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https://www.readbyqxmd.com/read/28928804/efficacy-of-a-leukotriene-receptor-antagonist-for-pediatric-cedar-pollen-allergy-complicated-by-asthma
#1
Shigemi Yoshihara, Yutaka Kikuchi, Mari Saitou, Susumu Yanagawa, Noriko Kanno, Hiroshi Igarashi, Hironobu Fukuda, Akiko Iimura, Toshio Abe, Yumi Yamada, Tamotsu Andou, Osamu Arisaka
Leukotriene receptor antagonists (LTRAs) are identified as a monotherapy for asthma and allergic rhinitis; however, their use in children for treatment of these diseases has not been examined. Accordingly, the present study investigated the efficacy of pranlukast dry syrup for children with both pollinosis and asthma. The subjects were children receiving treatment for asthma who were also diagnosed with cedar pollen allergy. Patients were divided into a group that received continuous treatment with pranlukast (group A; n=20) and a group that commenced add-on treatment for pollinosis following the onset of symptoms (group B; n=20)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28904968/the-prevalence-of-ocular-allergy-and-comorbidities-in-chinese-school-children-in-shanghai
#2
Yanqing Feng, Xiangning Wang, Fang Wang, Rongming Liu, Lu Chen, Shuqin Wu, Xia Yang, Miaoying Chen, Yu-Qing Rao, Jing Li
OBJECTIVE: To investigate the prevalence and features of ocular allergy (OA) and comorbidities among school children in Shanghai, China. METHODS: This was a population-based cross-sectional study. Each participant completed an ISAAC-based questionnaire. The prevalence of OA symptoms, allergic rhinitis (AR) asthma, atopic dermatitis (AD), and sensitization to mites, pollen, and food was analyzed. RESULTS: A total of 724 and 942 completed questionnaires from the 7-9-year-old (young group) and the 12-14-year-old (teen group) groups were analyzed, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28901856/recent-patents-and-emerging-therapeutics-on-ocular-inflammation-and-allergy
#3
Vibhuti Francisco Agrahari, Zach Aulgur, Siddhant Thukral, Nikhil Dhall, Ryan Conely, Ashim K Mitra
BACKGROUND: Ocular inflammation and allergic eye diseases range from mild to severe may disturbs visual function and affects quality of life. Since these diseases require intensive therapies, the pathophysiology and treatments of these conditions are highlighted. OBJECTIVE: The ocular diseases caused by inflammation and allergy are extensively studied in this review to provide an overview of the newer compounds, novel delivery approaches, preclinical and clinical trials for treatment of the allergic conjunctivitis, dry eye syndrome, and uveitis...
September 11, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28886234/validation-of-the-mask-rhinitis-visual-analogue-scale-on-smartphone-screens-to-assess-allergic-rhinitis-control
#4
D Caimmi, N Baiz, L K Tanno, P Demoly, S Arnavielhe, R Murray, A A Bedbrook, K C Bergmann, G De Vries, W J Fokkens, J Fonseca, T Haahtela, T Keil, P Kuna, J Mullol, N Papadopoulos, G Passalacqua, B Samolinski, P V Tomazic, A Valiulis, M van Eerd, M Wickman, I Annesi-Maesano, J Bousquet
BACKGROUND: Visual Analogue Scale (VAS) is a validated tool to assess control in allergic rhinitis patients. OBJECTIVE: The aim of the present study was to validate the use of VAS in the MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) on smartphones screens to evaluate allergic rhinitis symptoms and disease control. METHODS: Each user filled 4 different VAS measuring overall, nasal, ocular and asthma symptoms at least once...
September 8, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28840310/topical-cis-urocanic-acid-prevents-ocular-surface-irritation-in-both-ige-independent-and-mediated-rat-model
#5
Hanna-Mari Jauhonen, Jarmo Laihia, Olli Oksala, Johanna Viiri, Reijo Sironen, Päivi Alajuuma, Kai Kaarniranta, Lasse Leino
PURPOSE: Our purpose was to investigate the effect of locally administered cis-urocanic (cis-UCA) in two experimental models of allergic conjunctivitis. METHODS: The compound 48/80 (C48/80)-induced ocular irritation model (IgE-independent) and the ovalbumin (OA)-induced ocular allergy model (IgE-mediated) were used to test and compare the effect of cis-UCA on dexamethasone, ketotifen and olopatadine. In the C48/80 model, clinical severity scoring from photographs, immunohistochemical analysis of nuclear Ki-67 antigen to quantify actively proliferating epithelial cells and of caspase-3 enzyme to identify apoptotic activity in the conjunctival tissue were used...
August 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28832741/supratarsal-injection-of-triamcinolone-for-severe-vernal-keratoconjunctivitis-in-children
#6
Alexandre Xavier da Costa, José Álvaro Pereira Gomes, Leonardo Guedes Candido Marculino, Vera Lucia Liendo, Telma Pereira Barreiro, Myrna Serapião Dos Santos
PURPOSE: To evaluate the use of supratarsal injection of triamcinolone acetonide in severe vernal keratoconjunctivitis (VKC) in children. METHODS: Patients included in this open clinical trial were those with severe VKC-associated with keratitis, gelatinous limbal infiltrates, and/or giant papillae, with a history of recurrence and resistance to conventional topical antiallergic agents. Patients were treated with a supratarsal injection of 20 mg triamcinolone acetonide...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28831678/evaluation-of-allergic-sensitization-in-lebanese-patients-with-allergic-conjunctivitis
#7
Nicolas Arej, Carla Irani, Youssef Abdelmassih, Elise Slim, Joelle Antoun, Riad Bejjani, Alexandre Schakal, Naji Waked
PURPOSE: To describe the profile of patients with allergic conjunctivitis (AC) regarding their demographics, symptomatology and specific allergen sensitization, in a Lebanese tertiary hospital. METHODS: Cross-sectional study conducted at the Hôtel-Dieu de France hospital (Beirut, Lebanon) during a period of 18 months. Patients with seasonal or perennial AC presenting for ophthalmic consultation had measurements of total and specific IgE. A matching group of patients with AC seen at the allergist office during the same period underwent skin prick tests (SPTs)...
August 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28736450/screening-survey-of-ocular-nasal-respiratory-and-skin-symptoms-in-manicurists-in-poland
#8
Marta Kieć-Świerczyńska, Dominika Świerczyńska-Machura, Dorota Chomiczewska-Skóra, Beata Kręcisz, Jolanta Walusiak-Skorupa
OBJECTIVES: Manicurists are exposed to various chemicals in nail and skin care products and may develop ocular, nasal, respiratory or skin adverse reactions to them. To investigate the occurrence of ocular, nasal, respiratory and skin problems among manicurists and to identify their causal factors, particularly allergic etiology and occupational origin. MATERIAL AND METHODS: Manicurists employed in beauty salons in the central region of Poland were invited to fill in the questionnaire and undergo medical examination, skin prick tests with common aeroallergens, patch tests with European Baseline Series and (Meth)Acrylates Series-Nails and spirometry...
July 12, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28656780/brimonidine-and-brinzolamide-for-treating-glaucoma-and-ocular-hypertension-a-safety-evaluation
#9
REVIEW
Jed Asher Lusthaus, Ivan Goldberg
Brimonidine tartrate and brinzolamide eye drops are often used as third and fourth line treatment options to reduce intraocular pressure (IOP) in the management of glaucoma and ocular hypertension. Better tolerated, more effective topical agents requiring once daily instillation including prostaglandin analogues and beta-blockers usually are preferred as initial therapy, unless there are contraindications. Brimonidine and brinzolamide are often required owing to progressive glaucoma or intolerances to or ineffectiveness of front-line agents...
September 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28576753/the-function-of-regulatory-t-cells-at-the-ocular-surface-review
#10
REVIEW
William Foulsham, Anna Marmalidou, Afsaneh Amouzegar, Giulia Coco, Yihe Chen, Reza Dana
Regulatory T cells (Tregs) are critical modulators of immune homeostasis. Tregs maintain peripheral tolerance to self-antigens, thereby preventing autoimmune disease. Furthermore, Tregs suppress excessive immune responses deleterious to the host. Recent research has deepened our understanding of how Tregs function at the ocular surface. This manuscript describes the classification, the immunosuppressive mechanisms, and the phenotypic plasticity of Tregs. We review the contribution of Tregs to ocular surface autoimmune disease, as well as the function of Tregs in allergy and infection at the ocular surface...
May 30, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28573997/allergen-specific-exposure-associated-with-high-immunoglobulin-e-and-eye-rubbing-predisposes-to-progression-of-keratoconus
#11
Rohit Shetty, Shraddha Sureka, Pallak Kusumgar, Swaminathan Sethu, Kanchan Sainani
We report two male children with persistent allergic eye disease (AED) and keratoconus (KC). Both presented with symptoms of vernal keratoconjunctivitis and decreased vision. In view of unrelenting AED, serum immunoglobulin E (IgE) quantification and identification of specific allergens were advised. Increased serum IgE levels were observed in both cases. Sunflower and sheep wool were identified as specific allergens for the first and second patient respectively by skin patch test. There was complete resolution of symptoms of AED in both patients following avoidance of causative allergens...
May 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28540507/treatment-satisfaction-during-sublingual-immunotherapy-with-a-five-grass-pollen-tablet-for-allergic-rhinoconjunctivitis-a-prospective-non-interventional-study
#12
Udo Schäfer, Andrea Kienle-Gogolok, Meike Hadler, Efstrathios Karagiannis, Sylvia Schnitzer
BACKGROUND: Sublingual immunotherapy (SLIT) is a safe/well-tolerated alternative to allergen injection immunotherapy for allergic rhinoconjunctivitis (ARC). Patient adherence is essential and patient-related outcome measures including treatment satisfaction are informative/indicative of adherence. OBJECTIVE: The aim was to assess treatment satisfaction with five-grass pollen tablet SLIT under real-life conditions. METHODS: Treatment satisfaction among adults taking SLIT with a five-grass pollen tablet for grass pollen-related ARC was assessed with QUARTIS, a self-report questionnaire dedicated to the management of patients treated with SLIT for ARC...
June 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28538875/particular-characteristics-of-atopic-eczema-in-tropical-environments-the-tropical-environment-control-for-chronic-eczema-and-molecular-assessment-teccema-cohort-study
#13
Jorge Sánchez, Andrés Sánchez, Ricardo Cardona
Background: Atopic dermatitis is a prevalent health problem in the world. Allergic sensitization is an important risk factor, but the roles of other factors, inherent in tropic region, are unknown. Objective: A cohort study was designed in a tropical city to investigate molecular and environmental risk factors for eczema, considering as particular features perennial exposure to mites, poor living conditions and others tropical characteristics. Methods: 433 patients were included at baseline and biological samples were collected during 24 months of follow-up...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28493047/effects-of-cpap-in-patients-with-obstructive-apnoea-is-the-presence-of-allergic-rhinitis-relevant
#14
A Cisternas, F Aguilar, J M Montserrat, M Àvila, M Torres, A Iranzo, J Berenguer, I Vilaseca
PURPOSE: The aim of the study is to compare the effects of continuous positive airway pressure (CPAP) on the nasal cavities of patients with obstructive sleep apnoea (OSA) and with or without allergic rhinitis (AR/nonAR). METHODS: This paper is a prospective, longitudinal study. Thirty-four consecutive CPAP treatment-adherent patients with OSA (17 AR and 17 nonAR) were evaluated before and 2 months after treatment, by means of clinical (otorhinolaryngological symptoms, daytime sleepiness, overall and rhinoconjunctivitis-specific quality of life), anatomical (otorhinolaryngological examination), functional (auditory function, tubal function, nasal airflow, and mucociliary clearance), and biological variables (nasal cytology)...
May 10, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28480834/the-conjunctiva-associated-lymphoid-tissue-in-chronic-ocular-surface-diseases
#15
Rodolfo Mastropasqua, Luca Agnifili, Vincenzo Fasanella, Mario Nubile, Agbeanda A Gnama, Gennaro Falconio, Paolo Perri, Silvio Di Staso, Cesare Mariotti
Ocular surface diseases (OSDs) represent a widely investigated field of research given their growing incidence and the negative impact on quality of life. During OSDs, cytokines generated by damaged epithelia trigger and deregulate the lymphoid cells composing the eye-associated lymphoid tissues, inducing an immune-mediated chronic inflammation that amplifies and propagates the disease during time. The conjunctiva-associated lymphoid tissue (CALT), given its particular position that permits immune cells covering the cornea, might play a crucial role in the development of OSDs...
May 8, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28387952/work-productivity-in-rhinitis-using-cell-phones-the-mask-pilot-study
#16
J Bousquet, M Bewick, S Arnavielhe, E Mathieu-Dupas, R Murray, A Bedbrook, D P Caimmi, O Vandenplas, P W Hellings, C Bachert, J M Anto, K C Bergmann, C Bindslev-Jensen, S Bosnic-Anticevich, J Bouchard, G W Canonica, N H Chavannes, A A Cruz, R Dahl, P Demoly, G De Vries, P Devillier, A Fink-Wagner, W J Fokkens, J Fonseca, N A Guldemond, T Haahtela, B Hellqvist-Dahl, J Just, T Keil, L Klimek, M L Kowalski, P Kuna, V Kvedariene, D Laune, D Larenas-Linnemann, J Mullol, A M Pereira, P Carreiro-Martins, E Melén, M Morais-Almeida, L Nogueira-Silva, R E O'Hehir, N G Papadopoulos, G Passalacqua, F Portejoie, D Price, D Ryan, B Samolinski, A Sheikh, F E R Simons, O Spranger, A Todo Bom, P V Tomazic, M Triggiani, A Valero, E Valovirta, A Valiulis, M van Eerd, M Wickman, I Young, T Zuberbier
Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app (Allergy Diary, Google Play Store and Apple App Store) collects data from daily visual analogue scales (VAS) for overall allergic symptoms (VAS-global measured), nasal (VAS-nasal), ocular (VAS-ocular) and asthma symptoms (VAS-asthma) as well as work (VAS-work)...
April 7, 2017: Allergy
https://www.readbyqxmd.com/read/28387947/diagnostic-tools-in-ocular-allergy
#17
A Leonardi, S Doan, J L Fauquert, B Bozkurt, P Allegri, F Marmouz, C Rondon, M Jedrzejczak, P Hellings, L Delgado, V Calder
Ocular allergy (OA) includes a group of common and less frequent hypersensitivity disorders frequently misdiagnosed and not properly managed. The diagnosis of OA is usually based on clinical history and signs and symptoms, with the support of in vivo and in vitro tests when identification of the specific allergen is required. To date, no specific test is available for the diagnosis of the whole spectrum of the different forms of OA. The lack of recommendations on diagnosis of OA is considered a medical need not only for allergists but also for ophthalmologists...
April 7, 2017: Allergy
https://www.readbyqxmd.com/read/28372717/ocular-emergencies-red-eye
#18
REVIEW
Andreina Tarff, Ashley Behrens
"Red eye" is used as a general term to describe irritated or bloodshot eyes. It is a recognizable sign of an acute/chronic, localized/systemic underlying inflammatory condition. Conjunctival injection is most commonly caused by dryness, allergy, visual fatigue, contact lens overwear, and local infections. In some instances, red eye can represent a true ocular emergency that should be treated by an ophthalmologist. A comprehensive assessment of red eye conditions is required to preserve the patients visual function...
May 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28336223/paediatric-idiopathic-limbal-stem-cell-deficiency
#19
Stephen J Vincent, Graham A Lee
Acquired limbal stem cell deficiency (LSCD) describes a condition in which the corneal limbal stem cells are altered or destroyed, typically due to ocular trauma, chronic allergy or inflammation. Idiopathic LSCD is a term used to describe limbal stem cell failure in the absence of any identifiable causative factor. While several cases of adult-onset LSCD have been identified previously, this case report describes a rare presentation of bilateral asymmetric idiopathic paediatric limbal stem cell deficiency in a sixteen-year-old male with an otherwise unremarkable ocular history...
March 20, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28265747/the-effect-of-allergic-rhinitis-with-positive-skin-prick-test-on-choroidal-thickness
#20
Alper Yenigun, Ahmet Elbay, Remzi Dogan, Orhan Ozturan, Mehmet Hakan Ozdemir
Allergic rhinitis is an inflammatory disease that develops through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing and itchy nose. This study was designed to investigate the effect of allergic rhinitis on choroidal thickness. This study was planned as a case-control study. This study performed in a tertiary referral center. The study included 61 patients with allergic rhinitis and 35 healthy subjects. Patients in both groups underwent skin prick test...
June 2017: European Archives of Oto-rhino-laryngology
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