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Aspartic acid

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https://www.readbyqxmd.com/read/28804438/green-tea-extract-induces-genes-related-to-browning-of-white-adipose-tissue-and-limits-weight-gain-in-high-energy-diet-fed-rat
#1
Li-Han Chen, Yi-Wen Chien, Chung-Tiang Liang, Ching-Hung Chan, Meng-Han Fan, Hui-Yu Huang
Background: A wealth of research has reported on the anti-obesity effects of green tea extract (GTE). Although browning of white adipose tissue (WAT) has been reported to attenuate obesity, no study has disclosed the effects of GTE on browning in Sprague Dawley rats. Objectives: The aims of the study were to investigate the effects of GTE on anti-obesity and browning, and their underlying mechanisms. Methods: Four groups of rats (n=10/group) were used including a normal diet with vehicle treatment, and a high-energy diet (HED) with vehicle or GTE by oral gavage at 77...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28803469/chiral-ceramic-nanoparticles-of-tungsten-oxide-and-peptide-catalysis
#2
Shuang Jiang, Mahshid Chekini, Zhi-Bei Qu, Yichun Wang, Aydan Yeltik, Yuangang Liu, Alex Kotlyar, Tianyong Zhang, Bin Li, Hilmi Volkan Demir, Nicholas A Kotov
The chirality of nanoparticles (NPs) and their assemblies has been investigated predominantly for noble metals and II-VI semiconductors. However, ceramic NPs represent the majority of nanoscale materials in Nature. The robustness and other innate properties of ceramics offer technological opportunities in catalysis, biomedical sciences, and optics. Here we report the preparation of chiral ceramic NPs, as represented by tungsten oxide hydrate, WO3-x·H2O, dispersed in ethanol. The chirality of the metal oxide core, with an average size of ca 1...
August 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28802889/ameliorative-effect-of-propolis-supplementation-in-alleviating-bisphenol-a-toxicity-growth-performance-biochemical-variables-and-oxidative-stress-biomarkers-of-nile-tilapia-oreochromis-niloticus-l-fingerlings
#3
Heba S Hamed, Mohsen Abdel-Tawwab
Bisphenol-A (BPA) is one of the important pollutants in aquatic ecosystems and its detrimental effects on fish have a great concern. Propolis is a natural immune-stimulant that has various biological and pharmacological activities. Thus, its capability to alleviate the toxic effect of BPA on Nile tilapia, Oreochromis niloticus (L.) was assessed in a study based on a 2 × 2 factorial design with two levels of ethanolic extract of propolis (EEP) and two waterborne BPA concentrations in triplicates. Fish (33.9 ± 0...
August 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28801966/ursolic-acid-a-natural-nutraceutical-agent-targets-caspase3-and-alleviates-inflammation-associated-downstream-signal-transduction
#4
Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou, Gang Bai
SCOPE: Ursolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal transduction processes linked to the anti-inflammation pathway have not been thoroughly elucidated to date. METHODS AND RESULTS: Chemical biology strategies such as target fishing, click reaction synthesis of a UA probe and molecular imaging were used to identify potential target proteins of UA...
August 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28801775/plasticizers-and-bisphenol-a-in-packaged-foods-sold-in-the-tunisian-markets-study-of-their-acute-in-vivo-toxicity-and-their-environmental-fate
#5
Asma Beltifa, Anouar Feriani, Monia Machreki, Asma Ghorbel, Lakhdar Ghazouani, Giuseppa Di Bella, Joris Van Loco, Tim Reyns, Hedi Ben Mansour
Today, processed and packaged foods are considered as among the major sources of human exposure to plasticizers and bisphenol which migrate from plastic packing. In the present study, a wide range of food products sold on the Tunisian market such as grain and grain products, milk and dairy products, fats and oil, drink, fish, and sweets have been analyzed firstly in order to identify the presence of phthalates and bisphenol. Then, the identified chemical molecules were studied for their environmental fate and tested in vivo for its toxicity in mice models...
August 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28801651/discovery-of-novel-highly-active-and-stable-aspartate-dehydrogenases
#6
Hao Li, Taicheng Zhu, Liangtian Miao, Dan Zhang, Yongxian Li, Qi Li, Yin Li
Aspartate family amino acids (AFAAs) have important commercial values due to their wide spectrum of applications. Most if not all AFAAs are produced under aerobic conditions which is energy-intensive. To establish a cost-effective anaerobic process for production of AFAAs, it holds great promise to develop a new pathway enabling the conversion of oxoloacetate into aspartate through direct amination which is catalyzed by aspartate dehydrogenase (AspDH). Compared with the well studied aspartate aminotransferase and aspartate ammonia-lyase, only a few AspDHs are characterized till date, and failure to reproduce the high activity of AspDH from Rastonia eutropha documented in the literature encouraged us to screen and characterize novel AspDHs from different origins...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800423/relationship-of-executive-functioning-deficits-to-n-acetyl-aspartate-naa-and-gamma-aminobutyric-acid-gaba-in-youth-with-bipolar-disorder
#7
Rebekah S Huber, Douglas G Kondo, Xian-Feng Shi, Andrew P Prescot, Elaine Clark, Perry F Renshaw, Deborah A Yurgelun-Todd
BACKGROUND: Although cognitive deficits in bipolar disorder (BD) have been repeatedly observed, our understanding of these impairments at a mechanistic level remains limited. Few studies that investigated cognitive impairments in bipolar illness have examined the association with brain biochemistry. This pilot study utilized proton magnetic resonance spectroscopy ((1)H-MRS) to evaluate the relationship between neurocognitive performance and brain metabolites in youth with BD. METHODS: Thirty participants, twenty depressed BD participants and ten healthy comparison participants, ages 13-21, completed mood and executive function measures...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28797105/regulation-of-hepatic-stellate-cell-proliferation-and-activation-by-glutamine-metabolism
#8
Jiang Li, Mohammed Ghazwani, Ke Liu, Yixian Huang, Na Chang, Jie Fan, Fengtian He, Liying Li, Shizhong Bu, Wen Xie, Xiaochao Ma, Song Li
Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs). The mechanisms of activation and proliferation of HSCs, two key events after liver damage, have been studied for many years. Here we report a novel pathway to control HSCs by regulating glutamine metabolism. We demonstrated that the proliferation of HSCs is critically dependent on glutamine that is used to generate α-ketoglutarate (α-KG) and non-essential amino acid (NEAA)...
2017: PloS One
https://www.readbyqxmd.com/read/28797052/similarities-between-plant-traits-based-on-their-connection-to-underlying-gene-functions
#9
Jan-Peter Nap, Gabino F Sanchez-Perez, Aalt D J van Dijk
Understanding of phenotypes and their genetic basis is a major focus in current plant biology. Large amounts of phenotype data are being generated, both for macroscopic phenotypes such as size or yield, and for molecular phenotypes such as expression levels and metabolite levels. More insight in the underlying genetic and molecular mechanisms that influence phenotypes will enable a better understanding of how various phenotypes are related to each other. This will be a major step forward in understanding plant biology, with immediate value for plant breeding and academic plant research...
2017: PloS One
https://www.readbyqxmd.com/read/28796435/a-variant-of%C3%A2-hla-drb1-11-hla-drb1-11-143-discovered-in-a-chinese-hematopoietic-stem-cell-donor
#10
Xiao-Feng Li, Gui-Ji Li, Xu Zhang, Hua Fan, Jian-Ping Li
HLA-DRB1*11:143 has one nucleotide change from HLA-DRB1*11:01:01 where Aspartic Acid (70) is changed to Glycine.
August 10, 2017: HLA
https://www.readbyqxmd.com/read/28791525/substitution-with-a-single-cysteine-in-the-green-fluorescent-protein-based-calcium-indicator-gcamp3-enhances-calcium-sensitivity
#11
Tae Joon Kim, Ji Young Yoo, Won-Sik Shim
Genetically encoded calcium indicators (GECI) such as GCaMP3 are attracting significant attention as a good option for measuring intracellular calcium levels. Recently, a modified GCaMP3 called dCys-GCaMP3 was developed by replacing two threonine residues with cysteines. dCys-GCaMP3 proved to be a better calcium indicator, but it was not clear how and why the two cysteine residues were able to enhance the protein's calcium sensitivity. The aim of the present study was to investigate the possible roles of these cysteine residues in dCys-GCaMP3...
August 8, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28782925/adsorption-and-separation-of-aromatic-amino-acids-from-aqueous-solutions-using-metal-organic-frameworks
#12
Dries Jonckheere, Julian A Steele, Birgit Claes, Bart Bueken, Laurens Claes, Bert Lagrain, Maarten B J Roeffaers, Dirk E De Vos
Metal-organic frameworks (MOFs) are investigated for the adsorption of aromatic amino acids L-phenylalanine (L-Phe), L-tryptophan (L-Trp) and L-tyrosine (L-Tyr) from aqueous solutions. After screening a range of water-stable MOFs, the hydrophobic Zr-MOF MIL-140C emerged as the most performant material, exhibiting uptakes of 15 wt% for L-Trp and 20 wt% for L-Phe. These uptakes are 5 to 10 wt% higher than those of large-pore zeolites Beta and Y. Both single-compound and competitive adsorption isotherms for L-Phe and L-Trp were experimentally obtained at the natural pH of these amino acid mixtures without additional pH-modification (pH 6...
August 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28782772/green-tea-infusion-protects-against-alcoholic-liver-injury-by-attenuating-inflammation-and-regulating-the-pi3k-akt-enos-pathway-in-c57bl-6-mice
#13
Dongxu Wang, Qiang Gao, Taotao Wang, Guangshan Zhao, Frank Qian, Jinbao Huang, Haisong Wang, Xin Zhang, Yijun Wang
Alcohol intake is a major risk factor for the pathogenesis of alcoholic liver diseases. Accumulating evidence suggests that green tea protects against alcoholic liver injury; however, the underlying mechanisms remain unclear. The present study investigated the role of endothelial nitric oxide synthase (eNOS) in the protective effects of green tea against alcohol-induced liver injury and inflammation. Ethanol was intragastrically administered to male C57BL/6 mice once a day, and the mice were allowed free access to green tea infusion or water for two weeks...
August 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28780732/assessment-of-the-target-engagement-and-d-serine-biomarker-profiles-of-the-d-amino-acid-oxidase-inhibitors-sodium-benzoate-and-pgm030756
#14
Eimear Howley, Michael Bestwick, Rosa Fradley, Helen Harrison, Mathew Leveridge, Kengo Okada, Charlotte Fieldhouse, Will Farnaby, Hannah Canning, Andy P Sykes, Kevin Merchant, Katherine Hazel, Catrina Kerr, Natasha Kinsella, Louise Walsh, David G Livermore, Isaac Hoffman, Jonathan Ellery, Phillip Mitchell, Toshal Patel, Mark Carlton, Matt Barnes, David J Miller
Irregular N-methyl-D-aspartate receptor (NMDAR) function is one of the main hypotheses employed to facilitate understanding of the underlying disease state of schizophrenia. Although direct agonism of the NMDAR has not yielded promising therapeutics, advances have been made by modulating the NMDAR co-agonist site which is activated by glycine and D-serine. One approach to activate the co-agonist site is to increase synaptic D-serine levels through inhibition of D-amino acid oxidase (DAO), the major catabolic clearance pathway for this and other D-amino acids...
August 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28780693/foliar-application-of-aspartic-acid-lowers-cadmium-uptake-and-cd-induced-oxidative-stress-in-rice-under-cd-stress
#15
Muhammad Rizwan, Shafaqat Ali, Muhammad Zaheer Akbar, Muhammad Bilal Shakoor, Abid Mahmood, Wajid Ishaque, Afzal Hussain
Cadmium (Cd) contamination of farmland soils is a widespread problem around the globe, and rice (Oryza sativa L.) tends to accumulate more Cd and is considered as one of the major sources of Cd intake in humans, especially consuming rice-derived products. The current study investigated the effects of foliar applied aspartic acid (Asp) on growth parameters, biomass, chlorophyll concentration, gas exchange characteristics, Cd uptake, and antioxidative capacity in the shoots and roots of rice seedlings exposed to Cd stress...
August 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28776872/changes-in-some-blood-parameters-milk-composition-and-yield-of-buffaloes-bubalus-bubalis-during-the-transition-period
#16
Enrico Fiore, Sonia Giambelluca, Massimo Morgante, Barbara Contiero, Elisa Mazzotta, Domenico Vecchio, Irene Vazzana, Pasquale Rossi, Francesca Arfuso, Giuseppe Piccione, Matteo Gianesella
In this study changes in hematochemical parameters, milk composition and yield were investigated in buffaloes during the transition period. A total of 93 buffaloes 113.9 ± 8.03 months old and 535 ± 50 kg average body weight were used. Parity was recorded, blood samples were collected from 80 days pre-partum until 70 days post-partum; milk samples were collected from 5 days to 70 days post-partum. On serum samples, the values of non-esterified fatty acids, β-hydroxybutyrate, glucose, cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, urea, total proteins were evaluated...
August 4, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28776295/effects-of-pre-oxidation-and-adsorption-on-haloacetonitrile-and-trichloronitromethane-formation-during-subsequent-chlorination
#17
Zhigang Liu, Wei Chen, Hu Yu, Hui Tao, Hang Xu, Jingjing Yu, Yanmei Gu, Zhen Wan
In this study, the effects of pre-oxidants permanganate (PM), persulfate (PS), hydrogen peroxide (PO), and ozone (OZ)) and/or adsorption on pseudoboemite-chitosan shell magnetic nanoparticles (ACMNs) on haloacetonitrile (HAN) and trichloronitromethane (TCNM) formation from aspartic acid (Asp; positive charge) and/or histidine (His; negative charge) were compared. Asp and His apparently do not interact in aqueous solution during chlorination. Asp and/or His can undergo partially oxidation by PM, but are recalcitrant to direct oxidation by PS and PO...
August 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28773852/design-of-decorated-self-assembling-peptide-hydrogels-as-architecture-for-mesenchymal-stem-cells
#18
Annj Zamuner, Marta Cavo, Silvia Scaglione, Grazia Maria Lucia Messina, Teresa Russo, Antonio Gloria, Giovanni Marletta, Monica Dettin
Hydrogels from self-assembling ionic complementary peptides have been receiving a lot of interest from the scientific community as mimetic of the extracellular matrix that can offer three-dimensional supports for cell growth or can become vehicles for the delivery of stem cells, drugs or bioactive proteins. In order to develop a 3D "architecture" for mesenchymal stem cells, we propose the introduction in the hydrogel of conjugates obtained by chemoselective ligation between a ionic-complementary self-assembling peptide (called EAK) and three different bioactive molecules: an adhesive sequence with 4 Glycine-Arginine-Glycine-Aspartic Acid-Serine-Proline (GRGDSP) motifs per chain, an adhesive peptide mapped on h-Vitronectin and the growth factor Insulin-like Growth Factor-1 (IGF-1)...
August 26, 2016: Materials
https://www.readbyqxmd.com/read/28772717/rgdc-peptide-induced-biomimetic-calcium-phosphate-coating-formed-on-az31-magnesium-alloy
#19
Lin Cao, Lina Wang, Lingying Fan, Wenjun Xiao, Bingpeng Lin, Yimeng Xu, Jun Liang, Baocheng Cao
Magnesium alloys as biodegradable metal implants have received a lot of interest in biomedical applications. However, magnesium alloys have extremely high corrosion rates a in physiological environment, which have limited their application in the orthopedic field. In this study, calcium phosphate compounds (Ca-P) coating was prepared by arginine-glycine-aspartic acid-cysteine (RGDC) peptide-induced mineralization in 1.5 simulated body fluid (SBF) to improve the corrosion resistance and biocompatibility of the AZ31 magnesium alloys...
March 28, 2017: Materials
https://www.readbyqxmd.com/read/28770610/amino-acid-profiles-as-potential-biomarkers-for-pediatric-cancers-a-preliminary-communication
#20
Anna Synakiewicz, Malgorzata Sawicka-Zukowska, Natalia Adrianowska, Grazyna Galezowska, Joanna Ratajczyk, Anna Owczarzak, Lucyna Konieczna, Teresa Stachowicz-Stencel
AIM: Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS: Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors were enrolled in this study and compared with healthy children. Twenty-two plasma-free AAs were determined by HPLC with fluorometric detection. RESULTS: The results revealed significant decrease in glutamine levels for oncological patients and significant increase in aspartic acid, glutamic acid, asparagine, serine, citrulline, alanine, GABA, tryptophan, methionine, valine, phenylalanine and isoleucine levels in cancer children versus control...
August 3, 2017: Biomarkers in Medicine
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