keyword
MENU ▼
Read by QxMD icon Read
search

Ioannidis, john

keyword
https://www.readbyqxmd.com/read/28321561/ethics-and-epistemology-in-big-data-research
#1
Wendy Lipworth, Paul H Mason, Ian Kerridge, John P A Ioannidis
Biomedical innovation and translation are increasingly emphasizing research using "big data." The hope is that big data methods will both speed up research and make its results more applicable to "real-world" patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, and data analysis techniques...
March 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28320937/meta-assessment-of-bias-in-science
#2
Daniele Fanelli, Rodrigo Costas, John P A Ioannidis
Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated bias-related patterns and risk factors, in a large random sample of meta-analyses taken from all disciplines. The magnitude of these biases varied widely across fields and was overall relatively small. However, we consistently observed a significant risk of small, early, and highly cited studies to overestimate effects and of studies not published in peer-reviewed journals to underestimate them...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28306144/exclusion-of-elderly-people-from-randomized-clinical-trials-of-drugs-for-ischemic-heart-disease
#3
Florence T Bourgeois, Liat Orenstein, Sarita Ballakur, Kenneth D Mandl, John P A Ioannidis
OBJECTIVES: To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. DESIGN: Cross-sectional analysis. SETTING: Interventional clinical trials studying a drug intervention for IHD that started in 2006 and after were identified in ClinicalTrials.gov. Data were extracted on study features, including age-based inclusion criteria...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28298413/the-reproducibility-wars-successful-unsuccessful-uninterpretable-exact-conceptual-triangulated-contested-replication
#4
John P A Ioannidis
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28282371/increasing-efficiency-of-preclinical-research-by-group-sequential-designs
#5
Konrad Neumann, Ulrike Grittner, Sophie K Piper, Andre Rex, Oscar Florez-Vargas, George Karystianis, Alice Schneider, Ian Wellwood, Bob Siegerink, John P A Ioannidis, Jonathan Kimmelman, Ulrich Dirnagl
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28273140/a-simulation-study-of-the-strength-of-evidence-in-the-recommendation-of-medications-based-on-two-trials-with-statistically-significant-results
#6
Don van Ravenzwaaij, John P A Ioannidis
A typical rule that has been used for the endorsement of new medications by the Food and Drug Administration is to have two trials, each convincing on its own, demonstrating effectiveness. "Convincing" may be subjectively interpreted, but the use of p-values and the focus on statistical significance (in particular with p < .05 being coined significant) is pervasive in clinical research. Therefore, in this paper, we calculate with simulations what it means to have exactly two trials, each with p < .05, in terms of the actual strength of evidence quantified by Bayes factors...
2017: PloS One
https://www.readbyqxmd.com/read/28270433/waste-leaks-and-failures-in-the-biomarker-pipeline
#7
REVIEW
John P A Ioannidis, Patrick M M Bossuyt
BACKGROUND: The large, expanding literature on biomarkers is characterized by almost ubiquitous significant results, with claims about the potential importance, but few of these discovered biomarkers are used in routine clinical care. CONTENT: The pipeline of biomarker development includes several specific stages: discovery, validation, clinical translation, evaluation, implementation (and, in the case of nonutility, deimplementation). Each of these stages can be plagued by problems that cause failures of the overall pipeline...
March 7, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28253258/empirical-assessment-of-published-effect-sizes-and-power-in-the-recent-cognitive-neuroscience-and-psychology-literature
#8
Denes Szucs, John P A Ioannidis
We have empirically assessed the distribution of published effect sizes and estimated power by analyzing 26,841 statistical records from 3,801 cognitive neuroscience and psychology papers published recently. The reported median effect size was D = 0.93 (interquartile range: 0.64-1.46) for nominally statistically significant results and D = 0.24 (0.11-0.42) for nonsignificant results. Median power to detect small, medium, and large effects was 0.12, 0.44, and 0.73, reflecting no improvement through the past half-century...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28249046/impact-of-vaccine-herd-protection-effects-in-cost-effectiveness-analyses-of-childhood-vaccinations-a-quantitative-comparative-analysis
#9
Marisa Holubar, Maria Christina Stavroulakis, Yvonne Maldonado, John P A Ioannidis, Despina Contopoulos-Ioannidis
BACKGROUND: Inclusion of vaccine herd-protection effects in cost-effectiveness analyses (CEAs) can impact the CEAs-conclusions. However, empirical epidemiologic data on the size of herd-protection effects from original studies are limited. METHODS: We performed a quantitative comparative analysis of the impact of herd-protection effects in CEAs for four childhood vaccinations (pneumococcal, meningococcal, rotavirus and influenza). We considered CEAs reporting incremental-cost-effectiveness-ratios (ICERs) (per quality-adjusted-life-years [QALY] gained; per life-years [LY] gained or per disability-adjusted-life-years [DALY] avoided), both with and without herd protection, while keeping all other model parameters stable...
2017: PloS One
https://www.readbyqxmd.com/read/28241194/meta-analyses-can-be-credible-and-useful-a-new-standard
#10
John P A Ioannidis
No abstract text is available yet for this article.
February 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28223307/next-generation-systematic-reviews-prospective-meta-analysis-individual-level-data-networks-and-umbrella-reviews
#11
EDITORIAL
John Ioannidis
No abstract text is available yet for this article.
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28196819/outcome-reporting-bias-in-clinical-trials-why-monitoring-matters
#12
John Pa Ioannidis, Arthur L Caplan, Rafael Dal-Ré
No abstract text is available yet for this article.
February 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28192565/acknowledging-and-overcoming-nonreproducibility-in-basic-and-preclinical-research
#13
John P A Ioannidis
No abstract text is available yet for this article.
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28192563/evaluation-of-evidence-of-statistical-support-and-corroboration-of-subgroup-claims-in-randomized-clinical-trials
#14
Joshua D Wallach, Patrick G Sullivan, John F Trepanowski, Kristin L Sainani, Ewout W Steyerberg, John P A Ioannidis
Importance: Many published randomized clinical trials (RCTs) make claims for subgroup differences. Objective: To evaluate how often subgroup claims reported in the abstracts of RCTs are actually supported by statistical evidence (P < .05 from an interaction test) and corroborated by subsequent RCTs and meta-analyses. Data Sources: This meta-epidemiological survey examines data sets of trials with at least 1 subgroup claim, including Subgroup Analysis of Trials Is Rarely Easy (SATIRE) articles and Discontinuation of Randomized Trials (DISCO) articles...
February 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28190627/does-evidence-based-hearsay-determine-the-use-of-medical-treatments
#15
John P A Ioannidis
No abstract text is available yet for this article.
February 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28127782/finding-the-power-to-reduce-publication-bias
#16
T D Stanley, Hristos Doucouliagos, John P A Ioannidis
The central purpose of this study is to document how a sharper focus upon statistical power may reduce the impact of selective reporting bias in meta-analyses. We introduce the weighted average of the adequately powered (WAAP) as an alternative to the conventional random-effects (RE) estimator. When the results of some of the studies have been selected to be positive and statistically significant (i.e. selective reporting), our simulations show that WAAP will have smaller bias than RE at no loss to its other statistical properties...
January 27, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28114549/underperforming-big-ideas-in-biomedical-research-reply
#17
LETTER
Michael J Joyner, Nigel Paneth, John P A Ioannidis
No abstract text is available yet for this article.
January 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28077235/drivers-of-poor-medical-care
#18
REVIEW
Vikas Saini, Sandra Garcia-Armesto, David Klemperer, Valerie Paris, Adam G Elshaug, Shannon Brownlee, John P A Ioannidis, Elliott S Fisher
The global ubiquity of overuse and underuse of health-care resources and the gravity of resulting harms necessitate an investigation of drivers to inform potential solutions. We describe the network of influences that contribute to poor care and suggest that it is driven by factors that fall into three domains: money and finance; knowledge, bias, and uncertainty; and power and human relationships. In each domain the drivers operate at the global, national, regional, and individual level, and are modulated by the specific contexts within which they act...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28027950/dietfits-study-diet-intervention-examining-the-factors-interacting-with-treatment-success-study-design-and-methods
#19
Michael V Stanton, Jennifer L Robinson, Susan M Kirkpatrick, Sarah Farzinkhou, Erin C Avery, Joseph Rigdon, Lisa C Offringa, John F Trepanowski, Michelle E Hauser, Jennifer C Hartle, Rise J Cherin, Abby C King, John P A Ioannidis, Manisha Desai, Christopher D Gardner
Numerous studies have attempted to identify successful dietary strategies for weight loss, and many have focused on Low-Fat vs. Low-Carbohydrate comparisons. Despite relatively small between-group differences in weight loss found in most previous studies, researchers have consistently observed relatively large between-subject differences in weight loss within any given diet group (e.g., ~25kg weight loss to ~5kg weight gain). The primary objective of this study was to identify predisposing individual factors at baseline that help explain differential weight loss achieved by individuals assigned to the same diet, particularly a pre-determined multi-locus genotype pattern and insulin resistance status...
February 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28004846/short-term-economic-impact-of-the-zika-virus-outbreak
#20
Daniele Macciocchi, Simone Lanini, Francesco Vairo, Alimuddin Zumla, Luiz Tadeu Moraes Figueiredo, Francesco Nicola Lauria, Gino Strada, Philippe Brouqui, Vincenzo Puro, Sanjeev Krishna, Peter Kremsner, Paola Scognamiglio, Carsten Köhler, Emanuele Nicastri, Antonino Di Caro, Rodolfo Maria Cieri, John P A Ioannidis, Gary Kobinger, Marcelo Nascimento Burattini, Giuseppe Ippolito
Zika virus (ZIKV) is mainly transmitted by mosquitoes bites. However, transmission by sexual contacts has been reported in 11 non endemic countries. The rapid spread of ZIKV in Latin American and Caribbean Countries (LCR), person-to-person transmission and perceived risk on people's well being can affect the emerging economies of LCR which historically dependent on truism. Here we present an analysis on economic outputs for assessing the current impact of ZIKV on markets. Our analysis show an unexpected resilience of LCR markets to international alerts...
October 2016: New Microbiologica
keyword
keyword
5865
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"