keyword
MENU ▼
Read by QxMD icon Read
search

ocular allergy

keyword
https://www.readbyqxmd.com/read/27909980/omalizumab-in-severe-refractory-vernal-keratoconjunctivitis-in-children-case-series-and-review-of-the-literature
#1
Serge Doan, Flore Amat, Eric Gabison, Sarah Saf, Isabelle Cochereau, Jocelyne Just
INTRODUCTION: Vernal keratoconjunctivis (VKC) is a severe form of pediatric ocular allergy, characterized by acute and chronic corneoconjunctival inflammation that may lead to visual sequelae. Although topical immunosuppressive drugs such as cyclosporine are usually effective, some severe forms may be refractory and require prolonged steroid therapy. Very few papers report the use of omalizumab in VKC in the literature. In the present study, we describe our clinical experience with omalizumab in severe VKC children...
December 1, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27865948/neuronal-fc-epsilon-receptor-i-contributes-to-antigen-evoked-pruritus-in-a-murine-model-of-ocular-allergy
#2
Fan Liu, Lubin Xu, Naze Chen, Mo Zhou, Chunyan Li, Qian Yang, Yikuan Xie, Yuguang Huang, Chao Ma
Pruritus is the major symptom of ocular allergy but currently available treatments are often ineffective. Previous studies demonstrated that subpopulations of primary sensory neurons express Fc receptors and may contribute to antigen-specific pain. We investigated the role of neuronal Fc-epsilon Receptor I (FcεRI) in allergic ocular pruritus. Ovalbumin (OVA) was used as allergen together with alum adjuvant (OVA+alum) to produce a mouse model of ocular allergy with a significant elevation in the serum levels of both antigen-specific IgE and IgG...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27793114/knowledge-and-awareness-of-ocular-allergy-among-undergraduate-students-of-public-universities-in-ghana
#3
Samuel Kyei, Bernard Tettey, Kofi Asiedu, Agnes Awuah
BACKGROUND: Ocular allergy is a growing public health problem that greatly impacts the day-to-day life of sufferers and their families. Other aspects of their activities of daily living such as schooling, professional, and social life are affected hence an increased awareness and knowledge of ocular allergies, their detection and treatment is paramount. This study was to assess the level of knowledge and awareness of ocular allergy among undergraduate students of public universities in Ghana...
October 28, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27791954/ocular-beh%C3%A3-et-s-disease-is-less-complicated-with-allergic-disorders-a-nationwide-survey-in-japan
#4
Yukihiro Horie, Nobuyoshi Kitaichi, Kuniaki Hijioka, Koh-Hei Sonoda, Yoshitsugu Saishin, Takeshi Kezuka, Hiroshi Goto, Masaru Takeuchi, Satoshi Nakamura, Takashi Kimoto, Machiko Shimakawa, Mihori Kita, Sunao Sugita, Manabu Mochizuki, Junko Hori, Mitsuhiro Iwata, Jun Shoji, Masahide Fukuda, Toshikatsu Kaburaki, Jiro Numaga, Hidetoshi Kawashima, Astuki Fukushima, Takeshi Joko, Nanae Takai, Yoko Ozawa, Akira Meguro, Nobuhisa Mizuki, Kenichi Namba, Susumu Ishida, Shigeaki Ohno
OBJECTIVES: Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. METHODS: The study involved a large-scale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27786545/vitamin-d-levels-in-children-affected-by-vernal-keratoconjuctivitis
#5
Anna Maria Zicari, Arianna Cafarotti, Francesca Occasi, Valeria Lollobrigida, Marcella Nebbioso, Irene Pecorella, Giovanna De Castro, Alberto Spalice, Lorenzo Loffredo, Maria Pia Villa, Marzia Duse
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology remains still unclear although endocrine, genetic, neurogenic and environmental factors have been implied. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity...
October 27, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27785375/histamine-antagonist-bepotastine-suppresses-nasal-symptoms-caused-by-japanese-cedar-and-cypress-pollen-exposure
#6
Sho Kanzaki, Kazuhiro Hashiguchi, Ken-Ichiro Wakabayashi, Kiyochika Suematsu, Kimihiro Okubo
Objective: To determine the efficacy of the antihistamine bepotastine on treating nasal symptoms in patients with Japanese cedar and cypress pollinosis, based on two previous studies that looked at bepotastine OD's inhibitory effect on symptom onset after exposure. Design and methods: Randomized double-blind placebo controlled, parallel study. Twenty-eight volunteers with Japanese cedar and cypress pollinosis were randomly assigned into two experimental groups: a bepotastine-treated or a placebo control group...
2016: Journal of drug assessment
https://www.readbyqxmd.com/read/27755287/biofilm-formation-on-bandage-contact-lenses-worn-by-patients-with-the-boston-type-1-keratoprosthesis-a-pilot-comparison-study-of-prophylactic-topical-vancomycin-15-mg-ml-and-linezolid-0-2
#7
Asim V Farooq, Joshua H Hou, Sarmad Jassim, Zeeshan Haq, Elmer Y Tu, Jose de la Cruz, Maria S Cortina
OBJECTIVES: To determine the rate of biofilm formation on bandage contact lenses worn by patients with the Boston type 1 keratoprosthesis (K-Pro) while on prophylactic topical vancomycin versus linezolid. METHODS: Patients wearing a bandage contact lens (BCL) with a K-Pro were eligible for enrollment. After irrigation of the ocular surface with 5% povidone-iodine solution, each patient was placed on either topical vancomycin 15 mg/mL or linezolid 0.2% BID for one month...
October 13, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27738400/evaluation-of-the-patients-diagnosed-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-single-center-experience
#8
Şükrü Çekiç, Yakup Canıtez, Nihat Sapan
AIM: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years. MATERIAL AND METHODS: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludağ University School of Medicine were included in this study...
September 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27650868/mechanisms-safety-and-efficacy-of-a-b-cell-epitope-based-vaccine-for-immunotherapy-of-grass-pollen-allergy
#9
Petra Zieglmayer, Margarete Focke-Tejkl, René Schmutz, Patrick Lemell, René Zieglmayer, Milena Weber, Renata Kiss, Katharina Blatt, Peter Valent, Frank Stolz, Hans Huber, Angela Neubauer, Anette Knoll, Friedrich Horak, Rainer Henning, Rudolf Valenta
BACKGROUND: We have developed a recombinant B cell epitope-based vaccine (BM32) for allergen-specific immunotherapy (AIT) of grass pollen allergy. The vaccine contains recombinant fusion proteins consisting of allergen-derived peptides and the hepatitis B surface protein domain preS as immunological carrier. METHODS: We conducted a randomized, double-blind, placebo-controlled AIT study to determine safety, clinical efficacy and immunological mechanism of three subcutaneous injections of three BM32 doses adsorbed to aluminum hydroxide versus aluminum hydroxide (placebo) applied monthly to grass pollen allergic patients (n=70)...
September 2016: EBioMedicine
https://www.readbyqxmd.com/read/27628585/ophthalmic-manifestations-of-paederus-dermatitis
#10
Pawan Prasher, Mandeep Kaur, Shakeen Singh, Harpreet Kaur, Madhu Bala, Silonie Sachdeva
PURPOSE: To report the pattern of ophthalmic manifestations associated with Paederus dermatitis (PD). SETTING: Department of Ophthalmology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India. DESIGN: Clinic-based retrospective study. METHODS: Medical charts of patients presenting to the eye clinic with clinical features consistent with the diagnosis of PD from May 1, 2014 to April 30, 2016 were retrospectively reviewed...
September 15, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27600171/glucocorticoid-action-in-human-corneal-epithelial-cells-establishes-roles-for-corticosteroids-in-wound-healing-and-barrier-function-of-the-eye
#11
Mahita Kadmiel, Agnes Janoshazi, Xiaojiang Xu, John A Cidlowski
Glucocorticoids play diverse roles in almost all physiological systems of the body, including both anti-inflammatory and immunosuppressive roles. Synthetic glucocorticoids are one of the most widely prescribed drugs and are used in the treatment of conditions such as autoimmune diseases, allergies, ocular disorders and certain types of cancers. In the interest of investigating glucocorticoid actions in the cornea of the eye, we established that multiple cell types in mouse corneas express functional glucocorticoid receptor (GR) with corneal epithelial cells having robust expression...
November 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27595139/classical-dendritic-cells-mediate-fibrosis-directly-via-the-retinoic-acid-pathway-in-severe-eye-allergy
#12
Sarah D Ahadome, Rose Mathew, Nancy J Reyes, Priyatham S Mettu, Scott W Cousins, Virginia L Calder, Daniel R Saban
Fibrosis is a shared end-stage pathway to lung, liver, and heart failure. In the ocular mucosa (conjunctiva), fibrosis leads to blindness in trachoma, pemphigoid, and allergy. The indirect fibrogenic role of DCs via T cell activation and inflammatory cell recruitment is well documented. However, here we demonstrate that DCs can directly induce fibrosis. In the mouse model of allergic eye disease (AED), classical CD11b(+) DCs in the ocular mucosa showed increased activity of aldehyde dehydrogenase (ALDH), the enzyme required for retinoic acid synthesis...
August 4, 2016: JCI Insight
https://www.readbyqxmd.com/read/27585059/emerging-therapeutics-for-ocular-surface-disease
#13
Brett P Bielory, Steven P Shah, Terrence P O'Brien, Victor L Perez, Leonard Bielory
PURPOSE OF REVIEW: The present review provides an overview on the potential of different systemic and topical treatments in chronic forms of ocular allergy and dry eye disorder (DED). The impact on anterior surface of ocular inflammatory disorder encompasses an array of conditions, which are frequently underreported. This can contribute to underdiagnoses and ineffective management from healthcare providers such as an allergist and/or ophthalmologist who routinely provide care for these common disorders...
October 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27525014/reduced-work-academic-performance-and-quality-of-life-in-patients-with-allergic-rhinitis-and-impact-of-allergen-immunotherapy
#14
A Roger, E Arcalá Campillo, M C Torres, C Millan, I Jáuregui, E Mohedano, S Liñan, P Verdu, N Rubira, M Santaolalla, P González, A Orovitg, E Villarrubia
BACKGROUND: Allergic rhinitis (AR) is characterised by burdensome nasal and/or ocular symptoms. This inflammatory disease can be debilitating and thus result in considerable health-related and economic consequences. METHODS: In a cross-sectional study, adult subjects with AR (N = 683) completed three allergy-specific questionnaires that assessed the impact of AR on the work/academic performance, daily activities, health-related quality of life (HRQOL), and satisfaction with allergen immunotherapy (AIT)...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27519152/method-for-single-illumination-source-combined-optical-coherence-tomography-and-fluorescence-imaging-of-fluorescently-labeled-ocular-structures-in-transgenic-mice
#15
Ryan P McNabb, Tomas Blanco, Howard M Bomze, Henry C Tseng, Daniel R Saban, Joseph A Izatt, Anthony N Kuo
In vivo imaging permits longitudinal study of ocular disease processes in the same animal over time. Two different in vivo optical imaging modalities - optical coherence tomography (OCT) and fluorescence - provide important structural and cellular data respectively about disease processes. In this Methods in Eye Research article, we describe and demonstrate the combination of these two modalities producing a truly simultaneous OCT and fluorescence imaging system for imaging of fluorescently labeled animal models...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27516741/ophthalmic-combination-of-surr9-c84a-and-trichostatin-a-targeting-molecular-pathogenesis-of-alkali-burn
#16
Kislay Roy, Bhasker Sriramoju, Rupinder K Kanwar, Jagat R Kanwar
BACKGROUND: Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries. METHODS: We investigated the synergistic regenerative potential of dominant negative survivin mutant (SurR9-C84A) and histone deacetylase (HDAC) inhibitor trichostatin-A (TSA) against alkali burn and corneal haze using human keratocytes and rabbit alkali burn model (Female New Zealand white rabbits). RESULTS: Combination of SurR9-C84A and TSA suppressed levels of transforming growth factor (TGF)-β, alpha smooth-muscle actin (α-SMA), fibronectin and HDAC1, leading to apoptosis in myofibroblast cells and, showed the potential to clear the corneal haze...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27505314/pediatric-keratoconus-in-a-tertiary-referral-center-incidence-presentation-risk-factors-and-treatment
#17
Sylvain El-Khoury, Youssef Abdelmassih, Adib Hamade, Elise Slim, Carole G Cherfan, Elias Chelala, Jamal Bleik, Elias F Jarade
PURPOSE: To report the incidence, clinical presentation, risk factors, and treatment outcome of pediatric keratoconus in a tertiary referral eye hospital in Beirut, Lebanon. METHODS: In this retrospective study, the authors evaluated all patients with keratoconus 14 years or younger newly diagnosed at the Beirut Eye Specialist Hospital, Beirut, Lebanon, between January 2010 and December 2014. The incidence of pediatric keratoconus among all pediatric patients and among patients with keratoconus of all ages was assessed...
August 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27504320/therapeutic-effect-of-0-1-tacrolimus-eye-ointment-in-allergic-ocular-diseases
#18
Rakesh K Barot, Satish C Shitole, Nupur Bhagat, Deepak Patil, Pawan Sawant, Kalpita Patil
INTRODUCTION: Allergic Ocular Diseases (AODs) like Atopic Keratoconjunctivitis (AKC) and Vernal Keratoconjunctivitis (VKC) are chronic forms of ocular allergy that can cause severe visual complications. Pathogenesis of AODs is uncertain and treatment has been a challenge for ophthalmologists. Tacrolimus, a 23-member cyclic macrolide lactone derived from [streptomyces tsukubaensis] now in ointment form has been successfully used in AODs. AIM: To study the therapeutic effect of 0...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27490123/an-update-on-ocular-allergy
#19
Marcus Shaker, Erin Salcone
PURPOSE OF REVIEW: The update reviews prevalence, classification, cause, and treatment options for allergic eye disease. RECENT FINDINGS: The incidence of allergic eye disease is underreported but may affect almost all patients with allergic rhinitis. Increased rates of oculonasal symptoms have been reported in the United States resulting in significant economic expenditures. The spectrum of allergic conjunctivitis and its differential considerations include seasonal and perennial conjunctivitis, vernal and atopic keratoconjunctivitis, and giant papillary conjunctivitis...
October 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27468241/a-review-of-the-clinical-efficacy-and-safety-of-mp-azeflu-a-novel-intranasal-formulation-of-azelastine-hydrochloride-and-fluticasone-propionate-in-clinical-studies-conducted-during-different-allergy-seasons-in-the-us
#20
REVIEW
Bruce M Prenner
A novel intranasal formulation of azelastine HCl (AZE, an antihistamine) and fluticasone propionate (FP, a corticosteroid) in a single spray (MP-AzeFlu [Dymista®]) was studied in four randomized, double-blind, placebo-controlled trials of patients with seasonal allergic rhinitis conducted in the US. Study sites were distributed so that all major US geographic regions and the prevalent pollens within these regions were represented. Spring and summer studies included patients aged 12 years and older with allergy to grass and tree pollens...
2016: Journal of Asthma and Allergy
keyword
keyword
58633
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"