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Aquaporin 1

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https://www.readbyqxmd.com/read/28429509/co2-permeability-and-carbonic-anhydrase-activity-of-rat-cardiomyocytes
#1
Mariela Arias-Hidalgo, Samer Al-Samir, Natalie Weber, Cornelia Geers-Knörr, Gerolf Gros, Volker Endeward
AIM: We determine here the CO2 permeability (PCO2 ) of plasma membranes of cardiomyocytes. These cells were chosen because heart possesses the highest rate of O2 -consumption/CO2 -production in the body. METHODS: Cardiomyocytes were isolated from rat hearts using the Langendorff technique. Cardiomyocyte suspensions exhibited a vitality of 2-14% and were studied by the previously described mass spectrometric (18) O-exchange-technique deriving PCO2 . We show by mass spectrometry and by carbonic anhydrase (CA)-staining that non-vital cardiomyocytes are free of CA and thus do not contribute to the mass spectrometric signal, which is determined exclusively by the fully functional vital cardiomyocytes...
April 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28420330/anti-mog-antibody-positive-adem-following-infectious-mononucleosis-due-to-a-primary-ebv-infection-a-case-report
#2
Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima
BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection. CASE PRESENTATION: A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28409346/development-and-diseases-of-the-collecting-duct-system
#3
Lihe Chen, Paul J Higgins, Wenzheng Zhang
The collecting duct of the mammalian kidney is important for the regulation of extracellular volume, osmolarity, and pH. There are two major structurally and functionally distinct cell types: principal cells and intercalated cells. The former regulates Na(+) and water homeostasis, while the latter participates in acid-base homeostasis. In vivo lineage tracing using Cre recombinase or its derivatives such as CreGFP and CreER(T2) is a powerful new technique to identify stem/progenitor cells in their native environment and to decipher the origins of the tissue that they give rise to...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28409279/aquaporin-1-controls-the-functional-phenotype-of-pulmonary-smooth-muscle-cells-in-hypoxia-induced-pulmonary-hypertension
#4
Claudio Schuoler, Thomas J Haider, Caroline Leuenberger, Johannes Vogel, Louise Ostergaard, Grazyna Kwapiszewska, Malcolm Kohler, Max Gassmann, Lars C Huber, Matthias Brock
Vascular remodelling in hypoxia-induced pulmonary hypertension (PH) is driven by excessive proliferation and migration of endothelial and smooth muscle cells. The expression of aquaporin 1 (AQP1), an integral membrane water channel protein involved in the control of these processes, is tightly regulated by oxygen levels. The role of AQP1 in the pathogenesis of PH, however, has not been directly addressed so far. This study was designed to characterize expression and function of AQP1 in pulmonary vascular cells from human arteries and in the mouse model of hypoxia-induced PH...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28404667/distinct-clinical-characteristics-of-atypical-optic-neuritis-with-seronegative-aquaporin-4-antibody-among-chinese-patients
#5
Huanfen Zhou, Quangang Xu, Shuo Zhao, Wei Wang, Junqing Wang, Zhiye Chen, Dahe Lin, Xiaoming Li, Chunxia Peng, Nanping Ai, Shihui Wei
OBJECTIVE: To evaluate the clinical features and prognosis of atypical optic neuritis (ON) with seronegative aquaporin-4 (AQP4) antibody in Chinese patients. METHODS: All patients with first or relapsing ON were recruited from the Neuro-ophthalmology Department of the Chinese People's Liberation Army General Hospital from January 2013 to December 2014 and assigned to one of three groups based on diagnosis: atypical ON, typical ON and neuromyelitis optica spectrum disorder (NMOSD)-ON...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28402976/apelin-13-protects-against-ischemic-blood-brain-barrier-damage-through-the-effects-of-aquaporin-4
#6
Heling Chu, Xiaobo Yang, Chuyi Huang, Zidan Gao, Yuping Tang, Qiang Dong
BACKGROUND: Apelin-13 has been found to have protective effects on many neurological diseases, including cerebral ischemia. However, whether Apelin-13 acts on blood-brain barrier (BBB) disruption following cerebral ischemia is largely unknown. Aquaporin-4 (AQP4) has a close link with BBB due to the high concentration in astrocyte foot processes and regulation of astrocytes function. Here, we aimed to test Apelin-13's effects on ischemic BBB injury and examine whether the effects were dependent on AQP4...
April 13, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28400553/efficacy-and-safety-of-tacrolimus-treatment-for-neuromyelitis-optica-spectrum-disorder
#7
Bo Chen, Qian Wu, Gaotan Ke, Bitao Bu
Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease that mainly involves the optic nerves and spinal cord, causing blindness and paralysis. Although some immunosuppressants such as rituximab and azathioprine have proven to be effective in relapse prevention, the high costs or intolerable adverse events preclude their wide application. Thus, we have conducted a retrospective study in 25 NMOSD patients who were treated with tacrolimus, an immunosuppressant with high efficacy and good tolerance in other autoimmune diseases, to assess its efficacy and safety in NMOSD treatment during the last five years (2011-2016)...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399644/effects-of-gonadectomy-and-testosterone-treatment-on-aquaporin-expression-in-the-kidney-of-normotensive-and-hypertensive-rats
#8
Su Yi Loh, Nelli Giribabu, Naguib Salleh
We tested the hypothesis that testosterone-induced increase in blood pressure was due to changes in aquaporin (AQP) expression in kidneys. In this study, expression level of kidney AQPs was investigated under testosterone influence. Adult normotensive Wistar Kyoto (WKY) and hypertensive SHR male and female rats underwent gonadectomy. For female rats, testosterone was given for six weeks duration, two weeks following ovariectomy via subcutaneous silastic implant. Mean arterial pressure (MAP) was measured in all the rats after eight weeks via carotid artery cannulation and the rats were then sacrificed and kidneys were harvested for analyses of AQP-1, 2, 3, 4, 6, and 7 mRNA and protein expressions by quantitative real-time PCR and Western blotting, respectively...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28390076/sugar-and-hexokinase-suppress-expression-of-pip-aquaporins-and-reduce-leaf-hydraulics-that-preserves-leaf-water-potential
#9
Gilor Kelly, Nir Sade, Adi Doron-Faigenboim, Stephen Lerner, Arava Shatil-Cohen, Yelena Yeselson, Aiman Egbaria, Jayaram Kottapalli, Arthur A Schaffer, Menachem Moshelion, David Granot
Sugars affect central aspects of plant physiology, including photosynthesis, stomatal behavior and the loss of water through the stomata. Yet, the potential effects of sugars on plant aquaporins (AQPs) and water conductance have not been examined. We used database and transcriptional analyses, as well as cellular and whole-plant functional techniques to examine the link between sugar-related genes and AQPs. Database analyses revealed a high level of correlation between the expression of AQPs and that of sugar-related genes, including the Arabidopsis hexokinases 1 (AtHXK1)...
April 8, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28384265/growth-deficits-in-cystic-fibrosis-mice-begin-in-utero-prior-to-igf-1-reduction
#10
Rebecca Darrah, Ilya Bederman, Megan Vitko, Dana M Valerio, Mitchell L Drumm, Craig A Hodges
Growth deficits are common in cystic fibrosis (CF), but their cause is complex, with contributions from exocrine pancreatic insufficiency, pulmonary complications, gastrointestinal obstructions, and endocrine abnormalities. The CF mouse model displays similar growth impairment despite exocrine pancreatic function and in the absence of chronic pulmonary infection. The high incidence of intestinal obstruction in the CF mouse has been suggested to significantly contribute to the observed growth deficits. Previous studies by our group have shown that restoration of the cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium prevents intestinal obstruction but does not improve growth...
2017: PloS One
https://www.readbyqxmd.com/read/28382320/female-hormonal-exposures-and-neuromyelitis-optica-symptom-onset-in-a-multicenter-study
#11
Riley Bove, Liene Elsone, Enrique Alvarez, Nadja Borisow, Melissa M Cortez, Farrah J Mateen, Maureen A Mealy, Kerry Mutch, Sean Tobyne, Klemens Ruprecht, Guy Buckle, Michael Levy, Dean M Wingerchuk, Friedemann Paul, Anne H Cross, Brian Weinshenker, Anu Jacob, Eric C Klawiter, Tanuja Chitnis
OBJECTIVE: To study the association between hormonal exposures and disease onset in a cohort of women with neuromyelitis optica spectrum disorder (NMOSD). METHODS: Reproductive history and hormone use were assessed using a standardized reproductive survey administered to women with NMOSD (82% aquaporin-4 antibody positive) at 8 clinical centers. Using multivariable regression, we examined the association between reproductive exposures and age at first symptom onset (FS)...
May 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28380032/molecular-cloning-and-expression-analysis-of-the-aqp1aa-gene-in-half-smooth-tongue-sole-cynoglossus-semilaevis
#12
Hua Guo, Min Wei, Yang Liu, Ying Zhu, Wenteng Xu, Liang Meng, Na Wang, Changwei Shao, Sheng Lu, Fengtao Gao, Zhongkai Cui, Zhanfei Wei, Fazhen Zhao, Songlin Chen
Aquaporin 1 (AQP1) is a member of the transmembrane water channel family of proteins with special structural features, and two AQP1 paralogous genes (aqp1aa and aqp1ab) are reported in teleosts. In the present study, the aqp1aa gene of half-smooth tongue sole (Cynoglossus semilaevis) was cloned and characterized. The full-length cDNA of aqp1aa is 1411 bp with a 786 bp open reading frame encoding a 261-amino acid putative protein with a characteristic structure consisting of 6 membrane-spanning α-helical domains and two highly conserved asparagine-proline-alanine motifs...
2017: PloS One
https://www.readbyqxmd.com/read/28376076/effects-of-growth-hormone-treatment-on-growth-plate-bone-and-mineral-metabolism-of-young-rats-with-uremia-induced-by-adenine
#13
Débora Claramunt, Helena Gil-Peña, Rocío Fuente, Enrique García-López, Olaya Hernández Frías, Flor A Ordoñez, Julián Rodríguez-Suárez, Fernando Santos
BACKGROUND: In a model of growth retardation secondary to chronic kidney disease (CKD) induced by adenine, this study explores the effects of growth hormone (GH) therapy on growth plate and mineral metabolism. METHODS: Weaning female rats receiving 0.5% adenine diet during 21 days, untreated (AD) or treated with GH (ADGH) for one-week, were compared with control rats receiving normal diet, either ad libitum or pair-fed with AD animals. AD and ADGH rats had similarly elevated serum concentrations of urea nitrogen, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23)...
April 4, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28370569/aquaporin-9-is-expressed-in-the-epididymis-of-immature-and-mature-pigs
#14
B C Schimming, Cae Baumam, Pff Pinheiro, R de Matteis, R F Domeniconi
Aquaporins (AQPs) are channel proteins that facilitate the transepithelial and bidirectional movement of water. AQP9 is an aquaporin that is expressed in the mammalian epididymis. This water transport contributes to epididymal sperm concentration. This study aimed to examine the morphology of epididymal epithelium in piglets and boars, as well as the expression and immunolocalization of AQP9. The piglets presented an epididymal epithelium in differentiation with principal, basal and apical cells. The cellular population of the epididymal epithelium in boars consisted of principal, basal, apical, clear and narrow cells...
March 30, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28365776/deletion-of-aquaporin-4-curtails-extracellular-glutamate-elevation-in-cortical-spreading-depression-in-awake-mice
#15
Rune Enger, Didrik B Dukefoss, Wannan Tang, Klas H Pettersen, Daniel M Bjørnstad, P Johannes Helm, Vidar Jensen, Rolf Sprengel, Koen Vervaeke, Ole P Ottersen, Erlend A Nagelhus
Cortical spreading depression (CSD) is a phenomenon that challenges the homeostatic mechanisms on which normal brain function so critically depends. Analyzing the sequence of events in CSD holds the potential of providing new insight in the physiological processes underlying normal brain function as well as the pathophysiology of neurological conditions characterized by ionic dyshomeostasis. Here, we have studied the sequential progression of CSD in awake wild-type mice and in mice lacking aquaporin-4 (AQP4) or inositol 1,4,5-triphosphate type 2 receptor (IP3R2)...
January 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28348600/delivery-of-bone-marrow-derived-mesenchymal-stem-cells-improves-tear-production-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#16
Hema S Aluri, Mahta Samizadeh, Maria C Edman, Dillon R Hawley, Helene L Armaos, Srikanth R Janga, Zhen Meng, Victor G Sendra, Pedram Hamrah, Claire L Kublin, Sarah F Hamm-Alvarez, Driss Zoukhri
The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of sterile phosphate buffered saline (PBS, control) or murine BD-MSCs (1 × 10(6) cells). Tears production was measured at baseline and once a week after treatment using phenol red impregnated threads...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28344346/choroid-plexus-aquaporin-1-and-intracranial-pressure-are-increased-in-obese-rats-towards-an-idiopathic-intracranial-hypertension-model
#17
M Uldall, D K Bhatt, C Kruuse, M Juhler, I Jansen-Olesen, R Jensen
BACKGROUND/OBJECTIVES: Idiopathic intracranial hypertension (IIH) is a condition of increased intracranial pressure (ICP) without identifiable cause. The majority of IIH patients are obese, which suggests a connection between ICP and obesity. The aim of the study was to compare ICP in lean and obese rats. We also aimed to clarify if any ICP difference could be attributed to changes in some well-known ICP modulators; retinol and arterial partial pressure of CO2 (pCO2). Another potential explanation could be differences in water transport across the choroid plexus (CP) epithelia, and thus we furthermore investigated expression profiles of aquaporin 1 and Na/K ATPase...
March 27, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28344130/aquaporin-3-deletion-in-mice-results-in-renal-collecting-duct-abnormalities-and-worsens-ischemia-reperfusion-injury
#18
Lei Lei, Weiling Wang, Yingli Jia, Limin Su, Hong Zhou, Alan S Verkman, Baoxue Yang
Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. Here, we report that AQP3 deletion in mice affects renal function and modulates renal injury. We found collecting duct hyperplasia and cell swelling in kidneys of adult AQP3 null mice. After mild renal ischemia-reperfusion (IR), AQP3 null mice had significantly greater blood urea nitrogen (57mg/dl) and creatinine (136μM) than wild-type mice (35mg/dl and 48μM, respectively), and showed renal morphological changes, including tubular dilatation, erythrocyte diapedesis and collecting duct incompletion...
March 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28341892/aquaporin-4-forms-a-macromolecular-complex-with-glutamate-transporter-1-and-mu-opioid-receptor-in-astrocytes-and-participates-in-morphine-dependence
#19
Hui Wang, Shiqi Wang, Kang Zhang, Hua Wang, Liting Lan, Xiaoyun Ma, Xiaoyan Liu, Shuzhuo Zhang, Jianquan Zheng, Xiaoli Wei, Haitao Yan
The water channel aquaporin 4 (AQP4) is abundantly expressed in astrocytes and provides a mechanism by which water permeability of the plasma membrane can be regulated. Evidence suggests that AQP4 is associated with glutamate transporter-1 (GLT-1) for glutamate clearance and contributes to morphine dependence. Previous studies show that AQP4 deficiency changed the mu opioid receptor expression and opioid receptors' characteristics as well. In this study, we focused on whether AQP4 could form macromolecular complex with GLT-1 and mu opioid receptor (MOR) and participates in morphine dependence...
March 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28341573/quercetin-alters-uterine-fluid-volume-and-aquaporin-aqp-subunits-aqp-1-2-5-7-expression-in-the-uterus-in-the-presence-of-sex-steroids-in-rats
#20
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Sekaran Muniandy, Normadiah M Kassim, Naguib Salleh
Effects of quercetin on uterine fluid volume and aquaporin (AQP) expression in the uterus were investigated. Estradiol (E) or estradiol followed by progesterone (E+P) were given to ovariectomised rats with or without quercetin (10, 50 or 100mg/kg/day) treatment. Uteri were harvested and its inner/outer circumference ratio was determined. AQP-1, 2, 5 and 7 mRNA and protein levels in uterus were quantified by Real-time PCR and Western blotting respectively. Protein distribution was observed by immunohistochemistry...
March 22, 2017: Reproductive Toxicology
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