October 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27544193/prognostic-factors-for-profound-sudden-idiopathic-sensorineural-hearing-loss-a-multicenter-retrospective-study
#20
MULTICENTER STUDY
Ho Yun Lee, Dong-Kee Kim, Yong-Ho Park, Wang Woon Cha, Geun Jeon Kim, Seung Hun Lee
The aim of this study was to assess the outcomes of various treatment modalities for profound idiopathic sudden sensorineural hearing loss (ISSNHL) and confirm the prognostic factors. In total, 191 patients were enrolled after a thorough medical chart review of patients diagnosed with unilateral, profound ISSNHL (≥90 dB). Epidemiological profiles, therapeutic regimens, and the results of pure tone audiometry tests were recorded for all patients. Final recovery was assessed according to Siegel's criteria and by comparing the final hearing level of the affected ear with that of the unaffected ear...
January 2017: European Archives of Oto-rhino-laryngology
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