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Vicki Osborne, Deborah Layton, Carole Fogg, Edward Tong, Saad A W Shakir
OBJECTIVES: The aim of the study was to identify any unexpected clinical events associated with starting the new CFC-free formulation of Atrovent(®) MDI in general practice in England. METHODS: An active surveillance cohort study was conducted with a focus on selected clinical events, including respiratory symptoms, in past users of Atrovent(®) CFC MDI ('switchers') and Atrovent(®) naïve users. Incidence density rate ratios (with 99% confidence intervals) for events occurring in the first 3 months of exposure (risk period-ID1-3 ) compared to 3 months prior to starting treatment (reference period-IDR ) were calculated...
October 9, 2017: International Journal of Pharmacy Practice
N S Airapetova, E B Polikanova, O V Kulikova, O V Nitchenko, L A Sizyakova, N A Derevnina
This paper was designed to report the results of comparative clinical and functional studies involving 89 patients who presented with moderately severe chronic obstructive pulmonary disease and were given the combined treatment with yellow turpentine bathtubs and bronchodilators inhalations with the use of a nebulizer. The patients comprising group 1 (n=29) were treated with yellow turpentine bathtubs and bronchodilators inhalations, those making up group 2 (n=30) received monotherapy with yellow turpentine bathtubs alone, and the patients included in group 3 (n=3) served as controls treated with the use of therapeutic physical exercises and symptomatic medications analogous to those given to the patients of the two former groups...
July 2015: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
M Hedaiaty, N Eizadi-Mood, A M Sabzghabaee
Amlodipine overdose can be life-threatening when manifesting as noncardiogenic pulmonary edema. Treatment remains challenging. We describe a case of noncardiogenic pulmonary edema without refractory hypotension and bradycardia after ingestion of 500 milligram amlodipine with suicidal intent. Mechanical ventilation, dexamethasone, atrovent HFA (ipratropium), pulmicort inhalation, and antibiotic therapy were used for the management. Length of hospital stay was 11 days. The patient was discharged with full recovery...
2015: Case Reports in Emergency Medicine
Mohammad Waleed, Ali Raza, Tariq Minhaj, Timothy Houghton
A 67-year-old woman presented to the accident and emergency department with central chest pain for the past 4 months. She described the pain as severe, retrosternal, intermittent, indigestion/burning type, with radiations to the left arm. She had used antacids with no relief. Her medical history included hypertension, chronic obstructive pulmonary disease, pulmonary fibrosis, left mastectomy for breast cancer, hypercholesterolaemia and osteoarthritis. Her medications included anastrazole, indapamide, perindopril, aspirin, clopidogrel, atorvastatin, salbutamol and atrovent inhalers...
July 11, 2014: BMJ Case Reports
Katie L Tataris, Joseph M Weber, Leslee Stein-Spencer, Steven E Aks
BACKGROUND: Snorting or smoking heroin is a known trigger of acute asthma exacerbation. Heroin abuse may be a risk factor for more severe asthma exacerbations and intubation. Heroin and other opioids provoke pulmonary bronchoconstriction. Naloxone may play a role in decreasing opioid-induced bronchospasm. There are no known clinical cases describing the effect of naloxone on opioid-induced bronchospasm. METHODS: This is an observational study in which nebulized naloxone was administered to patients with suspected heroin-induced bronchospasm...
April 2013: American Journal of Emergency Medicine
Handoko Adi, Paul M Young, Daniela Traini
OBJECTIVES: The formulation of multi-drug pressurised metered dose inhalers (pMDIs) opens up exciting therapeutic opportunities for the treatment of asthma and chronic obstructive pulmonary disease (COPD). We have investigated the formulation of a solution-based triple therapy pMDI containing ipratropium, formoterol, budesonide and ethanol as co-solvent. METHODS: This system was characterised for in-vitro performance and compared with marketed pMDIs (Atrovent and Symbicort)...
September 2012: Journal of Pharmacy and Pharmacology
Mohammed Ali
A novel method for analyzing electromechanical properties (e.g., size, electrostatic charge, polarity) of therapeutic aerosols produced by four different commercially available pressurized metered dose inhalers (pMDIs), including Albuterol™, Atrovent™, Qvar™, and Ventolin™, is presented. Respiratory drug particles aerosolized from pulmonary drug delivery devices may not only have different aerodynamic particle size distributions but also electrostatic charge distributions. The interactive effects of these two electromechanical properties on regional deposition of inhaled aerosols in the lung airway have been acknowledged by the investigators of aerosol medicine research, which requires precise quantification for analytical perspective...
July 2010: PDA Journal of Pharmaceutical Science and Technology
Q T Dinh, H Suhling, A Fischer, A Braun, T Welte
Airway nerves have the capacity to control airway functions via neuronal reflexes and through neuromediators and neuropeptides. Neuronal mechanisms are known to play a key role in the initiation and modulation of airway hyperresponsiveness and inflammation. Therefore, the nerve fibres may contribute to airway narrowing in asthma and COPD. In addition to the traditional transmitters such as norepinephrine in postganglionic sympathetic nerve fibres and acetylcholine in parasympathetic nerve fibres, a large number of neuropeptides have been identified to have different pharmacological effects on the muscle tone of the vessels and bronchi, mucus secretion and immune cells...
May 2011: Pneumologie
Fei Zheng, Guo-qin Li, Yong-jun Bian
OBJECTIVE: To observe the clinical effects of Chinese Medicine internal-external combined therapy (consisting of orally taking Chinese drugs and external acupoint sticking) for treatment of chronic obstructive pulmonary disease (COPD) in the stable period. METHODS: One hundred and seventy-eight COPD patients were randomly assigned to two groups, the control group was treated with Atrovent Metered Dose Inhalation, oral taking Mucosolvan and Bailing Capsule, and acupoint sticking with dummy plaster; the treatment group was treated with ipratropium bromide aerosol, ambroxol hydrochloride, Chinese recipe prescribed according to syndrome differentiation, and combined with acupoint sticking with Xiaochuan Plaster applied in winters and summers (3 times in a season)...
April 2010: Chinese Journal of Integrated Traditional and Western Medicine
Philip Chi Lip Kwok, Sebastiaan J Trietsch, Michiko Kumon, Hak-Kim Chan
BACKGROUND: Liquid droplets can be spontaneously charged in the absence of applied electric fields by spraying. It has been shown by computational simulation that charges may influence particle deposition in the airways. The electrostatic properties of jet nebulized aerosols and their potential effects on lung deposition have hardly been studied. A modified electrical low pressure impactor (ELPI) was employed to characterize the aerosol charges generated from jet nebulized commercial products...
June 2010: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Daniel L Norwood, James O Mullis, Thomas N Feinberg, Letha K Davis
N-nitrosamines are chemical entities, some of which are considered to be possible human carcinogens, which can be found at trace levels in some types of foods, tobacco smoke, certain cosmetics, and certain types of rubber. N-nitrosamines are of regulatory concern as leachables in inhalation drug products, particularly metered dose inhalers, which incorporate rubber seals into their container closure systems. The United States Food and Drug Administration considers N-nitrosamines (along with polycyclic aromatic hydrocarbons and 2-mercaptobenzothiazole) to be "special case" leachables in inhalation drug products, meaning that there are no recognized safety or analytical thresholds and these compounds must therefore be identified and quantitated at the lowest practical level...
July 2009: PDA Journal of Pharmaceutical Science and Technology
M E M Hassouna, S A A Elsuccary
Ipratropium (IP(+)) ion-selective electrode (ISE) has been constructed from poly(vinyl chloride) matrix membrane containing Ipratropium-tetraphenylborate (IP-TPB) as the electroactive component using 2-nitrophenyloctylether as plasticizer. The electrode exhibits near Nernstian response to Ipratropium bromide (IPBr) over the concentration range 10(-5) to 10(-2) mol L(-1) and detection limit 5.1x10(-6) mol L(-1). The electrode offers significant advantages including long lifetime (>2 months), excellent stability and reproducibility, fast response time (<10 s), wide pH working range (pH 2-9), high thermal stability (isothermal coefficient 0...
June 15, 2008: Talanta
Wolfgang Kamin, Astrid Schwabe, Irene Krämer
The objective of this in-vitro study was to determine whether mixtures of three nebulizable drugs are physicochemically compatible. Drug combinations were prepared by mixing the content of one respule Flutide forte "ready to use" (fluticasone propionate) with 2 milliliter Atrovent LS (ipratropium bromide) and 0.5 milliliter Sultanol inhalation solution (albuterol sulfate). Test suspensions were stored at room temperature and exposed to normal laboratory light for 5 hours. Concentrations of fluticasone- 17-propionate, ipratropium bromide, and albuterol sulfate were determined by using stability-indicating high-performance liquid chromatography assays with ultraviolet detection...
2007: International Journal of Chronic Obstructive Pulmonary Disease
Solange Béliveau, Pierre Gaudreault, Lise Goulet, Marie-Noëlle Primeau, Danielle Marcoux
BACKGROUND: Soy lecithin is widely used as an emulsifier, not only in topical skin care products but also in various drugs administered either topically, orally, or intravenously or by inhalation. Patients strongly allergic to soy and/or peanuts can develop an anaphylactic reaction when exposed to soy lecithin. METHOD: We report a 3-year-old asthmatic boy, allergic to peanuts, who was treated at the emergency department for an exacerbation of asthma following an upper respiratory tract infection...
January 2008: Journal of Cutaneous Medicine and Surgery
I Krämer, A Schwabe, R Lichtinghagen, W Kamin
Patients suffering from cystic fibrosis (CF) often need to inhale multiple doses of different nebulizable drugs per day. Patients attempt to shorten the time consuming administration procedure by mixing drug solutions/suspensions for simultaneous inhalation. The objective of this experimental study was to determine whether mixtures of Pulmozyme inhalation solution with Atrovent or Sultano are physicochemically compatible. Drug combinations were prepared in accordance with the product information and clinical practice by mixing the content of one respule Pulmozyme with 2 mL Atrovent LS and 0...
October 2007: Die Pharmazie
T V Lobzhanidze, L P Sikharulidze, M R Kurdegeliia
The present review of literature, dedicated to the usage of anticholinergic drug Tiotropium Bromide (Spiriva) in the treatment of stable chronic obstructive pulmonary disease (COPD), demonstrates its supremacy over Ipratropium Bromide (Atrovent) and sympathomimetics in relation to broncholytic effect as well as in the capacity to improve the clinical symptoms of the disease, the quality of life for the patients, prevent the exacerbations, reduce the frequency of hospitalization of the diseased in the stationer and raise the physical capacity of work...
July 2007: Georgian Medical News
Martyn F Biddiscombe, Peter J Barnes, Omar S Usmani
Pharmacological aerosols of precisely controlled particle size and narrow dispersity can be generated using the spinning-top aerosol generator (STAG). The ability of the STAG to generate monodisperse aerosols from solutions of raw drug compounds makes it a valuable research instrument. In this paper, the versatility of this instrument has been further demonstrated by aerosolizing a range of commercially available nebulized pulmonary therapy preparations. Nebules of Flixotide (fluticasone propionate), Pulmicort (budesonide), Combivent (salbutamol sulphate and ipratropium bromide), Bricanyl (terbutaline sulphate), Atrovent(ipratropium bromide), and Salamol (salbutamol sulphate) were each mixed with ethanol and delivered to the STAG...
2006: Journal of Aerosol Medicine: the Official Journal of the International Society for Aerosols in Medicine
Kenneth T Kim, Edward Kerwin, Lawrence Landwehr, Jonathan A Bernstein, Dawn Bruner, Duane Harris, Kristin Drda, Jack Wanger, Chester C Wood et al.
BACKGROUND: Rhinorrhea from common colds or allergies in children is similar to that in adults, yet there are few data on the use of ipratropium bromide nasal spray in children younger than 5 years. OBJECTIVE: To evaluate the safety and efficacy of 0.06% ipratropium bromide nasal spray in 2- to 5-year-old children with rhinorrhea from a common cold or allergies. METHODS: A total of 230 children (43 with common colds and 187 with allergies) participated in an open-label, multicenter study...
January 2005: Annals of Allergy, Asthma & Immunology
L I Volkova, A A Budkova, N N Filonova, E I Khristoliubova, E B Kutuzova, N V Koroleva, T T Radzivil, Z R Aminova, A G Chuchalin
AIM: To compare efficacy of atrovent alone and in combination with erespal in patients with chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: Of 80 participants of the trial (51 male and 29 female--63.75 and 36.25%, respectively) who had CB or COPD, 39 patients (28 with CB and 11 with COPD) received 6-month combined treatment with erespal (160 mg/day) and atrovent (160 mcg/day) and 41 patients (32 with CB and 9 with COPD) received atrovent monotherapy in the same dosage...
2004: Terapevticheskiĭ Arkhiv
Mark Crampton, Rob Kinnersley, Jon Ayres
Evidence from both the air pollution and inhaled aerosol therapy fields suggests that the physiological impact of fine and ultrafine aerosols (defined as those below 1000 and 100 nm aerodynamic diameter, respectively) may be greater than their mass or volume of active agent alone might suggest. Traditionally, Andersen impactors and liquid impingers have been used for the sizing of particles produced by pressurized metered dose inhalers (pMDIs). However, these fail adequately to size particles in the ultrafine range (<100 nm aerodynamic diameter)...
2004: Journal of Aerosol Medicine: the Official Journal of the International Society for Aerosols in Medicine
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