keyword
MENU ▼
Read by QxMD icon Read
search

Aquaporin 1

keyword
https://www.readbyqxmd.com/read/28637277/measuring-co2-and-hco3-permeabilities-of-isolated-chloroplasts-using-a-mims-18o-approach
#1
Dimitri Tolleter, Vincent Chochois, Richard Poiré, G Dean Price, Murray R Badger
To support photosynthetic CO2 fixation by Rubisco, the chloroplast must be fed with inorganic carbon in the form of CO2 or bicarbonate. However, the mechanisms allowing the rapid passage of this gas and this charged molecule through the bounding membranes of the chloroplast envelope are not yet completely elucidated. We describe here a method allowing us to measure the permeability of these two molecules through the chloroplast envelope using a membrane inlet mass spectrometer and 18O-labelled inorganic carbon...
June 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28636801/water-channels-and-barriers-formed-by-claudins
#2
REVIEW
Rita Rosenthal, Dorothee Günzel, Dian Theune, Carolina Czichos, Jörg-Dieter Schulzke, Michael Fromm
Physiological studies in leaky epithelia, like kidney proximal tubules and the small intestine, have documented water transport via both transcellular and paracellular pathways. The discovery of aquaporin water channels provided a molecular basis for transcellular water movement. In contrast, the contribution, or even existence, of a specific paracellular water pathway has been disputed for a long time, until the cation channel-forming tight junction protein claudin-2 was shown to also permit the paracellular passage of water through its pore...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28633944/gene-expression-analysis-identify-a-metabolic-and-cell-function-alterations-as-a-hallmark-of-obesity-without-metabolic-syndrome-in-peripheral-blood-a-pilot-study
#3
Daniel Antonio de Luis, Raquel Almansa, Rocío Aller, Olatz Izaola, E Romero
BACKGROUND: Understanding molecular basis involved in overweight is an important first step in developing therapeutic pathways against excess in body weight gain. OBJECTIVE: The purpose of our pilot study was to evaluate the gene expression profiles in the peripheral blood of obese patients without other metabolic complications. DESIGN: A sample of 17 obese patients without metabolic syndrome and 15 non obese control subjects was evaluated in a prospective way...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28633427/genotypic-variation-in-tolerance-to-drought-stress-is-highly-coordinated-with-hydraulic-conductivity-photosynthesis-interplay-and-aquaporin-expression-in-field-grown-mulberry-morus-spp
#4
Kanubothula Sitarami Reddy, Kalva Madhana Sekhar, Attipalli Ramachandra Reddy
Hydraulic conductivity quantifies the efficiency of a plant to transport water from root to shoot and is a major constriction on leaf gas exchange physiology. Mulberry (Morus spp.) is the most economically important crop for sericulture industry. In this study, we demonstrate a finely coordinated control of hydraulic dynamics on leaf gas exchange characteristics in 1-year-old field-grown mulberry genotypes (Selection-13 (S13); Kollegal Local (KL) and Kanva-2 (K2)) subjected to water stress by withholding water for 20 days and subsequent recovery for 7 days...
June 14, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28627708/alterations-in-aqp4-expression-and-polarization-in-the-course-of-motor-neuron-degeneration-in-sod1g93a-mice
#5
Jiaying Dai, Weihao Lin, Minying Zheng, Qiang Liu, Baixuan He, Chuanming Luo, Xilin Lu, Zhong Pei, Huanxing Su, Xiaoli Yao
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The disease progression is associated with the astrocytic environment. Aquaporin-4 (AQP4) water channels are the most abundant AQPs expressed in astrocytes, exerting important influences on central nervous system homeostasis. The present study aimed to characterize the alterations in AQP4 expression and loca-lization in superoxide dismutase 1 (SOD1) G93A transgenic mice...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28615682/improved-retinal-function-in-rcs-rats-after-suppressing-the-over-activation-of-mglur5
#6
Jiaman Dai, Yan Fu, Yuxiao Zeng, Shiying Li, Zheng Qin Yin
Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptors, we injected either DL-α-aminoadipate or L-methionine sulfoximine-both inhibitors of glutamine synthetase-subretinally in rats. Following injection, the a-wave of the electroretinogram (ERG) was attenuated, and metabotropic glutamate receptor 5 (mGluR5) was activated. Selective antagonism of mGluR5 by 2-methyl-6-(phenylethynyl)-pyridine increased the ERG a-wave amplitude and also increased rhodopsin expression...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614812/the-discovery-of-water-channels-aquaporins
#7
Dennis Brown
The movement of water into and out of cells is a fundamental biological process that is essential for life. Such water movement not only regulates the activity of individual cells but also is responsible for the functioning of many organ systems and for maintaining whole body water balance. It had long been suspected that water movement across biological cell membranes was in some way enhanced or facilitated by pores or channels, but the search to identify these channels was long and tedious. As is often the case in science, the secret of the water channel was eventually discovered by chance in 1992 by Peter Agre and his colleagues at the Johns Hopkins University in Baltimore, who were working on red blood cell membrane proteins...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28611797/characterization-and-regulation-of-aquaporin-genes-of-sorghum-sorghum-bicolor-l-moench-in-response-to-waterlogging-stress
#8
Suhas Kadam, Alejandra Abril, Arun P Dhanapal, Robert P Koester, Wilfred Vermerris, Shibu Jose, Felix B Fritschi
Waterlogging is a significant environmental constraint to crop production, and a better understanding of plant responses is critical for the improvement of crop tolerance to waterlogged soils. Aquaporins (AQPs) are a class of channel-forming proteins that play an important role in water transport in plants. This study aimed to examine the regulation of AQP genes under waterlogging stress and to characterize the genetic variability of AQP genes in sorghum (Sorghum bicolor). Transcriptional profiling of AQP genes in response to waterlogging stress in nodal root tips and nodal root basal regions of two tolerant and two sensitive sorghum genotypes at 18 and 96 h after waterlogging stress imposition revealed significant gene-specific pattern with regard to genotype, root tissue sample, and time point...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28602064/notch-signaling-in-the-collecting-duct-regulates-renal-tubulointerstitial-fibrosis-induced-by-unilateral-ureteral-obstruction-in-mice
#9
Arum Choi, Sun Ah Nam, Wan-Young Kim, Sang Hee Park, Hyang Kim, Chul Woo Yang, Jin Kim, Yong Kyun Kim
Background/Aims: Mind bomb-1 (Mib1) encodes an E3 ubiquitin ligase, which is required for the initiation of Notch signaling. Recently, it was demonstrated that the renal collecting duct plays an important role in renal fibrosis. Here, we investigated the role of Notch signaling in renal fibrosis using conditional knockout mice with the specific ablation of Mib1 in renal collecting duct principal cells. Methods: Mib1-floxed mice (Mib1f/f) were crossed with aquaporin 2 (AQP2)-Cre mice in order to generate principal cell-specific Mib1 knockout mice (Mib1f/f :AQP2-Cre+)...
May 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28601290/suspected-bacterial-meningomyelitis-the-first-presenting-clinical-feature-of-neuromyelitis-optica-spectrum-disorder
#10
Xiang Li, Jie Lin, Sipei Pan, Yiyun Weng, Jia Li, Xu Zhang, Junhui Xia, Qiaowen Tong
A rare case of neuromyelitis optica spectrum disorder, suspected to be bacterial meningomyelitis as the initial manifestation, is reported. The patient presented with initial symptoms of meningomyelitis and fever. Cerebrospinal fluid analysis revealed pleocytosis (1280×10(6)/L [98% lymphocytes]) and glucose level of 1.8mmol/L. Magnetic resonance imaging revealed >3 vertebral, longitudinally extensive transverse myelitis and area postrema lesions. Right optic neuritis was experienced 20months after the first attack...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28597918/inflammation-in-the-developing-rat-modulates-astroglial-reactivity-to-seizures-in-the-mature-brain
#11
Zuzanna Setkowicz, Emilia Kosonowska, Krzysztof Janeczko
Astrocytes participate in neuronal development and excitability, and produce factors enhancing or suppressing inflammatory processes occurring due to neurodegenerative diseases, such as epilepsy. Seizures, in turn, trigger the release of inflammatory mediators, causing structural and functional changes in the brain. Therefore, it appears reasonable to determine whether generalized inflammation at developmental periods can affect astrocyte reactivity to epileptic seizures occurring in the adult brain. Lipopolysaccharide (LPS) was injected in 6- or 30-day-old rats (P6 or P30, respectively)...
June 9, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28597425/virus-induced-plasma-membrane-aquaporin-pspip2-1-silencing-inhibits-plant-water-transport-of-pisum-sativum
#12
Juanjuan Song, Guoliang Ye, Zhengjiang Qian, Qing Ye
BACKGROUND: Aquaporins (AQPs) are known to facilitate water transport across cell membranes, but the role of a single AQP in regulating plant water transport, particularly in plants other than Arabidopsis remains largely unexplored. In the present study, a virus-induced gene silencing (VIGS) technique was employed to suppress the expression of a specific plasma membrane aquaporin PsPIP2;1 of Pea plants (Pisum sativum), and subsequent effects of the gene suppression on root hydraulic conductivity (Lpr), leaf hydraulic conductivity (K leaf ), root cell hydraulic conductivity (Lprc), and leaf cell hydraulic conductivity (Lplc) were investigated, using hydroponically grown Pea plants...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28596233/adaptable-interaction-between-aquaporin-1-and-band-3-reveals-a-potential-role-of-water-channel-in-blood-co2-transport
#13
Kate Hsu, Ting-Ying Lee, Ammasi Periasamy, Fu-Jen Kao, Li-Tzu Li, Chuang-Yu Lin, Hui-Ju Lin, Marie Lin
Human CO2 respiration requires rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reaction inside red blood cells, and band 3 [anion exchange (AE)-1] provides a passage for HCO3(-) flux across the cell membrane. These 2 proteins are core components of the CO2 transport metabolon. Intracellular H2O is necessary for CO2/HCO3(-) conversion. However, abundantly expressed aquaporin (AQP)-1 in erythrocytes is thought not to be part of band 3 complexes or the CO2 transport metabolon...
June 8, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28594978/association-of-gel-forming-mucins-and-aquaporin-gene-expression-with-hearing-loss-effusion-viscosity-and-inflammation-in-otitis-media-with-effusion
#14
Tina L Samuels, Justin C Yan, Pawjai Khampang, Peter W Dettmar, Alexander MacKinnon, Wenzhou Hong, Nikki Johnston, Blake C Papsin, Robert H Chun, Michael E McCormick, Joseph E Kerschner
Importance: Persistent, viscous middle ear effusion in pediatric otitis media (OM) contributes to increased likelihood of anesthesia and surgery, conductive hearing loss, and subsequent developmental delays. Biomarkers of effusion viscosity and hearing loss have not yet been identified despite the potential that such markers hold for targeted therapy and screening. Objective: To investigate the association of gel-forming mucins and aquaporin 5 (AQP5) gene expression with inflammation, effusion viscosity, and hearing loss in pediatric OM with effusion (OME)...
June 8, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28589164/cns-aquaporin-4-specific-b-cells-connect-with-multiple-b-cell-compartments-in-neuromyelitis-optica-spectrum-disorder
#15
Markus C Kowarik, David Astling, Christiane Gasperi, Scott Wemlinger, Hannah Schumann, Monika Dzieciatkowska, Alanna M Ritchie, Bernhard Hemmer, Gregory P Owens, Jeffrey L Bennett
OBJECTIVES: Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system (CNS) targeted against aquaporin-4 (AQP4). The origin and trafficking of AQP4-specific B cells in NMOSD remains unknown. METHODS: Peripheral (n = 7) and splenic B cells (n = 1) recovered from seven NMOSD patients were sorted into plasmablasts, naïve, memory, and CD27-IgD- double negative (DN) B cells, and variable heavy chain (VH) transcriptome sequences were generated by deep sequencing...
June 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28588643/molecular-cloning-expression-and-characterization-of-four-novel-thermo-alkaliphilic-enzymes-retrieved-from-a-metagenomic-library
#16
Mukil Maruthamuthu, Jan Dirk van Elsas
BACKGROUND: Enzyme discovery is a promising approach to aid in the deconstruction of recalcitrant plant biomass in an industrial process. Novel enzymes can be readily discovered by applying metagenomics on whole microbiomes. Our goal was to select, examine, and characterize eight novel glycoside hydrolases that were previously detected in metagenomic libraries, to serve biotechnological applications with high performance. RESULTS: Here, eight glycosyl hydrolase family candidate genes were selected from metagenomes of wheat straw-degrading microbial consortia using molecular cloning and subsequent gene expression studies in Escherichia coli...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28588500/temporal-expression-patterns-of-clock-genes-and-aquaporin-5-anoctamin-1-in-rat-submandibular-gland-cells
#17
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, however, the relationship between the molecular mechanism of salivary secretion and peripheral circadian rhythm is not yet clear. Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28584298/role-of-aquaporin-7-in-ghrelin-and-glp-1-induced-improvement-of-pancreatic-%C3%AE-cell-function-after-sleeve-gastrectomy-in-obese-rats
#18
L Méndez-Giménez, S Becerril, S P Camões, I V da Silva, C Rodrigues, R Moncada, V Valentí, V Catalán, J Gómez-Ambrosi, J P Miranda, G Soveral, G Frühbeck, A Rodriguez
BACKGROUND/OBJECTIVES: Glycerol is a key metabolite for lipid accumulation in insulin-sensitive tissues as well as for pancreatic insulin secretion. We examined the role of aquaporin-7 (AQP7), the main glycerol channel in β-cells, and AQP12, a aquaporin related to pancreatic damage, in the improvement of pancreatic function and steatosis after sleeve gastrectomy in diet-induced obese rats. SUBJECTS/METHODS: Male Wistar obese rats (n=125) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary (pair-fed to the amount of food eaten by sleeve-gastrectomized animals) interventions...
June 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28577538/dai-huang-fu-zi-tang-alleviates-pulmonary-and-intestinal-injury-with-severe-acute-pancreatitis-via-regulating-aquaporins-in-rats
#19
Xin Kang, Xiao-Guang Lu, Li-Bin Zhan, Zheng-Kai Liang, Wen-Xiu Guo, Qi Ma, Yi Wang, Jian-Bo Song, Jin-Yu Feng, Cong-Han Wang, Li-Zhi Bai, Yi Song, Guo-Hui Liu
BACKGROUND: Dai-Huang-Fu-Zi-Tang (DHFZT) is a famous traditional Chinese prescription with intestinal obstruction, acute pancreatitis and cholecystalgia for thousands of years. Our previous work found that DHFZT could act against pulmonary and intestinal pathological injury in rats with severe acute pancreatitis (SAP). But the underlying mechanism has not been fully elucidated. The aim of present study was to investigate whether DHFZT could relieve pulmonary and intestinal injury by regulating aquaporins after SAP induced by sodium taurocholate in rats...
June 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28572277/immunotherapies-in-neuromyelitis-optica-spectrum-disorder-efficacy-and-predictors-of-response
#20
Jan-Patrick Stellmann, Markus Krumbholz, Tim Friede, Anna Gahlen, Nadja Borisow, Katrin Fischer, Kerstin Hellwig, Florence Pache, Klemens Ruprecht, Joachim Havla, Tania Kümpfel, Orhan Aktas, Hans-Peter Hartung, Marius Ringelstein, Christian Geis, Christoph Kleinschnitz, Achim Berthele, Bernhard Hemmer, Klemens Angstwurm, Kim Lea Young, Simon Schuster, Martin Stangel, Florian Lauda, Hayrettin Tumani, Christoph Mayer, Lena Zeltner, Ulf Ziemann, Ralf Andreas Linker, Matthias Schwab, Martin Marziniak, Florian Then Bergh, Ulrich Hofstadt-van Oy, Oliver Neuhaus, Uwe Zettl, Jürgen Faiss, Brigitte Wildemann, Friedemann Paul, Sven Jarius, Corinna Trebst, Ingo Kleiter
OBJECTIVE: To analyse predictors for relapses and number of attacks under different immunotherapies in patients with neuromyelitis optica spectrum disorder (NMOSD). DESIGN: This is a retrospective cohort study conducted in neurology departments at 21 regional and university hospitals in Germany. Eligible participants were patients with aquaporin-4-antibody-positive or aquaporin-4-antibody-negative NMOSD. Main outcome measures were HRs from Cox proportional hazard regression models adjusted for centre effects, important prognostic factors and repeated treatment episodes...
June 1, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
keyword
keyword
58649
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"