Zeynep Balçıkanlı, Irem Culha, Pelin Dilsiz, Mehmet Serif Aydin, Nilay Ates, Mustafa Caglar Beker, Saltuk Bugra Baltaci, Halil I Koc, Ahmet Yigitbasi, Mustafa Gündogar, Thorsten R Doeppner, Dirk M Hermann, Ertugrul Kilic
Spinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar mood disorder, lithium was reported to have neuroprotective activity in different neurodegenerative conditions, including SCI. In SCI, the effects of lithium on long-term neurological recovery and neuroplasticity have not been assessed. We herein investigated the effects of intraperitoneally administered lithium chloride (LiCl) on motor coordination recovery, electromyography (EMG) responses, histopathological injury and remodeling, and axonal plasticity in mice exposed to spinal cord transection...
2022: Frontiers in Cellular Neuroscience