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https://www.readbyqxmd.com/read/29144450/corrigendum-high-throughput-discovery-of-novel-developmental-phenotypes
#1
Mary E Dickinson, Ann M Flenniken, Xiao Ji, Lydia Teboul, Michael D Wong, Jacqueline K White, Terrence F Meehan, Wolfgang J Weninger, Henrik Westerberg, Hibret Adissu, Candice N Baker, Lynette Bower, James M Brown, L Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J Daly, James M Denegre, Brendan Doe, Mary E Dolan, Sarah M Edie Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R Horner, Chih-Wei Hsu, Sara J Johnson, Sowmya Kalaga, Lance C Keith, Louise Lanoue, Thomas N Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L McElwee, Susan Newbigging Lauryl M J Nutter, Kevin A Peterson, Ramiro Ramirez-Solis, Douglas J Rowland, Edward Ryder, Kaitlin E Samocha, John R Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B West, Leeyean Wong, Atsushi Yoshiki, Wolfgang Wurst, Daniel G MacArthur, Glauco P Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C Skarnes, Monica J Justice, Helen E Parkinson, Mark Moore, Sara Wells, Robert E Braun, Karen L Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R Mark Henkelman, Steve D M Brown, David J Adams, K C Kent Lloyd, Colin McKerlie, Arthur L Beaudet, Maja Bućan Stephen A Murray
This corrects the article DOI: 10.1038/nature19356.
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29139002/deinococcus-multiflagellatus-sp-nov-isolated-from-a-car-air-conditioning-system
#2
Dong-Uk Kim, Hyosun Lee, Suyeon Lee, Sooyeon Park, Jung-Hoon Yoon, Lei Zhao, Min-Kyu Kim, Jae-Hyung Ahn, Jong-Ok Ka
A gamma radiation-resistant and pink-to-red pigmented bacterial strain, designated ID1504(T), was isolated from a car air-conditioning system sampled in Korea. The cells were observed to be Gram-stain negative, aerobic, motile with peritrichous flagella and short rod-shaped. Phylogenetically, the strain groups with the members of the genus Deinococcus and exhibits high 16S rRNA gene sequence similarities with Deinococcus arenae SA1(T) (94.0%), Deinococcus actinosclerus BM2(T) (93.9%) and Deinococcus soli N5(T) (93...
November 14, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29137400/downregulation-of-the-sonic-hedgehog-gli-pathway-transcriptional-target-neogenin-1-is-associated-with-basal-cell-carcinoma-aggressiveness
#3
Bárbara S Casas, Christelle Adolphe, Pablo Lois, Nelson Navarrete, Natalia Solís, Eva Bustamante, Patricio Gac, Patricio Cabané, Ivan Gallegos, Brandon J Wainwright, Verónica Palma
Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive than others, although the molecular basis of this phenomenon remains unknown. We have previously reported that Neogenin-1 (NEO1) is a downstream target gene of the SHH/GLI pathway in neural tissue. Given that SHH participates in epidermal homeostasis, here we analyzed the epidermal expression of NEO1 in order to identify whether it plays a role in adult epidermis or BCC...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133884/epha2-is-an-epithelial-cell-pattern-recognition-receptor-for-fungal-%C3%AE-glucans
#4
Marc Swidergall, Norma V Solis, Michail S Lionakis, Scott G Filler
Oral epithelial cells discriminate between pathogenic and non-pathogenic stimuli, and only induce an inflammatory response when they are exposed to high levels of a potentially harmful microorganism. The pattern recognition receptors (PRRs) in epithelial cells that mediate this differential response are poorly understood. Here, we demonstrate that the ephrin type-A receptor 2 (EphA2) is an oral epithelial cell PRR that binds to exposed β-glucans on the surface of the fungal pathogen Candida albicans. Binding of C...
November 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29132915/human-recombinant-erythropoietin-reduces-sensorimotor-dysfunction-and-cognitive-impairment-in-rat-models-of-chronic-kidney-disease
#5
E E Reza-Zaldívar, S Sandoval-Avila, Y K Gutiérrez-Mercado, E Vázquez-Méndez, A A Canales-Aguirre, H Esquivel-Solís, U Gómez-Pinedo, A L Márquez-Aguirre
INTRODUCTION: Chronic kidney disease (CKD) can cause anaemia and neurological disorders. Recombinant human erythropoietin (rHuEPO) is used to manage anaemia in CKD. However, there is little evidence on the effects of rHuEPO on behaviour and cognitive function in CKD. This study aimed to evaluate the impact of rHuEPO in sensorimotor and cognitive functions in a CKD model. METHODS: Male Wistar rats were randomly assigned to 4 groups: control and CKD, with and without rHuEPO treatment (1050 IU per kg body weight, once weekly for 4 weeks)...
November 10, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29132653/prefrontal-and-striatal-gamma-aminobutyric-acid%C3%A2-levels-and-the-effect-of-antipsychotic-treatment-in-first-episode-psychosis-patients
#6
Camilo de la Fuente-Sandoval, Francisco Reyes-Madrigal, Xiangling Mao, Pablo León-Ortiz, Oscar Rodríguez-Mayoral, Helgi Jung-Cook, Rodolfo Solís-Vivanco, Ariel Graff-Guerrero, Dikoma C Shungu
BACKGROUND: Abnormally elevated levels of gamma-aminobutyric acid (GABA) in the medial prefrontal cortex (mPFC) have been reported in antipsychotic-free patients with schizophrenia. Whether such GABA elevations are also present in other brain regions and persist after antipsychotic treatment has not been previously investigated. METHODS: Twenty-eight antipsychotic-naïve patients with first-episode psychosis (FEP) and 18 healthy control subjects completed the study...
October 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29125459/pseudogracilibacillus-endophyticus-sp-nov-a-moderately-thermophilic-and-halophilic-species-isolated-from-plant-root
#7
Jisun Park, Min-Kyeong Kim, Bo-Ram Yun, Ji-Hye Han, Seung Bum Kim
A Gram-stain-positive strain, designated DT7-02(T), was isolated from the surface-sterilized root of Oenotherabiennis (evening primrose) and subjected to taxonomic characterization. Cells of DT7-02(T) were slender rod-shaped, motile by means of flagella, and oxidase- and catalase-positive. The colonies were circular, pinkish-yellow, opaque, glistering and 1-2 mm in diameter. The strain was moderately thermophilic and halophilic, as growth occurred at 20-44 °C (optimum 40 °C), pH 7-10 (optimum pH 8-9) and in the presence of 0-8 % of NaCl (optimum 4 %) in tryptic soy broth...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29123202/potential-damaging-mutation-in-lrp5-from-genome-sequencing-of-the-first-reported-chimpanzee-with-the-chiari-malformation
#8
Manuel Solis-Moruno, Marc de Manuel, Jessica Hernandez-Rodriguez, Claudia Fontsere, Alba Gomara-Castaño, Cristina Valsera-Naranjo, Dietmar Crailsheim, Arcadi Navarro, Miquel Llorente, Laura Riera, Olga Feliu-Olleta, Tomas Marques-Bonet
The genus Pan is the closest related to humans (Homo sapiens) and it includes two species: Pan troglodytes (chimpanzees) and Pan paniscus (bonobos). Different characteristics, some of biomedical aspect, separate them from us. For instance, some common human medical conditions are rare in chimpanzees (menopause, Alzheimer disease) although it is unclear to which extent longevity plays an active role in these differences. However, both humans and chimpanzees present similar pathologies, thus, understanding traits in chimpanzees can help unravel the molecular basis of human conditions...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117213/effect-of-microalgae-on-intestinal-inflammation-triggered-by-soybean-meal-and-bacterial-infection-in-zebrafish
#9
Karina Bravo-Tello, Nicole Ehrenfeld, Camila J Solís, Pilar E Ulloa, Manuel Hedrera, Marjorie Pizarro-Guajardo, Daniel Paredes-Sabja, Carmen G Feijóo
Soybean meal has been used in many commercial diets for farm fish; despite this component inducing intestinal inflammation. On the other hand, microalgae have increasingly been used as dietary supplements in fish feed. Nevertheless, the vast quantity of microalgae species means that many remain under- or unstudied, thus limiting wide scale commercial application. In this work, we evaluated the effects to zebrafish (Danio rerio) of including Tetraselmis sp (Ts); Phaeodactylum tricornutum (Pt); Chlorella sp (Ch); Nannochloropsis oculata (No); or Nannochloropsis gaditana (Ng) as additives in a soybean meal-based diet on intestinal inflammation and survival after Edwardsiella tarda infection...
2017: PloS One
https://www.readbyqxmd.com/read/29112532/speech-in-noise-perception-as-a-marker-of-cognitive-impairment-in-hiv-infection
#10
Yi Zhan, Abigail M Fellows, Tangkai Qi, Odile H Clavier, Sigfrid D Soli, Xiudong Shi, Jiang Gui, Yuxin Shi, Jay C Buckey
OBJECTIVES: Human immunodeficiency virus positive (HIV+) individuals report hearing difficulties, but standard audiological tests show no, or small, changes in peripheral hearing ability. The hearing complaints may reflect central nervous system (CNS) auditory processing deficits, rather than middle or inner ear problems, and may result from CNS damage due to HIV infection or treatment. If central auditory task performance and cognitive deficits in HIV+ individuals are shown to be related, then central auditory tests might serve as a "window" into CNS function in these patients...
November 4, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29111065/complexes-between-methyltestosterone-and-%C3%AE-cyclodextrin-for-application-in-aquaculture-production
#11
Lucas Bragança de Carvalho, Kepa Koldo Burusco, Carlos Jaime, Tiago Venâncio, Aline Ferreira Souza de Carvalho, Luis David Solis Murgas, Luciana de Matos Alves Pinto
The inclusion complexes between 17-α-methyltestosterone (MT) and β-cyclodextrin (bCD) were prepared and characterized in dissolution and solid phase. The complex promoted a sixfold increment in solubility of the hormone. It has a limited solubility and stoichiometry of 2:1 (bCD:MT) determined by DSC, NMR and solubility experiments, the association constant Ka=2846Lmol(-1) and complex fraction of 76% (assessed by DOSY-NMR, in (1:3) DMSO/D2O). The association constant obtained in water by the solubility isotherms is 7540Lmol(-1)...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29108780/-bayes-syndrome-in-cardiac-surgery-prevalence-of-interatrial-block-in-patients-younger-than-65-years-undergoing-cardiac-surgery-and-association-with-postoperative-atrial-fibrillation
#12
Eusebio García-Izquierdo Jaén, Pablo Cobo Rodríguez, Luis Solís Solís, Chinh Pham Trung, Diego Jiménez Sánchez, Manuel Sánchez García, Victor Castro Urda, Jorge Toquero Ramos, Ignacio Fernández Lozano
OBJECTIVE: Interatrial block (IAB) is a well-known entity that is associated with an increased risk of atrial fibrillation (AF). This association is called Bayes' syndrome. The aim of our study was to define the prevalence of IAB among patients younger than 65 years undergoing cardiac surgery and determine whether there is an association between the presence of interatrial conduction delay and postoperative atrial fibrillation (POAF). METHOD: A total of 207 patients were enrolled...
November 3, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29107723/results-of-a-policy-of-fast-tapering-of-steroids-after-resection-surgery-in-glioblastoma
#13
Ricardo Díez Valle, Victoria Becerra Castro, Miguel Marigil Sánchez, Jaime Gállego Pérez de Larraya, Jorge M Núñez-Córdoba, Sonia Tejada Solis
BACKGROUND: Corticosteroids are routinely used to treat brain tumors. While steroids have an immediate clinical benefit, their use can lead to a number of relevant complications, and a negative association with overall survival (OS) has been shown in glioblastoma (GBM) patients. There is no evidence in the literature regarding the ideal dose. We assessed the use of steroids in patients with GBM after resection surgery. METHODS: This is a cohort study of 131 newly diagnosed GBM patients that underwent tumor resection surgery...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106621/high-day-and-night-time-temperatures-affect-grain-growth-dynamics-in-contrasting-rice-genotypes
#14
Wanju Shi, Xinyou Yin, Paul C Struik, Celymar Solis, Fangming Xie, Ralf C Schmidt, Min Huang, Yingbin Zou, Changrong Ye, S V Krishna Jagadish
Rice grain yield and quality are predicted to be highly vulnerable to global warming. Five genotypes including heat-tolerant and susceptible checks, a heat-tolerant near-isogenic line and two hybrids were exposed to control (31 °C/23 °C, day/night), high night-time temperature (HNT; 31 °C/30 °C), high day-time temperature (HDT; 38 °C/23 °C) and high day- and night-time temperature (HNDT; 38 °C/30 °C) treatments for 20 consecutive days during the grain-filling stage. Grain-filling dynamics, starch metabolism enzymes, temporal starch accumulation patterns and the process of chalk formation were quantified...
November 2, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29104134/bifurcations-and-limit-cycles-in-cystosolic-yeast-calcium
#15
Guihong Fan, Rosalind Huff, Jennifer Muir, Zinayida Nektalova, Jane Kruchowsky, Jennifer L Kepler, Haiyan Wang, Pamela A Marshall, Francisco J Solis
Calcium homeostasis is a fundamental cellular process in yeast. The regulation of the cytosolic calcium concentration is required for volume preservation and to regulate many vital calcium dependent processes such as mating and response to stress. The homeostatic mechanism is often studied by applying calcium pulses: sharply changing the calcium concentration in the yeast environment and observing the cellular response. To address these experimental investigations, several mathematical models have been proposed to describe this response...
November 2, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29103289/effect-of-condensed-tannins-from-leucaena-leucocephala-on-rumen-fermentation-methane-production-and-population-of-rumen-protozoa-in-heifers-fed-low-quality-forage
#16
Angel Trinidad Piñeiro-Vázquez, Jorge Rodolfo Canul-Solis, Guillermo Jiménez-Ferrer, José Armando Alayón-Gamboa, Alfonso Juventino Chay-Canul, Armin Javier Ayala-Burgos, Carlos Fernando Aguilar-Pérez, Juan Carlos Ku-Vera
Objective: The aim of the experiment was to assess the effect of increasing amounts of Leucaena leucocephala forage on dry matter intake (DMI), organic matter intake (OMI), enteric methane production, rumen fermentation pattern and protozoa population in cattle fed Pennisetum purpureum and housed in respiration chambers. Methods: Five crossbred heifers (Bos taurus × Bos indicus) (BW: 295±6 kg) were fed chopped P. purpureum grass and increasing levels of L. leucocephala (0, 20, 40, 60 and 80% of DM) in a 5 × 5 Latin square design...
November 3, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29095015/-impact-of-pasteurization-freeze-drying-on-available-immunoglobulin-content-of-the-mature-human-milk-use-in-human-milk-banking-of-hospitals
#17
Jorge Castro Albarrán, Rosa Elena Navarro Hernández, Josué R Solís Pacheco, Itza Carmina Salazar Quiñones, Griselda G Macías López, Juan Carlos Barrera de León, Blanca Rosa Aguilar Uscanga
INTRODUCTION: This study analyzes the effect on the content of immunoglobulins and C3 complement of freeze drying after pasteurization by three different methods in mature human milk (MHM). OBJECTIVE: Freeze drying is proposed as a complementary method for the maintenance of MHM therapeutic properties with greater validity. METHODS: This was a descriptive study in which MHM samples were obtained. Next, aliquots of the samples obtained were pasteurized by three methods: 62...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29095004/-evaluation-of-the-nutritional-status-of-children-under-5-years-of-age-concordance-between-anthropometric-indices-in-the-indigenous-population-of-chiapas-mexico
#18
Héctor Ochoa-Díaz López, Esmeralda García-Parra, Elena Flores-Guillén, Rosario García-Miranda, Roberto Solís-Hernández
INTRODUCTION: Nutritional status is determined through various methods, including anthropometry. In children under 5 years of age indeces as weight/age (w/a), height/age (h/a), weight/height (w/h) and body mass index (BMI) are used. The purpose of this article is to analyze and compare the ability of different anthropometric indeces to identify children from marginalized communities in Chiapas (Mexico) with nutritional problems. OBJECTIVE: To analyze the correlation among the different anthropometric indeces to determine the nutritional status of children under 5 years of age in poor rural areas with a background of short stature...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29093765/text-based-vocabulary-intervention-training-study-supporting-fourth-graders-with-low-reading-comprehension-and-learning-disabilities
#19
Michael Solís, Nancy Scammacca, Amy E Barth, Garrett J Roberts
This experimental study examined the effectiveness of a text-based reading and vocabulary intervention with self-regulatory supports for 4(th) graders with low reading comprehension. Students with standard scores on the Gates MacGinitie Reading Test between 1.0 standard deviation (SD) and 0.5 SD below the normative sample were included (N=44) and randomly assigned to treatment condition (n=25) or no treatment comparison condition (n=19). Researchers provided the intervention to students in groups of approximately 2-3 students for eight 30 minute sessions...
2017: Learning Disabilities
https://www.readbyqxmd.com/read/29083403/an-objective-comparison-of-cell-tracking-algorithms
#20
Vladimír Ulman, Martin Maška, Klas E G Magnusson, Olaf Ronneberger, Carsten Haubold, Nathalie Harder, Pavel Matula, Petr Matula, David Svoboda, Miroslav Radojevic, Ihor Smal, Karl Rohr, Joakim Jaldén, Helen M Blau, Oleh Dzyubachyk, Boudewijn Lelieveldt, Pengdong Xiao, Yuexiang Li, Siu-Yeung Cho, Alexandre C Dufour, Jean-Christophe Olivo-Marin, Constantino C Reyes-Aldasoro, Jose A Solis-Lemus, Robert Bensch, Thomas Brox, Johannes Stegmaier, Ralf Mikut, Steffen Wolf, Fred A Hamprecht, Tiago Esteves, Pedro Quelhas, Ömer Demirel, Lars Malmström, Florian Jug, Pavel Tomancak, Erik Meijering, Arrate Muñoz-Barrutia, Michal Kozubek, Carlos Ortiz-de-Solorzano
We present a combined report on the results of three editions of the Cell Tracking Challenge, an ongoing initiative aimed at promoting the development and objective evaluation of cell segmentation and tracking algorithms. With 21 participating algorithms and a data repository consisting of 13 data sets from various microscopy modalities, the challenge displays today's state-of-the-art methodology in the field. We analyzed the challenge results using performance measures for segmentation and tracking that rank all participating methods...
October 30, 2017: Nature Methods
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