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Contrast ultrasound

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https://www.readbyqxmd.com/read/29457989/propylthiouracil-induced-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-mimicking-kawasaki-disease
#1
Yoshihiro Aoki, Katsuhiko Kitazawa, Hironobu Kobayashi
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children and is characterised as necrotising vasculitis predominantly affecting small and medium-sized vessels. Propylthiouracil (PTU), an antithyroid drug, has been implicated in drug-induced AAV. In contrast, Kawasaki disease (KD) is a common systemic vasculitis, typically observed in children, which affects the medium-sized vessels, including the coronary arteries. An 11-year-old girl who developed AAV while receiving PTU therapy for Graves' disease is described...
February 19, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29456413/value-of-contrast-enhanced-ultrasound-in-the-differential-diagnosis-of-gallbladder-lesion
#2
Hui-Ping Zhang, Min Bai, Ji-Ying Gu, Ying-Qian He, Xiao-Hui Qiao, Lian-Fang Du
AIM: To describe contrast-enhanced ultrasound (CEUS) features and evaluate differential diagnosis value of CEUS and conventional ultrasound for patients with benign and malignant gallbladder lesions. METHODS: This study included 105 gallbladder lesions. Before surgical resection and pathological examination, conventional ultrasound and CEUS were performed to examine for lesions. Then, all the lesions were diagnosed as (1) benign, (2) probably benign, (3) probably malignant or (4) malignant using both conventional ultrasound and CEUS...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29453131/the-incidence-of-associated-abnormalities-in-patients-with-sacrococcygeal-teratoma
#3
Marijke E B Kremer, Jessica F Althof, Joep P M Derikx, Robertine van Baren, Hugo A Heij, Marc H W A Wijnen, René M H Wijnen, David C van der Zee, L W Ernest van Heurn
BACKGROUND: Gross genetic causes for SCT are unknown; however, it might be associated with other abnormalities. We assessed the incidence of associated abnormalities in a large national cohort of neonates with SCT and aimed to identify predictive risk factors. PROCEDURE: The medical records were reviewed of 235 consecutive neonates with SCT treated at the six pediatric surgical centers in the Netherlands from 1970 to 2010. Potential risk factors for associated abnormalities analyzed included sex, gestational age, tumor-volume/histology and Altman-classification...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29452906/extracranial-arterial-wall-volume-is-increased-and-shows-relationships-with-vascular-mri-measures-in-idiopathic-parkinson-s-disease
#4
Stephen Ball, Sarah Al-Bachari, Laura M Parkes, Hedley C A Emsley, Charles N McCollum
OBJECTIVE: Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disorder, often complicated by dementia. Cardiovascular risk factors and spontaneous cerebral emboli (SCE) are strongly associated with Alzheimer's (AD) and vascular dementia (VaD). We measured SCE in the middle cerebral artery and arterial wall volume in the extracranial arteries in patients with IPD and controls, and explored the relationships with structural and physiological MRI brain neurovascular measures...
February 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29452833/endothelial-vascular-cell-adhesion-molecule-1-is-a-marker-for-high-risk-carotid-plaques-and-target-for-ultrasound-molecular-imaging
#5
Craig C Weinkauf, Kirsten Concha-Moore, Jonathan R Lindner, Edmund R Marinelli, Kyle P Hadinger, Sandipan Bhattacharjee, Scott S Berman, Kay Goshima, Luis R Leon, Terry O Matsunaga, Evan Unger
BACKGROUND: Molecular imaging of carotid plaque vulnerability to atheroembolic events is likely to lead to improvements in selection of patients for carotid endarterectomy (CEA). The aims of this study were to assess the relative value of endothelial inflammatory markers for this application and to develop molecular ultrasound contrast agents for their imaging. METHODS: Human CEA specimens were obtained prospectively from asymptomatic (30) and symptomatic (30) patients...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29452275/a-laser-activated-multifunctional-targeted-nanoagent-for-imaging-and-gene-therapy-in-a-mouse-xenograft-model-with-retinoblastoma-y79-cells
#6
Mingxing Wu, Haibo Xiong, Hongmi Zou, Meng Li, Pan Li, Yu Zhou, Yan Xu, Jia Jian, Fengqiu Liu, Hongyun Zhao, Zhigang Wang, Xiyuan Zhou
Retinoblastoma (RB) is the most common intraocular malignancy of childhood that urgently needs early detection and effective therapy methods. The use of nanosized gene delivery systems is appealing because of their highly adjustable structure to carry both therapeutic and imaging agents. Herein, we report a folic acid (FA)-modified phase-changeable cationic nanoparticle encapsulating liquid perfluoropentane (PFP) and indocyanine green (ICG) (FA-CN-PFP-ICG, FCNPI) with good plasmid DNA (pDNA) carrying capacity, favorable biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, enhanced gene transfection efficiency and therapeutic effect...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451774/organic-semiconducting-photoacoustic-nanodroplets-for-laser-activatable-ultrasound-imaging-and-combinational-cancer-therapy
#7
Wei Tang, Zhen Yang, Sheng Wang, Zhantong Wang, Jibin Song, Guocan Yu, Wenpei Fan, Yunlu Dai, Jingjing Wang, Lingling Shan, Gang Niu, Quli Fan, Xiaoyuan Chen
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potentials in applications in medical imaging. Development of PA/US dual-contrast agents with high contrast and excellent biocompatible is of great interest. Herein, an organic semiconducting photoacoustic nanodroplet, PS-PDI-PAnD, is developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet with a photoabsorber and photoacoustic agent of perylene diimide (PDI) molecules and co-encapsulating the droplet with photosensitizers of ZnF16Pc molecules...
February 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451124/copper-oxide-loaded-plga-nanospheres-towards-a-multifunctional-nanoscale-platform-for-ultrasound-based-imaging-and-therapy
#8
Or Perlman, Iris S Weitz, Sarit Sivan, Hiba Abu-Khalla, Madeleine Benguigui, Yuval Shaked, Haim Azhari
Copper oxide nanoparticles (CuO-NPs) are increasingly investigated for diagnostic and therapeutic purposes. Recent work have demonstrated their anticancer potential as well as contrast agent capabilities for magnetic resonance imaging (MRI) and through-transmission ultrasound. However, no capabilities of CuO-NPS were demonstrated using conventional ultrasound systems, which, unlike the formers, are widely deployed in the clinic. Furthermore, in spite of their potential as multifunctional nano-based materials for diagnosis and therapy, CuO-NPs were delayed from further clinical translation due to their inherent toxicity...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29450615/contrast-enhanced-ultrasound-ceus-in-abdominal-intervention
#9
REVIEW
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Raymond Ramnarine, Annamaria Deganello, Maria E Sellars, Paul S Sidhu
The introduction of ultrasound contrast agents has rendered contrast-enhanced ultrasound (CEUS) a valuable complementary technique to address clinically significant problems. This pictorial review describes the use of CEUS guidance in abdominal intervention and illustrates such application for a range of clinical indications. Clinical application of CEUS discussed include commonly performed abdominal interventional procedures, such as biopsy, drainage, nephrostomy, biliary intervention, abdominal tumor ablation and its subsequent monitoring, and imaging of vascular complications following abdominal intervention...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29449144/a-dynamic-graph-cuts-method-with-integrated-multiple-feature-maps-for-segmenting-kidneys-in-2d-ultrasound-images
#10
Qiang Zheng, Steven Warner, Gregory Tasian, Yong Fan
RATIONALE AND OBJECTIVES: Automatic segmentation of kidneys in ultrasound (US) images remains a challenging task because of high speckle noise, low contrast, and large appearance variations of kidneys in US images. Because texture features may improve the US image segmentation performance, we propose a novel graph cuts method to segment kidney in US images by integrating image intensity information and texture feature maps. MATERIALS AND METHODS: We develop a new graph cuts-based method to segment kidney US images by integrating original image intensity information and texture feature maps extracted using Gabor filters...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29446261/enhanced-linear-array-photoacoustic-beamforming-using-modified-coherence-factor
#11
Moein Mozaffarzadeh, Yan Yan, Mohammad Mehrmohammadi, Bahador Makkiabadi
Photoacoustic imaging (PAI) is a promising medical imaging modality providing the spatial resolution of ultrasound imaging and the contrast of optical imaging. For linear-array PAI, a beamformer can be used as the reconstruction algorithm. Delay-and-sum (DAS) is the most prevalent beamforming algorithm in PAI. However, using DAS beamformer leads to low-resolution images as well as high sidelobes due to nondesired contribution of off-axis signals. Coherence factor (CF) is a weighting method in which each pixel of the reconstructed image is weighted, based on the spatial spectrum of the aperture, to mainly improve the contrast...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29445433/upright-catheter-based-cerebral-angiography
#12
Adnan I Qureshi, Muhammad A Saleem, Omer Naveed, Mohtasim A Qureshi, Shawn S Wallery
Background: Several studies using Doppler ultrasound have suggested cerebral venous drainage is through paravertebral venous plexus due to the collapse of internal jugular veins in an upright position. Methods: We present a technique of acquiring venographic images during an upright position as part of catheter-based angiography to provide additional information regarding cerebral venous diseases. Angiographic images in anteroposterior projection were acquired in lying position and after patients were placed at 60° using radiolucent supporting wedges on angiographic table...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445015/influence-of-ageing-on-quantitative-contrast-enhanced-ultrasound-of-the-kidneys-in-healthy-cats
#13
Emmelie Stock, Dominique Paepe, Sylvie Daminet, Luc Duchateau, Jimmy H Saunders, Katrien Vanderperren
The degenerative effects of ageing on the kidneys have been extensively studied in humans. However, only recently interest has been focused on renal ageing in veterinary medicine. Contrast-enhanced ultrasound allows non-invasive evaluation of renal perfusion in conscious cats. Renal perfusion parameters were obtained in 43 healthy cats aged 1-16 years old, and the cats were divided in four age categories: 1-3 years, 3-6 years, 6-10 years and over 10 years. Routine renal parameters as serum creatinine, serum urea, urine-specific gravity, urinary protein:creatinine ratio and systolic blood pressure were also measured...
February 14, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29443073/percutaneous-contrast-echocardiography-guided-intramyocardial-injection-and-cell-delivery-in-a-large-preclinical-model
#14
Alejandro Giraldo, Jesús Talavera López, Maria Josefa Fernandez-Del-Palacio, Obdulio García-Nicolás, Juan Seva, Gavin Brooks, José María Moraleda
Cell and gene therapy are exciting and promising strategies for the purpose of cardiac regeneration in the setting of heart failure with reduced ejection fraction (HFrEF). Before they can be considered for use, and implemented in humans, extensive preclinical studies are required in large animal models to evaluate the safety, efficacy, and fate of the injectate (e.g., stem cells) once delivered into the myocardium. Small rodent models offer advantages (e.g., cost effectiveness, amenability for genetic manipulation); however, given inherent limitations of these models, the findings in these rarely translate into the clinic...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442152/pediatric-contrast-enhanced-ultrasound-in-the-united-states-a-survey-by-the-contrast-enhanced-ultrasound-task-force-of-the-society-for-pediatric-radiology
#15
Susan J Back, Carolina Maya, Kassa Darge, Patricia T Acharya, Carol E Barnewolt, Jamie L Coleman, Jonathan R Dillman, Lynn Ansley Fordham, Misun Hwang, Annie Lim, M Beth McCarville, Marthe M Munden, Harriet J Paltiel, Frank M Volberg
BACKGROUND: The United States Food and Drug Administration (FDA) recently approved an ultrasound (US) contrast agent for intravenous and intravesical administration in children. OBJECTIVE: Survey the usage, interest in and barriers for contrast-enhanced US among pediatric radiologists. MATERIALS AND METHODS: The Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology (SPR) surveyed the membership of the SPR in January 2017 regarding their current use and opinions about contrast-enhanced US in pediatrics...
February 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29441284/infected-renal-hematoma-in-a-healthy-adolescent-with-no-renal-structural-anomaly
#16
Sabrina Huq, Sherry Pejka, Dilip R Patel
Renal abscesses are uncommon in otherwise healthy children and adolescents who have no underlying renal structural anomalies. A previously healthy, immunocompetent, 14-year-old male without a history of abdominal trauma or urinary tract infection (UTI) was found to have a renal hematoma that became infected and developed into a renal abscess. He presented with a 2-day history of nausea, vomiting, fever and 1-day history of abdominal pain that radiated to the right flank. Clinical examination, blood work, and initial imaging indicated likely infection; however, findings were normal on urinalysis and urine culture had no growth...
January 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29439295/transcriptional-profiling-of-synovial-macrophages-using-minimally-invasive-ultrasound-guided-synovial-biopsies-in-rheumatoid-arthritis
#17
Arthur M Mandelin, Philip J Homan, Alexander M Shaffer, Carla M Cuda, Salina T Dominguez, Emily Bacalao, Mary Carns, Monique Hinchcliff, Jungwha Lee, Kathleen Aren, Anjali Thakrar, Anna B Montgomery, S Louis Bridges, Joan M Bathon, John P Atkinson, David A Fox, Eric L Matteson, Christopher D Buckley, Costantino Pitzalis, Deborah Parks, Laura B Hughes, Laura Geraldino-Pardilla, Robert Ike, Kristine Phillips, Kerry Wright, Andrew Filer, Stephen Kelly, Eric M Ruderman, Vince Morgan, Hiam Abdala-Valencia, Alexander V Misharin, G Scott Budinger, Elizabeth T Bartom, Richard M Pope, Harris Perlman, Deborah R Winter
OBJECTIVE: Currently, there are no reliable biomarkers for predicting therapeutic response in patients with rheumatoid arthritis (RA). The synovium may unlock critical information for determining efficacy as reduction in numbers of sublining synovial macrophages remains the most reproducible biomarker. Thus, a clinically actionable method for collection of synovial tissue, which can be analyzed using high-throughput strategies, must become a reality. METHODS: Rheumatologists at six United States academic sites were trained in minimally invasive ultrasound-guided synovial tissue biopsy...
February 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29437024/uric-acid-metabolic-syndrome-and-atherosclerosis-the-chicken-or-the-egg-which-comes-first
#18
Giovanni De Pergola, Francesca Cortese, Gaetano Termine, Giovanni Meliota, Michele Masiello, Anna Maria Cortese, Francesco Silvestris, Domenico Caccavo, Marco Matteo Ciccone
BACKGROUND: A great debate in literature exists nowadays on the role of uric acid as a marker of cardiovascular and metabolic organ damage or a risk factor for cardiovascular and metabolic disease. METHODS: to determine the relationship among serum uric acid and metabolic syndrome and atherosclerosis, by mean of carotid intima media-thickness, in a cohort of 811 otherwise healthy overweight/obese subjects, without overt atherosclerosis not using any kind of drug...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29435190/experiment-research-of-focused-ultrasound-combined-with-drug-and-microbubble-for-treatment-of-central-nervous-system-leukemia
#19
Xiao-Ping Xi, Yu-Jin Zong, Yan-Hong Ji, Bing Wang, Hua-Sheng Liu
It has been shown that low frequency ultrasound in the presence of microbubble can effectively open the blood brain barrier (BBB) to allow the drugs to be delivered into the brain with an increased concentration. We aim to apply this method to increase the efficacy of Cytarabine (Ara-c) to treat central nervous system leukemia (CNSL). In the present study, we validated this ultrasound contrast agent Sonovue® targeting treatment via in vivo and in vitro experiments. The results showed that Sonovue® combined with Cytarabine could significantly inhibit K562 cell (chronic myeloid leukemia cell line) proliferation...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434750/comparative-analysis-of-3d-time-resolved-contrast-enhanced-magnetic-resonance-angiography-color-doppler-ultrasound-and-digital-subtraction-angiography-in-symptomatic-carotid-stenosis
#20
Hongkai Cui, Ruifang Yan, Zhansheng Zhai, Jipeng Ren, Zheng Li, Qiang Li, Shouying Wang
The present study aimed to compare the diagnostic value of contrast-enhanced magnetic resonance angiography (CE MRA) with 3D time-resolved imaging of contrast kinetics, color Doppler ultrasound (CDUS) and digital subtraction angiography (DSA) in extracranial carotid stenosis (CS). A total of 54 patients with symptomatic CS were subjected to CDUS, CE MRA and DSA examination. Results of DSA were defined as the standard, and a total of 216 vessels were examined. In each patient four vessels were examined, namely the bilateral common carotid arteries and the bilateral internal carotid arteries...
February 2018: Experimental and Therapeutic Medicine
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