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https://www.readbyqxmd.com/read/29032305/physicochemical-pharmacokinetics-as-an-optimization-tool-for-generic-development-a-case-study
#1
Stefan Horkovics-Kovats, Ivan Ulč, Ladislav Vít, Bohdan Němec, Václav Rada
In spite of the fact that dissolution time profiles of 250mg ursodeoxycholic acid (UCDA) capsules developed by Sponsor and 250mg hard capsules produced by Ursofalk®, Dr. Falk Pharma GmbH, indicated similarity (f2=60.6), a bioavailability study indicated unexpected differences in the formulations. To find an explanation of the in vivo performance of the compared formulations, the dissolution profiles were analyzed using a novel dissolution theory considering: The dissolution model was applied to the measured data using SADAPT...
October 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29028756/financial-performance-of-hospitals-in-the-mississippi-delta-region-under-the-hospital-readmissions-reduction-program-and-hospital-value-based-purchasing-program
#2
Hsueh-Fen Chen, Saleema Karim, Fei Wan, Adrienne Nevola, Michael E Morris, T Mac Bird, J Mick Tilford
BACKGROUND: Previous studies showed that the Hospital Readmissions Reduction Program (HRRP) and the Hospital Value-based Purchasing Program (HVBP) disproportionately penalized hospitals caring for the poor. The Mississippi Delta Region (Delta Region) is among the most socioeconomically disadvantaged areas in the United States. The financial performance of hospitals in the Delta Region under both HRRP and HVBP remains unclear. OBJECTIVE: To compare the differences in financial performance under both HRRP and HVBP between hospitals in the Delta Region (Delta hospitals) and others in the nation (non-Delta hospitals)...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29021009/optimizing-the-use-of-discharge-medication-lists-in-nursing-facilities
#3
Andrea C Backes, Patricia Cash, Jessica Jordan
OBJECTIVE: To highlight the need to optimize the use of discharge medication lists in nursing facilities. SETTING: In January 2014, the care transitions (CT) pharmacists at Frederick Memorial Hospital, Frederick, Maryland, began a pilot project in which they identified and followed high-risk patients transitioning from hospital to nursing facility and from nursing facility to home. PRACTICE DESCRIPTION: This pilot project served as a needs assessment to identify opportunities to improve patients' transition from nursing facility to home with the goal of reducing hospital readmissions...
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29020578/hospital-quality-and-hospital-value-based-purchasing
#4
LETTER
Dale Schumacher, Mark Dietz
No abstract text is available yet for this article.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29020577/hospital-quality-and-hospital-value-based-purchasing
#5
LETTER
(no author information available yet)
New England Journal of Medicine, Volume 377, Issue 15, Page 1500-1502, October 2017.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28975604/association-between-race-neighborhood-and-medicaid-enrollment-and-outcomes-in-medicare-home-health-care
#6
Karen E Joynt Maddox, Lena M Chen, Rachael Zuckerman, Arnold M Epstein
BACKGROUND/OBJECTIVES: More than 3 million Medicare beneficiaries use home health care annually, yet little is known about how vulnerable beneficiaries fare in the home health setting. This is particularly important given the recent launch of Medicare's Home Health Value-Based Purchasing model. The objective of this study was to determine odds of adverse clinical outcomes associated with dual enrollment in Medicaid and Medicare as a marker of individual poverty, residence in a low-income ZIP code tabulation area (ZCTA), and black race...
October 4, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28975311/notice-of-retraction-and-replacement-favini-et-al-comparative-trends-in-payment-adjustments-between-safety-net-and-other-hospitals-since-the-introduction-of-the-hospital-readmission-reduction-program-and-value-based-purchasing-jama-2017-317-15-1578-1580
#7
Nathan Favini, Jason M Hockenberry, Matlin Gilman, Sanjula Jain, Michael K Ong, E Kathleen Adams, Edmund R Becker
No abstract text is available yet for this article.
September 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28973634/age-differences-in-hospital-mortality-for-acute-myocardial-infarction-implications-for-hospital-profiling
#8
Kumar Dharmarajan, Robert L McNamara, Yongfei Wang, Frederick A Masoudi, Joseph S Ross, Erica E Spatz, Nihar R Desai, James A de Lemos, Gregg C Fonarow, Paul A Heidenreich, Deepak L Bhatt, Susannah M Bernheim, Lara E Slattery, Yosef M Khan, Jeptha P Curtis
Background: Publicly reported hospital risk-standardized mortality rates (RSMRs) for acute myocardial infarction (AMI) are calculated for Medicare beneficiaries. Outcomes for older patients with AMI may not reflect general outcomes. Objective: To examine the relationship between hospital 30-day RSMRs for older patients (aged ≥65 years) and those for younger patients (aged 18 to 64 years) and all patients (aged ≥18 years) with AMI. Design: Retrospective cohort study...
September 26, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28971031/using-bayesian-model-to-estimate-the-cost-of-traffic-injuries-in-iran-in-2013
#9
Elaheh Ainy, Hamid Soori, Mojtaba Ganjali, Ayad Bahadorimonfared
BACKGROUND AND AIM: A significant social and economic burden inflicts by road traffic injuries (RTIs). We aimed to use Bayesian model, to present the precise method, and to estimate the cost of RTIs in Iran in 2013. MATERIALS AND METHODS: In a cross-sectional study on costs resulting from traffic injuries, 846 people per road user were randomly selected and investigated during 3 months (1(st) September-1(st) December) in 2013. The research questionnaire was prepared based on the standard for willingness to pay (WTP) method considering perceived risks, especially in Iran...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28961643/hospital-value-based-purchasing-the-association-between-patient-experience-and-clinical-outcome
#10
D Rob Haley, Hanadi Hamadi, Mei Zhao, Jing Xu, Yi Wang
The Affordable Care Act of 2010 introduced a Hospital Value-Based Purchasing Total Performance Score for payment purposes and to evaluate hospital quality of care. In fiscal year 2016, Total Performance Score was composed of (1) Clinical Processes of Care, (2) Patient Experience of Care, (3) Outcome, and (4) Efficiency domains. The objective of this study was to examine the association between the Patient Experience of Care and Outcome domains. The Donabedian model of structure, process, and outcome was used as a conceptual framework for this study...
September 28, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28944728/performance-based-risk-sharing-arrangements-u-s-payer-experience
#11
Joseph A Goble, Brian Ung, Sascha van Boemmel-Wegmann, Robert P Navarro, Andrew Parece
BACKGROUND: As a result of global concern about rising drug costs, many U.S. payers and European agencies such as the National Health Service have partnered with pharmaceutical companies in performance-based risk-sharing arrangements (PBRSAs) by which manufacturers share financial risk with health care purchasing entities and authorities. However, PBRSAs present many administrative and legal challenges that have minimized successful contract experiences in the United States. OBJECTIVE: To (a) identify drug and disease characteristics and contract components that contribute to successful PBRSA experiences and the primary barriers to PBRSA execution and (b) explore solutions to facilitate contract negotiation and execution...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28930760/medical-education-and-health-care-delivery-a-call-to-better-align-goals-and-purposes
#12
David P Sklar, Paul A Hemmer, Steven J Durning
The transformation of the U.S. health care system is under way, driven by the needs of an aging population, rising health care spending, and the availability of health information. However, the speed and effectiveness of the transformation of health care delivery will depend, in large part, upon engagement of the health professions community and changes in clinicians' practice behaviors. Current efforts to influence practice behaviors emphasize changes in the health payment system with incentives to move from fee-for-service to alternative payment models...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28895674/activity-of-cesium-137cs-and-potassium-content-in-new-potatoes-imported-to-poland
#13
Wanda Wadas, Elżbieta Królak, Jadwiga Karwowska
Background: Potatoes are an important component of the human diet. In addition to components which determine the nutrition and dietary values, potato tubers also contain anti-nutritional substances, inter alia radioactive elements. Natural and artifical radionuclides are released to the environment as a result of antropogenic activity, in a controlled or uncontrolled manner, and they are transferred to the human body through the food chain. Objective: The aim of the study was to determine the activity of radioactive cesium 137Cs isotope and potassium content, including the activity of 40K isotope, in new potatoes imported to Poland during the winter period from Mediterranean countries...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28895389/study-of-nutritional-value-of-dried-tea-leaves-and-infusions-of-black-green-and-white-teas-from-chinese-plantations
#14
Maria Czernicka, Grzegorz Zaguła, Marcin Bajcar, Bogdan Saletnik, Czesław Puchalski
Background: The processing of tea leaves determines the contents of bioactive ingredients, hence it should be expected that each variety of tea, black, red or green, will represent a different package of compounds of physiological importance. Taste and aroma, as well as price and brand are the main factors impacting consumers’ preferences with regard to tea of their choice; on the other hand consumers less frequently pay attention to the chemical composition and nutritional value of tea...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28876264/energetic-flexibility-on-wastewater-treatment-plants
#15
M Schäfer, I Hobus, T G Schmitt
In the future, an additional potential of control reserve as well as storage capacities will be required to compensate fluctuating renewable energy availability. The operation of energy systems will change and flexibility in energy generation and consumption will rise to a valuable asset. Wastewater treatment plants (WWTPs) are capable of providing the flexibility needed, not only with their energy generators but also in terms of their energy consuming aggregates on the plant. To meet challenges of the future in regard to energy purchase and to participate in and contribute to such a volatile energy market, WWTPs have to reveal their energetic potential as a flexible service provider...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28868141/we-need-a-nice-for-global-development-spending
#16
Kalipso Chalkidou, Anthony J Culyer, Amanda Glassman, Ryan Li
With aid budgets shrinking in richer countries and more money for healthcare becoming available from domestic sources in poorer ones, the rhetoric of value for money or improved efficiency of aid spending is increasing. Taking healthcare as one example, we discuss the need for and potential benefits of (and obstacles to) the establishment of a national institute for aid effectiveness. In the case of the UK, such an institute would help improve development spending decisions made by DFID, the country's aid agency, as well as by the various multilaterals, such as the Global Fund, through which British aid monies is channelled...
2017: F1000Research
https://www.readbyqxmd.com/read/28845347/introducing-value-based-purchasing-into-tricare-reform
#17
Susan D Hosek, Melony E Sorbero, Grant Martsolf, Ryan Kandrack
TRICARE, the health benefits program created for beneficiaries of the U.S. Department of Defense, covers health care provided in military treatment facilities and by civilian providers. Congress is now considering how to update TRICARE, which was first developed in the 1980s drawing on managed care concepts from civilian health plans. This article places TRICARE's current managed care strategy in historical context and describes recent innovations by private insurers and Medicare intended to enhance the value---cost and quality---of the care they purchase for their members...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28836947/country-and-regional-variations-in-purchase-prices-for-essential-cancer-medications
#18
Raphael E Cuomo, Robert L Seidman, Tim K Mackey
BACKGROUND: Accessibility to essential cancer medications in low- and middle-income countries is threatened by insufficient availability and affordability. The objective of this study is to characterize variation in transactional prices for essential cancer medications across geographies, medication type, and time. METHODS: Drug purchase prices for 19 national and international buyers (representing 29 total countries) between 2010 and 2014 were obtained from Management Sciences for Health...
August 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28830223/defining-the-costs-of-reusable-flexible-ureteroscope-reprocessing-using-time-driven-activity-based-costing
#19
Dylan Isaacson, Tessnim Ahmad, Ian Metzler, David T Tzou, Kazumi Taguchi, Manint Usawachintachit, Samuel Zetumer, Benjamin Sherer, Marshall Stoller, Thomas Chi
PURPOSE: Careful decontamination and sterilization of reusable flexible ureteroscopes used in ureterorenoscopy cases prevent the spread of infectious pathogens to patients and technicians. However, inefficient reprocessing and unavailability of ureteroscopes sent out for repair can contribute to expensive operating room (OR) delays. Time-driven activity-based costing (TDABC) was applied to describe the time and costs involved in reprocessing. MATERIALS AND METHODS: Direct observation and timing were performed for all steps in reprocessing of reusable flexible ureteroscopes following operative procedures...
September 20, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28817779/the-price-may-not-be-right-the-value-of-comparison-shopping-for-prescription-drugs
#20
Sanjay Arora, Neeraj Sood, Sophie Terp, Geoffrey Joyce
OBJECTIVES: To measure variations in drug prices across and within zip codes that may reveal simple strategies to improve patients' access to prescribed medications. STUDY DESIGN: We compared drug prices at different types of pharmacies across and within local markets. In-store prices were compared with a Web-based service providing discount coupons for prescription medications. Prices were collected for 2 generic antibiotics because most patients have limited experience with them and are less likely to know the price ranges for them...
July 2017: American Journal of Managed Care
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