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Idiopathic sudden sensorineural hearing loss

Hasan Demirhan, Ali Rıza Gökduman, Bahtiyar Hamit, Müge Fethiye Yürekli Altındağ, Özgür Yiğit
OBJECTIVE: The primary objective is to investigate the contribution of intratympanic steroids in the primary treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The secondary objective is to compare methylprednisolone (MP) and dexamethasone in terms of their effectiveness and injection-site pain. METHODS: Two hundred and four patients with ISSNHL, 144 patients underwent systemic steroid therapy (SST) alone and 60 patients underwent combined therapy (CT)...
March 7, 2018: Acta Oto-laryngologica
Anwuli Anyah, Devin Mistry, Erin Kevern, Kenneth Markiewicz
Objectives To determine how long after symptom onset that the average patient with an idiopathic sudden sensorineural hearing loss (ISSNHL) presents to the otolaryngology clinic.  In late presentations, to determine the time to presentation cutoff after which intervention may not be effective.  To evaluate the effectiveness of oral steroids versus a combination of oral and intratympanic steroid therapy in late presentations of ISSNHL.  Methods and procedures Sixty-four patients met inclusion criteria after chart review of 2,037 patients seen at Metro Health Hospital from 2006 to 2016 for sensorineural hearing loss...
December 14, 2017: Curēus
M Chroni, E Prappa, I Kokkevi
BACKGROUND: Septic emboli are an unusual cause of sudden sensorineural hearing loss, for which few reports exist in the literature. CASE REPORT: This paper presents two cases of sudden sensorineural hearing loss, initially considered as idiopathic, but which were caused by septic emboli. Hearing loss in these cases was bilateral, sequential and total. The first patient had mild fever one week prior to their presentation with sudden sensorineural hearing loss; the other patient had no additional symptoms at presentation...
February 21, 2018: Journal of Laryngology and Otology
Tzu-Hang Chi, M C Chiang, R F Chen, C H Yuan
BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is defined as a 30-decibel (dB) loss in hearing over three contiguous frequencies within 3 days. The cause remains unknown, and there is currently no consensus in the literature as to how it is best treated. Conventional treatment in our unit comprises steroids, pentoxyphiline and dextran, with the potential addition of hyperbaric oxygen therapy (HBOT). METHODS: A prospective randomised trial was performed on all soldiers diagnosed with ISSNHL in our institution from 1 January 2007 to 31 December 2016...
February 3, 2018: Journal of the Royal Army Medical Corps
Hideaki Suzuki, Tetsuro Wakasugi, Takuro Kitamura, Hiroki Koizumi, Ba Hung Do, Toyoaki Ohbuchi
OBJECTIVE: We studied the effect of intratympanic steroid administration with different total injection times on hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: The subjects were 191 consecutive patients (192 ears) with ISSNHL (hearing level ≥40 dB, interval between onset and treatment ≤30 days). They received systemic prednisolone (100 mg followed by tapered doses) combined with intratympanic injection of dexamethasone (4 mg/ml)...
February 1, 2018: Annals of Otology, Rhinology, and Laryngology
Dorota Olex-Zarychta
RATIONALE: According to the World Health Organization reports, adult-onset hearing loss is the 15th leading cause of burden of disease, and is projected to move up to 7th by the year 2030, especially in high-income countries. Sudden sensorineural hearing loss is considered by otologists as a true otologic emergency. The current standard treatment for sudden hearing loss is a tapered course of oral high-dose corticosteroids. The described clinical case points to the validity of undertaking early hyperbaric oxygenation (HBO) therapy together with corticosteroids for full recovery of adult onset idiopathic sudden sensorineural hearing loss...
December 2017: Medicine (Baltimore)
Dan Lai, Fei Zhao, Nasim Jalal, Yun Zheng
BACKGROUND AND OBJECTIVE: Glucocorticoids are the standard treatment for idiopathic sudden sensorineural hearing loss (ISSNHL), but whether intratympanic or systemic therapy is superior remains controversial. Previous meta-analyses of this question have omitted key clinical trials or included observational studies. METHODS: English-language randomized controlled trials in OvidSP, PubMed, Embase, CINAHL, and the Cochrane Library comparing intratympanic versus systemic glucocorticoid therapy for ISSNHL were meta-analyzed using RevMan 5...
December 2017: Medicine (Baltimore)
Dan Bing, Da-Yong Wang, Lan Lan, Li-Dong Zhao, Zi-Fang Yin, Lan Yu, Guo-Hui Chen, Jing Guan, Qiu-Ju Wang
BACKGROUND: Bilateral sudden sensorineural hearing loss (BSSHL) is rare and assumed to be a different clinical entity compared to unilateral SSHL (USSHL). This study examined the differences between the idiopathic BSSHL and USSHL. METHODS: Forty-six sequential BSSHL patients (Se-BSSHL) and 68 simultaneous BSSHL (Si-BSSHL) were consecutively admitted between June 2008 and December 2015. Two sets of patients served as control groups: (1) USSHL patients with healthy contralateral ear and (2) USSHL patients with contralateral preexisting hearing loss (USSHLwCHL)...
February 5, 2018: Chinese Medical Journal
Anne Heuschkel, Katharina Geißler, Daniel Boeger, Jens Buentzel, Dirk Esser, Kerstin Hoffmann, Peter Jecker, Andreas Mueller, Gerald Radtke, Orlando Guntinas-Lichius
PURPOSE: The aim was to determine inpatient treatment rates of idiopathic sudden sensorineural hearing loss (ISSNHL) with focus on diagnostics, treatment, and outcome. METHODS: A retrospective population-based study in the federal state Thuringia in 2011 and 2012 was performed on all 490 inpatients (51% females, median age: 60 years) treated for ISSNHL (Median duration: 7 days). The association between analyzed parameters and the probability of recovery was tested using univariable and multivariable statistics...
March 2018: European Archives of Oto-rhino-laryngology
Melissa Bravenboer de Sousa, Selma Cazemier, Inge Stegeman, Hans Thomeer
To compare the effect of vasodilators with that of corticosteroids in patients with idiopathic sudden sensorineural hearing loss (ISSHL). A search in PubMed, Cochrane, and Embase was conducted. Two reviewers screened the data sources to identify articles that comply with predefined inclusion criteria. Studies that compared the therapeutic effect of vasodilators with prednisone or placebo in patients with ISSHL were identified. Five articles were selected, involving a total of 611 patients. The odds ratios for perceptive hearing levels (pure tone average) post treatment varied between 0...
December 2017: Journal of International Advanced Otology
Masoud Motasaddi Zarandy, Mohammad Taghi Ashtiani, Shahin Bastaninejad, Sasan Dabiri Satri, Sevil Nasirmohtaram, Nourullah Agha Ebrahimi
This is an analytic-descriptive study, parallel with a randomized, controlled trial performed at Amir'Alam Hospital, a tertiary referral center, with the aim of evaluating the correlation between otoacoustic emission (OAE) and auditory brainstem response (ABR) findings with hearing outcome after treatment of idiopathic sudden sensorineural hearing loss (SSNHL). Sixty patients with idiopathic SSNHL who presented to the emergency services and otology clinics between 2012 and 2014, and whose symptoms had begun <10 days previously, enrolled in this study...
December 2017: Ear, Nose, & Throat Journal
Michael Tsounis, George Psillas, Miltiadis Tsalighopoulos, Victor Vital, Nicolas Maroudias, Konstantinos Markou
PURPOSE: The purpose of this prospective, randomized, multicenter clinical trial was to compare the therapeutic efficacy of systemic versus intratympanic versus combined administration of steroids in the treatment of idiopathic sudden sensorineural hearing loss. METHODS: 102 patients with an up to 14 days history of idiopathic sudden sensorineural hearing loss were randomized to 1 of 3 arms and followed prospectively. Group A (35 patients) received prednisolone intravenously followed by methylprednisolone orally, whereas Group B (34 patients) were administered intratympanic methylprednisolone...
January 2018: European Archives of Oto-rhino-laryngology
Špela Kordiš, Saba Battelino
OBJECTIVE: The aim of this study was to assess the efficacy of a single high dose intratympanic (IT) dexamethasone (DEX) as salvage therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) after unsuccessful treatment with oral corticosteroid (CS). MATERIALS AND METHODS: This was a prospective open-label study of 59 patients treated with IT DEX after systemic CS therapy has failed. All patients received high dose (24 mg/mL) IT DEX in a single injection through myringotomy...
December 2017: Journal of International Advanced Otology
Mohammadtaghi Khorsandi Ashtiani, Farzad Firouzi, Shahin Bastaninejad, Sasan Dabiri, Sevil Nasirmohtaram, Niloufar Saeedi, Hossein Ghazavi, Leyla Sahebi
OBJECTIVE: The present study was conducted to compare the rates of recovery from idiopathic sudden deafness after the treatment with oral and intratympanic corticosteroids in both mono and combination therapies. STUDY DESIGN: Triple-blind randomized clinical trial. SETTINGS: Tertiary referral hospital. SUBJECTS AND METHODS: A total of 112 patients who were admitted to the ENT emergency department randomly divided into three groups: an oral corticosteroid plus intratympanic placebo (systemic corticosteroid monotherapy group); an intratympanic corticosteroid plus oral placebo group (IT monotherapy group); and a combination therapy group (IT plus systemic combination group)...
January 2018: European Archives of Oto-rhino-laryngology
Min Jae Kim, Kyung Wook Heo, Pil Hyun Jeon, Jae Jun Lee, Jun Ho Lee
OBJECTIVES: The purpose of this study was to determine the prognostic potential of admission of a patient for idiopathic sudden sensorineural hearing loss (ISSNHL). STUDY DESIGN: Retrospective clinical study. METHODS: We conducted a retrospective study of 301 patients with ISSNHL. The patients were divided into a study (57 patients at out-patients department (OPD) based treatment, using systemic steroids and intra-tympanic (IT) steroid injection) and a control groups (301 patients at admission, using systemic steroids and IT steroid injection)...
November 13, 2017: Acta Oto-laryngologica
Yildiz Arslan, İlker Burak Arslan, Huriye Aydin, Özlem Yağiz, Figen Tokuçoğlu, İbrahim Çukurova
OBJECTIVES: To investigate the relationship between sudden sensorineural hearing loss (SSNHL) and migraine, assess the prevalence of migraine in patients with idiopathic SSNHL, and determine a possible common vascular etiopathogenesis for migraine and SSNHL. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary referral center. PATIENTS: This study initially assessed 178 SSNHL cases obtained from the Head and Neck Surgery Clinic patient database at a tertiary hospital in Turkey between January 2011 and March 2016...
December 2017: Otology & Neurotology
Shaobing Xie, Qingfen Qiang, Lingyun Mei, Chufeng He, Yong Feng, Hong Sun, Xuewen Wu
The objective of this study is to evaluate possible prognostic factors of idiopathic sudden sensorineural hearing loss (ISSNHL) treated with adjuvant hyperbaric oxygen therapy (HBOT) using univariate and multivariate analyses. From January 2008 to October 2016, records of 178 ISSNHL patients treated with auxiliary hyperbaric oxygen therapy were reviewed to assess hearing recovery and evaluate associated prognostic factors (gender, age, localization, initial hearing threshold, presence of tinnitus, vertigo, ear fullness, hypertension, diabetes, onset of HBOT, number of HBOT, and audiogram), by using univariate and multivariate analyses...
January 2018: European Archives of Oto-rhino-laryngology
Daeyoung Roh, Janet Ren Chao, Do Hoon Kim, Kyung Hee Yoon, Jae Hoon Jung, Chang Hyun Lee, Ji-Hyeon Shin, Min Jae Kim, Chan Hum Park, Jun Ho Lee
OBJECTIVE: Early prediction of therapeutic outcomes could reduce exposure to ineffective treatments and optimize clinical outcomes. However, none of the known otologic predictors is amenable to therapeutic intervention for idiopathic sudden sensorineural hearing loss (ISSNHL). The aims of this study were to investigate psychological stress as a potential predictor to discriminate outcomes in ISSNHL. METHODS: Various psychological measures were conducted including structured interview assessment tools in patients with recently diagnosed ISSNHL before initiating treatment...
November 2017: Journal of Psychosomatic Research
Jiwon Cho, Hanjae Cheon, Jung Hye Park, Hyo-Jeong Lee, Hyung-Jong Kim, Hyo Geun Choi, Ja-Won Koo, Sung Kwang Hong
Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48...
2017: PloS One
Ferhat Arslan, Ergenekon Karagöz, Hüseyin Saffet Beköz, Bahadir Ceylan, Ali Mert
Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening catastrophic and rarely seen complication of EBV infection especially in adults. While typical presentation of EBV infection is easily diagnosed as mononucleosis syndrome in teenagers and adults, some atypical clinical presentations may be challenged. We did not encounter any patient presenting with sudden sensorineural hearing loss associated with EBV infection in our English medical literature research (1966-2016)...
September 1, 2017: Le Infezioni in Medicina
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