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Idiopathic sudden sensorineural hearing loss

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https://www.readbyqxmd.com/read/27846752/chronic-cerebrospinal-venous-insufficiency-as-a-cause-of-inner-ear-diseases
#1
Giuseppe Attanasio, Laura Cagnoni, Eleonora Masci, Francesco Ciciarello, Francesco Diaferia, Aldo Bruno, Antonio Greco, Marco De Vincentiis
CONCLUSION: The present study confirms a correlation between chronic cerebrospinal venous insufficiency (CCSVI) diagnosis and Ménière's disease (MD). CCSVI could be considered a new ultrasound vascular pattern of the cerebrospinal venous system in patients affected by definite MD. Conversely, the present results showed that CCSVI cannot be considered a pathogenic mechanism for idiopathic sudden sensorineural hearing loss (ISSNHL). OBJECTIVES: The aim of this study is to investigate the correlation between CCSVI and MD and to evaluate if CCSVI can be considered a risk factor also for ISSNHL...
November 16, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27846039/activation-of-igf1-signaling-in-the-cochlea-induces-the-transcription-of-its-mediators-during-the-protection-of-cochlear-hair-cells-against-aminoglycoside
#2
Yushi Hayashi, Norio Yamamoto, Takayuki Nakagawa, Koichi Omori, Juichi Ito
HYPOTHESIS: Transcription of the Erk and Akt genes and phosphorylation of their products are promoted by insulin-like growth factor 1 (IGF1) during hair cell protection. BACKGROUND: IGF1 protects mammalian hair cells in animal models from various types of damage, including aminoglycoside. Moreover, clinical trials have revealed that IGF1 was effective for idiopathic sudden sensorineural hearing loss. In this process, activation of the downstream of IGF1 signaling, including the phosphorylation of extracellular signal-regulated kinase (ERK) and AKT proteins, is involved...
November 14, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27842665/revisiting-the-relationship-of-three-dimensional-fluid-attenuation-inversion-recovery-imaging-and-hearing-outcomes-in-adults-with-idiopathic-unilateral-sudden-sensorineural-hearing-loss
#3
Wen-Huei Liao, Hsiu-Mei Wu, Hung-Yi Wu, Tzong-Yang Tu, An-Suey Shiao, Mauricio Castillo, Sheng-Che Hung
BACKGROUND AND PURPOSE: Three-dimensional fluid attenuation inversion recovery (3D FLAIR) may demonstrate high signal in the inner ears of patients with idiopathic sudden sensorineural hearing loss (ISSNHL), but the correlations of this finding with outcomes are still controversial. Here we compared 4 3D MRI sequences with the outcomes of patients with ISSNHL. MATERIALS AND METHODS: 77 adult patients with ISSNHL underwent MRI with pre contrast FLAIR, fast imaging employing steady-state acquisition images (FIESTA-C), post contrast T1WI and post contrast FLAIR...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27817938/metabolomic-analysis-of-urine-with-nuclear-magnetic-resonance-spectroscopy-in-patients-with-idiopathic-sudden-sensorineural-hearing-loss-a-preliminary-study
#4
Filippo Carta, Milena Lussu, Fabrizio Bandino, Noto Antonio, Marcello Peppi, Natalia Chuchueva, Atzori Luigi, Vassilios Fanos, Roberto Puxeddu
OBJECTIVE: Idiopathic sudden sensorineural hearing loss is a frequent emergency, with unknown aetiology and usually treated with empiric therapy. Steroids represent the only validated treatment but prognosis is unpredictable and the possibility to select the patients who will not respond to steroids could avoid unnecessary treatments. Metabolomic profiling of the biofluids target the analysis of the final product of genic expression and enzymatic activity, defining the biochemical phenotype of a whole biologic system...
November 3, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27800104/epidemiological-and-clinical-aspects-of-ear-nose-and-throat-sensorineural-emergencies-in-the-yaound%C3%A3-reference-hospital
#5
François Djomou, Yves Christian Andjock Nkouo, Eko David Mindja, Choffor Nchinda, Luc Meka, Emilia Mbamyah-Lyonga, Alexis Ndjolo
INTRODUCTION: Sensorineural emergencies (SNE) are rare clinical situations. Few patients consult early explaining subsequent difficulty in having accurate data and management. Three clinical conditions are considered SNE in otolaryngology; they include sudden sensorineural hearing loss (SSHL), Bell's palsy and acute vertigo. There is very little data available on sensorineural emergencies in our setting. The aim of this study was to provide preliminary data on the management of Ear Nose and Throat (ENT) sensorineural emergency cases in Yaoundé Reference Hospital...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27723017/hyperbaric-oxygen-therapy-in-the-treatment-of-sudden-sensorineural-hearing-loss-a-retrospective-analysis-of-outcomes
#6
Susannah Sherlock, Kenneth Thistlethwaite, Alessandro Rubini, Mohsina Khatun, Christopher Perry, Alexis Tabah
OBJECTIVE: To analyse predictive factors affecting outcome after treatment with hyperbaric oxygen (HBOT) in patients with idiopathic sudden sensorineural hearing loss (ISSHL). METHODS: This is a retrospective audit of outcome in 77 consecutive patients referred for consideration of HBOT for ISSHL for either adjunctive treatment or after failure of steroid therapy. The hearing measured from the pre- and post-HBOT pure-tone audiogram (PTA4) at four frequencies; 500 Hz, 1 kHz, 2 kHz and 4 kHz, was averaged and compared...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27614879/a-comprehensive-study-of-oxidative-stress-in-sudden-hearing-loss
#7
Fatih Gul, Togay Muderris, Gokhan Yalciner, Ergun Sevil, Sami Bercin, Merve Ergin, Mehmet Ali Babademez, Muzaffer Kiris
Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated...
September 10, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27609270/sudden-hearing-loss-as-the-initial-symptom-in-japanese-patients-with-multiple-sclerosis-and-seropositive-neuromyelitis-optica-spectrum-disorders
#8
Masami Tanaka, Keiko Tanaka
Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective analysis of the medical records of 173 consecutive patients with multiple sclerosis (MS) and 101 consecutive patients with NMOSD who tested positive for anti-aquaporin-4 antibodies in addition to 37 consecutive patients with clinically isolated syndromes (CIS) to investigate the frequency and onset timing of SNHL...
September 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27588164/endothelial-dysfunction-in-idiopathic-sudden-sensorineural-hearing-loss-a-review
#9
REVIEW
Nicola Quaranta, Vincenzo De Ceglie, Alessandra D'Elia
An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade...
April 20, 2016: Audiology Research
https://www.readbyqxmd.com/read/27572676/is-hyperbaric-oxygen-therapy-a-salvage-treatment-option-for-sudden-sensorineural-hearing-loss
#10
Y Alimoglu, E Inci
OBJECTIVE: To investigate of the efficacy of hyperbaric oxygen therapy as a salvage treatment after unsuccessful oral corticosteroid therapy. METHODS: Case notes of patients who were followed up because of idiopathic sudden sensorineural hearing loss between 2005 and 2011 in a tertiary care centre were examined retrospectively. Audiograms from before and after hyperbaric oxygen therapy were examined in terms of mean gains in pure tone average and at 0.25, 0.5, 1, 2, 4 and 8 kHz...
August 30, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27544193/prognostic-factors-for-profound-sudden-idiopathic-sensorineural-hearing-loss-a-multicenter-retrospective-study
#11
Ho Yun Lee, Dong-Kee Kim, Yong-Ho Park, Wang Woon Cha, Geun Jeon Kim, Seung Hun Lee
The aim of this study was to assess the outcomes of various treatment modalities for profound idiopathic sudden sensorineural hearing loss (ISSNHL) and confirm the prognostic factors. In total, 191 patients were enrolled after a thorough medical chart review of patients diagnosed with unilateral, profound ISSNHL (≥90 dB). Epidemiological profiles, therapeutic regimens, and the results of pure tone audiometry tests were recorded for all patients. Final recovery was assessed according to Siegel's criteria and by comparing the final hearing level of the affected ear with that of the unaffected ear...
August 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27516239/prognostic-value-of-labyrinthine-3d-flair-abnormalities-in-idiopathic-sudden-sensorineural-hearing-loss
#12
J I Lee, R G Yoon, J H Lee, J W Park, M H Yoo, J H Ahn, J W Chung, H J Park
BACKGROUND AND PURPOSE: According to recent research, modern MR imaging can detect the presense of abnormalities on labyrinthine. Our aim was to report the patterns and prognostic role of abnormal findings on labyrinthine imaging in patients with sudden sensorineural hearing loss. MATERIALS AND METHODS: This study comprised 113 patients who were diagnosed with unilateral sudden sensorineural hearing loss and underwent 3T MR imaging, including pre-/postcontrast 3D fluid-attenuated inversion recovery and T1-weighted imaging...
August 11, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27460341/the-place-of-hyperbaric-oxygen-therapy-and-ozone-therapy-in-sudden-hearing-loss
#13
Gülin Ergun Taşdöven, Alper Tunga Derin, Neslihan Yaprak, Hasan Ümit Özçağlar
INTRODUCTION: It is difficult to evaluate the effect of drugs clinically used for idiopathic sudden sensorineural hearing loss, mainly because the underlying mechanism of it has remained unknown. OBJECTIVE: This study assessed the efficacy of hyperbaric oxygen therapy or ozone therapy in the treatment of idiopathic sudden sensorineural hearing loss, when either therapy was included with steroid treatment. METHODS: A retrospective analysis examined 106 patients with idiopathic sudden sensorineural hearing loss seen between January 2010 and June 2012...
July 6, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27459199/does-herpes-virus-reactivation-affect-prognosis-in-idiopathic-sudden-sensorineural-hearing-loss
#14
Sang Man Park, Chun Han, Jae Woo Lee, Tae Hoon Kong, Young Joon Seo
Objectives: Several etiologies have been proposed to underlie idiopathic sudden sensorineural hearing loss (ISSNHL), including viral infection, vascular disturbance, and immune-mediated mechanisms. However, none of these mechanisms are conclusive. Should ISSNHL be caused by reactivation of a viral infection, antiviral treatment would be an important option. Thus, in this study, we reported the prognosis according to serologic test results of herpes viruses in patients with ISSNHL. We also evaluated treatment response with acyclovir and corticosteroids versus corticosteroids alone in herpes simplex virus (HSV) seropositive ISSNHL patients...
July 27, 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27379548/management-of-sudden-sensorineural-hearing-loss
#15
Aaron M Metrailer, Seilesh C Babu
PURPOSE OF REVIEW: Sudden sensorineural hearing loss (SNHL) is an otologic emergency and should be managed quickly and effectively. This review focuses on the management of sudden SNHL, primarily idiopathic sudden SNHL as it is the most common cause. RECENT FINDINGS: Management options include observation, oral steroids, intratympanic steroids, or combined oral/intratympanic steroids. One-third to two-thirds of patients will achieve spontaneous recovery, most likely within the first 2 weeks...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27379547/primary-treatment-of-idiopathic-sudden-sensorineural-hearing-loss-with-intratympanic-dexamethasone
#16
Candace E Hobson, Thomas H Alexander, Jeffrey P Harris
PURPOSE OF REVIEW: Systemic corticosteroids have been the mainstay of treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) for over 30 years. Recently, intratympanic steroids have risen in popularity; however, there is no consensus regarding the details of their application. The purpose of this article is to review the current literature and share our opinion that intratympanic dexamethasone (alone or with systemic steroids) should be offered as primary treatment of ISSNHL...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27371620/ethics-of-placebo-control-in-trials-for-idiopathic-sudden-sensorineural-hearing-loss-counterpoint
#17
Andrew G Shuman
No abstract text is available yet for this article.
July 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27371619/ethics-of-placebo-control-in-trials-for-idiopathic-sudden-sensorineural-hearing-loss
#18
Miguel Maldonado Fernández, Susan Kornetsky, Laura Rubio Rodriguez
Idiopathic sudden sensorineural hearing loss (ISSHL) involves sudden loss of hearing from cochlear or retrocochlear origin of unknown cause. Systemic corticosteroids may be considered in the management of ISSNHL. However, an updated Cochrane systematic review concludes that "the value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomized controlled trials is contradictory in outcome." Therefore, a new clinical trial that addresses this question is mandatory...
July 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27355976/red-blood-cell-distribution-width-predicts-prognosis-in-idiopathic-sudden-sensorineural-hearing-loss
#19
Hiroshi Nonoyama, Tohru Tanigawa, Rei Shibata, Yoshio Nakao, Yuichiro Horibe, Nobuyuki Katahira, Kunihiro Nishimura, Kenta Murotani, Toyoaki Murohara, Hiromi Ueda
CONCLUSION: Red cell distribution width (RDW) can predict outcome in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Further studies are required to clarify the potential pathophysiological explanations for these findings. OBJECTIVES: RDW is one of the parameters reported in a complete blood count, and is elevated in direct proportion to variation in red cell size (anisocytosis). High RDW values are strongly associated with poor clinical outcomes in various diseases, including inflammatory and thrombotic diseases...
June 29, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27348351/current-concepts-in-the-management-of-idiopathic-sudden-sensorineural-hearing-loss
#20
Brendan P O'Connell, Jacob B Hunter, David S Haynes
PURPOSE OF REVIEW: The purpose of this manuscript is to review the initial management strategies for idiopathic sudden sensorineural hearing loss, with an emphasis on the role that steroids play in treatment of this condition, and discuss options for auditory rehabilitation of persistent unilateral hearing loss. RECENT FINDINGS: Recent data suggest that hearing improvement may be greater for patients initially treated with both systemic and intratympanic steroid when compared with those treated with systemic steroids alone...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
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